The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-18a [Full Text] [PDF]  

Special Features:

Karsten Müssig, Mehmet Özer Öksüz, Christina Pfannenberg, Patrick Adam, Jozef Zustin, Stefan Beckert, and Stephan Petersenn

IMAGE IN ENDOCRINOLOGY:Somatostatin Receptor Expression in an Epitheloid Hemangioma Causing Oncogenic Osteomalacia
J Clin Endocrinol Metab 2009 94: 4123-4124 , doi:10.1210/jc.2009-0927 [Full Text] [PDF]  

Editorials:

Michael A. Nauck and Juris J. Meier

EDITORIAL:For Insulinomas, No Place to Hide
J Clin Endocrinol Metab 2009 94: 4125-4126 doi:10.1210/jc.2009-2023 [Full Text] [PDF]  

Endocrine Care:

Rita Rastogi Kalyani, Manuel Franco, Adrian S. Dobs, Pamela Ouyang, Dhananjay Vaidya, Alain Bertoni, Susan M. Gapstur, and Sherita Hill Golden

The Association of Endogenous Sex Hormones, Adiposity, and Insulin Resistance with Incident Diabetes in Postmenopausal Women
J Clin Endocrinol Metab 2009 94: 4127-4135 , doi:10.1210/jc.2009-0910 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In postmenopausal women, higher bioavailable testosterone, higher estradiol, and lower sex hormone binding globulin predict diabetes with variable contributions from adiposity and insulin resistance.

Roksana Karim, Wendy J. Mack, Howard N. Hodis, Subir Roy, and Frank Z. Stanczyk

Influence of Age and Obesity on Serum Estradiol, Estrone, and Sex Hormone Binding Globulin Concentrations following Oral Estrogen Administration in Postmenopausal Women
J Clin Endocrinol Metab 2009 94: 4136-4143 , doi:10.1210/jc.2009-0643 [Abstract] [Full Text] [PDF]  
It may be useful to consider age and obesity when prescribing hormone therapy to minimize the risk of venous thrombosis or stroke in postmenopausal women.

Pauliina Utriainen, Jarmo Jääskeläinen, Anne Saarinen, Esko Vanninen, Outi Mäkitie, and Raimo Voutilainen

Body Composition and Bone Mineral Density in Children with Premature Adrenarche and the Association of LRP5 Gene Polymorphisms with Bone Mineral Density
J Clin Endocrinol Metab 2009 94: 4144-4151 , doi:10.1210/jc.2009-0315 [Abstract] [Full Text] [PDF]  
Children with premature adrenarche have increased areal bone mineral density determined by their enhanced growth in height.

Susan M. Resnick, Mark A. Espeland, Yang An, Pauline M. Maki, Laura H. Coker, Rebecca Jackson, Marcia L. Stefanick, Robert Wallace, Stephen R. Rapp for the Women’s Health Initiative Study of Cognitive Aging Investigators

Effects of Conjugated Equine Estrogens on Cognition and Affect in Postmenopausal Women with Prior Hysterectomy
J Clin Endocrinol Metab 2009 94: 4152-4161 , doi:10.1210/jc.2009-1340 [Abstract] [Full Text] [PDF]  
Conjugated equine estrogen does not appear to have enduring effects on domain-specific cognitive changes over time in older postmenopausal women with prior hysterectomy, indicating an overall lack of benefit or harm to specific cognitive functions.

Oscar Rubio-Cabezas, Ann-Marie Patch, Jayne A. L. Minton, Sarah E. Flanagan, Emma L. Edghill, Khalid Hussain, Amina Balafrej, Asma Deeb, Charles R. Buchanan, Ian G. Jefferson, Angham Mutair, the Neonatal Diabetes International Collaborative Group, Andrew T. Hattersley, and Sian Ellard

Wolcott-Rallison Syndrome Is the Most Common Genetic Cause of Permanent Neonatal Diabetes in Consanguineous Families
J Clin Endocrinol Metab 2009 94: 4162-4170 , doi:10.1210/jc.2009-1137 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Wolcott-Rallison syndrome is the most common genetic subtype of permanent neonatal diabetes in consanguineous pedigrees. Homozygosity mapping has proved effective to identify candidates for genetic testing before the full clinical diagnosis is evident.

R. Elisei, M. Schlumberger, A. Driedger, C. Reiners, R. T. Kloos, S. I. Sherman, B. Haugen, C. Corone, E. Molinaro, L. Grasso, S. Leboulleux, I. Rachinsky, M. Luster, M. Lassmann, N. L. Busaidy, R. L. Wahl, F. Pacini, S. Y. Cho, J. Magner, A. Pinchera, and P. W. Ladenson

Follow-Up of Low-Risk Differentiated Thyroid Cancer Patients Who Underwent Radioiodine Ablation of Postsurgical Thyroid Remnants after Either Recombinant Human Thyrotropin or Thyroid Hormone Withdrawal
J Clin Endocrinol Metab 2009 94: 4171-4179 , doi:10.1210/jc.2009-0869 [Abstract] [Full Text] [PDF]  
After a mean follow up of 3.7 years, no differences were found in the success of thyroid remnant 131-I therapy or clinical outcomes between patients who were prepared by endogenous TSH stimulation and those prepared with exogenous recombinant human TSH.

Patrik Romerius, Olof Ståhl, Christian Moëll, Thomas Relander, Eva Cavallin-Ståhl, Thomas Wiebe, Yvonne Lundberg Giwercman, and Aleksander Giwercman

Hypogonadism Risk in Men Treated for Childhood Cancer
J Clin Endocrinol Metab 2009 94: 4180-4186 , doi:10.1210/jc.2009-0337 [Abstract] [Full Text] [PDF]  
Adult male survivors of childhood cancer are at risk of hypogonadism, which should be acknowledged in the long-term follow up of these men.

Annalisa Nicoletti, Milva Bal, Giuseppina De Marco, Lilia Baldazzi, Patrizia Agretti, Soara Menabò, Elisa Ballarini, Alessandro Cicognani, Massimo Tonacchera, and Alessandra Cassio

Thyrotropin-Stimulating Hormone Receptor Gene Analysis in Pediatric Patients with Non-Autoimmune Subclinical Hypothyroidism
J Clin Endocrinol Metab 2009 94: 4187-4194 , doi:10.1210/jc.2009-0618 [Abstract] [Full Text] [PDF]  
TSHR gene mutations were identified in 29% of children with non-autoimmune subclinical hypothyroidism not selected by neonatal screening.

Andrea Secco, Natascia di Iorgi, Flavia Napoli, Erika Calandra, Annalisa Calcagno, Michele Ghezzi, Costanza Frassinetti, Nadia Fratangeli, Stefano Parodi, Monica Benassai, Yvonne Leitner, Roberto Gastaldi, Renata Lorini, Mohamad Maghnie, and Giorgio Radetti

Reassessment of the Growth Hormone Status in Young Adults with Childhood-Onset Growth Hormone Deficiency: Reappraisal of Insulin Tolerance Testing
J Clin Endocrinol Metab 2009 94: 4195-4204 , doi:10.1210/jc.2009-0602 [Abstract] [Full Text] [PDF]  
Peak GH to ITT<5.62 µg/L and IGF-I <2.83 SDS are accurate diagnostic cut-off points for permanent GH deficiency in young adults with childhood-onset GH deficiency.

Roderick F. A. de Lind van Wijngaarden, Elbrich P. C. Siemensma, Dederieke A. M. Festen, Barto J. Otten, Edgar G. A. H. van Mil, Joost Rotteveel, Roelof J. H. Odink, G. C. B. (Karen) Bindels-de Heus, Mariëtte van Leeuwen, Danny A. J. P. Haring, Gianni Bocca, E. C. A. Mieke Houdijk, J. J. Gera Hoorweg-Nijman, René C. F. M. Vreuls, Petr E. Jira, A. S. Paul van Trotsenburg, Boudewijn Bakker, Eelco J. Schroor, Jan Willem Pilon, Jan M. Wit, Stenvert L. S. Drop, and Anita C. S. Hokken-Koelega

Efficacy and Safety of Long-Term Continuous Growth Hormone Treatment in Children with Prader-Willi Syndrome
J Clin Endocrinol Metab 2009 94: 4205-4215 , doi:10.1210/jc.2009-0454 [Abstract] [Full Text] [PDF]  
Long-term growth hormone treatment is effective and safe in children with Prader-Willi syndrome.

M. Sherlock, R. C. Reulen, A. Aragon Alonso, J. Ayuk, R. N. Clayton, M. C. Sheppard, M. M. Hawkins, A. S. Bates, and P. M. Stewart

ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly
J Clin Endocrinol Metab 2009 94: 4216-4223 , doi:10.1210/jc.2009-1097 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Radiotherapy, ACTH deficiency, and doses of hydrocortisone replacement therapy >25 mg per day are significantly associated with increased mortality in patients with acromegaly.

Shalender Bhasin, E. Jiaxiu He, Miwa Kawakubo, E. Todd Schroeder, Kevin Yarasheski, Gregory J. Opiteck, Alise Reicin, Fabian Chen, Raymond Lam, Jeffrey A. Tsou, Carmen Castaneda-Sceppa, Ellen F. Binder, Stanley P. Azen, and Fred R. Sattler

N-Terminal Propeptide of Type III Procollagen as a Biomarker of Anabolic Response to Recombinant Human GH and Testosterone
J Clin Endocrinol Metab 2009 94: 4224-4233 , doi:10.1210/jc.2009-1434 [Abstract] [Full Text] [PDF]  
Biomarkers that predict musculoskeletal response to anabolic therapies should expedite drug development; serum P3NP is a useful early predictive biomarker of anabolic response to growth hormone and testosterone.

David E. Henley, Georgina M. Russell, Jennie A. Douthwaite, Susan A. Wood, Fiona Buchanan, Rosemary Gibson, Wolfram W. Woltersdorf, James R. Catterall, and Stafford L. Lightman

Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy
J Clin Endocrinol Metab 2009 94: 4234-4242 , doi:10.1210/jc.2009-1174 [Abstract] [Full Text] [PDF]  
Untreated obstructive sleep apnea (OSA), compared to treated OSA, is associated with disturbances in hypothalamic-pituitary-adrenal axis functioning including altered ACTH and cortisol secretory dynamics, resulting in prolonged tissue exposure to disordered, elevated hormone levels which are ameliorated by 3 months compliant continuous positive airway pressure therapy.

Gerthe F. Kerkhof, Ralph W. J. Leunissen, Ruben H. Willemsen, Frank H. de Jong, Theo Stijnen, and Anita C. S. Hokken-Koelega

Influence of Preterm Birth and Birth Size on Gonadal Function in Young Men
J Clin Endocrinol Metab 2009 94: 4243-4250 , doi:10.1210/jc.2009-1036 [Abstract] [Full Text] [PDF]  
Preterm birth and small birth size for gestational age do not affect male gonadal function in early adulthood.

Andrea Secco, Natascia di Iorgi, Flavia Napoli, Erika Calandra, Michele Ghezzi, Costanza Frassinetti, Stefano Parodi, Maria Rosaria Casini, Renata Lorini, Sandro Loche, and Mohamad Maghnie

The Glucagon Test in the Diagnosis of Growth Hormone Deficiency in Children With Short Stature Younger than 6 Years
J Clin Endocrinol Metab 2009 94: 4251-4257 , doi:10.1210/jc.2009-0779 [Abstract] [Full Text] [PDF]  
Glucagon has a strong GH-releasing activity in young children with short stature. Normative data need to be established before use in clinical practice.

Robert H. Coker, Rick H. Williams, Sophie E. Yeo, Patrick M. Kortebein, Don L. Bodenner, Philip A. Kern, and William J. Evans

The Impact of Exercise Training Compared to Caloric Restriction on Hepatic and Peripheral Insulin Resistance in Obesity
J Clin Endocrinol Metab 2009 94: 4258-4266 , doi:10.1210/jc.2008-2033 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Compared to caloric restriction, weight loss induced entirely by exercise training promotes superior reductions in visceral adipose tissue and hepatic insulin resistance.

Clemens Bergwitz, Santanu Banerjee, Hilal Abu-Zahra, Hiroshi Kaji, Akimitsu Miyauchi, Toshitsugu Sugimoto, and Harald Jüppner

Defective O-Glycosylation due to a Novel Homozygous S129P Mutation Is Associated with Lack of Fibroblast Growth Factor 23 Secretion and Tumoral Calcinosis
J Clin Endocrinol Metab 2009 94: 4267-4274 , doi:10.1210/jc.2009-0961 [Abstract] [Full Text] [PDF]  
Tumoral calcinosis is caused by missense mutations in FGF23 which impair O-glycosylation of the mutant hormone, leading to poor secretion and loss-of-function.

J. Smith, K. Cianflone, S. Biron, F. S. Hould, S. Lebel, S. Marceau, O. Lescelleur, L. Biertho, S. Simard, J. G. Kral, and P. Marceau

Effects of Maternal Surgical Weight Loss in Mothers on Intergenerational Transmission of Obesity
J Clin Endocrinol Metab 2009 94: 4275-4283 , doi:10.1210/jc.2009-0709 [Abstract] [Full Text] [PDF] [Supplemental Data]  
This unique study of children aged 2.5–26 years old born after maternal anti-obesity surgery demonstrates significant improvement of cardio-metabolic markers sustained into adolescence.

Montserrat Balsells, A. García-Patterson, I. Gich, and R. Corcoy

Maternal and Fetal Outcome in Women with Type 2 Versus Type 1 Diabetes Mellitus: A Systematic Review and Metaanalysis
J Clin Endocrinol Metab 2009 94: 4284-4291 , doi:10.1210/jc.2009-1231 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Despite lower HbA1c, women with type 2 diabetes mellitus have similar, if not worse, fetal outcomes than those with type 1 diabetes.

Gert-Jan van der Heijden, Gianna Toffolo, Erica Manesso, Pieter J. J. Sauer, and Agneta L. Sunehag

Aerobic Exercise Increases Peripheral and Hepatic Insulin Sensitivity in Sedentary Adolescents
J Clin Endocrinol Metab 2009 94: 4292-4299 , doi:10.1210/jc.2009-1379 [Abstract] [Full Text] [PDF]  
A moderate aerobic exercise program that is well accepted by sedentary Hispanic adolescents significantly increases both peripheral and hepatic insulin sensitivity in lean and obese participants.

Bruno Lapauw, Youri Taes, Stefan Goemaere, Kaatje Toye, Hans-Georg Zmierczak, and Jean-Marc Kaufman

Anthropometric and Skeletal Phenotype in Men with Idiopathic Osteoporosis and Their Sons Is Consistent with Deficient Estrogen Action during Maturation
J Clin Endocrinol Metab 2009 94: 4300-4308 , doi:10.1210/jc.2009-0568 [Abstract] [Full Text] [PDF]  
Idiopathic osteoporosis in men involves trabecular and cortical bone through deficits in bone mineral density and cortical size, with features suggestive for deficient estrogen action.

Massimo Tonacchera, Giuseppina De Marco, Patrizia Agretti, Lucia Montanelli, Caterina Di Cosmo, Andrea Claudia Freitas Ferreira, Antonio Dimida, Eleonora Ferrarini, Helton Estrela Ramos, Claudia Ceccarelli, Federica Brozzi, Aldo Pinchera, and Paolo Vitti

Identification and Functional Studies of Two New Dual-Oxidase 2 (DUOX2) Mutations in a Child with Congenital Hypothyroidism and a Eutopic Normal-Size Thyroid Gland
J Clin Endocrinol Metab 2009 94: 4309-4314 , doi:10.1210/jc.2009-0426 [Abstract] [Full Text] [PDF]  
A new case of congenital hypothyroidism with a normally located thyroid gland and two new mutations in DUOX2 protein partially impairing H₂O₂ generation is described.

Channa N. Jayasena, Gurjinder M. K. Nijher, Owais B. Chaudhri, Kevin G. Murphy, Amita Ranger, Adrian Lim, Daksha Patel, Amrish Mehta, Catriona Todd, Radha Ramachandran, Victoria Salem, Gordon W. Stamp, Mandy Donaldson, Mohammad A. Ghatei, Stephen R. Bloom, and Waljit S. Dhillo

Subcutaneous Injection of Kisspeptin-54 Acutely Stimulates Gonadotropin Secretion in Women with Hypothalamic Amenorrhea, But Chronic Administration Causes Tachyphylaxis
J Clin Endocrinol Metab 2009 94: 4315-4323 , doi:10.1210/jc.2009-0406 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Subcutaneous administration of kisspeptin-54 acutely and potently stimulates gonadotrophin release in women with hypothalamic amenorrhoea, but twice-daily administration over a 2-week period leads to desensitisation to its effects.

Samantha Alvarez-Madrazo, Sandosh Padmanabhan, Bongani M. Mayosi, Hugh Watkins, Peter Avery, A. Michael Wallace, Robert Fraser, Eleanor Davies, Bernard Keavney, and John M. Connell

Familial and Phenotypic Associations of the Aldosterone Renin Ratio
J Clin Endocrinol Metab 2009 94: 4324-4333 , doi:10.1210/jc.2009-1406 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The aldosterone-to-renin ratio is continuously distributed, is influenced by genetic and environmental factors, and is not a marker of a distinct pathological abnormality.

Jacques Pantel, Marie Legendre, Sylvie Nivot, Séverine Morisset, Marie-Pierre Vie-Luton, Yves le Bouc, Jacques Epelbaum, and Serge Amselem

Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor
J Clin Endocrinol Metab 2009 94: 4334-4341 , doi:10.1210/jc.2009-1327 [Abstract] [Full Text] [PDF]  
The first case of recessive isolated GH deficiency with GH secretagogue receptor mutations underlines the importance of the ghrelin system in somatic growth.

Anat Ben-Shlomo, Herbert Schmid, Kolja Wawrowsky, Oxana Pichurin, Erika Hubina, Vera Chesnokova, Ning-Ai Liu, Michael Culler, and Shlomo Melmed

Differential Ligand-Mediated Pituitary Somatostatin Receptor Subtype Signaling: Implications for Corticotroph Tumor Therapy
J Clin Endocrinol Metab 2009 94: 4342-4350 , doi:10.1210/jc.2009-1311 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The SRIF receptor ligand pasireotide, unlike octreotide, signals predominantly through the SST5 receptor, thus providing a mechanistic rationale for use in treating Cushing’s disease.

Adi Cohen, X. Sherry Liu, Emily M. Stein, Donald J. McMahon, Halley F. Rogers, Jeanette LeMaster, Robert R. Recker, Joan M. Lappe, X. Edward Guo, and Elizabeth Shane

Bone Microarchitecture and Stiffness in Premenopausal Women with Idiopathic Osteoporosis
J Clin Endocrinol Metab 2009 94: 4351-4360 , doi:10.1210/jc.2009-0996 [Abstract] [Full Text] [PDF]  
Premenopausal women with idiopathic osteoporosis have marked trabecular microarchitectural deterioration at radius and tibia measured by high-resolution peripheral quantitative computed tomography.

Andrea D. Coviello, Susan Sam, Richard S. Legro, and Andrea Dunaif

High Prevalence of Metabolic Syndrome in First-Degree Male Relatives of Women with Polycystic Ovary Syndrome Is Related to High Rates of Obesity
J Clin Endocrinol Metab 2009 94: 4361-4366 , doi:10.1210/jc.2009-1333 [Abstract] [Full Text] [PDF]  
The high prevalence of metabolic syndrome in first degree male relatives of women affected by PCOS compared to similar men in the NHANES III population is attributable to higher rates of obesity than the general population.

José Gaal, Francien H. van Nederveen, Zoran Erlic, Esther Korpershoek, Rogier Oldenburg, Carsten C. Boedeker, Udo Kontny, Hartmut P. Neumann, Winand N. M. Dinjens, and Ronald R. de Krijger

Parasympathetic Paragangliomas Are Part of the Von Hippel-Lindau Syndrome
J Clin Endocrinol Metab 2009 94: 4367-4371 , doi:10.1210/jc.2009-1479 [Abstract] [Full Text] [PDF]  
Parasympathetic paragangliomas are a rare but true manifestation of Von Hippel-Lindau disease.

Steven A. Lietman, Yardena Tenenbaum-Rakover, Tjin Shing Jap, Wu Yi-Chi, Yang De-Ming, Changlin Ding, Najat Kussiny, and Michael A. Levine

A Novel Loss-of-Function Mutation, Gln459Arg, of the Calcium-Sensing Receptor Gene Associated with Apparent Autosomal Recessive Inheritance of Familial Hypocalciuric Hypercalcemia
J Clin Endocrinol Metab 2009 94: 4372-4379 , doi:10.1210/jc.2008-2484 [Abstract] [Full Text] [PDF]  
An extended kindred with familial hypocalciuric hypercalcemia possessed a novel inactivating mutation of the CaSR with highly variable biochemical phenotypes and apparent autosomal recessive inheritance.

Taneli Raivio, Yisrael Sidis, Lacey Plummer, Huaibin Chen, Jinghong Ma, Abir Mukherjee, Elka Jacobson-Dickman, Richard Quinton, Guy Van Vliet, Helene Lavoie, Virginia A. Hughes, Andrew Dwyer, Frances J. Hayes, Shuyun Xu, Susan Sparks, Ursula B. Kaiser, Moosa Mohammadi, and Nelly Pitteloud

Impaired Fibroblast Growth Factor Receptor 1 Signaling as a Cause of Normosmic Idiopathic Hypogonadotropic Hypogonadism
J Clin Endocrinol Metab 2009 94: 4380-4390 , doi:10.1210/jc.2009-0179 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Loss-of-function mutations in fibroblast growth factor receptor 1 underlie normosmic idiopathic hypogonadotropic hypogonadism, either alone or in combination with other gene defects.

María Solanas-Barca, Rocío Mateo-Gallego, Pilar Calmarza, Estíbaliz Jarauta, Ana M. Bea, Ana Cenarro, and Fernando Civeira

Mutations in HFE Causing Hemochromatosis Are Associated with Primary Hypertriglyceridemia
J Clin Endocrinol Metab 2009 94: 4391-4397 , doi:10.1210/jc.2009-0814 [Abstract] [Full Text] [PDF]  
Mutations in the HFE gene, favoring iron overload and causing hereditary hemochromatosis, are associated with primary hypertriglyceridemic phenotypes.

Emanuel Christ, Damian Wild, Flavio Forrer, Michael Brändle, Rahel Sahli, Thomas Clerici, Beat Gloor, Ferdinand Martius, Helmut Maecke, and Jean Claude Reubi

Glucagon-Like Peptide-1 Receptor Imaging for Localization of Insulinomas
J Clin Endocrinol Metab 2009 94: 4398-4405 , doi:10.1210/jc.2009-1082 [Abstract] [Full Text] [PDF]  
In vivo GLP-1R imaging is an innovative, non-invasive diagnostic approach that successfully localizes small insulinomas pre- and intraoperatively, and that may in the future affect the strategy of insulinoma localization.

Tae-Woong Noh, Hyeong Jae Jeong, Mi-Kyung Lee, Tai Seung Kim, Sun Ho Kim, and Eun Jig Lee

Predicting Recurrence of Nonfunctioning Pituitary Adenomas
J Clin Endocrinol Metab 2009 94: 4406-4413 , doi:10.1210/jc.2009-0471 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Recurrence of nonfunctioning pituitary adenomas is associated with elevated Ki-67 and TUNEL labeling indexes; immunohistochemical staining could help determine whether patients need intensive follow-up examinations.

Annamaria Colao, Carolina Di Somma, Silvia Savastano, Francesca Rota, Maria Cristina Savanelli, Gianluca Aimaretti, and Gaetano Lombardi

A Reappraisal of Diagnosing GH Deficiency in Adults: Role of Gender, Age, Waist Circumference, and Body Mass Index
J Clin Endocrinol Metab 2009 94: 4414-4422 , doi:10.1210/jc.2009-1134 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The GH peak after GHRH plus arginine test is predicted by waist circumference and body mass index, and is higher in the young than in the adult and the elderly patients, either when lean or overweight and obese.

Apostolia Maria Tsimberidou, Christos Vaklavas, Sijin Wen, David Hong, Jennifer Wheler, Chaan Ng, Aung Naing, Susan Tse, Naifa Busaidy, Maurie Markman, Steven I. Sherman, and Razelle Kurzrock

Phase I Clinical Trials in 56 Patients with Thyroid Cancer: The M. D. Anderson Cancer Center Experience
J Clin Endocrinol Metab 2009 94: 4423-4432 , doi:10.1210/jc.2009-0743 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Patients with advanced thyroid cancer treated on phase I clinical trials had high rates of partial response and prolonged stable disease.

Amanda L. Tencza, Shoji Ichikawa, Anna Dang, David Kenagy, Edward McCarthy, Michael J. Econs, and Michael A. Levine

BRIEF REPORT:Hypophosphatemic Rickets with Hypercalciuria due to Mutation in SLC34A3/Type IIc Sodium-Phosphate Cotransporter: Presentation as Hypercalciuria and Nephrolithiasis
J Clin Endocrinol Metab 2009 94: 4433-4438 , doi:10.1210/jc.2009-1535 [Abstract] [Full Text] [PDF]  
Hypophosphatemic rickets can present as hypercalciuria without typical clinical features of rickets.

Thomas Heiberg Brix, Pia Skov Hansen, Kirsten Ohm Kyvik, and Laszlo Hegedüs

BRIEF REPORT:Aggregation of Thyroid Autoantibodies in Twins from Opposite-Sex Pairs Suggests that Microchimerism May Play a Role in the Early Stages of Thyroid Autoimmunity
J Clin Endocrinol Metab 2009 94: 4439-4443 , doi:10.1210/jc.2009-0813 [Abstract] [Full Text] [PDF]  
Microchimerism may play a role in the development of thyroid autoantibodies.

Hye Rim Chung, Choong Ho Shin, Sei Won Yang, Chang Won Choi, and Beyong Il Kim

BRIEF REPORT:Subclinical Hypothyroidism in Korean Preterm Infants Associated with High Levels of Iodine in Breast Milk
J Clin Endocrinol Metab 2009 94: 4444-4447 , doi:10.1210/jc.2009-0632 [Abstract] [Full Text] [PDF]  
An excessive amount of iodine in breast milk causes subclinical hypothyroidism in preterm infants.

Claudia Brufani, Armando Grossi, Danilo Fintini, Alberto Tozzi, Valentina Nocerino, Patrizia Ippolita Patera, Graziamaria Ubertini, Ottavia Porzio, Fabrizio Barbetti, and Marco Cappa

BRIEF REPORT:Obese Children with Low Birth Weight Demonstrate Impaired β-Cell Function during Oral Glucose Tolerance Test
J Clin Endocrinol Metab 2009 94: 4448-4452 , doi:10.1210/jc.2009-1079 [Abstract] [Full Text] [PDF]  
Small for gestational age obese children manifest a deficit in the early insulin response that results in a higher glucose area under the curve.

Tim B. Koenen, Cees J. Tack, Jeanne Margot Kroese, Ad R. Hermus, Fred C. G. Sweep, Jeroen van der Laak, Anton F. H. Stalenhoef, Jacqueline de Graaf, Lambertus J. H. van Tits, and Rinke Stienstra

BRIEF REPORT:Pioglitazone Treatment Enlarges Subcutaneous Adipocytes in Insulin-Resistant Patients
J Clin Endocrinol Metab 2009 94: 4453-4457 , doi:10.1210/jc.2009-0517 [Abstract] [Full Text] [PDF]  
Pioglitazone results in subcutaneous adipocyte hypertrophy and benefits adipose tissue metabolism.

F. Tassone, L. Gianotti, I. Emmolo, M. Ghio, and G. Borretta

BRIEF REPORT:Glomerular Filtration Rate and Parathyroid Hormone Secretion in Primary Hyperparathyroidism
J Clin Endocrinol Metab 2009 94: 4458-4461 , doi:10.1210/jc.2009-0587 [Abstract] [Full Text] [PDF]  
In a large series of contemporary PHPT patients, only a severe impairment of glomerular filtration rate (i.e., <30 ml/min/1.73 m²) is characterized by a further PTH elevation.

Endocrine Research:

Jefferson P. Lomenick, Maria S. Melguizo, Sabrina L. Mitchell, Marshall L. Summar, and James W. Anderson

Effects of Meals High in Carbohydrate, Protein, and Fat on Ghrelin and Peptide YY Secretion in Prepubertal Children
J Clin Endocrinol Metab 2009 94: 4463-4471 , doi:10.1210/jc.2009-0949 [Abstract] [Full Text] [PDF]  
The macronutrient content of foods has differential effects on ghrelin and peptide YY secretion and appetite ratings in prepubertal children.

Patricia Iozzo, Riikka Lautamaki, Ronald Borra, Hanna-Riikka Lehto, Marco Bucci, Antti Viljanen, Jussi Parkka, Virva Lepomaki, Romina Maggio, Riitta Parkkola, Juhani Knuuti, and Pirjo Nuutila

Contribution of Glucose Tolerance and Gender to Cardiac Adiposity
J Clin Endocrinol Metab 2009 94: 4472-4482 , doi:10.1210/jc.2009-0436 [Abstract] [Full Text] [PDF]  
Glycemia and gender are predictors of heart adiposity, and cardiac steatosis deteriorates rapidly with glucose tolerance in women.

Helen Vlassara, Weijing Cai, Susan Goodman, Renata Pyzik, Angie Yong, Xue Chen, Li Zhu, Tina Neade, Michal Beeri, Jeremy M. Silverman, Luigi Ferrucci, Laurie Tansman, Gary E. Striker, and Jaime Uribarri

Protection against Loss of Innate Defenses in Adulthood by Low Advanced Glycation End Products (AGE) Intake: Role of the Antiinflammatory AGE Receptor-1
J Clin Endocrinol Metab 2009 94: 4483-4491 , doi:10.1210/jc.2009-0089 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Reduction of advanced glycation endproducts (AGE) in normal diets lowers oxidant stress/inflammation, and restores levels of AGE receptor-1 in healthy, aging, and chronic kidney disease-3 patients.

Joachim H. Ix, Christina L. Wassel, Glenn M. Chertow, Annemarie Koster, Karen C. Johnson, Frances A. Tylavsky, Jane A. Cauley, Steven R. Cummings, Tamara B. Harris, Michael G. Shlipak for the Health Aging and Body Composition Study

Fetuin-A and Change in Body Composition in Older Persons
J Clin Endocrinol Metab 2009 94: 4492-4498 , doi:10.1210/jc.2009-0916 [Abstract] [Full Text] [PDF]  
Higher serum fetuin-A levels are associated with accumulation of visceral adipose tissue over time in community-living older adults.

David M. Selva, Albert Lecube, Cristina Hernández, Juan A. Baena, José M. Fort, and Rafael Simó

Lower Zinc-2-Glycoprotein Production by Adipose Tissue and Liver in Obese Patients Unrelated to Insulin Resistance
J Clin Endocrinol Metab 2009 94: 4499-4507 , doi:10.1210/jc.2009-0758 [Abstract] [Full Text] [PDF]  
A downregulation of zinc-2 glycoprotein in adipose tissue and liver exists in obese patients, and it is unrelated to insulin resistance.

Giuseppe Murdolo, Ann Hammarstedt, Martin Schmelz, Per-Anders Jansson, and Ulf Smith

Acute Hyperinsulinemia Differentially Regulates Interstitial and Circulating Adiponectin Oligomeric Pattern in Lean and Insulin-Resistant, Obese Individuals
J Clin Endocrinol Metab 2009 94: 4508-4516 , doi:10.1210/jc.2009-0431 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In human obesity, the impaired adiponectin oligomeric pattern in serum is mimicked at the level of adipose tissue, and acute hyperinsulinemia may affect the compartmental distribution of adiponectin complexes.

Taylor M. Triolo, Erin E. Baschal, Taylor K. Armstrong, Carrie S. Toews, Pamela R. Fain, Marian J. Rewers, Liping Yu, Dongmei Miao, George S. Eisenbarth, Peter A. Gottlieb, and Jennifer M. Barker

Homozygosity of the Polymorphism MICA5.1 Identifies Extreme Risk of Progression to Overt Adrenal Insufficiency among 21-Hydroxylase Antibody-Positive Patients with Type 1 Diabetes
J Clin Endocrinol Metab 2009 94: 4517-4523 , doi:10.1210/jc.2009-1308 [Abstract] [Full Text] [PDF] [Supplemental Data]  
MICA5.1 homozygosity is associated with an increased risk for Addison’s disease in subjects positive for 21-hydroxylase autoantibodies.

Louise Moller, Helene Norrelund, Niels Jessen, Allan Flyvbjerg, Steen B. Pedersen, Bruce D. Gaylinn, Jianhua Liu, Michael O. Thorner, Niels Moller, and Jens Otto Lunde Jorgensen

Impact of Growth Hormone Receptor Blockade on Substrate Metabolism during Fasting in Healthy Subjects
J Clin Endocrinol Metab 2009 94: 4524-4532 , doi:10.1210/jc.2009-0381 [Abstract] [Full Text] [PDF]  
GH receptor blockade during fasting in healthy subjects suppresses lipid metabolism without a change in insulin sensitivity or protein metabolism.

Xia Luo, Ping Yin, Scott Reierstad, Hiroshi Ishikawa, Zhihong Lin, Mary Ellen Pavone, Hong Zhao, Erica E. Marsh, and Serdar E. Bulun

Progesterone and Mifepristone Regulate L-Type Amino Acid Transporter 2 and 4F2 Heavy Chain Expression in Uterine Leiomyoma Cells
J Clin Endocrinol Metab 2009 94: 4533-4539 , doi:10.1210/jc.2009-1286 [Abstract] [Full Text] [PDF]  
Progesterone and its antagonist mifepristone regulate the amino acid transporter system LAT2/4F2hc in leiomyoma tissues and cells.

Azzedine Aboura, Claire Dupas, Gérard Tachdjian, Marie-France Portnoï, Nathalie Bourcigaux, Didier Dewailly, René Frydman, Bart Fauser, Nathalie Ronci-Chaix, Bruno Donadille, Philippe Bouchard, and Sophie Christin-Maitre

Array Comparative Genomic Hybridization Profiling Analysis Reveals Deoxyribonucleic Acid Copy Number Variations Associated with Premature Ovarian Failure
J Clin Endocrinol Metab 2009 94: 4540-4546 , doi:10.1210/jc.2009-0186 [Abstract] [Full Text] [PDF]  
Eight copy number variations were identified in a large cohort of Caucasian women with premature ovarian failure.

Kurt Højlund, Jesper B. Birk, Ditte K. Klein, Klaus Levin, Adam J. Rose, Bo F. Hansen, Jakob N. Nielsen, Henning Beck-Nielsen, and Jørgen F. P. Wojtaszewski

Dysregulation of Glycogen Synthase COOH- and NH₂-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 2009 94: 4547-4556 , doi:10.1210/jc.2009-0897 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Phosphorylation of glycogen synthase by insulin is dysregulated in skeletal muscle of obese subjects and patients with type 2 diabetes, leading to impaired glycogen synthase activation.

Pei-an Betty Shih, Lei Wang, Stephane Chiron, Gen Wen, Caroline Nievergelt, Manjula Mahata, Srikrishna Khandrika, Fangwen Rao, Maple M. Fung, Sushil K. Mahata, Bruce A. Hamilton, and Daniel T. O'Connor

Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo
J Clin Endocrinol Metab 2009 94: 4557-4566 , doi:10.1210/jc.2009-0465 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genetic variation in peptide YY (PYY) contributes to susceptibility for obesity, as illustrated by identification of polymorphisms that confer functional changes in gene expression.

Sarah Berndt, Silvia Blacher, Sophie Perrier d'Hauterive, Marc Thiry, Marie Tsampalas, André Cruz, Christel Péqueux, Sophie Lorquet, Carine Munaut, Agnès Noël, and Jean-Michel Foidart

Chorionic Gonadotropin Stimulation of Angiogenesis and Pericyte Recruitment
J Clin Endocrinol Metab 2009 94: 4567-4574 , doi:10.1210/jc.2009-0443 [Abstract] [Full Text] [PDF]  
Our data provide evidence for a novel function of hCG in vessel maturation through the stimulation of pericyte recruitment, migration, and proliferation.

Kari Luotola, Rauni Pääkkönen, Mervi Alanne, Timo Lanki, Leena Moilanen, Ida Surakka, Arto Pietilä, Mika Kähönen, Markku S. Nieminen, Y. Antero Kesäniemi, Annette Peters, Antti Jula, Markus Perola, Veikko Salomaa for the Health 2000 AIRGENE Study Groups

Association of Variation in the Interleukin-1 Gene Family with Diabetes and Glucose Homeostasis
J Clin Endocrinol Metab 2009 94: 4575-4583 , doi:10.1210/jc.2009-0666 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genetic variation in the IL-1 gene family is associated with measures of glucose homeostasis and prevalent diabetes.

Angelo B. Cefalù, Davide Noto, Maria Luisa Arpi, Fen Yin, Rossella Spina, Hannele Hilden, Carlo M. Barbagallo, Antonio Carroccio, Patrizia Tarugi, Sebastiano Squatrito, Riccardo Vigneri, Marja-Riitta Taskinen, Miklós Péterfy, and Maurizio R. Averna

Novel LMF1 Nonsense Mutation in a Patient with Severe Hypertriglyceridemia
J Clin Endocrinol Metab 2009 94: 4584-4590 , doi:10.1210/jc.2009-0594 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Identification and functional analysis of a novel nonsense mutation of the LMF1 gene in a patient with severe hypertriglyceridemia.

Lyndal J. Tacon, Patsy S. Soon, Anthony J. Gill, Angela S. Chou, Adele Clarkson, Johan Botling, Peter L. H. Stalberg, Britt M. Skogseid, Bruce G. Robinson, Stanley B. Sidhu, and Roderick J. Clifton-Bligh

The Glucocorticoid Receptor Is Overexpressed in Malignant Adrenocortical Tumors
J Clin Endocrinol Metab 2009 94: 4591-4599 , doi:10.1210/jc.2009-0546 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The glucocorticoid receptor is overexpressed in malignant adrenocortical tumors.

Otto Tschritter, Hubert Preissl, Anita M. Hennige, Tina Sartorius, Yuko Grichisch, Norbert Stefan, Martina Guthoff, Stephan Düsing, Jürgen Machann, Erwin Schleicher, Alexander Cegan, Niels Birbaumer, Andreas Fritsche, and Hans-Ulrich Häring

The Insulin Effect on Cerebrocortical Theta Activity Is Associated with Serum Concentrations of Saturated Nonesterified Fatty Acids
J Clin Endocrinol Metab 2009 94: 4600-4607 , doi:10.1210/jc.2009-0469 [Abstract] [Full Text] [PDF] [Supplemental Data]  
High serum concentrations of saturated nonesterified fatty acids are associated with a decreased insulin effect on cortical activity in the human brain.

Beverley M. Shields, Rachel M. Freathy, Bridget A. Knight, Anita Hill, Michael N. Weedon, Timothy M. Frayling, Andrew T. Hattersley, and Bijay Vaidya

BRIEF REPORT:Phosphodiesterase 8B Gene Polymorphism Is Associated with Subclinical Hypothyroidism in Pregnancy
J Clin Endocrinol Metab 2009 94: 4608-4612 , doi:10.1210/jc.2009-1298 [Abstract] [Full Text] [PDF]  
Variation in the PDE8B gene leads to alteration in serum TSH concentration and different proportions of women picked up with subclinical hypothyroidism in pregnancy.

Manoj Garg, Deepika Kanojia, Sushma Suri, Sameer Gupta, Anju Gupta, and Anil Suri

BRIEF REPORT:Sperm-Associated Antigen 9: A Novel Diagnostic Marker for Thyroid cancer
J Clin Endocrinol Metab 2009 94: 4613-4618 , doi:10.1210/jc.2009-0703 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The SPAG9 gene is a candidate target for early diagnosis of thyroid carcinoma.

Judith Aron-Wisnewsky, Joan Tordjman, Christine Poitou, Froogh Darakhshan, Danielle Hugol, Arnaud Basdevant, Abdelhalim Aissat, Michèle Guerre-Millo, and Karine Clément

BRIEF REPORT:Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss
J Clin Endocrinol Metab 2009 94: 4619-4623 , doi:10.1210/jc.2009-0925 [Abstract] [Full Text] [PDF]  
Immunohistochemistry analyses suggest that gastric surgery switches the activation state of adipose tissue macrophages towards a M2-oriented, less pro-inflammatory phenotype in morbidly obese subjects.

Translational Highlights from Endocrinology:

D. B. Martinez-Arguelles, M. Culty, B. R. Zirkin, and V. Papadopoulos

Abstracts:In Utero Exposure to Di-(2-Ethylhexyl) Phthalate Decreases Mineralocorticoid Receptor Expression in the Adult Testis
J Clin Endocrinol Metab 2009 94: 4624 [Full Text] [PDF]  

Brooke S. Middlebrook, Karen Eldin, Xiaohui Li, Sujatha Shivasankaran, and Stephanie A. Pangas

Abstracts:Smad1-Smad5 Ovarian Conditional Knockout Mice Develop a Disease Profile Similar to the Juvenile Form of Human Granulosa Cell Tumors
J Clin Endocrinol Metab 2009 94: 4624-a [Full Text] [PDF]  

Thorsten Braun, Shaofu Li, Deborah M. Sloboda, Wei Li, Melanie C. Audette, Timothy J. M. Moss, Stephen G. Matthews, Graeme Polglase, Ilias Nitsos, John P. Newnham, and John R. G. Challis

Abstracts:Effects of Maternal Dexamethasone Treatment in Early Pregnancy on Pituitary-Adrenal Axis in Fetal Sheep
J Clin Endocrinol Metab 2009 94: 4625 [Full Text] [PDF]  

Giorgio Ramadori, Laurent Gautron, Teppei Fujikawa, Claudia R. Vianna, Joel K. Elmquist, and Roberto Coppari

Abstracts:Central Administration of Resveratrol Improves Diet-Induced Diabetes
J Clin Endocrinol Metab 2009 94: 4625-a [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Yoshitaka Hayashi, Michiyo Yamamoto, Hiroyuki Mizoguchi, Chika Watanabe, Ryoichi Ito, Shiori Yamamoto, Xiao-yang Sun, and Yoshiharu Murata

Abstracts:Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia and Hyperplasia of Islet -Cells But Not of Intestinal L-cells
J Clin Endocrinol Metab 2009 94: 4626 [Full Text] [PDF]  

Helen L. Storr, Barbara Kind, David A. Parfitt, J. Paul Chapple, M. Lorenz, Katrin Koehler, Angela Huebner, and Adrian J. L. Clark

Abstracts:Deficiency of Ferritin Heavy-Chain Nuclear Import in Triple A Syndrome Implies Nuclear Oxidative Damage as the Primary Disease Mechanism
J Clin Endocrinol Metab 2009 94: 4626-a [Full Text] [PDF]  

Fiona O'Mahony, Rodrigo Alzamora, Ho-Lam Chung, Warren Thomas, and Brian J. Harvey

Abstracts:Genomic Priming of the Antisecretory Response to Estrogen in Rat Distal Colon throughout the Estrous Cycle
J Clin Endocrinol Metab 2009 94: 4627-4628 [Full Text] [PDF]  

Fabrizio Barbetti, Nadia Cobo-Vuilleumier, Carlo Dionisi-Vici, Sonia Toni, Paolo Ciampalini, Ornella Massa, Pablo Rodriguez-Bada, Carlo Colombo, Lorenzo Lenzi, María A. Garcia-Gimeno, Francisco J. Bermudez, Fernando Rodriguez de Fonseca, Patrizia Banin, Juan C. Aledo, Elena Baixeras, Pascual Sanz, and Antonio L. Cuesta-Muñoz

Abstracts:Opposite Clinical Phenotypes of Glucokinase Disease: Description of a Novel Activating Mutation and Contiguous Inactivating Mutations in Human Glucokinase (GCK) Gene
J Clin Endocrinol Metab 2009 94: 4627-a [Full Text] [PDF]  

Baohua Zhang, Douglas V. Faller, and Sheng Wang

Abstracts:HIC1 Regulates Tumor Cell Responses to Endocrine Therapies
J Clin Endocrinol Metab 2009 94: 4627-b [Full Text] [PDF]  

Announcements and Resources:

Erratum
J Clin Endocrinol Metab 2009 94: 4629 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Silvio Inzucchi, Lawrence A. Leiter, and Julio Rosenstock

Patient Information Page from The Hormone Foundation:Diabetes de Tipo 2 y las TZD (Tiazolidinedionas) Fritz 9.24.09
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Silvio Inzucchi, Lawrence A. Leiter, and Julio Rosenstock

Patient Information Page from The Hormone Foundation:Type 2 Diabetes and TZDs (Thiazolidinediones) Fritz 9.24.09
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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