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Regional brain activity was assessed with [¹⁸F]-fluorodeoxyglucose positron emission tomography in hypothyroid patients before (top row) and after (bottom row) 3 months of levothyroxine therapy. In the top row, blue areas indicate brain areas where the hypothyroid patients exhibited lower relative activity than healthy controls. Reduction of neuropsychiatric symptoms during thyroid hormone therapy was associated with restoration of metabolic activity in brain areas integral to regulation of affect and cognition. In the bottom row, red and yellow areas indicate brain areas where brain activity increased after treatment of hypothyroid patients compared to the control group. From the article by Bauer et al., in this issue, pages 2922–2929.