The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

The Endocrine Society Laureate Awards
J Clin Endocrinol Metab 2009 94: 3102-3103 [Full Text] [PDF]  

THE ENDOCRINE SOCIETY 2009 LAUREATE AWARDS
J Clin Endocrinol Metab 2009 94: 3104-3115 [Full Text] [PDF]  

Special Features:

Hartmut P. H. Neumann and Charis Eng

APPROACH TO THE PATIENT:The Approach to the Patient with Paraganglioma
J Clin Endocrinol Metab 2009 94: 2677-2683 doi:10.1210/jc.2009-0496 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Pheochromocytoma in genetic disorders]
Multidisciplinary management of patients with paragangliomas and pheochromocytomas requires genetic classification and management in a tertiary care referral center.

Kashinath Dixit, Ilonka Kreitschmann-Andermahr, Ambar Basu, Jeremy P. R. Dick, Prakash Manoharan, Stephen Shalet, and Georg Brabant

IMAGE IN ENDOCRINOLOGY:Human Growth Hormone-Related Iatrogenic Creutzfeldt-Jakob Disease—Being Aware of Diagnostic Features 25 Years Later
J Clin Endocrinol Metab 2009 94: 2684-2685 doi:10.1210/jc.2009-0167 [Full Text] [PDF]  

Raja Padidela, Dan Kelberman, Martin Press, M. Al-Khawari, Peter C. Hindmarsh, and Mehul T. Dattani

CLINICAL CASE SEMINAR:Mutation in the TBCE Gene Is Associated with Hypoparathyroidism-Retardation-Dysmorphism Syndrome Featuring Pituitary Hormone Deficiencies and Hypoplasia of the Anterior Pituitary and the Corpus Callosum
J Clin Endocrinol Metab 2009 94: 2686-2691 , doi:10.1210/jc.2008-2788 [Abstract] [Full Text] [PDF]  
The Hypoparathyroidism-Retardation-Dysmorphism syndrome is associated with TBCE mutations, and anterior pituitary hypoplasis with consequent variable hypopituitarism, and may contribute to the short stature associated with the syndrome.

Panagiotis Anagnostis, Vasilios G. Athyros, Konstantinos Tziomalos, Asterios Karagiannis, and Dimitri P. Mikhailidis

CLINICAL REVIEW:The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis
J Clin Endocrinol Metab 2009 94: 2692-2701 , doi:10.1210/jc.2009-0370 [Abstract] [Full Text] [PDF]  
The metabolic syndrome shares many characteristics of Cushing’s syndrome, and cortisol might play a role in the development of metabolic syndrome.

Kevin C. J. Yuen, Beverly M. K. Biller, Mark E. Molitch, and David M. Cook

CLINICAL REVIEW:Is Lack of Recombinant Growth Hormone (GH)-Releasing Hormone in the United States a Setback or Time to Consider Glucagon Testing for Adult GH Deficiency?
J Clin Endocrinol Metab 2009 94: 2702-2707 , doi:10.1210/jc.2009-0299 [Abstract] [Full Text] [PDF]  
When recombinant GHRH is unavailable, the glucagon stimulation test may be a suitable alternative GH stimulation test in diagnosing adult GH deficiency.

Hadas Stiebel-Kalish, Eyal Robenshtok, Murat Hasanreisoglu, David Ezrachi, Ilan Shimon, and Leonard Leibovici

REVIEW:Treatment Modalities for Graves’ Ophthalmopathy: Systematic Review and Metaanalysis
J Clin Endocrinol Metab 2009 94: 2708-2716 , doi:10.1210/jc.2009-0376 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Treatment of Graves' ophthalmopathy (orbitopathy)]
Current evidence supports the use of corticosteroids for moderate to severe Graves’ ophthalmopathy, best given intravenously followed by the oral route.

Kerstin Krause, Beate Jeßnitzer, and Dagmar Fuhrer

REVIEW:Proteomics in Thyroid Tumor Research
J Clin Endocrinol Metab 2009 94: 2717-2724 , doi:10.1210/jc.2009-0308 [Abstract] [Full Text] [PDF]  
The application of proteomics is feasible in comprehensively analyzing differences in protein expression in thyroid tumors.

Editorials:

Satish C. Kalhan

EDITORIAL:Fatty Acids, Insulin Resistance, and Protein Metabolism
J Clin Endocrinol Metab 2009 94: 2725-2727 doi:10.1210/jc.2009-1235 [Full Text] [PDF]  

Endocrine Care:

M. Kars, P. C. Souverein, R. M. C. Herings, J. A. Romijn, J. P. Vandenbroucke, A. de Boer, and O. M. Dekkers

Estimated Age- and Sex-Specific Incidence and Prevalence of Dopamine Agonist-Treated Hyperprolactinemia
J Clin Endocrinol Metab 2009 94: 2729-2734 , doi:10.1210/jc.2009-0177 [Abstract] [Full Text] [PDF]  
Incidence and prevalence of dopamine agonist-treated hyperprolactinemia shows an overall preponderance in women, with a strong peak for women aged 25–34 years.

Iva Miljkovic, Jane A. Cauley, Moira A. Petit, Kristine E. Ensrud, Elsa Strotmeyer, Yahtyng Sheu, Christopher L. Gordon, Bret H. Goodpaster, Clareann H. Bunker, Alan L. Patrick, Victor W. Wheeler, Lewis H. Kuller, Kimberly A. Faulkner, Joseph M. Zmuda for the Osteoporotic Fractures in Men (MrOS) Research Group the Tobago Health Studies Research Group

Greater Adipose Tissue Infiltration in Skeletal Muscle among Older Men of African Ancestry
J Clin Endocrinol Metab 2009 94: 2735-2742 , doi:10.1210/jc.2008-2541 [Abstract] [Full Text] [PDF]  
Despite having lower total adiposity, Afro-Caribbean men have greater calf skeletal muscle fat infiltration than Caucasian men.

Bregje Van Zaane, Erfan Nur, Alessandro Squizzato, Olaf M. Dekkers, Marcel (Th) B. Twickler, Eric Fliers, Victor E. A. Gerdes, Harry R. Büller, and Dees P. M. Brandjes

Hypercoagulable State in Cushing’s Syndrome: A Systematic Review
J Clin Endocrinol Metab 2009 94: 2743-2750 , doi:10.1210/jc.2009-0290 [Abstract] [Full Text] [PDF] [Supplemental Data]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Clinical manifestations of Cushing's syndrome]
Patients with Cushing’s syndrome are at high risk for venous thrombosis, mainly due to glucocorticoid-induced hypercoagulability, as well as surgery and obesity.

Antonio Ceriello, Katherine Esposito, Michael Ihnat, Jessica Thorpe, and Dario Giugliano

Long-Term Glycemic Control Influences the Long-Lasting Effect of Hyperglycemia on Endothelial Function in Type 1 Diabetes
J Clin Endocrinol Metab 2009 94: 2751-2756 , doi:10.1210/jc.2009-0762 [Abstract] [Full Text] [PDF]  
Poor long-term glycemic control influences endothelial function in type 1 diabetes.

Dalia L. Batista, Edward H. Oldfield, Margaret F. Keil, and Constantine A. Stratakis

Postoperative Testing to Predict Recurrent Cushing Disease in Children
J Clin Endocrinol Metab 2009 94: 2757-2765 , doi:10.1210/jc.2009-0302 [Abstract] [Full Text] [PDF] [Supplemental Data]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Primary therapy of Cushing's disease: Transsphenoidal surgery and pituitary irradiation]
After transsphenoidal surgery for Cushing’s disease, the postoperative ovine CRH stimulation test, morning ACTH, and cortisol are useful tests in identifying pediatric patients with persistent disease, or at risk of recurrence.

Claudio Marcocci, Philippe Chanson, Dolores Shoback, John Bilezikian, Laureano Fernandez-Cruz, Jacques Orgiazzi, Christoph Henzen, Sunfa Cheng, Lulu Ren Sterling, John Lu, and Munro Peacock

Cinacalcet Reduces Serum Calcium Concentrations in Patients with Intractable Primary Hyperparathyroidism
J Clin Endocrinol Metab 2009 94: 2766-2772 , doi:10.1210/jc.2008-2640 [Abstract] [Full Text] [PDF] [Supplemental Data]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Management of asymptomatic primary hyperparathyroidism]
In patients with intractable primary hyperparathyroidism, cinacalcet reduces serum calcium, is generally well tolerated, and has the potential to fulfill an unmet medical need.

Kristine E. Ensrud, Brent C. Taylor, Misti L. Paudel, Jane A. Cauley, Peggy M. Cawthon, Steven R. Cummings, Howard A. Fink, Elizabeth Barrett-Connor, Joseph M. Zmuda, James M. Shikany, Eric S. Orwoll for the Osteoporotic Fractures in Men (MrOS) Study Group

Serum 25-Hydroxyvitamin D Levels and Rate of Hip Bone Loss in Older Men
J Clin Endocrinol Metab 2009 94: 2773-2780 , doi:10.1210/jc.2008-2786 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Calcium and vitamin D supplementation in osteoporosis]
Older community-dwelling men with total 25-hydroxyvitamin D levels <20 ng/mL have greater rates of hip bone loss, while rates of loss are similar among men with higher levels.

Seth D. Marks, Christina Haines, Ivan M. Rebeyka, and Robert M. Couch

Hypothalamic-Pituitary-Thyroid Axis Changes in Children after Cardiac Surgery
J Clin Endocrinol Metab 2009 94: 2781-2786 , doi:10.1210/jc.2008-2722 [Abstract] [Full Text] [PDF]  
Non-thyroidal illness syndrome is present in this population of critically ill children and is related to, and predictive of, clinical outcome and illness severity.

Georges Gelwane, Nicolas de Roux, Didier Chevenne, Jean Claude Carel, and Juliane Léger

Pituitary-Thyroid Feedback in a Patient with a Sporadic Activating Thyrotropin (TSH) Receptor Mutation: Implication That Thyroid-Secreted Factors Other Than Thyroid Hormones Contribute to Serum TSH Levels
J Clin Endocrinol Metab 2009 94: 2787-2791 , doi:10.1210/jc.2008-2524 [Abstract] [Full Text] [PDF]  
These data provide insight into the regulation of serum TSH concentrations and suggest an alternative mechanism, in addition to serum thyroid hormone levels, for adjusting TSH secretion.

Daniel H. Solomon, Suzanne M. Cadarette, Niteesh K. Choudhry, Claire Canning, Raisa Levin, and Til Stürmer

A Cohort Study of Thiazolidinediones and Fractures in Older Adults with Diabetes
J Clin Endocrinol Metab 2009 94: 2792-2798 , doi:10.1210/jc.2008-2157 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Thiazolidinediones may be associated with an increased risk of fractures in older adults with diabetes.

Siân M. Robinson, Lynne D. Marriott, Sarah R. Crozier, Nick C. Harvey, Catharine R. Gale, Hazel M. Inskip, Janis Baird, Catherine M. Law, Keith M. Godfrey, Cyrus Cooper Southampton Women’s Survey Study Group

Variations in Infant Feeding Practice Are Associated with Body Composition in Childhood: A Prospective Cohort Study
J Clin Endocrinol Metab 2009 94: 2799-2805 , doi:10.1210/jc.2009-0030 [Abstract] [Full Text] [PDF]  
Variations in milk feeding in infancy and in the weaning diet are independently linked to differences in body composition in early childhood.

Jaeduk Yoshimura Noh, Shigemitu Yasuda, Shotaro Sato, Masako Matsumoto, Yo Kunii, Yoshihiko Noguchi, Koji Mukasa, Kunihiko Ito, Koichi Ito, Osamu Sugiyama, Hiroshi Kobayashi, Shigeru Nihojima, Masaru Okazaki, and Shunji Yokoyama

Clinical Characteristics of Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Caused by Antithyroid Drugs
J Clin Endocrinol Metab 2009 94: 2806-2811 , doi:10.1210/jc.2008-2700 [Abstract] [Full Text] [PDF]  
The onset of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis caused by antithyroid drugs varied widely.

Melania Pulcrano, Emiliano Antonio Palmieri, Deborah Mannavola Michele Ciulla, Irene Campi, Danila Covelli, Gaetano Lombardi, Bernadette Biondi, and Paolo Beck-Peccoz

Impact of Resistance to Thyroid Hormone on the Cardiovascular System in Adults
J Clin Endocrinol Metab 2009 94: 2812-2816 , doi:10.1210/jc.2009-0096 [Abstract] [Full Text] [PDF]  
Our study suggests the presence of cardiovascular alterations in asymptomatic and untreated resistance to thyroid hormone patients is similar to those reported in hypothyroid patients.

Nelly Burnichon, Vincent Rohmer, Laurence Amar, Philippe Herman, Sophie Leboulleux, Vincent Darrouzet, Patricia Niccoli, Dominique Gaillard, Gérard Chabrier, Frédéric Chabolle, Isabelle Coupier, Philippe Thieblot, Pierre Lecomte, Jérôme Bertherat, Nelly Wion-Barbot, Arnaud Murat, Annabelle Venisse, Pierre-François Plouin, Xavier Jeunemaitre, Anne-Paule Gimenez-Roqueplo for the PGL.NET network

The Succinate Dehydrogenase Genetic Testing in a Large Prospective Series of Patients with Paragangliomas
J Clin Endocrinol Metab 2009 94: 2817-2827 , doi:10.1210/jc.2008-2504 [Abstract] [Full Text] [PDF] [Supplemental Data]  
SDH genetic testing, using a strategy combining direct sequencing and a method detecting large genomic deletions, is indicated in all patients with paraganglioma except those with a single tympanic tumor.

Sowmya Surya, Jeffrey F. Horowitz, Naila Goldenberg, Alla Sakharova, Matthew Harber, Andrea S. Cornford, Kathy Symons, and Ariel L. Barkan

The Pattern of Growth Hormone Delivery to Peripheral Tissues Determines Insulin-Like Growth Factor-1 and Lipolytic Responses in Obese Subjects
J Clin Endocrinol Metab 2009 94: 2828-2834 , doi:10.1210/jc.2009-0638 [Abstract] [Full Text] [PDF]  
In obese subjects, GH regulated different physiological parameters (e.g., lipolytic rate, IGF-1 production) in a tissue- and pattern-specific manner.

Jean-Baptiste Armengaud, Marie-Laure Charkaluk, Christine Trivin, Véronique Tardy, Gérard Bréart, Raja Brauner, and Martin Chalumeau

Precocious Pubarche: Distinguishing Late-Onset Congenital Adrenal Hyperplasia from Premature Adrenarche
J Clin Endocrinol Metab 2009 94: 2835-2840 , doi:10.1210/jc.2009-0314 [Abstract] [Full Text] [PDF]  
Three plasma predictors of late-onset congenital adrenal hyperplasia were identified in patients presenting with precocious pubarche.

Wilhelmina H. A. de Jong, Graeme Eisenhofer, Wendy J. Post, Frits A. J. Muskiet, Elisabeth G. E. de Vries, and Ido P. Kema

Dietary Influences on Plasma and Urinary Metanephrines: Implications for Diagnosis of Catecholamine-Producing Tumors
J Clin Endocrinol Metab 2009 94: 2841-2849 , doi:10.1210/jc.2009-0303 [Abstract] [Full Text] [PDF]  
Dietary restrictions should be considered to minimize false-positive results for urinary and plasma deconjugated metanephrines during diagnosis of pheochromocytoma, but not for free metanephrines, indicating advantages of measurements of the free compared to deconjugated metabolites.

Kaoru Nomura, Hironari Kimura, Satoru Shimizu, Hitomi Kodama, Takahiro Okamoto, Takao Obara, and Kazue Takano

Survival of Patients with Metastatic Malignant Pheochromocytoma and Efficacy of Combined Cyclophosphamide, Vincristine, and Dacarbazine Chemotherapy
J Clin Endocrinol Metab 2009 94: 2850-2856 , doi:10.1210/jc.2008-2697 [Abstract] [Full Text] [PDF]  
The present study reveals a long survival of malignant pheochromocytoma and no effect of chemotherapy to extend it.

Henning Schrader, Bjoern A. Menge, Thomas G. K. Breuer, Peter R. Ritter, Waldemar Uhl, Wolfgang E. Schmidt, Jens J. Holst, and Juris J. Meier

Impaired Glucose-Induced Glucagon Suppression after Partial Pancreatectomy
J Clin Endocrinol Metab 2009 94: 2857-2863 , doi:10.1210/jc.2009-0826 [Abstract] [Full Text] [PDF]  
The glucose-induced suppression of glucagon secretion appears to be lost after hemipancreatectomy in humans.

M. Russell, M. Bredella, P. Tsai, N. Mendes, K. K. Miller, A. Klibanski, and M. Misra

Relative Growth Hormone Deficiency and Cortisol Excess Are Associated with Increased Cardiovascular Risk Markers in Obese Adolescent Girls
J Clin Endocrinol Metab 2009 94: 2864-2871 , doi:10.1210/jc.2009-0380 [Abstract] [Full Text] [PDF]  
Serum markers of cardiovascular risk are increased in obese adolescent girls and are predicted by hormonal and body composition alterations.

Anja Lisbeth Frederiksen, Tina Dysgaard Jeppesen, John Vissing, Marianne Schwartz, Kirsten Ohm Kyvik, Ole Schmitz, Per Løgstrup Poulsen, and Per Heden Andersen

High Prevalence of Impaired Glucose Homeostasis and Myopathy in Asymptomatic and Oligosymptomatic 3243A>G Mitochondrial DNA Mutation-Positive Subjects
J Clin Endocrinol Metab 2009 94: 2872-2879 , doi:10.1210/jc.2009-0235 [Abstract] [Full Text] [PDF]  
There is high prevalence of impaired glucose homeostasis and myopathy in presumed asymptomatic and oligosymptomatic 3243A>G mtDNA mutation positive subjects.

Pamela U. Freda, Wei Shen, Carlos M. Reyes-Vidal, Eliza B. Geer, Fernando Arias-Mendoza, Dympna Gallagher, and Steven B. Heymsfield

Skeletal Muscle Mass in Acromegaly Assessed by Magnetic Resonance Imaging and Dual-Photon X-Ray Absorptiometry
J Clin Endocrinol Metab 2009 94: 2880-2886 , doi:10.1210/jc.2009-0026 [Abstract] [Full Text] [PDF]  
The DXA prediction model of skeletal muscle has the potential to be successfully applied to the study of skeletal muscle in GH disorders and during their therapy.

Ola Lindgren, Andrea Mari, Carolyn F. Deacon, Richard D. Carr, Maria Sörhede Winzell, Jenny Vikman, and Bo Ahrén

Differential Islet and Incretin Hormone Responses in Morning Versus Afternoon after Standardized Meal in Healthy Men
J Clin Endocrinol Metab 2009 94: 2887-2892 , doi:10.1210/jc.2009-0366 [Abstract] [Full Text] [PDF]  
Insulin secretion to equivalent meals is faster in the morning than in the afternoon, corresponding to more pronounced incretin responses in the morning.

Suzanne Holewijn, Martin den Heijer, Dorine W. Swinkels, Anton F. H. Stalenhoef, and Jacqueline de Graaf

The Metabolic Syndrome and Its Traits as Risk Factors for Subclinical Atherosclerosis
J Clin Endocrinol Metab 2009 94: 2893-2899 , doi:10.1210/jc.2009-0084 [Abstract] [Full Text] [PDF] [Supplemental Data]  
For cardiovascular risk prediction it is more important to take into account the presence of each individual trait and the number of traits of the metabolic syndrome, than to diagnose the presence of the metabolic syndrome.

Anne-Marie Aas, Kristian F. Hanssen, Jens Petter Berg, Per M. Thorsby, and Kåre I. Birkeland

Insulin-Stimulated Increase in Serum Leptin Levels Precedes and Correlates with Weight Gain during Insulin Therapy in Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 2900-2906 , doi:10.1210/jc.2008-1005 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In this post-hoc study, acute and long-term insulin administration increased serum leptin levels, and this increase correlated with weight gain in insulin-treated type 2 diabetic patients.

Annamaria Colao, Renata S. Auriemma, Silvia Savastano, Mariano Galdiero, Ludovica F. S. Grasso, Gaetano Lombardi, and Rosario Pivonello

Glucose Tolerance and Somatostatin Analog Treatment in Acromegaly: A 12-Month Study
J Clin Endocrinol Metab 2009 94: 2907-2914 , doi:10.1210/jc.2008-2627 [Abstract] [Full Text] [PDF]  
This open, prospective study conducted in 112 patients newly diagnosed with acromegaly and treated with depot somatostatin analogues for 12 months did not demonstrate any significant rate of deteriorated glucose tolerance.

Benjamin Z. Leder, Robert M. Neer, Jason J. Wyland, Hang W. Lee, Sherri-Ann M. Burnett-Bowie, and Joel S. Finkelstein

Effects of Teriparatide Treatment and Discontinuation in Postmenopausal Women and Eugonadal Men with Osteoporosis
J Clin Endocrinol Metab 2009 94: 2915-2921 , doi:10.1210/jc.2008-2630 [Abstract] [Full Text] [PDF]  
This study demonstrates that the response to teriparatide discontinuation differs between osteoporotic men and women.

M. Bauer, D. H. S. Silverman, F. Schlagenhauf, E. D. London, C. L. Geist, K. van Herle, N. Rasgon, D. Martinez, K. Miller, A. van Herle, S. M. Berman, M. E. Phelps, and P. C. Whybrow

Brain Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study before and after Thyroid Hormone Replacement Therapy
J Clin Endocrinol Metab 2009 94: 2922-2929 , doi:10.1210/jc.2008-2235 [Abstract] [Full Text] [PDF]  
Results indicate that the behavioral symptoms of which many hypothyroid patients complain may be an integral part of the symptomatology of the illness.

Hui-Pin Hsiao, Lawrence S. Kirschner, Isabelle Bourdeau, Margaret F. Keil, Sosipatros A. Boikos, Somya Verma, Audrey J. Robinson-White, Maria Nesterova, André Lacroix, and Constantine A. Stratakis

Clinical and Genetic Heterogeneity, Overlap with Other Tumor Syndromes, and Atypical Glucocorticoid Hormone Secretion in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Compared with Other Adrenocortical Tumors
J Clin Endocrinol Metab 2009 94: 2930-2937 , doi:10.1210/jc.2009-0516 [Abstract] [Full Text] [PDF]  
ACTH-independent macronodular adrenal hyperplasia is a heterogeneous disorder often associated with genetic defects at the germline or the somatic level.

Viviane Pardo, Jussara Vono-Toniolo, Ileana G. S. Rubio, Meyer Knobel, Roberta F. Possato, Hector M. Targovnik, Peter Kopp, and Geraldo Medeiros-Neto

The p.A2215D Thyroglobulin Gene Mutation Leads to Deficient Synthesis and Secretion of the Mutated Protein and Congenital Hypothyroidism with Wide Phenotype Variation
J Clin Endocrinol Metab 2009 94: 2938-2944 , doi:10.1210/jc.2009-0150 [Abstract] [Full Text] [PDF]  
Patients included at this study had homozygous and heterozygous inactivating mutations, varying degrees of hypothyroidism, and a wide phenotype spectrum.

Sybil Crawford, Nanette Santoro, Gail A. Laughlin, Mary Fran Sowers, Daniel McConnell, Kim Sutton-Tyrrell, Gerson Weiss, Marike Vuga, John Randolph, and Bill Lasley

Circulating Dehydroepiandrosterone Sulfate Concentrations during the Menopausal Transition
J Clin Endocrinol Metab 2009 94: 2945-2951 , doi:10.1210/jc.2009-0386 [Abstract] [Full Text] [PDF]  
A longitudinal analysis of circulating dehydroepiandrosterone in mid-aged women reveals a positive inflection during the menopausal transition.

Edwin W. Lai, Bharat H. Joshi, Lucia Martiniova, Ritika Dogra, Toshio Fujisawa, Pamela Leland, Ronald R. de Krijger, Irina A. Lubensky, Abdel G. Elkahloun, John C. Morris, Raj K. Puri, and Karel Pacak

BRIEF REPORT:Overexpression of Interleukin-13 Receptor-2 in Neuroendocrine Malignant Pheochromocytoma: A Novel Target for Receptor Directed Anti-Cancer Therapy
J Clin Endocrinol Metab 2009 94: 2952-2957 , doi:10.1210/jc.2009-0309 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Human and murine neuroendocrine pheochromocytoma tumors overexpress the IL-13R2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients.

Panayota Mitrou, Eleni Boutati, Vaia Lambadiari, Eirini Maratou, Alexandros Papakonstantinou, Vasiliki Komesidou, Labros Sidossis, Nikolaos Tountas, Nikolaos Katsilambros, Theofanis Economopoulos, Sotirios A. Raptis, and George Dimitriadis

BRIEF REPORT:Rates of Glucose Uptake in Adipose Tissue and Muscle in Vivo after a Mixed Meal in Women with Morbid Obesity
J Clin Endocrinol Metab 2009 94: 2958-2961 , doi:10.1210/jc.2008-2297 [Abstract] [Full Text] [PDF]  
Increased fat mass provides a sink for the excess of glucose in women with morbid obesity.

Marina S. Zemskova, Eric S. Nylen, Nicholas J. Patronas, Edward H. Oldfield, Kenneth L. Becker, and Lynnette K. Nieman

BRIEF REPORT:Diagnostic Accuracy of Chromogranin A and Calcitonin Precursors Measurements for the Discrimination of Ectopic ACTH Secretion from Cushing’s Disease
J Clin Endocrinol Metab 2009 94: 2962-2965 , doi:10.1210/jc.2009-0604 [Abstract] [Full Text] [PDF]  
Measurement of chromogranin A, calcitonin, procalcitonin, or its amino terminus may provide additional tools for the differential diagnosis and management of patients with ACTH-dependent Cushing’s syndrome.

Kaspar Sørensen, Lise Aksglaede, Thor Munch-Andersen, Niels Jacob Aachmann-Andersen, Henrik Leffers, Jørn Wulff Helge, Linda Hilsted, and Anders Juul

BRIEF REPORT:Impact of the Growth Hormone Receptor Exon 3 Deletion Gene Polymorphism on Glucose Metabolism, Lipids, and Insulin-Like Growth Factor-I Levels during Puberty
J Clin Endocrinol Metab 2009 94: 2966-2969 , doi:10.1210/jc.2009-0313 [Abstract] [Full Text] [PDF]  
The presence of the exon 3 deleted growth hormone receptor gene is associated with higher insulin secretion with an oral glucose challenge in healthy pubertal children.

Patricia Doyle, Christian Düren, Kai Nerlich, Frederik A. Verburg, Inge Grelle, Hanne Jahn, Martin Fassnacht, Uwe Mäder, Christoph Reiners, and Markus Luster

BRIEF REPORT:Potency and Tolerance of Calcitonin Stimulation with High-Dose Calcium Versus Pentagastrin in Normal Adults
J Clin Endocrinol Metab 2009 94: 2970-2974 , doi:10.1210/jc.2008-2403 [Abstract] [Full Text] [PDF]  
High-dose calcium is a more potent and better-tolerated secretagogue of human calcitonin than is pentagastrin in young thyroid-healthy human subjects.

Nelly Mauras, Kim Bishop, Debbie Merinbaum, Ugochi Emeribe, Felix Agbo, and Elizabeth Lowe

BRIEF REPORT:Pharmacokinetics and Pharmacodynamics of Anastrozole in Pubertal Boys with Recent-Onset Gynecomastia
J Clin Endocrinol Metab 2009 94: 2975-2978 , doi:10.1210/jc.2008-2527 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Management of gynecomastia]
Pharmacokinetics of oral anastrozole in adolescent males with gynecomastia show rapid absorption and slow elimination kinetics; an observed reduction in breast size deserves further study.

Endocrine Research:

Mustafa Akcakoyun, Hasan Kaya, Ramazan Kargin, Selcuk Pala, Yunus Emiroglu, Ozlem Esen, Hekim Karapinar, Zekeriya Kaya, and Ali Metin Esen

Abnormal Left Ventricular Longitudinal Functional Reserve Assessed by Exercise Pulsed Wave Tissue Doppler Imaging in Patients with Subclinical Hypothyroidism
J Clin Endocrinol Metab 2009 94: 2979-2983 , doi:10.1210/jc.2009-0117 [Abstract] [Full Text] [PDF]  
Assessment of left ventricular longitudinal functional reserve with exercise using tissue Doppler echocardiography appears to be helpful in identifying early myocardial dysfunction in subclinical hypothyroidism.

Christos S. Katsanos, Asle Aarsland, Melanie G. Cree, and Robert R. Wolfe

Muscle Protein Synthesis and Balance Responsiveness to Essential Amino Acids Ingestion in the Presence of Elevated Plasma Free Fatty Acid Concentrations
J Clin Endocrinol Metab 2009 94: 2984-2990 , doi:10.1210/jc.2008-2686 [Abstract] [Full Text] [PDF]  
Essential amino acids stimulated muscle protein turnover in the presence of elevated plasma free fatty acids.

Ferdinand Roelfsema, Petra Kok, Marijke Frolich, Alberto M. Pereira, and Hanno Pijl

Disordered and Increased Adrenocorticotropin Secretion with Diminished Adrenocorticotropin Potency in Obese in Premenopausal Women
J Clin Endocrinol Metab 2009 94: 2991-2997 , doi:10.1210/jc.2009-0350 [Abstract] [Full Text] [PDF]  
Increased serum leptin concentrations may be responsible for the amplified CRH-ACTH signaling in obese premenopausal women, in concert with decreased adrenal responsiveness to ACTH.

E. J. Payne, E. Ingley, I. M. Dick, S. G. Wilson, C. S. Bond, and R. L. Prince

In Vitro Kinetic Properties of the Thr²⁰¹Met Variant of Human Aromatase Gene CYP19A1: Functional Responses to Substrate and Product Inhibition and Enzyme Inhibitors
J Clin Endocrinol Metab 2009 94: 2998-3002 , doi:10.1210/jc.2008-2309 [Abstract] [Full Text] [PDF]  
Loss-of-function mutations in aromatase (CYP19A1) have been characterized previously. A new Thr²⁰¹Met variant, previously associated with reduced prostate cancer progression, demonstrates substantial gain of function in enzyme activity.

John N. Flanagan, Kristina Linder, Niklas Mejhert, Elisabeth Dungner, Kerstin Wahlen, Pauline Decaunes, Mikael Rydén, Peyman Björklund, Stefan Arver, Shalender Bhasin, Anne Bouloumie, Peter Arner, and Ingrid Dahlman

Role of Follistatin in Promoting Adipogenesis in Women
J Clin Endocrinol Metab 2009 94: 3003-3009 , doi:10.1210/jc.2008-2005 [Abstract] [Full Text] [PDF]  
Down-regulated white adipose tissue expression of follistatin in obesity may counteract adiposity, but could, by inhibiting adipogenesis, contribute to hypertrophic obesity (large fat cells) and insulin resistance in women.

Haim Mayan, Semyon Melnikov, Ilya Novikov, Eliezer J. Holtzman, and Zvi Farfel

Familial Hyperkalemia and Hypertension: Pathogenetic Insights Based on Lithium Clearance
J Clin Endocrinol Metab 2009 94: 3010-3016 , doi:10.1210/jc.2008-2572 [Abstract] [Full Text] [PDF]  
Familial hyperkalemia and hypertension subjects have presumably increased distal and decreased proximal nephron sodium reabsorption; however, lithium clearance is decreased, reflecting probable lithium distal reabsorption.

Francesca Porcellati, Paolo Rossetti, Paola Candeloro, Paola Lucidi, Patrizia Cioli, Anna Marinelli Andreoli, Ezio Ghigo, Geremia B. Bolli, and Carmine G. Fanelli

Short-Term Effects of the Long-Acting Insulin Analog Detemir and Human Insulin on Plasma Levels of Insulin-Like Growth Factor-I and Its Binding Proteins in Humans
J Clin Endocrinol Metab 2009 94: 3017-3024 , doi:10.1210/jc.2008-2838 [Abstract] [Full Text] [PDF]  
Short-term hyperinsulinemia induced by insulin detemir and human insulin elicit comparable responses on plasma levels of IGF-I and IGF-binding proteins (IGFBP-1, -3) in humans.

M. Laloi-Michelin, T. Meas, C. Ambonville, C. Bellanné-Chantelot, S. Beaufils, P. Massin, B. Vialettes, H. Gin, J. Timsit, B. Bauduceau, L. Bernard, E. Bertin, J.-F. Blickle, J. Cahen-Varsaux, A. Cailleba, S. Casanova, P. Cathebras, G. Charpentier, P. Chedin, T. Crea, B Delemer, D. Dubois-Laforgue, F. Duchemin, P. H. Ducluzeau, B. Bouhanick, L. Dusselier, T. Gabreau, A. Grimaldi, B. Guerci, V. Jacquin, E. Kaloustian, E. Larger, A. Lecleire-Collet, F. Lorenzini, J. Louis, J. Mausset, A. Murat, S. Nadler-Fluteau, F. Olivier, V. Paquis-Flucklinger, D. Paris-Bockel, I. Raynaud, Y. Reznik, J. P. Riveline, S. Schneebeli, E. Sonnet, A. Sola-Gazagnes, J. L. Thomas, B. Trabulsi, M. Virally, P. J. Guillausseau (GEDIAM, Mitochondrial Diabetes French Study Group)

The Clinical Variability of Maternally Inherited Diabetes and Deafness Is Associated with the Degree of Heteroplasmy in Blood Leukocytes
J Clin Endocrinol Metab 2009 94: 3025-3030 , doi:10.1210/jc.2008-2680 [Abstract] [Full Text] [PDF]  
Heteroplasmy levels are at least one of the determinants of the severity of the phenotype of maternally inherited diabetes and deafness.

Ippei Kanazawa, Toru Yamaguchi, Mika Yamauchi, Masahiro Yamamoto, Soichi Kurioka, Shozo Yano, and Toshitsugu Sugimoto

Adiponectin Is Associated with Changes in Bone Markers during Glycemic Control in Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 2009 94: 3031-3037 , doi:10.1210/jc.2008-2187 [Abstract] [Full Text] [PDF]  
In patients with poorly controlled diabetes, the serum adiponectin level predicts subsequent improvement in bone remodeling markers during glycemic control.

Liping Chung, Anne E. Nelson, Ken K. Y. Ho, and Robert C. Baxter

Proteomic Profiling of Growth Hormone-Responsive Proteins in Human Peripheral Blood Leukocytes
J Clin Endocrinol Metab 2009 94: 3038-3043 , doi:10.1210/jc.2009-0778 [Abstract] [Full Text] [PDF]  
Proteomic analysis of white blood cell extracts from healthy subjects treated with GH indicates the suppression of the pro-inflammatory calgranulins S100A8, S100A9, and S100A12.

Christelle Guillet, Ingrid Delcourt, Melanie Rance, Christophe Giraudet, Stephane Walrand, Mario Bedu, Pascale Duche, and Yves Boirie

Changes in Basal and Insulin and Amino Acid Response of Whole Body and Skeletal Muscle Proteins in Obese Men
J Clin Endocrinol Metab 2009 94: 3044-3050 , doi:10.1210/jc.2008-2216 [Abstract] [Full Text] [PDF]  
Obesity is associated with disturbances of muscle protein metabolism, notably a reduced basal skeletal muscle and mitochondria protein turnover and a limited stimulatory action of insulin upon mitochondrial protein synthesis.

Ewa Szalowska, Marieke G. L. Elferink, Annemiek Hoek, Geny M. M. Groothuis, and Roel J. Vonk

Resistin Is More Abundant in Liver Than Adipose Tissue and Is Not Up-Regulated by Lipopolysaccharide
J Clin Endocrinol Metab 2009 94: 3051-3057 , doi:10.1210/jc.2008-2787 [Abstract] [Full Text] [PDF]  
The "adipokine" resistin is more abundant in human liver than in adipose tissue and it is not ubiquitously up-regulated by lipopolysaccharide.

Vivek Dhir, Nicole Reisch, Caroline M. Bleicken, Jan Lebl, Clemens Kamrath, Hans-Peter Schwarz, Joachim Grötzinger, Wolfgang G. Sippell, Felix G. Riepe, Wiebke Arlt, and Nils Krone

Steroid 17-Hydroxylase Deficiency: Functional Characterization of Four Mutations (A174E, V178D, R440C, L465P) in the CYP17A1 Gene
J Clin Endocrinol Metab 2009 94: 3058-3064 , doi:10.1210/jc.2009-0172 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The in vitro and in silico analysis of novel CYP17A1 mutations proves their pathogenicity in compound heterozygous individuals with 17-hydroxylase deficiency.

Marcela Julio-Pieper, Patricia Lozada, Veronica Tapia, Margarita Vega, Cristián Miranda, David Vantman, Sergio R. Ojeda, and Carmen Romero

Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway
J Clin Endocrinol Metab 2009 94: 3065-3071 , doi:10.1210/jc.2009-0542 [Abstract] [Full Text] [PDF]  
NGF participates in ovarian angiogenesis by increasing VEGF expression through trkA receptor activation and MAPK-ERK2 signaling.

Nifang Niu, Venkatraman Manickam, Krishna R. Kalari, Irene Moon, Linda L. Pelleymounter, Bruce W. Eckloff, Eric D. Wieben, Daniel J. Schaid, and Liewei Wang

Human Glucocorticoid Receptor Gene (NR3C1) Pharmacogenomics: Gene Resequencing and Functional Genomics
J Clin Endocrinol Metab 2009 94: 3072-3084 , doi:10.1210/jc.2008-2109 [Abstract] [Full Text] [PDF] [Supplemental Data]  
We identified 108 polymorphisms in the GR gene by resequencing 240 DNA samples from 4 ethnic groups, and these efforts followed by functional characterization and genotype-phenotype association studies represent a step toward understanding the potential impact of GR polymorphisms on GR function.

Kiymet Bozaoglu, David Segal, Katherine A. Shields, Nik Cummings, Joanne E. Curran, Anthony G. Comuzzie, Michael C. Mahaney, David L. Rainwater, John L. VandeBerg, Jean W. MacCluer, Greg Collier, John Blangero, Ken Walder, and Jeremy B.M. Jowett

BRIEF REPORT:Chemerin Is Associated with Metabolic Syndrome Phenotypes in a Mexican-American Population
J Clin Endocrinol Metab 2009 94: 3085-3088 , doi:10.1210/jc.2008-1833 [Abstract] [Full Text] [PDF]  
The novel adipokine chemerin is associated with metabolic syndrome components in different populations, suggesting it may play a role in pathogenesis and disease risk.

Taninee Sahakitrungruang, Meng Kian Tee, Phyllis W. Speiser, and Walter L. Miller

BRIEF REPORT:Novel P450c17 Mutation H373D Causing Combined 17-Hydroxylase/17,20-Lyase Deficiency
J Clin Endocrinol Metab 2009 94: 3089-3092 , doi:10.1210/jc.2009-0645 [Abstract] [Full Text] [PDF]  
A 14-year-old prepubertal, hypertensive girl carried P450c17 mutations R96W and H373D, both inactive in COS-1 cells; novel mutant H373D adsorbed at 420 nm, indicating protein misfolding.

J. Frystyk, D. J. Brick, A. V. Gerweck, A. L. Utz, and K. K. Miller

BRIEF REPORT:Bioactive Insulin-Like Growth Factor-I in Obesity
J Clin Endocrinol Metab 2009 94: 3093-3097 , doi:10.1210/jc.2009-0614 [Abstract] [Full Text] [PDF]  
Despite a linear decrease in GH secretion with increasing BMI and reduced total IGF-I levels in obese women, bioactive IGF-I levels are not reduced in obesity.

Translational Highlights from Endocrinology:

William G. Nelson, Angelo M. De Marzo, and Srinivasan Yegnasubramanian

Abstracts:Minireview: Epigenetic Alterations in Human Prostate Cancers
J Clin Endocrinol Metab 2009 94: 3098 [Full Text] [PDF]  

Curt Balch, Fang Fang, Daniela E. Matei, Tim H.-M. Huang, and Kenneth P. Nephew

Abstracts:Minireview: Epigenetic Changes in Ovarian Cancer
J Clin Endocrinol Metab 2009 94: 3098-a [Full Text] [PDF]  

Lauren Anton, David C. Merrill, Liomar A. A. Neves, Debra I. Diz, Jenny Corthran, Gloria Valdes, Kathryn Stovall, Patricia E. Gallagher, Cheryl Moorefield, Courtney Gruver, and K. Bridget Brosnihan

Abstracts:The Uterine Placental Bed Renin-Angiotensin System in Normal and Preeclamptic Pregnancy
J Clin Endocrinol Metab 2009 94: 3099 [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Kumaran Sundaram, Joseph Senn, Sambandam Yuvaraj, D. Sudhaker Rao, and Sakamuri V. Reddy

Abstracts:FGF-2 Stimulation of RANK Ligand Expression in Paget’s Disease of Bone
J Clin Endocrinol Metab 2009 94: 3100 [Full Text] [PDF]  

Shiguang Liu, Wen Tang, Jianwen Fang, Jinyu Ren, Hua Li, Zhousheng Xiao, and L. D. Quarles

Abstracts:Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone
J Clin Endocrinol Metab 2009 94: 3100-a [Full Text] [PDF]  

Wilbert Zwart, Mariska Rondaij, Kees Jalink, Z. Dave Sharp, Michael A. Mancini, Jacques Neefjes, and Rob Michalides

Abstracts:Resistance to Antiestrogen Arzoxifene Is Mediated by Overexpression of Cyclin D1
J Clin Endocrinol Metab 2009 94: 3101 [Full Text] [PDF]  

Lowenna J. Holt, Ruth J. Lyons, Ashleigh S. Ryan, Susan M. Beale, Andrew Ward, Gregory J. Cooney, and Roger J. Daly

Abstracts:Dual Ablation of Grb10 and Grb14 in Mice Reveals Their Combined Role in Regulation of Insulin Signaling and Glucose Homeostasis
J Clin Endocrinol Metab 2009 94: 3101-a [Full Text] [PDF]  

Announcements and Resources:

Erratum
J Clin Endocrinol Metab 2009 94: 3116 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Lee M. Kaplan, John Morton, Kevin D. Niswender, and Brent E. Wisse

Patient Information Page from The Hormone Foundation:Cirugía bariátrica y el sistema endocrino: beneficios y riesgos
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

John Morton, Kevin D. Niswender, and Brent E. Wisse

Patient Information Page from The Hormone Foundation:Bariatric Surgery and the Endocrine System: Benefits and Risks
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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