The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

Special Features:

Bing-bing Shi, Han-zhong Li, Lei Zhao, Qiuning Sun, Hua Fan, Hong-jun Li, Yong-qiang Li, and Yujiang Fang

IMAGE IN ENDOCRINOLOGY:Paraneoplastic Pemphigus Caused by Castleman’s Disease Masquerading as an Adrenal Neoplasm
J Clin Endocrinol Metab 2009 94: 1841-1842 doi:10.1210/jc.2009-0100 [Full Text] [PDF]  

Rania Abu-Hamdah, Atoosa Rabiee, Graydon S. Meneilly, Richard P. Shannon, Dana K. Andersen, and Dariush Elahi

CLINICAL REVIEW:The Extrapancreatic Effects of Glucagon-Like Peptide-1 and Related Peptides
J Clin Endocrinol Metab 2009 94: 1843-1852 , doi:10.1210/jc.2008-1296 [Abstract] [Full Text] [PDF]  
GLP-1 and analogs have physiological effects on several organ systems other than pancreas, and the mechanisms of action are independent of insulin regulated pathways.

Sherita H. Golden, Karen A. Robinson, Ian Saldanha, Blair Anton, and Paul W. Ladenson

CLINICAL REVIEW:Prevalence and Incidence of Endocrine and Metabolic Disorders in the United States: A Comprehensive Review
J Clin Endocrinol Metab 2009 94: 1853-1878 doi:10.1210/jc.2008-2291 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The Endocrinology and Metabolism Epidemiology Database provides epidemiological trends to show clues to environmental predispositions and the underlying causes of diseases in the United States.

M. Terzolo, M. Fassnacht, G. Ciccone, B. Allolio, and A. Berruti

COMMENTARY:Adjuvant Mitotane for Adrenocortical Cancer—Working through Uncertainty
J Clin Endocrinol Metab 2009 94: 1879-1880 doi:10.1210/jc.2009-0120 [Full Text] [PDF]  

David S. Cooper and Scott A. Rivkees

COMMENTARY:Putting Propylthiouracil in Perspective
J Clin Endocrinol Metab 2009 94: 1881-1882 , doi:10.1210/jc.2009-0850 [Full Text] [PDF] [Supplemental Data]  

Editorials:

Vasantha Padmanabhan

EDITORIAL:Polycystic Ovary Syndrome — "A Riddle Wrapped in a Mystery inside an Enigma"
J Clin Endocrinol Metab 2009 94: 1883-1885 doi:10.1210/jc.2009-0492 [Full Text] [PDF]  

Errol R. Norwitz

EDITORIAL:A Blood Test to Predict Preterm Birth: Don’t Mess with Maternal-Fetal Stress
J Clin Endocrinol Metab 2009 94: 1886-1889 doi:10.1210/jc.2009-0706 [Full Text] [PDF]  

Eberhard Nieschlag

EDITORIAL:Male Hormonal Contraception: Love’s Labour’s Lost?
J Clin Endocrinol Metab 2009 94: 1890-1892 doi:10.1210/jc.2009-0704 [Full Text] [PDF]  

P. Reed Larsen

EDITORIAL:Type 2 Iodothyronine Deiodinase in Human Skeletal Muscle: New Insights into Its Physiological Role and Regulation
J Clin Endocrinol Metab 2009 94: 1893-1895 doi:10.1210/jc.2009-0791 [Full Text] [PDF]  

Endocrine Care:

Frederic Castinetti, Monique Martinie, Isabelle Morange, Henry Dufour, Nathalie Sturm, Jean-Guy Passagia, Bernard Conte-Devolx, Olivier Chabre, and Thierry Brue

A Combined Dexamethasone Desmopressin Test as an Early Marker of Postsurgical Recurrence in Cushing’s Disease
J Clin Endocrinol Metab 2009 94: 1897-1903 , doi:10.1210/jc.2008-2234 [Abstract] [Full Text] [PDF]  
Combined dexamethasone desmopressin testing for postoperative follow-up of Cushing’s disease patients diagnoses persistent disease.

Robert D. van Beek, Marry M. van den Heuvel-Eibrink, Friederike G. Hakvoort-Cammel, Cor van den Bos, Heleen J. H. van der Pal, Eric P. Krenning, Yolande B. de Rijke, Rob Pieters, and Sabine M. P. F. de Muinck Keizer-Schrama

Bone Mineral Density, Growth, and Thyroid Function in Long-Term Survivors of Pediatric Hodgkin’s Lymphoma Treated with Chemotherapy Only
J Clin Endocrinol Metab 2009 94: 1904-1909 , doi:10.1210/jc.2008-0622 [Abstract] [Full Text] [PDF]  
Long-term survivors of pediatric Hodgkin’s lymphoma, treated with chemotherapy only, have normal lean body mass and thyroid function, while the use of MOPP leads to decreased height and increased BMI in men and decreased BMD-TB in women.

Yiqun Gu, Xiaowei Liang, Weixiong Wu, Minli Liu, Shuxiu Song, Lifa Cheng, Liwei Bo, Chengliang Xiong, Xinghai Wang, Xiaozhang Liu, Lin Peng, and Kangshou Yao

Multicenter Contraceptive Efficacy Trial of Injectable Testosterone Undecanoate in Chinese Men
J Clin Endocrinol Metab 2009 94: 1910-1915 , doi:10.1210/jc.2008-1846 [Abstract] [Full Text] [PDF]  
Monthly injection of 500 mg testosterone undecanoate in tea seed oil provides safe, effective, reversible, and reliable contraception in a high proportion of fertile Chinese men.

Dexter Canoy, Anneli Pouta, Aimo Ruokonen, Anna-Liisa Hartikainen, Pekka Saikku, and Marjo-Riitta Järvelin

Weight at Birth and Infancy in Relation to Adult Leukocyte Count: A Population-Based Study of 5619 Men and Women Followed from the Fetal Period to Adulthood
J Clin Endocrinol Metab 2009 94: 1916-1922 , doi:10.1210/jc.2008-2545 [Abstract] [Full Text] [PDF]  
Reduced fetal and infant growth is associated with increased circulating levels of leukocyte count in adulthood.

Teresa Sir-Petermann, Ethel Codner, Virginia Pérez, Bárbara Echiburú, Manuel Maliqueo, Amanda Ladrón de Guevara, Jessica Preisler, Nicolás Crisosto, Fernando Sánchez, Fernando Cassorla, and Shalender Bhasin

Metabolic and Reproductive Features before and during Puberty in Daughters of Women with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 1923-1930 , doi:10.1210/jc.2008-2836 [Abstract] [Full Text] [PDF]  
Hyperinsulinemia and increased ovarian volume are present in daughters of PCOS women before the onset of puberty, while ovarian hyperandrogenism appears to be present only during late puberty.

Leonardo Vieira Neto, Evelyn de O. Machado, Raul M. Luque, Giselle F. Taboada, Jorge B. Marcondes, Leila M. C. Chimelli, Leonardo Pereira Quintella, Paulo Niemeyer, Jr., Denise P. de Carvalho, Rhonda D. Kineman, and Mônica R. Gadelha

Expression Analysis of Dopamine Receptor Subtypes in Normal Human Pituitaries, Nonfunctioning Pituitary Adenomas and Somatotropinomas, and the Association between Dopamine and Somatostatin Receptors with Clinical Response to Octreotide-LAR in Acromegaly
J Clin Endocrinol Metab 2009 94: 1931-1937 , doi:10.1210/jc.2008-1826 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Dopamine receptor (DR) subtype 2 is the predominant DR in normal pituitaries and adenomas and DR1 and DR5 are negatively and positively associated with octreotide-LAR response, respectively.

Carsten C. Boedeker, Zoran Erlic, Stéphane Richard, Udo Kontny, Anne-Paule Gimenez-Roqueplo, Alberto Cascon, Mercedes Robledo, José M. de Campos, Francien H. van Nederveen, Ronald R. de Krijger, Nelly Burnichon, José Gaal, Martin A. Walter, Kirsten Reschke, Thorsten Wiech, Johannes Weber, Klaus Rückauer, Pierre Francois Plouin, Vincent Darrouzet, Sophie Giraud, Charis Eng, and Hartmut P. H. Neumann

Head and Neck Paragangliomas in Von Hippel-Lindau Disease and Multiple Endocrine Neoplasia Type 2
J Clin Endocrinol Metab 2009 94: 1938-1944 , doi:10.1210/jc.2009-0354 [Abstract] [Full Text] [PDF]  
Head and neck paragangliomas represent a very rare feature in von Hippel-Lindau disease–multiple endocrine neoplasia type 2 and neurofibromatosis type 1.

Ferdinand Roelfsema, Nienke R. Biermasz, Marijke Frolich, Daniel M. Keenan, Johannes D. Veldhuis, and Johannes A. Romijn

Diminished and Irregular Thyrotropin Secretion with Preserved Diurnal Rhythm in Patients with Active Acromegaly
J Clin Endocrinol Metab 2009 94: 1945-1950 , doi:10.1210/jc.2009-0174 [Abstract] [Full Text] [PDF]  
Euthyroid patients with active (untreated) acromegaly maintain subnormal TSH concentration profiles, which are characterized by diminutive secretory bursts, irregular secretion patterns, and suppressed diurnal TSH rhythmicity.

Marcella D. Walker, Donald J. McMahon, William B. Inabnet, Ronald M. Lazar, Ijeoma Brown, Susan Vardy, Felicia Cosman, and Shonni J. Silverberg

Neuropsychological Features in Primary Hyperparathyroidism: A Prospective Study
J Clin Endocrinol Metab 2009 94: 1951-1958 , doi:10.1210/jc.2008-2574 [Abstract] [Full Text] [PDF]  
Mild primary hyperparathyroidism is associated with cognitive changes affecting verbal memory and non-verbal abstraction that improve after parathyroidectomy and are independent of anxiety and depressive symptoms.

V. Radha, J. Ek, S. Anuradha, T. Hansen, O. Pedersen, and V. Mohan

Identification of Novel Variants in the Hepatocyte Nuclear Factor-1 Gene in South Indian Patients with Maturity Onset Diabetes of Young
J Clin Endocrinol Metab 2009 94: 1959-1965 , doi:10.1210/jc.2008-2371 [Abstract] [Full Text] [PDF]  
Mutations in HNF 1A gene comprise about 9% of clinically diagnosed MODY subjects in Southern India, and a novel mutation cosegregates with MODY in one family.

Sam P. L. Rice, Neera Agarwal, Hemanth Bolusani, Robert Newcombe, Maurice F. Scanlon, Marian Ludgate, and D. Aled Rees

Effects of Dehydroepiandrosterone Replacement on Vascular Function in Primary and Secondary Adrenal Insufficiency: A Randomized Crossover Trial
J Clin Endocrinol Metab 2009 94: 1966-1972 , doi:10.1210/jc.2008-2636 [Abstract] [Full Text] [PDF] [Supplemental Data]  
DHEA does not affect vascular function in patients with adrenal insufficiency.

Johanna Puurunen, Terhi Piltonen, Päivi Jaakkola, Aimo Ruokonen, Laure Morin-Papunen, and Juha S. Tapanainen

Adrenal Androgen Production Capacity Remains High up to Menopause in Women with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 1973-1978 , doi:10.1210/jc.2008-2583 [Abstract] [Full Text] [PDF]  
Serum adrenal steroid levels and adrenal steroid production capacity remain enhanced in premenopausal women with PCOS.

Brian A. Irving, J. Y. Weltman, James T. Patrie, Christopher K. Davis, David W. Brock, Damon Swift, Eugene J. Barrett, Glenn A. Gaesser, and Arthur Weltman

Effects of Exercise Training Intensity on Nocturnal Growth Hormone Secretion in Obese Adults with the Metabolic Syndrome
J Clin Endocrinol Metab 2009 94: 1979-1986 , doi:10.1210/jc.2008-2256 [Abstract] [Full Text] [PDF]  
Sixteen weeks of supervised exercise training in adults with the metabolic syndrome increases spontaneous nocturnal GH secretion independent of exercise training intensity.

Esther A. M. Kuijper, Jacqueline M. Vink, Cornelis B. Lambalk, and Dorret I. Boomsma

Prevalence of Polycystic Ovary Syndrome in Women from Opposite-Sex Twin Pairs
J Clin Endocrinol Metab 2009 94: 1987-1990 , doi:10.1210/jc.2009-0191 [Abstract] [Full Text] [PDF]  
The prevalence of PCOS is equal in women from opposite-sex and same-sex twin pairs.

Fred R. Sattler, Carmen Castaneda-Sceppa, Ellen F. Binder, E. Todd Schroeder, Ying Wang, Shalender Bhasin, Miwa Kawakubo, Yolanda Stewart, Kevin E. Yarasheski, Jagadish Ulloor, Patrick Colletti, Ronenn Roubenoff, and Stanley P. Azen

Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men
J Clin Endocrinol Metab 2009 94: 1991-2001 , doi:10.1210/jc.2008-2338 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Supplemental testosterone produces significant gains in total and appendicular lean mass, muscle strength, and aerobic endurance with significant reductions in whole body and trunk fat that are enhanced with growth hormone supplementation.

Maya B. Lodish, Ninet Sinaii, Nicholas Patronas, Dalia L. Batista, Meg Keil, Jonelle Samuel, Jason Moran, Somya Verma, Jadranka Popovic, and Constantine A. Stratakis

Blood Pressure in Pediatric Patients with Cushing Syndrome
J Clin Endocrinol Metab 2009 94: 2002-2008 , doi:10.1210/jc.2008-2694 [Abstract] [Full Text] [PDF]  
Children with Cushing’s syndrome are at risk for residual hypertension despite a significant improvement after surgical cure.

Zeina M. Nabhan, Linda A. DiMeglio, Rong Qi, Susan M. Perkins, and Erica A. Eugster

Conjugated Oral versus Transdermal Estrogen Replacement in Girls with Turner Syndrome: A Pilot Comparative Study
J Clin Endocrinol Metab 2009 94: 2009-2014 , doi:10.1210/jc.2008-2123 [Abstract] [Full Text] [PDF]  
In girls with Turner syndrome, transdermal estradiol results in faster bone accrual and increased uterine growth following one year of treatment, compared with conjugated oral estrogen.

Antonio Bianchi, Andrea Giustina, Vincenzo Cimino, Roberto Pola, Flavia Angelini, Alfredo Pontecorvi, and Laura De Marinis

Influence of Growth Hormone Receptor d3 and Full-Length Isoforms on Biochemical Treatment Outcomes in Acromegaly
J Clin Endocrinol Metab 2009 94: 2015-2022 , doi:10.1210/jc.2008-1337 [Abstract] [Full Text] [PDF]  
Growth hormone receptor polymorphism has relevant impact on post-treatment biochemical assessment of acromegaly.

Lamise Ay, Vera A. A. Van Houten, Eric A. P. Steegers, Albert Hofman, Jacqueline C. M. Witteman, Vincent W. V. Jaddoe, and Anita C. S. Hokken-Koelega

Fetal and Postnatal Growth and Body Composition at 6 Months of Age
J Clin Endocrinol Metab 2009 94: 2023-2030 , doi:10.1210/jc.2008-2045 [Abstract] [Full Text] [PDF]  
Catch-down in weight in the third trimester is associated with postnatal catch-up within 6 weeks postnatally, and both are associated with increased fat-mass at 6 months.

Samuel Dagogo-Jack, Hasan Askari, and Gunjan Tykodi

Glucoregulatory Physiology in Subjects with Low-Normal, High-Normal, or Impaired Fasting Glucose
J Clin Endocrinol Metab 2009 94: 2031-2036 , doi:10.1210/jc.2008-1348 [Abstract] [Full Text] [PDF]  
This cross-section study shows that variations in fasting plasma glucose (FPG) within the nondiabetic range (70–125 mg/dl) are associated with a >3-fold difference in insulin sensitivity, varying degrees of β-cell dysfunction, and altered disposition index.

Natasha B. Khazai, Suzanne E. Judd, Leo Jeng, Linda L. Wolfenden, Arlene Stecenko, Thomas R. Ziegler, and Vin Tangpricha

Treatment and Prevention of Vitamin D Insufficiency in Cystic Fibrosis Patients: Comparative Efficacy of Ergocalciferol, Cholecalciferol, and UV Light
J Clin Endocrinol Metab 2009 94: 2037-2043 , doi:10.1210/jc.2008-2012 [Abstract] [Full Text] [PDF]  
Adult cystic fibrosis patients can be given an oral regimen of vitamin D to improve vitamin D status during the winter months.

Helena Forsblad-d'Elia, Hans Carlsten, Fernand Labrie, Yrjö T. Konttinen, and Claes Ohlsson

Low Serum Levels of Sex Steroids Are Associated with Disease Characteristics in Primary Sjogren’s Syndrome; Supplementation with Dehydroepiandrosterone Restores the Concentrations
J Clin Endocrinol Metab 2009 94: 2044-2051 , doi:10.1210/jc.2009-0106 [Abstract] [Full Text] [PDF]  
Disease manifestations in women with primary Sjogren’s syndrome were associated with low sex hormone levels, which were restored by supplementation with dehydroepiandrosterone.

Emily C. Walvoord, Amparo de la Peña, Soomin Park, Bernard Silverman, Leona Cuttler, Susan R. Rose, Gordon Cutler, Stenvert Drop, and John J. Chipman

Inhaled Growth Hormone (GH) Compared with Subcutaneous GH in Children with GH Deficiency: Pharmacokinetics, Pharmacodynamics, and Safety
J Clin Endocrinol Metab 2009 94: 2052-2059 , doi:10.1210/jc.2008-1897 [Abstract] [Full Text] [PDF]  
Inhaled growth hormone administered to growth hormone deficient children for 7 days is well tolerated and results in dose-dependent increases in serum GH and IGF-1 levels.

Cristina Hernández, Beatriz Rodríguez, Eladio Losada, Lidia Corraliza, Marta García-Ramírez, and Rafael Simó

Normoalbuminuric Type 1 Diabetic Patients with Retinopathy Have an Impaired Tubular Response to Desmopressin: Its Relationship with Plasma Endothelin-1
J Clin Endocrinol Metab 2009 94: 2060-2065 , doi:10.1210/jc.2008-2784 [Abstract] [Full Text] [PDF]  
Normoalbuminuric type 1 diabetic patients with diabetic retinopathy have impaired renal response to desmopressin, which is related to plasma endothelin-1 levels.

Roger Smith, Julia I. Smith, Xiaobin Shen, Patricia J. Engel, Maria E. Bowman, Shaun A. McGrath, Andrew M. Bisits, Patrick McElduff, Warwick B. Giles, and David W. Smith

Patterns of Plasma Corticotropin-Releasing Hormone, Progesterone, Estradiol, and Estriol Change and the Onset of Human Labor
J Clin Endocrinol Metab 2009 94: 2066-2074 , doi:10.1210/jc.2008-2257 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Significant late gestational changes in maternal plasma P/E3 and E3/E2 ratios indicate a corticotrophin-releasing hormone driven switch from progesterone to estrogen dominance in human pregnancy at labor.

Nicolas Aide, Natacha Heutte, Jean-Pierre Rame, Elise Rousseau, Cédric Loiseau, Michel Henry-Amar, and Stéphane Bardet

Clinical Relevance of Single-Photon Emission Computed Tomography/Computed Tomography of the Neck and Thorax in Postablation ¹³¹I Scintigraphy for Thyroid Cancer
J Clin Endocrinol Metab 2009 94: 2075-2084 , doi:10.1210/jc.2008-2313 [Abstract] [Full Text] [PDF]  
Since SPECT-CT allows to confirm or to rule out residual disease in most cases where whole-body scan remains indeterminate, we recommend its use when available.

Jérôme Bertherat, Anélia Horvath, Lionel Groussin, Sophie Grabar, Sosipatros Boikos, Laure Cazabat, Rosella Libe, Fernande René-Corail, Sotirios Stergiopoulos, Isabelle Bourdeau, Thalia Bei, Eric Clauser, Alain Calender, Lawrence S. Kirschner, Xavier Bertagna, J. Aidan Carney, and Constantine A. Stratakis

Mutations in Regulatory Subunit Type 1A of Cyclic Adenosine 5'-Monophosphate-Dependent Protein Kinase (PRKAR1A): Phenotype Analysis in 353 Patients and 80 Different Genotypes
J Clin Endocrinol Metab 2009 94: 2085-2091 , doi:10.1210/jc.2008-2333 [Abstract] [Full Text] [PDF]  
Carney complex is genetically and clinically heterogeneous. Certain tumors are more frequent with specific mutations providing some genotype-phenotype correlation for PRKAR1A mutations.

Yuri E. Nikiforov, David L. Steward, Toni M. Robinson-Smith, Bryan R. Haugen, Joshua P. Klopper, Zhaowen Zhu, James A. Fagin, Mercedes Falciglia, Katherine Weber, and Marina N. Nikiforova

Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules
J Clin Endocrinol Metab 2009 94: 2092-2098 , doi:10.1210/jc.2009-0247 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Testing for a panel of mutations in thyroid fine needle aspiration samples improves cancer detection, particularly in thyroid nodules with indeterminate cytology.

Gang Hu, Pekka Jousilahti, Jaakko Tuomilehto, Riitta Antikainen, Jouko Sundvall, and Veikko Salomaa

Association of Serum C-Reactive Protein Level with Sex-Specific Type 2 Diabetes Risk: A Prospective Finnish Study
J Clin Endocrinol Metab 2009 94: 2099-2105 , doi:10.1210/jc.2008-2260 [Abstract] [Full Text] [PDF]  
Elevated serum C-reactive protein levels were associated with increased diabetes risk, particularly in women.

Guntram Borck, Ora Seewi, Alexander Jung, Eckhard Schönau, and Christian Kubisch

BRIEF REPORT:Genetic Causes of Goiter and Deafness: Pendred Syndrome in a Girl and Cooccurrence of Pendred Syndrome and Resistance to Thyroid Hormone in Her Sister
J Clin Endocrinol Metab 2009 94: 2106-2109 , doi:10.1210/jc.2008-2361 [Abstract] [Full Text] [PDF]  
Two sisters with goiter and deafness are reported, one of whom has Pendred syndrome while the other one has both Pendred syndrome and resistance to thyroid hormone.

Lisa M. L. van Winsen, Laura Manenschijn, Elisabeth F. C. van Rossum, Bart A. Crusius, Jan Willem Koper, Chris H. Polman, and Bernard M. J. Uitdehaag

BRIEF REPORT:A Glucocorticoid Receptor Gene Haplotype (TthIII1/ER22/23EK/9β) Is Associated with a More Aggressive Disease Course in Multiple Sclerosis
J Clin Endocrinol Metab 2009 94: 2110-2114 , doi:10.1210/jc.2008-2194 [Abstract] [Full Text] [PDF]  
Multiple sclerosis patients carrying the haplotype TthIII1/ER22/23EK/9β, which causes a decreased glucocorticoid sensitivity, have a more aggressive disease course.

Teck Kim Khoo, Santhi Swaroop Vege, Haitham S. Abu-Lebdeh, Euijung Ryu, Sarah Nadeem, and Robert A. Wermers

BRIEF REPORT:Acute Pancreatitis in Primary Hyperparathyroidism: A Population-Based Study
J Clin Endocrinol Metab 2009 94: 2115-2118 , doi:10.1210/jc.2008-1965 [Abstract] [Full Text] [PDF]  
In community patients with primary hyperparathyroidism, acute pancreatitis is not increased, suggesting a chance association between these entities.

Mirja Nurmio, Victoria Keros, Päivi Lähteenmäki, Toivo Salmi, Markku Kallajoki, and Kirsi Jahnukainen

BRIEF REPORT:Effect of Childhood Acute Lymphoblastic Leukemia Therapy on Spermatogonia Populations and Future Fertility
J Clin Endocrinol Metab 2009 94: 2119-2122 , doi:10.1210/jc.2009-0060 [Abstract] [Full Text] [PDF]  
Treatment for childhood leukemia without high-dose cyclophosphamide seldom depletes the spermatogonial stem cell pool.

Anubha Mahajan, Rubina Tabassum, Sreenivas Chavali, Om Prakash Dwivedi, Mausumi Bharadwaj, Nikhil Tandon, and Dwaipayan Bharadwaj

BRIEF REPORT:High-Sensitivity C-Reactive Protein Levels and Type 2 Diabetes in Urban North Indians
J Clin Endocrinol Metab 2009 94: 2123-2127 , doi:10.1210/jc.2008-2754 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Low-grade systemic inflammation is associated with type 2 diabetes as indicated by elevated high-sensitivity C-reactive protein levels in a North Indian population.

Endocrine Research:

Miriam A. Bredella, Pouneh K. Fazeli, Karen K. Miller, Madhusmita Misra, Martin Torriani, Bijoy J. Thomas, Reza Hosseini Ghomi, Clifford J. Rosen, and Anne Klibanski

Increased Bone Marrow Fat in Anorexia Nervosa
J Clin Endocrinol Metab 2009 94: 2129-2136 , doi:10.1210/jc.2008-2532 [Abstract] [Full Text] [PDF]  
Patients with anorexia nervosa have increased lumbar and femoral bone marrow fat compared to normal weight controls.

Johannes D. Veldhuis, Daniel M. Keenan, Joy N. Bailey, Adebordurin M. Adeniji, John M. Miles, and Cyril Y. Bowers

Novel Relationships of Age, Visceral Adiposity, Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein Concentrations to Growth Hormone (GH) Releasing-Hormone and GH Releasing-Peptide Efficacies in Men during Experimental Hypogonadal Clamp
J Clin Endocrinol Metab 2009 94: 2137-2143 , doi:10.1210/jc.2009-0136 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The influences of body composition and IGF-I should be recognized in framing normative ranges for the efficacies of GHRH and GHRP-2 in short-term hypogonadal men.

Karen A. Heemstra, Maarten R. Soeters, Eric Fliers, Mireille J. Serlie, Jacobus Burggraaf, Martijn B. van Doorn, Agatha A. van der Klaauw, Johannes A. Romijn, Johannes W. Smit, Eleonora P. Corssmit, and Theo J. Visser

Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting
J Clin Endocrinol Metab 2009 94: 2144-2150 , doi:10.1210/jc.2008-2520 [Abstract] [Full Text] [PDF]  
Human skeletal muscle D2 mRNA expression is modulated by fasting and insulin, but not by hypothyroidism.

Huating Li, Yuqian Bao, Aimin Xu, Xiaoping Pan, Junxi Lu, Haiya Wu, Huijuan Lu, Kunsan Xiang, and Weiping Jia

Serum Fibroblast Growth Factor 21 Is Associated with Adverse Lipid Profiles and -Glutamyltransferase But Not Insulin Sensitivity in Chinese Subjects
J Clin Endocrinol Metab 2009 94: 2151-2156 , doi:10.1210/jc.2008-2331 [Abstract] [Full Text] [PDF]  
Serum levels of FGF21 are closely related to adiposity, lipid metabolism, and biomarkers of liver injury, but not insulin secretion and sensitivity in humans.

John Doupis, Thomas E. Lyons, Szuhuei Wu, Charalambos Gnardellis, Thanh Dinh, and Aristidis Veves

Microvascular Reactivity and Inflammatory Cytokines in Painful and Painless Peripheral Diabetic Neuropathy
J Clin Endocrinol Metab 2009 94: 2157-2163 , doi:10.1210/jc.2008-2385 [Abstract] [Full Text] [PDF]  
Peripheral diabetic neuropathy is associated with increased biochemical markers of inflammation and endothelial dysfunction, and these are more prominent in painful neuropathy.

C. J. Lockwood, W. Murk, U. A. Kayisli, L. F. Buchwalder, S.-T. Huang, E. F. Funai, G. Krikun, and F. Schatz

Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells
J Clin Endocrinol Metab 2009 94: 2164-2170 , doi:10.1210/jc.2009-0065 [Abstract] [Full Text] [PDF]  
Elevated decidual cell-expressed tissue factor at the maternal-fetal interface is positioned to promote hemostasis and protect against hemorrhage during labor and delivery.

Mark B. Zimering and Zui Pan

Autoantibodies in Type 2 Diabetes Induce Stress Fiber Formation and Apoptosis in Endothelial Cells
J Clin Endocrinol Metab 2009 94: 2171-2177 , doi:10.1210/jc.2008-2354 [Abstract] [Full Text] [PDF]  
Autoantibodies from adults with type 2 diabetes activate the RhoA/Rho kinase signaling pathway and induce apoptosis in endothelial cells.

Mabrouka Doghman, Julie Cazareth, Dominique Douguet, Franck Madoux, Peter Hodder, and Enzo Lalli

Inhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists
J Clin Endocrinol Metab 2009 94: 2178-2183 , doi:10.1210/jc.2008-2163 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Drugs targeting transcription factor SF-1 inhibit proliferation of adrenocortical carcinoma cells.

Akira Iwase, Maki Goto, Toko Harata, Sachiko Takigawa, Tatsuo Nakahara, Kyosuke Suzuki, Shuichi Manabe, and Fumitaka Kikkawa

Insulin Attenuates the Insulin-Like Growth Factor-I (IGF-I)-Akt Pathway, not IGF-I-Extracellularly Regulated Kinase Pathway, in Luteinized Granulosa Cells with an Increase in PTEN
J Clin Endocrinol Metab 2009 94: 2184-2191 , doi:10.1210/jc.2008-1948 [Abstract] [Full Text] [PDF]  
Insulin attenuates IGF-1-Akt pathway in luteinized granulosa cells with increased PTEN, of which expression in luteinized granulosa cells is higher in PCOS patients than non-PCOS patients.

Yasuhiro Nakamura, Peter J. Hornsby, Peter Casson, Ryo Morimoto, Fumitoshi Satoh, Yewei Xing, Michael R. Kennedy, Hironobu Sasano, and William E. Rainey

Type 5 17β-Hydroxysteroid Dehydrogenase (AKR1C3) Contributes to Testosterone Production in the Adrenal Reticularis
J Clin Endocrinol Metab 2009 94: 2192-2198 , doi:10.1210/jc.2008-2374 [Abstract] [Full Text] [PDF]  
AKR1C3 is expressed in the human adrenal reticularis and plays a role in adrenal testosterone production.

Rebecca E. Schweppe, Anna A. Kerege, Jena D. French, Vibha Sharma, Rachel L. Grzywa, and Bryan R. Haugen

BRIEF REPORT:Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer
J Clin Endocrinol Metab 2009 94: 2199-2203 , doi:10.1210/jc.2008-2511 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Focal adhesion kinase (FAK) and Src are activated in thyroid cancer cell lines, and cells with high phospho-FAK are more sensitive to treatment with the Src inhibitor AZD0530.

Niels Møller, Lars C. Gormsen, Ole Schmitz, Sten Lund, Jens Otto L. Jørgensen, and Niels Jessen

BRIEF REPORT:Free Fatty Acids Inhibit Growth Hormone/Signal Transducer and Activator of Transcription-5 Signaling in Human Muscle: A Potential Feedback Mechanism
J Clin Endocrinol Metab 2009 94: 2204-2207 , doi:10.1210/jc.2008-2624 [Abstract] [Full Text] [PDF]  
GH-induced phosphorylation of STAT5 in human skeletal muscle is inhibited by plasma free fatty acids in a dose-dependent manner.

Translational Highlights from Endocrinology:

Eran Elinav, Leonora Niv-Spector, Meirav Katz, Tulin O. Price, Mohammed Ali, Michal Yacobovitz, Gili Solomon, Shay Reicher, Jessica L. Lynch, Zamir Halpern, William A. Banks, and Arieh Gertler

Abstracts:Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity
J Clin Endocrinol Metab 2009 94: 2208-2209 [Full Text] [PDF]  

Annette D. De Kloet and Stephen C. Woods

Abstracts:Minireview: Endocannabinoids and Their Receptors as Targets for Obesity Therapy
J Clin Endocrinol Metab 2009 94: 2208-a-2209 [Full Text] [PDF]  

Joshua P. Thaler and David E. Cummings

Abstracts:Minireview: Hormonal and Metabolic Mechanisms of Diabetes Remission after Gastrointestinal Surgery
J Clin Endocrinol Metab 2009 94: 2208-b-2209 [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Linda L. Grasfeder, Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-yi Chang, and Donald P. McDonnell

Abstracts:Fasting-Induced Hepatic Production of DHEA is Regulated by PGC-1, ERR and HNF4
J Clin Endocrinol Metab 2009 94: 2210 [Full Text] [PDF]  

Francine M. Gregoire, Fang Zhang, Holly J. Clarke, Thomas A. Gustafson, Dorothy D. Sears, Svetlana Favelyukis, James Lenhard, Dennis Rentzeperis, L. Edward Clemens, Yi Mu, and Brian E. Lavan

Abstracts:MBX-102/JNJ39659100, a Novel Peroxisome Proliferator Activated Receptor- Ligand with Weak Transactivation Activity Retains Full Anti-Diabetic Properties in the Absence of Side Effects
J Clin Endocrinol Metab 2009 94: 2210-a [Full Text] [PDF]  

Geun Hyang Kim, Keunhee Park, Seon-Yong Yeom, Kyung Jin Lee, Gukhan Kim, Jesang Ko, Dong-Kwon Rhee, Young Hoon Kim, Hye Kyung Lee, Hae Won Kim, Goo Taeg Oh, Ki-Up Lee, Jae W. Lee, and Seung-Whan Kim

Abstracts:Characterization of ASC-2 as an Anti-Atherogenic Transcriptional Coactivator of Liver X Receptors in Macrophages
J Clin Endocrinol Metab 2009 94: 2211 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Linn Goldberg, Alan D. Rogol, and Peter H. Sonksen

Patient Information Page from The Hormone Foundation:Hormona del crecimiento: Uso y abuso
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Linn Goldberg, Alan D. Rogol, and Peter H. Sonksen

Patient Information Page from The Hormone Foundation:Growth Hormone: Use and Abuse
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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