The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

Special Features:

Peter R. Ebeling

APPROACH TO THE PATIENT:Approach to the Patient with Transplantation-Related Bone Loss
J Clin Endocrinol Metab 2009 94: 1483-1490 doi:10.1210/jc.2009-0205 [Abstract] [Full Text] [PDF]  
Pre-transplantation bone disease and immunosuppressive therapy cause rapid bone loss and increased fracture rates after organ transplantation. Oral or intravenous bisphosphonates prevent post-transplantation bone loss.

Jin Young Kwak, Eun-Kyung Kim, Soon Won Hong, Hee Jung Moon, Min Jung Kim, Eun Ju Son, and Cheong Soo Park

IMAGE IN ENDOCRINOLOGY:Diffuse Sclerosing Variant of Papillary Carcinoma of the Thyroid Gland: Specimen Radiographic Features with Histopathological Correlation
J Clin Endocrinol Metab 2009 94: 1491-1492 doi:10.1210/jc.2009-0072 [Full Text] [PDF]  

Steven I. Sherman

CLINICAL REVIEW:Advances in Chemotherapy of Differentiated Epithelial and Medullary Thyroid Cancers
J Clin Endocrinol Metab 2009 94: 1493-1499 , doi:10.1210/jc.2008-0923 [Abstract] [Full Text] [PDF]  
Novel therapies targeting angiogenesis and activated oncogenes are proving useful to control metastatic thyroid carcinoma, reflecting a new treatment paradigm.

Gherardo Mazziotti, Irene Floriani, Stefania Bonadonna, Valter Torri, Philippe Chanson, and Andrea Giustina

REVIEW:Effects of Somatostatin Analogs on Glucose Homeostasis: A Metaanalysis of Acromegaly Studies
J Clin Endocrinol Metab 2009 94: 1500-1508 , doi:10.1210/jc.2008-2332 [Abstract] [Full Text] [PDF]  
A meta-analysis suggests that changes in examined parameters of glucose homeostasis, induced by somatostatin analog therapy in acromegaly, may have an overall minor clinical impact.

S. Melmed, A. Colao, A. Barkan, M. Molitch, A. B. Grossman, D. Kleinberg, D. Clemmons, P. Chanson, E. Laws, J. Schlechte, M. L. Vance, K. Ho, and A. Giustina

CONSENSUS STATEMENTS:Guidelines for Acromegaly Management: An Update
J Clin Endocrinol Metab 2009 94: 1509-1517 , doi:10.1210/jc.2008-2421 [Abstract] [Full Text] [PDF]  
Guidelines for acromegaly management were developed with critical literature evaluation by a global consensus workshop.

Editorials:

Alberto Falchetti and Maria Luisa Brandi

EDITORIAL:Multiple Endocrine Neoplasia Type I Variants and Phenocopies: More than a Nosological Issue?
J Clin Endocrinol Metab 2009 94: 1518-1520 doi:10.1210/jc.2009-0494 [Full Text] [PDF]  

Brian W. Kim and Antonio C. Bianco

EDITORIAL:For Some, L-Thyroxine Replacement Might Not Be Enough: A Genetic Rationale
J Clin Endocrinol Metab 2009 94: 1521-1523 doi:10.1210/jc.2009-0410 [Full Text] [PDF]  

Gregory C. Henderson, Brian A. Irving, and K. Sreekumaran Nair

EDITORIAL:Potential Application of Essential Amino Acid Supplementation to Treat Sarcopenia in Elderly People
J Clin Endocrinol Metab 2009 94: 1524-1526 doi:10.1210/jc.2009-0458 [Full Text] [PDF]  

Endocrine Care:

Ken K. Ong, Pauline Emmett, Kate Northstone, Jean Golding, Imogen Rogers, Andrew R. Ness, Jonathan C. Wells, and David B. Dunger

Infancy Weight Gain Predicts Childhood Body Fat and Age at Menarche in Girls
J Clin Endocrinol Metab 2009 94: 1527-1532 , doi:10.1210/jc.2008-2489 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In a developed setting, rapid weight gain during the first 9 months of life is a risk factor for both increased childhood adiposity and early menarche in girls.

Rebecca L. Robker, Lisa K. Akison, Brenton D. Bennett, Penny N. Thrupp, Lindsay R. Chura, Darryl L. Russell, Michelle Lane, and Robert J. Norman

Obese Women Exhibit Differences in Ovarian Metabolites, Hormones, and Gene Expression Compared with Moderate-Weight Women
J Clin Endocrinol Metab 2009 94: 1533-1540 , doi:10.1210/jc.2008-2648 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Increasing body mass index is associated with alterations in the ovarian follicular environment.

Massimo Mannelli, Maurizio Castellano, Francesca Schiavi, Sebastiano Filetti, Mara Giacchè, Luigi Mori, Viviana Pignataro, Gianpaolo Bernini, Valentino Giachè, Alessandra Bacca, Bernadette Biondi, Giovanni Corona, Giuseppe Di Trapani, Erika Grossrubatscher, Giuseppe Reimondo, Giorgio Arnaldi, Gilberta Giacchetti, Franco Veglio, Paola Loli, Annamaria Colao, Maria Rosaria Ambrosio, Massimo Terzolo, Claudio Letizia, Tonino Ercolino, Giuseppe Opocher the Italian Pheochromocytoma/Paraganglioma Network

Clinically Guided Genetic Screening in a Large Cohort of Italian Patients with Pheochromocytomas and/or Functional or Nonfunctional Paragangliomas
J Clin Endocrinol Metab 2009 94: 1541-1547 , doi:10.1210/jc.2008-2419 [Abstract] [Full Text] [PDF]  
Family history and clinical evaluation are important clues in directing genetic analysis in patients with pheochromocytomas and/or paragangliomas.

Miguel Debono, Cyrus Ghobadi, Amin Rostami-Hodjegan, Hiep Huatan, Michael J. Campbell, John Newell-Price, Ken Darzy, Deborah P. Merke, Wiebke Arlt, and Richard J. Ross

Modified-Release Hydrocortisone to Provide Circadian Cortisol Profiles
J Clin Endocrinol Metab 2009 94: 1548-1554 , doi:10.1210/jc.2008-2380 [Abstract] [Full Text] [PDF]  
A modified release formulation of hydrocortisone that allows for delayed and sustained release of hydrocortisone can potentially replicate normal un-stressed physiological cortisol levels.

Qingju Wang, Sulin Cheng, Markku Alén, Ego Seeman The Finnish Calex Study Group

Bone’s Structural Diversity in Adult Females Is Established before Puberty
J Clin Endocrinol Metab 2009 94: 1555-1561 , doi:10.1210/jc.2008-2339 [Abstract] [Full Text] [PDF]  
Early established variance in bone traits suggesting skeletal fragility in advanced age has its antecedents partly established in early life.

Karen L. Teff, Joanne Grudziak, Raymond R. Townsend, Tamara N. Dunn, Ryan W. Grant, Sean H. Adams, Nancy L. Keim, Bethany P. Cummings, Kimber L. Stanhope, and Peter J. Havel

Endocrine and Metabolic Effects of Consuming Fructose- and Glucose-Sweetened Beverages with Meals in Obese Men and Women: Influence of Insulin Resistance on Plasma Triglyceride Responses
J Clin Endocrinol Metab 2009 94: 1562-1569 , doi:10.1210/jc.2008-2192 [Abstract] [Full Text] [PDF]  
Compared to glucose-sweetened beverages, consumption of fructose-sweetened beverages increases postprandial triglycerides in obese subjects, potentially exacerbating the known adverse metabolic profile associated with obesity.

Maud Bidet, Christine Bellanné-Chantelot, Marie-Béatrice Galand-Portier, Véronique Tardy, Line Billaud, Kathleen Laborde, Christiane Coussieu, Yves Morel, Christelle Vaury, Jean-Louis Golmard, Aurélie Claustre, Etienne Mornet, Zeina Chakhtoura, Irene Mowszowicz, Anne Bachelot, Philippe Touraine, and Frédérique Kuttenn

Clinical and Molecular Characterization of a Cohort of 161 Unrelated Women with Nonclassical Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency and 330 Family Members
J Clin Endocrinol Metab 2009 94: 1570-1578 , doi:10.1210/jc.2008-1582 [Abstract] [Full Text] [PDF]  
The clinical expression of NC-CAH is variable; as two-thirds of the patients have at least one severe mutation, it is essential to genotype the partner(s) of patients with a severe mutation in order to offer genetic counseling.

Monica Mortensen, David A. Ehrmann, Elizabeth Littlejohn, and Robert L. Rosenfield

Asymptomatic Volunteers with a Polycystic Ovary Are a Functionally Distinct but Heterogeneous Population
J Clin Endocrinol Metab 2009 94: 1579-1586 , doi:10.1210/jc.2008-2771 [Abstract] [Full Text] [PDF]  
Asymptomatic volunteers with a polycystic ovary are a heterogeneous population with respect to PCOS-type ovarian dysfunction, rather than a single intermediate phenotype.

Jennifer Hirshfeld-Cytron, Randall B. Barnes, David A. Ehrmann, Anthony Caruso, Monica M. Mortensen, and Robert L. Rosenfield

Characterization of Functionally Typical and Atypical Types of Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 1587-1594 , doi:10.1210/jc.2008-2248 [Abstract] [Full Text] [PDF]  
In contrast to the gonadotropin-hypersensitivity of typical PCOS, atypical PCOS is due to a unique type of ovarian dysfunction that is relatively gonadotropin-hyporesponsive.

Jill P. Crandall, Harry Shamoon, Hillel W. Cohen, Migdalia Reid, Srikanth Gajavelli, Georgeta Trandafirescu, Vafa Tabatabaie, and Nir Barzilai

Post-Challenge Hyperglycemia in Older Adults Is Associated with Increased Cardiovascular Risk Profile
J Clin Endocrinol Metab 2009 94: 1595-1601 , doi:10.1210/jc.2008-1829 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Older adults with post-challenge hyperglycemia experience significant postprandial metabolic dysregulation, which is accompanied by an unfavorable vascular risk profile.

Pedro Del Corral, Paula C. Chandler-Laney, Krista Casazza, Barbara A. Gower, and Gary R. Hunter

Effect of Dietary Adherence with or without Exercise on Weight Loss: A Mechanistic Approach to a Global Problem
J Clin Endocrinol Metab 2009 94: 1602-1607 , doi:10.1210/jc.2008-1057 [Abstract] [Full Text] [PDF]  
Dietary adherence is strongly associated with rates of weight loss and adversely affected by the severity of caloric restriction; therefore weight loss programs should consider moderate caloric restriction relative to estimates of energy requirements rather than generic low-calorie diets.

Rubina A. Heptulla, Luisa M. Rodriguez, Kimberly J. Mason, and Morey W. Haymond

Twenty-Four-Hour Simultaneous Subcutaneous Basal-Bolus Administration of Insulin and Amylin in Adolescents with Type 1 Diabetes Decreases Postprandial Hyperglycemia
J Clin Endocrinol Metab 2009 94: 1608-1611 , doi:10.1210/jc.2008-2580 [Abstract] [Full Text] [PDF]  
Amylin and insulin deficiency in type 1 diabetes can be overcome by the physiologic replacement of these hormones via a simultaneous, subcutaneous basal-bolus regimen.

Haixia Guan, Meiju Ji, Rong Bao, Hongyu Yu, Yangang Wang, Peng Hou, Yong Zhang, Zhongyan Shan, Weiping Teng, and Mingzhao Xing

Association of High Iodine Intake with the T1799A BRAF Mutation in Papillary Thyroid Cancer
J Clin Endocrinol Metab 2009 94: 1612-1617 , doi:10.1210/jc.2008-2390 [Abstract] [Full Text] [PDF]  
High iodine intake is associated with occurrence of BRAF mutation in papillary thyroid cancer and may therefore be a risk factor for this cancer.

Paolo Miccoli, Aldo Pinchera, Gabriele Materazzi, Agnese Biagini, Piero Berti, Pinuccia Faviana, Eleonora Molinaro, David Viola, and Rossella Elisei

Surgical Treatment of Low- and Intermediate-Risk Papillary Thyroid Cancer with Minimally Invasive Video-Assisted Thyroidectomy
J Clin Endocrinol Metab 2009 94: 1618-1622 , doi:10.1210/jc.2008-1418 [Abstract] [Full Text] [PDF]  
The follow-up of papillary thyroid cancer patients treated with MIVAT or conventional thyroidectomy demonstrated no differences in the outcome and complications of the two groups.

Vijay Panicker, Ponnusamy Saravanan, Bijay Vaidya, Jonathan Evans, Andrew T. Hattersley, Timothy M. Frayling, and Colin M. Dayan

Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients
J Clin Endocrinol Metab 2009 94: 1623-1629 , doi:10.1210/jc.2008-1301 [Abstract] [Full Text] [PDF]  
In subjects on thyroid hormone replacement, a D2 deiodinase genotype is associated with poorer psychological well-being and increased likelihood of improvement with addition of triiodothyronine.

Edgar L. Dillon, Melinda Sheffield-Moore, Douglas Paddon-Jones, Charles Gilkison, Arthur P. Sanford, Shanon L. Casperson, Jie Jiang, David L. Chinkes, and Randall J. Urban

Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women
J Clin Endocrinol Metab 2009 94: 1630-1637 , doi:10.1210/jc.2008-1564 [Abstract] [Full Text] [PDF]  
Twice daily between-meal ingestion of essential amino acid for 3 months increased lean body mass and the basal synthetic rate of muscle protein in healthy older women.

Sandra Iuliano-Burns, John Hopper, and Ego Seeman

The Age of Puberty Determines Sexual Dimorphism in Bone Structure: A Male/Female Co-Twin Control Study
J Clin Endocrinol Metab 2009 94: 1638-1643 , doi:10.1210/jc.2008-1522 [Abstract] [Full Text] [PDF]  
Larger bone size in males results from a longer growth period, not greater growth velocity, and greater bone widths in males are partly established before puberty.

M. Konopko-Zubrzycka, A. Baniukiewicz, E. Wróblewski, I. Kowalska, W. Zarzycki, M. Górska, and A. Dabrowski

The Effect of Intragastric Balloon on Plasma Ghrelin, Leptin, and Adiponectin Levels in Patients with Morbid Obesity
J Clin Endocrinol Metab 2009 94: 1644-1649 , doi:10.1210/jc.2008-1083 [Abstract] [Full Text] [PDF]  
After endoscopic treatment with Bioenterics Intragastric Balloon, body mass reduction and the accompanying changes in carbohydrate and lipid metabolism does not alter the level of adiponectin.

Amy D. DiVasta, Henry A. Feldman, Ashley E. Quach, Maria Balestrino, and Catherine M. Gordon

The Effect of Bed Rest on Bone Turnover in Young Women Hospitalized for Anorexia Nervosa: A Pilot Study
J Clin Endocrinol Metab 2009 94: 1650-1655 , doi:10.1210/jc.2008-1654 [Abstract] [Full Text] [PDF]  
Limitation of physical activity during hospitalization for patients with anorexia nervosa leads to a suppression of bone formation and resorption, and an imbalance of bone turnover.

Gerd G. Gauglitz, David N. Herndon, Gabriela A. Kulp, Walter J. Meyer, III, and Marc G. Jeschke

Abnormal Insulin Sensitivity Persists up to Three Years in Pediatric Patients Post-Burn
J Clin Endocrinol Metab 2009 94: 1656-1664 , doi:10.1210/jc.2008-1947 [Abstract] [Full Text] [PDF]  
A burn injury is associated with stress-induced diabetes that persists not only for a short period of time but for up to 3 years post-burn.

Nicole Reisch, Linda Flade, Michael Scherr, Marietta Rottenkolber, Francesco Pedrosa Gil, Martin Bidlingmaier, Hans Wolff, Hans-Peter Schwarz, Marcus Quinkler, Felix Beuschlein, and Martin Reincke

High Prevalence of Reduced Fecundity in Men with Congenital Adrenal Hyperplasia
J Clin Endocrinol Metab 2009 94: 1665-1670 , doi:10.1210/jc.2008-1414 [Abstract] [Full Text] [PDF]  
Poor semen parameters are common in male congenital adrenal hyperplasia patients and testicular adrenal rest tumors, most likely reflecting under-treatment; and inhibin B are important indicators of low fecundity.

Ichiro Tatsuno, Takao Sugiyama, Sawako Suzuki, Tomohiko Yoshida, Tomoaki Tanaka, Makoto Sueishi, and Yasushi Saito

Age Dependence of Early Symptomatic Vertebral Fracture with High-Dose Glucocorticoid Treatment for Collagen Vascular Diseases
J Clin Endocrinol Metab 2009 94: 1671-1677 , doi:10.1210/jc.2008-1578 [Abstract] [Full Text] [PDF]  
In patients treated with high-dose glucocorticoids, symptomatic vertebral fractures were prevalent and age-dependent, in which the duration before fracture was significantly shorter in older patients.

Liora Lazar, Rachel Ben-David Frumkin, Erez Battat, Yael Lebenthal, Moshe Phillip, and Joseph Meyerovitch

Natural History of Thyroid Function Tests over 5 Years in a Large Pediatric Cohort
J Clin Endocrinol Metab 2009 94: 1678-1682 , doi:10.1210/jc.2008-2615 [Abstract] [Full Text] [PDF]  
Most children with mild subclinical thyroid dysfunctions revert to normal TSH levels; those with TSH > 7.5 mU/liter are at greater risk for sustained abnormal levels.

Yoshiko Orito, Hisato Oku, Sumihisa Kubota, Nobuyuki Amino, Kayoko Shimogaki, Mitsutaka Hata, Kazumi Manki, Yukiko Tanaka, Shoko Sugino, Michio Ueta, Kaori Kawakita, Takaaki Nunotani, Nobuya Tatsumi, Kiyoshi Ichihara, Akira Miyauchi, and Megumi Miyake

Thyroid Function in Early Pregnancy in Japanese Healthy Women: Relation to Urinary Iodine Excretion, Emesis, and Fetal and Child Development
J Clin Endocrinol Metab 2009 94: 1683-1688 , doi:10.1210/jc.2008-2111 [Abstract] [Full Text] [PDF]  
Subclinical hypothyroidism with dietary iodine excess during early pregnancy seems to have no adverse effects on the fetus in healthy Japanese woman.

William H. Herman, Kathleen M. Dungan, Bruce H. R. Wolffenbuttel, John B. Buse, Jessie L. Fahrbach, Honghua Jiang, and Sherry Martin

Racial and Ethnic Differences in Mean Plasma Glucose, Hemoglobin A_1c, and 1,5-Anhydroglucitol in Over 2000 Patients with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 1689-1694 , doi:10.1210/jc.2008-1940 [Abstract] [Full Text] [PDF]  
There are considerable differences in A1c and 1,5-AG among racial/ethnic groups; this could limit the comparison of these measurements of overall glycemia across groups.

Ruben H. Willemsen, Ralph W. J. Leunissen, Theo Stijnen, and Anita C. S. Hokken-Koelega

Prematurity Is Not Associated with Reduced Insulin Sensitivity in Adulthood
J Clin Endocrinol Metab 2009 94: 1695-1700 , doi:10.1210/jc.2008-1769 [Abstract] [Full Text] [PDF]  
Preterm birth is not associated with reduced insulin sensitivity in young adulthood, but oral contraceptive use and adult fat mass are the most important predictors of insulin sensitivity.

Alberto Cascón, Guillermo Pita, Nelly Burnichon, Iñigo Landa, Elena López-Jiménez, Cristina Montero-Conde, Susanna Leskelä, Luis Javier Leandro-García, Rocío Letón, Cristina Rodríguez-Antona, José Ángel Díaz, Emilio López-Vidriero, Anna González-Neira, Ana Velasco, Xavier Matias-Guiu, Anne-Paule Gimenez-Roqueplo, and Mercedes Robledo

Genetics of Pheochromocytoma and Paraganglioma in Spanish Patients
J Clin Endocrinol Metab 2009 94: 1701-1705 , doi:10.1210/jc.2008-2756 [Abstract] [Full Text] [PDF] [Supplemental Data]  
SDHB genetic testing should be a priority in patients developing isolated pheochromocytomas or paragangliomas at any age.

Yardena Tenenbaum-Rakover, Helmut Grasberger, Sunee Mamanasiri, Usanee Ringkananont, Lucia Montanelli, Marla S. Barkoff, Ahmad Mahameed-Hag Dahood, and Samuel Refetoff

Loss-of-Function Mutations in the Thyrotropin Receptor Gene as a Major Determinant of Hyperthyrotropinemia in a Consanguineous Community
J Clin Endocrinol Metab 2009 94: 1706-1712 , doi:10.1210/jc.2008-1938 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Subjects with TSHR mutations producing partial loss-of-function show no significant change of thyroid function over time.

Lionel Groussin, Gérald Bonardel, Stéphane Silvéra, Frédérique Tissier, Joël Coste, Gwenaelle Abiven, Rossella Libé, Marie Bienvenu, Jean-Louis Alberini, Sylvie Salenave, Philippe Bouchard, Jérôme Bertherat, Bertrand Dousset, Paul Legmann, Bruno Richard, Hervé Foehrenbach, Xavier Bertagna, and Florence Tenenbaum

¹⁸F-Fluorodeoxyglucose Positron Emission Tomography for the Diagnosis of Adrenocortical Tumors: A Prospective Study in 77 Operated Patients
J Clin Endocrinol Metab 2009 94: 1713-1722 , doi:10.1210/jc.2008-2302 [Abstract] [Full Text] [PDF]  
8F-FDG PET helps to manage suspicious CT scan lesions, and an adrenal to liver maxSUV ratio under 1.45 is highly predictive of a benign lesion.

Maki Fukami, Gen Nishimura, Keiko Homma, Toshiro Nagai, Keiichi Hanaki, Ayumi Uematsu, Tomohiro Ishii, Chikahiko Numakura, Hirotake Sawada, Mariko Nakacho, Takanori Kowase, Katsuaki Motomura, Hidenori Haruna, Mihoko Nakamura, Akira Ohishi, Masanori Adachi, Toshihiro Tajima, Yukihiro Hasegawa, Tomonobu Hasegawa, Reiko Horikawa, Kenji Fujieda, and Tsutomu Ogata

Cytochrome P450 Oxidoreductase Deficiency: Identification and Characterization of Biallelic Mutations and Genotype-Phenotype Correlations in 35 Japanese Patients
J Clin Endocrinol Metab 2009 94: 1723-1731 , doi:10.1210/jc.2008-2816 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Molecular and clinical studies in cytochrome P450 oxidoreductase deficiency identify biallelic mutations and underlying factors involved in the development of each phenotype.

Nele Friedrich, Robin Haring, Matthias Nauck, Jan Lüdemann, Dieter Rosskopf, Elisabeth Spilcke-Liss, Stephan B. Felix, Marcus Dörr, Georg Brabant, Henry Völzke, and Henri Wallaschofski

Mortality and Serum Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein 3 Concentrations
J Clin Endocrinol Metab 2009 94: 1732-1739 , doi:10.1210/jc.2008-2138 [Abstract] [Full Text] [PDF]  
Low insulin-like growth factor-I (IGF-1) or IGF-binding protein 3 levels were associated with increased mortality in men.

Peng Fang, I. David Schwartz, Betty D. Johnson, Michael A. Derr, Charles T. Roberts, Jr., Vivian Hwa, and Ron G. Rosenfeld

Familial Short Stature Caused by Haploinsufficiency of the Insulin-Like Growth Factor I Receptor due to Nonsense-Mediated Messenger Ribonucleic Acid Decay
J Clin Endocrinol Metab 2009 94: 1740-1747 , doi:10.1210/jc.2008-1903 [Abstract] [Full Text] [PDF]  
A heterozygous mutation in the human IGF1R gene is indentified, which, through nonsense-mediated mRNA decay, results in IGF1R haploinsufficiency and severe short stature.

Eleonora Horvath, Sergio Majlis, Ricardo Rossi, Carmen Franco, Juan P. Niedmann, Alex Castro, and Miguel Dominguez

BRIEF REPORT:An Ultrasonogram Reporting System for Thyroid Nodules Stratifying Cancer Risk for Clinical Management
J Clin Endocrinol Metab 2009 94: 1748-1751 , doi:10.1210/jc.2008-1724 [Abstract] [Full Text] [PDF]  
The TIRADS system is a ultrasonographic classification for thyroid nodules that is cost-effective and also improves patient management.

Hiroshi Ishikawa, Scott Reierstad, Masashi Demura, Alfred W. Rademaker, Tadayuki Kasai, Masaki Inoue, Hirokazu Usui, Makio Shozu, and Serdar E. Bulun

BRIEF REPORT:High Aromatase Expression in Uterine Leiomyoma Tissues of African-American Women
J Clin Endocrinol Metab 2009 94: 1752-1756 , doi:10.1210/jc.2008-2327 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Aromatase in uterine leiomyoma tissues from African-American women is expressed at significantly higher levels compared with those from Japanese women.

A. N. Paisley, S. V. Rowles, D. Brandon, and P. J. Trainer

BRIEF REPORT:A Subnormal Peak Cortisol Response to Stimulation Testing Does Not Predict a Subnormal Cortisol Production Rate
J Clin Endocrinol Metab 2009 94: 1757-1760 , doi:10.1210/jc.2008-2392 [Abstract] [Full Text] [PDF]  
A sub-optimal peak cortisol response to the insulin tolerance test does not equate to a low cortisol production rate.

Endocrine Research:

Marina Montagnani Marelli, Roberta M. Moretti, Stefania Mai, Joanna Januszkiewicz-Caulier, Marcella Motta, and Patrizia Limonta

Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells
J Clin Endocrinol Metab 2009 94: 1761-1767 , doi:10.1210/jc.2008-1741 [Abstract] [Full Text] [PDF]  
GnRH-II exerts a significant antiproliferative effect on prostate cancer cells; this activity is mediated by the type I GnRH receptor.

Anna V. Hoekstra, Elizabeth C. Sefton, Emily Berry, Zhenxiao Lu, Jennifer Hardt, Erica Marsh, Ping Yin, Jon Clardy, Debabrata Chakravarti, Serdar Bulun, and J. Julie Kim

Progestins Activate the AKT Pathway in Leiomyoma Cells and Promote Survival
J Clin Endocrinol Metab 2009 94: 1768-1774 , doi:10.1210/jc.2008-2093 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The rapid activation of the AKT pathway by progesterone in leiomyoma cells is demonstrated, providing a mechanism by which progesterone promotes growth of uterine leiomyomas.

Axel Haupt, Martina Guthoff, Silke A. Schäfer, Kerstin Kirchhoff, Fausto Machicao, Baptist Gallwitz, Harald Staiger, Norbert Stefan, Andreas Fritsche, and Hans-Ulrich Häring

The Inhibitory Effect of Recent Type 2 Diabetes Risk Loci on Insulin Secretion Is Modulated by Insulin Sensitivity
J Clin Endocrinol Metab 2009 94: 1775-1780 , doi:10.1210/jc.2008-1876 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Negative effects of type 2 diabetes risk loci on insulin secretion appear additive in subjects with low insulin sensitivity but not with high insulin sensitivity.

Toralph Ruge, Leanne Hodson, Jane Cheeseman, A. Louise Dennis, Barbara A. Fielding, Sandy M. Humphreys, Keith N. Frayn, and Fredrik Karpe

Fasted to Fed Trafficking of Fatty Acids in Human Adipose Tissue Reveals a Novel Regulatory Step for Enhanced Fat Storage
J Clin Endocrinol Metab 2009 94: 1781-1788 , doi:10.1210/jc.2008-2090 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Adipose tissue metabolic responses to repeated meals shows sequential upregulation of fatty acid re-esterification with reduced fatty acid spillover resulting in enhanced fat storage.

Jeanette J. McCarthy, Aleefia Somji, Lauren A. Weiss, Brian Steffy, Raquel Vega, Elizabeth Barrett-Connor, Gregory Talavera, and Richard Glynne

Polymorphisms of the Scavenger Receptor Class B Member 1 Are Associated with Insulin Resistance with Evidence of Gene by Sex Interaction
J Clin Endocrinol Metab 2009 94: 1789-1796 , doi:10.1210/jc.2008-2800 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Polymorphisms of the SCARB1 gene are associated with insulin resistance with evidence of gene by sex interaction.

Raymond S. Douglas, Thomas H. Brix, Catherine J. Hwang, Laszlo Hegedüs, and Terry J. Smith

Divergent Frequencies of IGF-I Receptor-Expressing Blood Lymphocytes in Monozygotic Twin Pairs Discordant for Graves’ Disease: Evidence for a Phenotypic Signature Ascribable to Nongenetic Factors
J Clin Endocrinol Metab 2009 94: 1797-1802 , doi:10.1210/jc.2008-2810 [Abstract] [Full Text] [PDF]  
Monozygotic twins manifesting Graves’ disease exhibit an increased frequency of lymphocytes expressing IGF-1 receptor while their unaffected siblings do not.

Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi, Silvia Frascerra, Eleonora Santini, Stefano Sellari Franceschini, and Ele Ferrannini

Monokine Induced by Interferon (IFN) (CXCL9) and IFN Inducible T-Cell -Chemoattractant (CXCL11) Involvement in Graves’ Disease and Ophthalmopathy: Modulation by Peroxisome Proliferator-Activated Receptor- Agonists
J Clin Endocrinol Metab 2009 94: 1803-1809 , doi:10.1210/jc.2008-2450 [Abstract] [Full Text] [PDF]  
Thyrocytes and retrobulbar cells participate in the self-perpetuation of inflammation in Graves’ ophthalmopathy; releasing CXCL9 and CXCL11 when stimulated with IFN - PPAR inhibits this process.

Christine Poitou, Adeline Divoux, Aurélie Faty, Joan Tordjman, Danielle Hugol, Abdelhaim Aissat, Mayoura Keophiphath, Corneliu Henegar, Stéphane Commans, and Karine Clément

Role of Serum Amyloid A in Adipocyte-Macrophage Cross Talk and Adipocyte Cholesterol Efflux
J Clin Endocrinol Metab 2009 94: 1810-1817 , doi:10.1210/jc.2008-2040 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Serum amyloid A is related to adipocyte size, macrophage infiltration, and cholesterol efflux, suggesting a role in the cross-talk between hypertrophied adipocyte and macrophages.

Kahina Boukari, Geri Meduri, Sylvie Brailly-Tabard, Jean Guibourdenche, Maria Luisa Ciampi, Nathalie Massin, Laetitia Martinerie, Jean-Yves Picard, Rodolfo Rey, Marc Lombès, and Jacques Young

Lack of Androgen Receptor Expression in Sertoli Cells Accounts for the Absence of Anti-Mullerian Hormone Repression during Early Human Testis Development
J Clin Endocrinol Metab 2009 94: 1818-1825 , doi:10.1210/jc.2008-1909 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The presence of functional androgen receptor in human Sertoli cells is essential for testicular testosterone-mediated anti-Müllerian hormone repression.

Sunita K. Agarwal, Carmen M. Mateo, and Stephen J. Marx

Rare Germline Mutations in Cyclin-Dependent Kinase Inhibitor Genes in Multiple Endocrine Neoplasia Type 1 and Related States
J Clin Endocrinol Metab 2009 94: 1826-1834 , doi:10.1210/jc.2008-2083 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Some patients who have MEN1 or related states and who test negative for germline mutations in the MEN1 gene are now shown to have germline mutations in one of several cyclin-dependent kinase inhibitor genes.

Translational Highlights from Endocrinology:

Agatha Kokot, Dieter Metze, Nicolas Mouchet, Marie-Dominique Galibert, Meinhard Schiller, Thomas A. Luger, and Markus Böhm

Abstracts:-MSH Counteracts the Suppressive Effect of Ultraviolet B on Nrf1/2 and Nrf-Dependent Gene Expression in Human Skin
J Clin Endocrinol Metab 2009 94: 1835 [Full Text] [PDF]  

Akihiro Yasoda, Hidetomo Kitamura, Toshihito Fujii, Eri Kondo, Naoaki Murao, Masako Miura, Naotetsu Kanamoto, Yasato Komatsu, Hiroshi Arai, and Kazuwa Nakao

Abstracts:Systemic Administration of C-Type Natriuretic Peptide as a Novel Therapeutic Strategy for Skeletal Dysplasias
J Clin Endocrinol Metab 2009 94: 1835-a [Full Text] [PDF]  

Jason G. Bromer, Jie Wu, Yuping Zhou, and Hugh S. Taylor

Abstracts:Hypermethylation of HOXA10 by in utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
J Clin Endocrinol Metab 2009 94: 1836 [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Sandra M. Malakauskas, Wissam M. Kourany, Xiao Yin Zhang, Danhong Lu, Robert D. Stevens, Timothy R. Koves, Hans E. Hohmeier, Deborah M. Muoio, Christopher B. Newgard, and Thu H. Le

Abstracts:Increased Insulin Sensitivity in Mice Lacking Collectrin, a Downstream Target of HNF-1
J Clin Endocrinol Metab 2009 94: 1837 [Full Text] [PDF]  

Shinichi Miyagawa, Yoshihiko Satoh, Ryuma Haraguchi, Kentaro Suzuki, Taisen Iguchi, Makoto M. Taketo, Naomi Nakagata, Takahiro Matsumoto, Ken-ichi Takeyama, Shigeaki Kato, and Gen Yamada

Abstracts:Genetic Interactions of the Androgen and Wnt/β-Catenin Pathways for the Masculinization of External Genitalia
J Clin Endocrinol Metab 2009 94: 1837-a [Full Text] [PDF]  

Jeffrey S. Davies, Pia Kotokorpi, Sinan R. Eccles, Sarah K. Barnes, Pawel F. Tokarczuk, Sophie K. Allen, Hilary S. Whitworth, Irina A. Guschina, Bronwen A. J. Evans, Agneta Mode, Jeffrey M. Zigman, and Timothy Wells

Abstracts:Ghrelin Induces Abdominal Obesity via GHS-R-Dependent Lipid Retention
J Clin Endocrinol Metab 2009 94: 1838 [Full Text] [PDF]  

Marcos Rivas, Britt Mellström, Begoña Torres, Gaetano Cali, Alfonso M. Ferrara, Daniela Terracciano, Mariastella Zannini, Gabriella Morreale de Escobar, and Jose R. Naranjo

Abstracts:The DREAM Protein Is Associated to Thyroid Enlargement and Nodular Development
J Clin Endocrinol Metab 2009 94: 1838-a [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Rosalind S. Brown, Stephen LaFranchi, and Susan R. Rose

Patient Information Page from The Hormone Foundation:Congenital Hypothyroidism
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Rosalind S. Brown, Stephen LaFranchi, and Susan R. Rose

Patient Information Page from The Hormone Foundation:Hipotiroidismo congénito
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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