The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

Special Features:

Wiebke Arlt

APPROACH TO THE PATIENT:The Approach to the Adult with Newly Diagnosed Adrenal Insufficiency
J Clin Endocrinol Metab 2009 94: 1059-1067 doi:10.1210/jc.2009-0032 [Abstract] [Full Text] [PDF]  
The diagnostic and therapeutic approach to the patient with acute adrenal insufficiency and the management of subsequent chronic replacement therapy represent a continuous challenge.

Jay B. Mepani and James W. Findling

IMAGE IN ENDOCRINOLOGY:Reversible Bone Marrow Edema of the Hip Due to Severe Hypothyroidism
J Clin Endocrinol Metab 2009 94: 1068 doi:10.1210/jc.2008-1523 [Full Text] [PDF]  

Kimberly A. Placzkowski, Adrian Vella, Geoffrey B. Thompson, Clive S. Grant, Carl C. Reading, J. William Charboneau, James C. Andrews, Ricardo V. Lloyd, and F. John Service

EXTENSIVE CLINICAL EXPERIENCE:Secular Trends in the Presentation and Management of Functioning Insulinoma at the Mayo Clinic, 1987–2007
J Clin Endocrinol Metab 2009 94: 1069-1073 , doi:10.1210/jc.2008-2031 [Abstract] [Full Text] [PDF]  
Patients with insulinoma had exclusively postprandial symptoms with increasing albeit low frequency, a predominance of outpatient evaluation and avoidance of "blind" pancreatic exploration.

Jean-Marc Guettier, Anthony Kam, Richard Chang, Monica C. Skarulis, Craig Cochran, H. Richard Alexander, Steven K. Libutti, James F. Pingpank, and Phillip Gorden

EXTENSIVE CLINICAL EXPERIENCE:Localization of Insulinomas to Regions of the Pancreas by Intraarterial Calcium Stimulation: The NIH Experience
J Clin Endocrinol Metab 2009 94: 1074-1080 , doi:10.1210/jc.2008-1986 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The CaStim is vastly superior to abdominal ultrasound, CT or MRI as a preoperative localizing tool for insulinomas.

Editorials:

Sergio Fazio and MacRae F. Linton

EDITORIAL:Elevated High-Density Lipoprotein (HDL) Levels due to Hepatic Lipase Mutations Do Not Reduce Cardiovascular Disease Risk: Another Strike against the HDL Dogma
J Clin Endocrinol Metab 2009 94: 1081-1083 doi:10.1210/jc.2009-0344 [Full Text] [PDF]  

Richard S. Legro and Jan M. McAllister

EDITORIAL:Heirarchical Clustering and Beyond in PCOS Endometrium: Brave New World
J Clin Endocrinol Metab 2009 94: 1084-1085 doi:10.1210/jc.2009-0326 [Full Text] [PDF]  

Ernest L. Mazzaferri

EDITORIAL:A Vision for the Surgical Management of Papillary Thyroid Carcinoma: Extensive Lymph Node Compartmental Dissections and Selective Use of Radioiodine
J Clin Endocrinol Metab 2009 94: 1086-1088 doi:10.1210/jc.2009-0298 [Full Text] [PDF]  

Christos S. Mantzoros

EDITORIAL:Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome?
J Clin Endocrinol Metab 2009 94: 1089-1091 doi:10.1210/jc.2009-0340 [Full Text] [PDF]  

Michael F. Holick

EDITORIAL:MrOs Is D-ficient
J Clin Endocrinol Metab 2009 94: 1092-1093 doi:10.1210/jc.2009-0388 [Full Text] [PDF]  

R. Jeffrey Chang

EDITORIAL:Obesity and the Emergence of Sleep-Wake Gonadotropin Secretion in Girls during Early Pubertal Development
J Clin Endocrinol Metab 2009 94: 1094-1096 doi:10.1210/jc.2009-0327 [Full Text] [PDF]  

Endocrine Care:

Sherri-Ann M. Burnett-Bowie, Kenneth Saag, Anthony Sebba, Anne E. de Papp, Erluo Chen, Elizabeth Rosenberg, and Susan L. Greenspan

Prediction of Changes in Bone Mineral Density in Postmenopausal Women Treated with Once-Weekly Bisphosphonates
J Clin Endocrinol Metab 2009 94: 1097-1103 , doi:10.1210/jc.2008-1122 [Abstract] [Full Text] [PDF]  
In groups of patients, short-term changes in bone turnover markers were predictive of longer term bone mineral density response and non-response to bisphosphonate therapy.

Christine G. Lee, Molly C. Carr, Susan J. Murdoch, Ellen Mitchell, Nancy F. Woods, Mark H. Wener, Wayne L. Chandler, Edward J. Boyko, and John D. Brunzell

Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study
J Clin Endocrinol Metab 2009 94: 1104-1110 , doi:10.1210/jc.2008-0701 [Abstract] [Full Text] [PDF]  
During the menopausal transition, women develop adverse alterations in adipokines and inflammatory markers in relation to increasing visceral adiposity.

Angela N. Paisley, Ashley S. Izzard, Islay Gemmell, Kennedy Cruickshank, Peter J. Trainer, and Anthony M. Heagerty

Small Vessel Remodeling and Impaired Endothelial-Dependent Dilatation in Subcutaneous Resistance Arteries from Patients with Acromegaly
J Clin Endocrinol Metab 2009 94: 1111-1117 , doi:10.1210/jc.2008-0948 [Abstract] [Full Text] [PDF]  
Active acromegaly is associated with hypertrophic remodeling of the vascular wall and endothelial dysfunction.

Christiaan de Bruin, Alberto M. Pereira, Richard A. Feelders, Johannes A. Romijn, Ferdinand Roelfsema, Diane M. Sprij-Mooij, Maarten O. van Aken, Aart-Jan van der Lelij, Wouter W. de Herder, Steven W. J. Lamberts, and Leo J. Hofland

Coexpression of Dopamine and Somatostatin Receptor Subtypes in Corticotroph Adenomas
J Clin Endocrinol Metab 2009 94: 1118-1124 , doi:10.1210/jc.2008-2101 [Abstract] [Full Text] [PDF]  
Sst₅ and especially D₂ are highly expressed in the majority of human corticotroph adenomas with co-expression of sst₅ and D₂ being a common phenomenon.

E. Born-Frontsberg, M. Reincke, L. C. Rump, S. Hahner, S. Diederich, R. Lorenz, B. Allolio, J. Seufert, C. Schirpenbach, F. Beuschlein, M. Bidlingmaier, S. Endres, M. Quinkler for the participants of the German Conn’s Registry

Cardiovascular and Cerebrovascular Comorbidities of Hypokalemic and Normokalemic Primary Aldosteronism: Results of the German Conn’s Registry
J Clin Endocrinol Metab 2009 94: 1125-1130 , doi:10.1210/jc.2008-2116 [Abstract] [Full Text] [PDF]  
The hypokalemic variant of primary aldosteronism is associated with higher blood pressure, higher plasma aldosterone concentrations, and more cardiovascular co-morbidities than the normokalemic variant.

Susannah O'Sullivan, Anne Horne, Diana Wattie, Fran Porteous, Karen Callon, Greg Gamble, Peter Ebeling, Peter Browett, and Andrew Grey

Decreased Bone Turnover Despite Persistent Secondary Hyperparathyroidism during Prolonged Treatment with Imatinib
J Clin Endocrinol Metab 2009 94: 1131-1136 , doi:10.1210/jc.2008-2324 [Abstract] [Full Text] [PDF]  
Long-term therapy with imatinib mesylate leads to persistent mild secondary hyperparathyroidism, decreased bone turnover, and stable or increased bone density.

Kathleen Mulligan, Hootan Khatami, Jean-Marc Schwarz, Giorgos K. Sakkas, Alex M. DePaoli, Viva W. Tai, Michael J. Wen, Grace A. Lee, Carl Grunfeld, and Morris Schambelan

The Effects of Recombinant Human Leptin on Visceral Fat, Dyslipidemia, and Insulin Resistance in Patients with Human Immunodeficiency Virus-Associated Lipoatrophy and Hypoleptinemia
J Clin Endocrinol Metab 2009 94: 1137-1144 , doi:10.1210/jc.2008-1588 [Abstract] [Full Text] [PDF]  
Leptin treatment improves lipids and hepatic insulin sensitivity and decreases visceral fat and thus may have therapeutic potential in patients with HIV-associated lipoatrophy and hypoleptinemia.

Nicté Figueroa-Vega, Paloma Sanz-Cameno, Ricardo Moreno-Otero, Francisco Sánchez-Madrid, Roberto González-Amaro, and Mónica Marazuela

Serum Levels of Angiogenic Molecules in Autoimmune Thyroid Diseases and Their Correlation with Laboratory and Clinical Features
J Clin Endocrinol Metab 2009 94: 1145-1153 , doi:10.1210/jc.2008-1571 [Abstract] [Full Text] [PDF]  
Angiopoietin-2 and soluble Tie-2 appear to participate in Graves' disease pathogenesis, and their serum levels could potentially be used as markers of Graves' ophtalmopathy activity.

Berit Kriström, Anna-Maija Zdunek, Anders Rydh, Håkan Jonsson, Petra Sehlin, and Stefan A. Escher

A Novel Mutation in the LIM Homeobox 3 Gene Is Responsible for Combined Pituitary Hormone Deficiency, Hearing Impairment, and Vertebral Malformations
J Clin Endocrinol Metab 2009 94: 1154-1161 , doi:10.1210/jc.2008-0325 [Abstract] [Full Text] [PDF]  
Malformations in the occipito-atlanto-axial joints, limiting neck mobility, are presented in a cohort of 6 children with a common gene source dating back to the seventeenth century.

Stéphane Bonnet, Dana Hartl, Sophie Leboulleux, Eric Baudin, Jean D. Lumbroso, Abir Al Ghuzlan, Linda Chami, Martin Schlumberger, and Jean Paul Travagli

Prophylactic Lymph Node Dissection for Papillary Thyroid Cancer Less Than 2 cm: Implications for Radioiodine Treatment
J Clin Endocrinol Metab 2009 94: 1162-1167 , doi:10.1210/jc.2008-1931 [Abstract] [Full Text] [PDF]  
Prophylactic lymph node dissection for papillary thyroid carcinoma initially staged T1N0 modified the indication for radioiodine ablation for 30% of patients.

Brian Bordini, Elizabeth Littlejohn, and Robert L. Rosenfield

Blunted Sleep-Related Luteinizing Hormone Rise in Healthy Premenarcheal Pubertal Girls with Elevated Body Mass Index
J Clin Endocrinol Metab 2009 94: 1168-1175 , doi:10.1210/jc.2008-1655 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Healthy excessive-weight pubertal premenarcheal girls have blunted sleep-related gonadotropin production in the absence of hyperandrogenemia.

Petra Kok, Ferdinand Roelfsema, Marijke Frölich, Johannes van Pelt, A. Edo Meinders, and Hanno Pijl

Bromocriptine Reduces Augmented Thyrotropin Secretion in Obese Premenopausal Women
J Clin Endocrinol Metab 2009 94: 1176-1181 , doi:10.1210/jc.2008-2303 [Abstract] [Full Text] [PDF]  
Short-term treatment with the dopamine D₂ receptor agonist bromocriptine redirects diurnal activity of the pituitary-thyroid ensemble in obese women towards those observed in normal weight controls without affecting body weight.

G. Binder, S. Weber, M. Ehrismann, N. Zaiser, C. Meisner, M. B. Ranke, L. Maier, S. A. Wudy, M. F. Hartmann, U. Heinrich, M. Bettendorf, H. G. Doerr, R. W. Pfaeffle, E. Keller and the South German Working Group for Pediatric Endocrinology

Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial
J Clin Endocrinol Metab 2009 94: 1182-1190 , doi:10.1210/jc.2008-1982 [Abstract] [Full Text] [PDF]  
Atrichia pubis vanished and psychological well-being improved significantly when adolescent girls with central adrenal insufficiency were treated with 25 mg dehydroepiandrosterone p.o. daily.

Leonardo A. Sechi, Alessandro Di Fabio, Massimo Bazzocchi, Alessandro Uzzau, and Cristiana Catena

Intrarenal Hemodynamics in Primary Aldosteronism before and after Treatment
J Clin Endocrinol Metab 2009 94: 1191-1197 , doi:10.1210/jc.2008-2245 [Abstract] [Full Text] [PDF]  
In primary aldosteronism, decreased intrarenal vascular resistance is associated with glomerular hyperfiltration, and both adrenalectomy and spironolactone revert the intrarenal hemodynamic pattern and decrease albuminuria.

Heidi K. White, Charles D. Petrie, William Landschulz, David MacLean, Ann Taylor, Kenneth Lyles, Jeanne Y. Wei, Andrew R. Hoffman, Roberto Salvatori, Mark P. Ettinger, Miriam C. Morey, Marc R. Blackman, George R. Merriam for the Capromorelin Study Group

Effects of an Oral Growth Hormone Secretagogue in Older Adults
J Clin Endocrinol Metab 2009 94: 1198-1206 , doi:10.1210/jc.2008-0632 [Abstract] [Full Text] [PDF]  
In pre-frail seniors, 12 months’ treatment with an oral ghrelin-mimetic GH secretagogue increases circulating IGF-I in a dose-related manner and improves some physical performance measures.

Meryl S. LeBoff, Rupali Narweker, Andrea LaCroix, LieLing Wu, Rebecca Jackson, Jennifer Lee, Douglas C. Bauer, Jane Cauley, Charles Kooperberg, Cora Lewis, Asha M. Thomas, and Steven Cummings

Homocysteine Levels and Risk of Hip Fracture in Postmenopausal Women
J Clin Endocrinol Metab 2009 94: 1207-1213 , doi:10.1210/jc.2008-1777 [Abstract] [Full Text] [PDF] [Supplemental Data]  
High homocysteine levels are associated with an increased risk of hip fractures, which could be accounted for by poor renal function.

Eric Orwoll, Carrie M. Nielson, Lynn M. Marshall, Lori Lambert, Kathleen F. Holton, Andrew R. Hoffman, Elizabeth Barrett-Connor, James M. Shikany, Tien Dam, Jane A. Cauley for the Osteoporotic Fractures in Men (MrOS) Study Group

Vitamin D Deficiency in Older Men
J Clin Endocrinol Metab 2009 94: 1214-1222 , doi:10.1210/jc.2008-1784 [Abstract] [Full Text] [PDF]  
Vitamin D deficiency is highly prevalent in older men in the United States, despite the common use of vitamin D supplements.

N. Ahmad Aziz, Hanno Pijl, Marijke Frölich, A. W. Maurits van der Graaf, Ferdinand Roelfsema, and Raymund A. C. Roos

Increased Hypothalamic-Pituitary-Adrenal Axis Activity in Huntington’s Disease
J Clin Endocrinol Metab 2009 94: 1223-1228 , doi:10.1210/jc.2008-2543 [Abstract] [Full Text] [PDF]  
Increased hypothalamic-pituitary-adrenal axis activity is an early feature of Huntington’s disease and is likely to result from disturbed central glucocorticoid feedback due to hypothalamic pathology.

Elmar Aigner, Nora Bachofner, Kerstin Klein, Christian De Geyter, Florian Hohla, Wolfgang Patsch, and Christian Datz

Retinol-Binding Protein 4 in Polycystic Ovary Syndrome—Association with Steroid Hormones and Response to Pioglitazone Treatment
J Clin Endocrinol Metab 2009 94: 1229-1235 , doi:10.1210/jc.2008-2156 [Abstract] [Full Text] [PDF]  
Adiponectin and retinol-binding protein 4 (RBP4) serum concentrations in PCOS respond to pioglitazone treatment, and RBP4 levels are related to steroid hormones and hirsutism scores.

Bo Ahrén, Anja Schweizer, Sylvie Dejager, Beth E. Dunning, Peter M. Nilsson, Margaretha Persson, and James E. Foley

Vildagliptin Enhances Islet Responsiveness to Both Hyper- and Hypoglycemia in Patients with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 1236-1243 , doi:10.1210/jc.2008-2152 [Abstract] [Full Text] [PDF]  
Vildagliptin enhances -cell responsiveness to both the suppressive effects of hyperglycemia and the stimulatory effects of hypoglycemia.

Natalia O. Kuchuk, Saskia M. F. Pluijm, Natasja M. van Schoor, Caspar W. N. Looman, Johannes H. Smit, and Paul Lips

Relationships of Serum 25-Hydroxyvitamin D to Bone Mineral Density and Serum Parathyroid Hormone and Markers of Bone Turnover in Older Persons
J Clin Endocrinol Metab 2009 94: 1244-1250 , doi:10.1210/jc.2008-1832 [Abstract] [Full Text] [PDF]  
Bone health and physical performance in older persons are likely to improve when serum 25(OH)D is raised over 50-60 nmol/l.

Gil Atzmon, Nir Barzilai, Joseph G. Hollowell, Martin I. Surks, and Ilan Gabriely

Extreme Longevity Is Associated with Increased Serum Thyrotropin
J Clin Endocrinol Metab 2009 94: 1251-1254 , doi:10.1210/jc.2008-2325 [Abstract] [Full Text] [PDF]  
In individuals who achieve extreme longevity, median and upper reference limits of serum TSH are shifted to levels even higher than the oldest groups reported in NHANES surveys, suggesting that routine levothyroxine treatment should not be recommended.

M. Sherlock, E. Fernandez-Rodriguez, A. Aragon Alonso, R. C. Reulen, J. Ayuk, R. N. Clayton, G. Holder, M. C. Sheppard, A. Bates, and P. M. Stewart

Medical Therapy in Patients with Acromegaly: Predictors of Response and Comparison of Efficacy of Dopamine Agonists and Somatostatin Analogues
J Clin Endocrinol Metab 2009 94: 1255-1263 , doi:10.1210/jc.2008-1420 [Abstract] [Full Text] [PDF]  
In patients with acromegaly, prolactin does not determine response to dopamine agonists and prior radiotherapy is associated with differences in GH/IGF-I response to medical therapies.

Trine Holm Johannsen, Pia R. Kamstrup, Rolf V. Andersen, Gorm B. Jensen, Henrik Sillesen, Anne Tybjærg-Hansen, and Børge G. Nordestgaard

Hepatic Lipase, Genetically Elevated High-Density Lipoprotein, and Risk of Ischemic Cardiovascular Disease
J Clin Endocrinol Metab 2009 94: 1264-1273 , doi:10.1210/jc.2008-1342 [Abstract] [Full Text] [PDF]  
Hepatic lipase genetic variants with elevated levels of HDL cholesterol did not associate with risk of ischemic cardiovascular disease.

Roderick F. A. de Lind van Wijngaarden, Luuk W. L. de Klerk, Dederieke A. M. Festen, Hugo J. Duivenvoorden, Barto J. Otten, and Anita C. S. Hokken-Koelega

Randomized Controlled Trial to Investigate the Effects of Growth Hormone Treatment on Scoliosis in Children with Prader-Willi Syndrome
J Clin Endocrinol Metab 2009 94: 1274-1280 , doi:10.1210/jc.2008-1844 [Abstract] [Full Text] [PDF]  
Scoliosis should not be considered a contra-indication for growth hormone treatment in children with Prader-Willi syndrome.

Maarit Hakanen, Olli T. Raitakari, Terho Lehtimäki, Nina Peltonen, Katja Pahkala, Lauri Sillanmäki, Hanna Lagström, Jorma Viikari, Olli Simell, and Tapani Rönnemaa

FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity
J Clin Endocrinol Metab 2009 94: 1281-1287 , doi:10.1210/jc.2008-1199 [Abstract] [Full Text] [PDF]  
This longitudinal study with follow up from age 7 months to age 15 years shows that rs9939609 in the FTO gene associates with BMI and risk of overweight in children older than 7 years of age.

Tomoko Kitagawa, Ken-Ichi Matsuda, Shigeki Inui, Hideya Takenaka, Norito Katoh, Satoshi Itami, Saburo Kishimoto, and Mitsuhiro Kawata

Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells
J Clin Endocrinol Metab 2009 94: 1288-1294 , doi:10.1210/jc.2008-1053 [Abstract] [Full Text] [PDF]  
Wnt signaling in DP cells is regulated by androgen, and this regulation plays a pivotal role in androgen’s action on hair growth.

Françoise Montravers, Khaldoun Kerrou, Valérie Nataf, Virginie Huchet, Jean-Pierre Lotz, Philippe Ruszniewski, Philippe Rougier, Françoise Duron, Philippe Bouchard, Jean-Didier Grangé, Sydney Houry, and Jean-Noël Talbot

Impact of Fluorodihydroxyphenylalanine-(18F) Positron Emission Tomography on Management of Adult Patients with Documented or Occult Digestive Endocrine Tumors
J Clin Endocrinol Metab 2009 94: 1295-1301 , doi:10.1210/jc.2008-1349 [Abstract] [Full Text] [PDF]  
F-DOPA-PET appears to be a valuable tool for management of gastrointestinal carcinoid tumors with excellent diagnostic performance capable of bringing about changes in patient management.

Scott M. Blackman, Stephanie Hsu, Lori L. Vanscoy, J. Michael Collaco, Sarah E. Ritter, Kathleen Naughton, and Garry R. Cutting

Genetic Modifiers Play a Substantial Role in Diabetes Complicating Cystic Fibrosis
J Clin Endocrinol Metab 2009 94: 1302-1309 , doi:10.1210/jc.2008-2186 [Abstract] [Full Text] [PDF]  
Genes other than CFTR contribute substantially to the risk of diabetes in cystic fibrosis patients.

S. Leboulleux, P. R. Schroeder, N. L. Busaidy, A. Auperin, C. Corone, H. A. Jacene, M. E. Ewertz, C. Bournaud, R. L. Wahl, S. I. Sherman, P. W. Ladenson, and M. Schlumberger

Assessment of the Incremental Value of Recombinant Thyrotropin Stimulation before 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography Imaging to Localize Residual Differentiated Thyroid Cancer
J Clin Endocrinol Metab 2009 94: 1310-1316 , doi:10.1210/jc.2008-1747 [Abstract] [Full Text] [PDF]  
The use of recombinant human TSH (rhTSH) before FDG-PET/CT significantly increases the number of lesions detected, but lesions found only by rhTSH-PET contributed to treatment changes in 13% patients, among whom only half were true-positive on pathology.

Satoshi Narumi, Koji Muroya, Yoichiro Abe, Masato Yasui, Yumi Asakura, Masanori Adachi, and Tomonobu Hasegawa

TSHR Mutations as a Cause of Congenital Hypothyroidism in Japan: A Population-Based Genetic Epidemiology Study
J Clin Endocrinol Metab 2009 94: 1317-1323 , doi:10.1210/jc.2008-1767 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In Japan, inactivating TSHR mutations are relatively common among patients with congenital hypothyroidism, and a founder mutation (p.R450H) accounts for about 70% of mutants.

Grigoris Effraimidis, Jan G. P. Tijssen, and Wilmar M. Wiersinga

BRIEF REPORT:Discontinuation of Smoking Increases the Risk for Developing Thyroid Peroxidase Antibodies and/or Thyroglobulin Antibodies: A Prospective Study
J Clin Endocrinol Metab 2009 94: 1324-1328 , doi:10.1210/jc.2008-1548 [Abstract] [Full Text] [PDF]  
Discontinuation of smoking in euthyroid women with a family history of autoimmune thyroid disease is associated with an increased risk of the occurrence of thyroid peroxidase-Ab and/or thyroglobulin-Ab.

Ahmad Hammoud, Mark Gibson, Steven C. Hunt, Ted D. Adams, Douglass T. Carrell, Ronette L. Kolotkin, and A. Wayne Meikle

BRIEF REPORT:Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men
J Clin Endocrinol Metab 2009 94: 1329-1332 , doi:10.1210/jc.2008-1598 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Hormonal alterations and diminished sexual quality of life among obese men are related to degree of obesity, and both are improved after gastric bypass surgery.

Khalil Khoury, Elie Barbar, Youssef Ainmelk, Annie Ouellet, and Jean-Guy LeHoux

BRIEF REPORT:Gonadal Function, First Cases of Pregnancy, and Child Delivery in a Woman with Lipoid Congenital Adrenal Hyperplasia
J Clin Endocrinol Metab 2009 94: 1333-1337 , doi:10.1210/jc.2008-1694 [Abstract] [Full Text] [PDF]  
Pregnancy and child delivery are possible in a patient with lipoid congenital adrenal hyperplasia.

Sophia D. Sakka, Ariadne Malamitsi-Puchner, Dimitrios Loutradis, George P. Chrousos, and Christina Kanaka-Gantenbein

BRIEF REPORT:Euthyroid Hyperthyrotropinemia in Children Born after in Vitro Fertilization
J Clin Endocrinol Metab 2009 94: 1338-1341 , doi:10.1210/jc.2008-1624 [Abstract] [Full Text] [PDF] [Supplemental Data]  
An increased incidence of euthyroid hyperthyrotropinemia is observed in in vitro fertilization children compared to controls, probably reflecting an epigenetic modification of TSH set point.

Lily L. Somwaru, Alice M. Arnold, Neha Joshi, Linda P. Fried, and Anne R. Cappola

BRIEF REPORT:High Frequency of and Factors Associated with Thyroid Hormone Over-Replacement and Under-Replacement in Men and Women Aged 65 and Over
J Clin Endocrinol Metab 2009 94: 1342-1345 , doi:10.1210/jc.2008-1696 [Abstract] [Full Text] [PDF]  
Older individuals taking thyroid hormone preparations, especially those of lower weight or with diabetes, should be monitored for thyroid function abnormalities.

Endocrine Research:

Cecilia Mattsson, Rebecca M. Reynolds, Kotryna Simonyte, Tommy Olsson, and Brian R. Walker

Combined Receptor Antagonist Stimulation of the Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative Feedback Sensitivity to Cortisol in Obese Men
J Clin Endocrinol Metab 2009 94: 1347-1352 , doi:10.1210/jc.2008-2054 [Abstract] [Full Text] [PDF]  
Combined receptor antagonist stimulation may be employed to dissect endogenous negative feedback in the HPA axis in other disorders such as depression, age-associated cognitive dysfunction, and the metabolic syndrome.

Karsten Müssig, Harald Staiger, Fausto Machicao, Alena Stancáková, Johanna Kuusisto, Markku Laakso, Claus Thamer, Jürgen Machann, Fritz Schick, Claus D. Claussen, Norbert Stefan, Andreas Fritsche, and Hans-Ulrich Häring

Association of Common Genetic Variation in the FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, and Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 1353-1360 , doi:10.1210/jc.2008-1048 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Common genetic variation within the FOXO1 gene affects insulin secretion and glucose tolerance and associates with an increased risk of type 2 diabetes.

Dileep V. Menon, Debbie Arbique, Zhongyun Wang, Beverley Adams-Huet, Richard J. Auchus, and Wanpen Vongpatanasin

Differential Effects of Chlorthalidone Versus Spironolactone on Muscle Sympathetic Nerve Activity in Hypertensive Patients
J Clin Endocrinol Metab 2009 94: 1361-1366 , doi:10.1210/jc.2008-2660 [Abstract] [Full Text] [PDF]  
Chlorthalidone therapy for hypertension causes persistent activation of sympathetic nervous system and insulin resistance in hypertensive patients; these side effects can be avoided with spironolactone, which caused a similar reduction in blood pressure.

E. A. Lawson, M. Misra, E. Meenaghan, L. Rosenblum, D. A. Donoho, D. Herzog, A. Klibanski, and K. K. Miller

Adrenal Glucocorticoid and Androgen Precursor Dissociation in Anorexia Nervosa
J Clin Endocrinol Metab 2009 94: 1367-1371 , doi:10.1210/jc.2008-2558 [Abstract] [Full Text] [PDF]  
Reduced adrenal androgen precursor secretion is not a mechanism underlying low testosterone levels in anorexia nervosa.

Rasmus Rabøl, Patricia M. V. Højberg, Thomas Almdal, Robert Boushel, Steen B. Haugaard, Sten Madsbad, and Flemming Dela

Effect of Hyperglycemia on Mitochondrial Respiration in Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 1372-1378 , doi:10.1210/jc.2008-1475 [Abstract] [Full Text] [PDF]  
Skeletal muscle mitochondrial respiration and content is not increased after significant improvements in glycemic control in type 2 diabetes.

Kirsten Vollmer, Husai Gardiwal, Bjoern A. Menge, Oliver Goetze, Carolyn F. Deacon, Wolfgang E. Schmidt, Jens J. Holst, and Juris J. Meier

Hyperglycemia Acutely Lowers the Postprandial Excursions of Glucagon-Like Peptide-1 and Gastric Inhibitory Polypeptide in Humans
J Clin Endocrinol Metab 2009 94: 1379-1385 , doi:10.1210/jc.2008-2197 [Abstract] [Full Text] [PDF]  
The post-prandial release of gastric inhibitory polypeptide and glucagon-like peptide 1 is significantly lower during hyperglycaemia compared to euglycaemia.

Daniëlle van der Kaay, Cheri Deal, Sandra de Kort, Ruben Willemsen, Ralph Leunissen, Wietske Ester, Jean Paquette, Jaap van Doorn, and Anita Hokken-Koelega

Insulin-Like Growth Factor-Binding Protein-1: Serum Levels, Promoter Polymorphism, and Associations with Components of the Metabolic Syndrome in Short Subjects Born Small for Gestational Age
J Clin Endocrinol Metab 2009 94: 1386-1392 , doi:10.1210/jc.2008-1430 [Abstract] [Full Text] [PDF]  
IGFr-binding protein 1 (IGFBP), modulated by polymorphic variability, seems to be an additional player in the complex interaction between the IGF-IGFBP axis, glucose homeostasis, and lipid metabolism.

Eléonore Maury, Laurence Noël, Roger Detry, and Sonia M. Brichard

In Vitro Hyperresponsiveness to Tumor Necrosis Factor- Contributes to Adipokine Dysregulation in Omental Adipocytes of Obese Subjects
J Clin Endocrinol Metab 2009 94: 1393-1400 , doi:10.1210/jc.2008-2196 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Amplified paracrine cross-talk between adipocytes and stromal-vascular cell in human obesity ultimately leads to worsening of the inflammatory state and the metabolic syndrome.

Hua Wang, Nicholas P. Hays, Swapan K. Das, Rebekah L. Craig, Winston S. Chu, Neeraj Sharma, and Steven C. Elbein

Phenotypic and Molecular Evaluation of a Chromosome 1q Region with Linkage and Association to Type 2 Diabetes in Humans
J Clin Endocrinol Metab 2009 94: 1401-1408 , doi:10.1210/jc.2008-2132 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Noncoding DNA polymorphisms near the liver pyruvate kinase gene are associated with reduced insulin suppression of hepatic glucose production in humans.

Magnus H. Fasting, Emily Oken, Christos S. Mantzoros, Janet W. Rich-Edwards, Joseph A. Majzoub, Ken Kleinman, Sheryl L. Rifas-Shiman, Torstein Vik, and Matthew W. Gillman

Maternal Levels of Corticotropin-Releasing Hormone during Pregnancy in Relation to Adiponectin and Leptin in Early Childhood
J Clin Endocrinol Metab 2009 94: 1409-1415 , doi:10.1210/jc.2008-1424 [Abstract] [Full Text] [PDF]  
Increased maternal corticotropin-releasing hormone is associated with increased adiponectin and unchanged leptin levels in offspring blood at age 3 years.

Jin Yeong Kim, Haengseok Song, Hyunjoo Kim, Hee Jung Kang, Jin Hyun Jun, Sung Ran Hong, Mi Kyoung Koong, and In Sun Kim

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2009 94: 1416-1426 , doi:10.1210/jc.2008-1612 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genome-wide transcriptional profiling showed systemic down-regulation of various signaling pathways, including cell cycle and glucose metabolism in the endometrium of patients with PCOS.

Paul A. Fowler, Samantha Flannigan, Anna Mathers, Kim Gillanders, Richard G. Lea, Maureen J. Wood, Abha Maheshwari, Siladitya Bhattacharya, Elaina S. R. Collie-Duguid, Paul J. Baker, Ana Monteiro, and Peter J. O'Shaughnessy

Gene Expression Analysis of Human Fetal Ovarian Primordial Follicle Formation
J Clin Endocrinol Metab 2009 94: 1427-1435 , doi:10.1210/jc.2008-2619 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Transcriptomic analysis of the onset of primordial follicle formation in the human fetal ovary demonstrates up-regulation of 61 genes, including the maternal effect gene NALP5, which may have an important role in this key process.

Marianne S. Elston, Anthony J. Gill, John V. Conaglen, Adele Clarkson, Raymond J. Cook, Nicholas S. Little, Bruce G. Robinson, Roderick J. Clifton-Bligh, and Kerrie L. McDonald

Nuclear Accumulation of E-Cadherin Correlates with Loss of Cytoplasmic Membrane Staining and Invasion in Pituitary Adenomas
J Clin Endocrinol Metab 2009 94: 1436-1442 , doi:10.1210/jc.2008-2075 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Nuclear staining for E-cadherin is common in pituitary adenomas, particularly nonfunctioning adenomas, and is associated with tumor invasion.

Mick Rae, Amirah Mohamad, Deborah Price, Patrick W. F. Hadoke, Brian R. Walker, J. Ian Mason, Stephen G. Hillier, and Hilary O. D. Critchley

Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation
J Clin Endocrinol Metab 2009 94: 1443-1450 , doi:10.1210/jc.2008-1879 [Abstract] [Full Text] [PDF]  
Increased inactivation of cortisol by 11β-hydroxysteroid dehydrogenase-2 in the endometrium may cause reduced thrombospondin-1 levels and increased angiogenesis, hence contributing to abnormal menstrual bleeding.

Michael West, Erin Greason, Antonina Kolmakova, Anisa Jahangiri, Bela Asztalos, Toni I. Pollin, and Annabelle Rodriguez

Scavenger Receptor Class B Type I Protein as an Independent Predictor of High-Density Lipoprotein Cholesterol Levels in Subjects with Hyperalphalipoproteinemia
J Clin Endocrinol Metab 2009 94: 1451-1457 , doi:10.1210/jc.2008-1223 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Scavenger receptor, class B, type I protein is a predictor of HDL levels in hyperalphalipoproteinemia subjects.

Maria Justina B. Villano, Amanda K. Huber, David A. Greenberg, Brian K. Golden, Erlinda Concepcion, and Yaron Tomer

Autoimmune Thyroiditis and Diabetes: Dissecting the Joint Genetic Susceptibility in a Large Cohort of Multiplex Families
J Clin Endocrinol Metab 2009 94: 1458-1466 , doi:10.1210/jc.2008-2193 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Whole genome screening in families with autoimmune diabetes and thyroiditis identified shared susceptibility genes/loci. The CTLA-4, HLA-class-II, and FOXP3 genes predispose to autoimmune diabetes and thyroiditis in the same individual.

Mahesh Subramanian, Tania Pilli, Palash Bhattacharya, Furio Pacini, Yuri E. Nikiforov, Prasad V. Kanteti, and Bellur S. Prabhakar

BRIEF REPORT:Knockdown of IG20 Gene Expression Renders Thyroid Cancer Cells Susceptible to Apoptosis
J Clin Endocrinol Metab 2009 94: 1467-1471 , doi:10.1210/jc.2008-2378 [Abstract] [Full Text] [PDF]  
IG20 gene is over-expressed and acts as a pro-survival factor in thyroid cancers. IG20 knockdown renders thyroid cancer cells more susceptible to spontaneous, TRAIL/TNF-induced apoptosis.

Translational Highlights from Endocrinology:

Frédéric Tremblay, Ann-Marie T. Richard, Sarah Will, Jameel Syed, Nancy Stedman, Mylène Perreault, and Ruth E. Gimeno

Abstracts:Disruption of GPR39 Impairs Insulin Secretion In Vivo
J Clin Endocrinol Metab 2009 94: 1472 [Full Text] [PDF]  

Maria Izabel Chiamolera and Fredric E. Wondisford

Abstracts:Minireview: Thyrotropin-Releasing Hormone and the Thyroid Hormone Feedback Mechanism
J Clin Endocrinol Metab 2009 94: 1472-a [Full Text] [PDF]  

Nicole H. Rogers, James W. Perfield, II, Katherine J. Strissel, Martin S. Obin, and Andrew S. Greenberg

Abstracts:Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity
J Clin Endocrinol Metab 2009 94: 1473 [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Gautam Rajpal, Ming Liu, Yi Zhang, and Peter Arvan

Abstracts:Single-Chain Insulins as Receptor Agonists
J Clin Endocrinol Metab 2009 94: 1474 [Full Text] [PDF]  

Ting Wen, Bonnie Peng, and John E. Pintar

Abstracts:The MOR-1 Opioid Receptor Regulates Glucose Homeostasis by Modulating Insulin Secretion
J Clin Endocrinol Metab 2009 94: 1474-a [Full Text] [PDF]  

Martina Kocan, Heng B. See, Natália G. Sampaio, Karin A. Eidne, Brian J. Feldman, and Kevin D. G. Pfleger

Abstracts:Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis
J Clin Endocrinol Metab 2009 94: 1475 [Full Text] [PDF]  

Martina Zikova, Alicia Corlett, Zdenka Bendova, Petr Pajer, and Petr Bartunek

Abstracts:DISP3, a Sterol-Sensing Domain-Containing Protein that Links Thyroid Hormone Action and Cholesterol Metabolism
J Clin Endocrinol Metab 2009 94: 1475-a doi:10.1210/me.2008-0271 [Full Text] [PDF]  

Announcements and Resources:

Erratum
J Clin Endocrinol Metab 2009 94: 1476 [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2009 94: 1476-a [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2009 94: 1478 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Laura Bachrach, Luiz Claudio Castro, and Alan Rogol

Patient Information Page from The Hormone Foundation:Children and Bone Health
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Laura Bachrach, Luiz Claudio Castro, and Alan Rogol

Patient Information Page from The Hormone Foundation:Los Niños y la Salud Osea
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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