The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

Special Features:

Philip E. Cryer, Lloyd Axelrod, Ashley B. Grossman, Simon R. Heller, Victor M. Montori, Elizabeth R. Seaquist, and F. John Service

CLINICAL PRACTICE GUIDELINE:Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline
J Clin Endocrinol Metab 2009 94: 709-728 , doi:10.1210/jc.2008-1410 [Abstract] [Full Text] [PDF]  
The Endocrine Society Guideline for the evaluation and management of adults with hypoglycemic disorders including those with diabetes mellitus.

Mitra M. Fatourechi, Yogish C. Kudva, M. Hassan Murad, Mohamed B. Elamin, Claudia C. Tabini, and Victor M. Montori

CLINICAL REVIEW:Hypoglycemia with Intensive Insulin Therapy: A Systematic Review and Meta-Analyses of Randomized Trials of Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections
J Clin Endocrinol Metab 2009 94: 729-740 , doi:10.1210/jc.2008-1415 [Abstract] [Full Text] [PDF]  
Meta-analyses of 15 trials find that, compared to multiple insulin injections, insulin pumps slightly reduce HbA1c in adults with DM1 although the impact of pump therapy on hypoglycemia is unclear.

M. Hassan Murad, Fernando Coto-Yglesias, Amy T. Wang, Nasim Sheidaee, Rebecca J. Mullan, Mohamed B. Elamin, Patricia J. Erwin, and Victor M. Montori

CLINICAL REVIEW:Drug-Induced Hypoglycemia: A Systematic Review
J Clin Endocrinol Metab 2009 94: 741-745 , doi:10.1210/jc.2008-1416 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Very low quality evidence substantiates the association between hypoglycemia and the use of numerous non-diabetic drugs.

Takashi Kimura, Takeshi Usui, Susumu Inamoto, Sachiko Minamiguchi, Hiroshi Okuno, Hironobu Sasano, Hanae Hagiwara, Daisuke Nagata, Tetsuya Tagami, Mitsuhide Naruse, and Akira Shimatsu

IMAGE IN ENDOCRINOLOGY:Pheochromocytoma with Subclinical Cushing’s Syndrome Caused by Corticomedullary Mixed Tumor of the Adrenal Gland
J Clin Endocrinol Metab 2009 94: 746-747 doi:10.1210/jc.2008-2013 [Full Text] [PDF]  

Helle-Brit Fiebrich, Adrienne H. Brouwers, Leo van Bergeijk, and Gerrit van den Berg

IMAGE IN ENDOCRINOLOGY:Localization of an Adrenocorticotropin-Producing Pheochromocytoma Using ¹⁸F-Dihydroxyphenylalanine Positron Emission Tomography
J Clin Endocrinol Metab 2009 94: 748-749 doi:10.1210/jc.2008-2099 [Full Text] [PDF]  

Antoine Lampron, Isabelle Bourdeau, Sylvie Oble, Ariane Godbout, Walter Schürch, Philippe Arjane, Pavel Hamet, and André Lacroix

CLINICAL CASE SEMINAR:Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma
J Clin Endocrinol Metab 2009 94: 750-756 , doi:10.1210/jc.2008-1340 [Abstract] [Full Text] [PDF]  
New evidence implicates several aberrant hormone receptors in the regulation of aldosterone production in primary aldosteronism.

Chandra Mohan and Anil K. Agarwal

EDITORIAL:Melanocortin-4-Receptor Autoantibodies: A New Player in Obesity
J Clin Endocrinol Metab 2009 94: 757-759 doi:10.1210/jc.2008-2748 [Full Text] [PDF]  

Endocrine Care:

Manivannan Srinivasan, Brian A. Irving, Ketan Dhatariya, Katherine A. Klaus, Stacy J. Hartman, Joseph P. McConnell, and K. Sreekumaran Nair

Effect of Dehydroepiandrosterone Replacement on Lipoprotein Profile in Hypoadrenal Women
J Clin Endocrinol Metab 2009 94: 761-764 , doi:10.1210/jc.2008-1774 [Abstract] [Full Text] [PDF]  
Dehydroepiandrosterone versus placebo administration for 3 months in a crossover study design demonstrated unfavorable lipoprotein profile in hypoadrenal women.

Adrian Sayers and Jonathan H. Tobias

Estimated Maternal Ultraviolet B Exposure Levels in Pregnancy Influence Skeletal Development of the Child
J Clin Endocrinol Metab 2009 94: 765-771 , doi:10.1210/jc.2008-2146 [Abstract] [Full Text] [PDF]  
Background UVB in pregnancy is positively related to bone size at age 10, which is partly, but not completely, explained by an effect on height.

Tuija Männistö, Marja Vääräsmäki, Anneli Pouta, Anna-Liisa Hartikainen, Aimo Ruokonen, Heljä-Marja Surcel, Aini Bloigu, Marjo-Riitta Järvelin, and Eila Suvanto-Luukkonen

Perinatal Outcome of Children Born to Mothers with Thyroid Dysfunction or Antibodies: A Prospective Population-Based Cohort Study
J Clin Endocrinol Metab 2009 94: 772-779 , doi:10.1210/jc.2008-1520 [Abstract] [Full Text] [PDF]  
Thyroid autoantibodies seem to have an adverse effect on perinatal outcome and therefore their screening might be advisable.

Terry Y. Segal, Ameeta Mehta, Antoinette Anazodo, Peter C. Hindmarsh, and Mehul T. Dattani

Role of Gonadotropin-Releasing Hormone and Human Chorionic Gonadotropin Stimulation Tests in Differentiating Patients with Hypogonadotropic Hypogonadism from Those with Constitutional Delay of Growth and Puberty
J Clin Endocrinol Metab 2009 94: 780-785 , doi:10.1210/jc.2008-0302 [Abstract] [Full Text] [PDF]  
GnRH tests in combination with both a 3-day and 19-day human chorionic gonadotropin test may aid in differentiating between a diagnosis of constitutional delay of growth and puberty and hypogonadotropic hypogonadism in adolescent males.

Erik A. H. Knauff, Marinus J. C. Eijkemans, Cornelius B. Lambalk, Marianne J. ten Kate-Booij, Annemieke Hoek, Catharina C. M. Beerendonk, Joop S. E. Laven, Angelique J. Goverde, Frank J. M. Broekmans, Axel P. N. Themmen, Frank H. de Jong, Bart C. J. M. Fauser on behalf of the Dutch Premature Ovarian Failure Consortium

Anti-Müllerian Hormone, Inhibin B, and Antral Follicle Count in Young Women with Ovarian Failure
J Clin Endocrinol Metab 2009 94: 786-792 , doi:10.1210/jc.2008-1818 [Abstract] [Full Text] [PDF]  
Anti-Müllerian hormone seems to be a reliable, clinically useful marker to assess the extent of follicle pool depletion in young hypergonadotropic women.

Jean-Christophe Peter, Akkiz Bekel, Anne-Catherine Lecourt, Géraldine Zipfel, Pierre Eftekhari, Maya Nesslinger, Matthias Breidert, Sylviane Muller, Laurence Kessler, and Karl G. Hofbauer

Anti-Melanocortin-4 Receptor Autoantibodies in Obesity
J Clin Endocrinol Metab 2009 94: 793-800 , doi:10.1210/jc.2008-1749 [Abstract] [Full Text] [PDF]  
Blockade of central melanocortin-4 receptors by circulating autoantibodies against its N-terminal sequence may contribute to the pathogenesis of obesity in a small subgroup of patients.

Peter Y. Liu, H. W. Gordon Baker, Veena Jayadev, Margaret Zacharin, Ann J. Conway, and David J. Handelsman

Induction of Spermatogenesis and Fertility during Gonadotropin Treatment of Gonadotropin-Deficient Infertile Men: Predictors of Fertility Outcome
J Clin Endocrinol Metab 2009 94: 801-808 , doi:10.1210/jc.2008-1648 [Abstract] [Full Text] [PDF]  
Larger testes and prior gonadotropin exposure are independently associated with faster induction of spermatogenesis and fertility whereas prior androgen treatment is independently associated with slower induction.

Galina Götherström, Mariam Elbornsson, Katharina Stibrant-Sunnerhagen, Bengt-Åke Bengtsson, Gudmundur Johannsson, and Johan Svensson

Ten Years of Growth Hormone (GH) Replacement Normalizes Muscle Strength in GH-Deficient Adults
J Clin Endocrinol Metab 2009 94: 809-816 , doi:10.1210/jc.2008-1538 [Abstract] [Full Text] [PDF]  
Ten years of GH replacement in hypopituitary adults increased muscle strength and protected against the normal age-related decline in muscle strength and neuromuscular function.

Silvia Savastano, Carolina Di Somma, Luigi Angrisani, Francesco Orio, Salvatore Longobardi, Gaetano Lombardi, and Annamaria Colao

Growth Hormone Treatment Prevents Loss of Lean Mass after Bariatric Surgery in Morbidly Obese Patients: Results of a Pilot, Open, Prospective, Randomized, Controlled Study
J Clin Endocrinol Metab 2009 94: 817-826 , doi:10.1210/jc.2008-1476 [Abstract] [Full Text] [PDF]  
Six-month GH treatment after laparoscopic-adjustable silicone gastric banding reduces lean and appendicular muscle mass loss and improves lipid profile without a deterioration of glucose tolerance.

Anastassios G. Pittas, Susan S. Harris, Myrto Eliades, Paul Stark, and Bess Dawson-Hughes

Association between Serum Osteocalcin and Markers of Metabolic Phenotype
J Clin Endocrinol Metab 2009 94: 827-832 , doi:10.1210/jc.2008-1422 [Abstract] [Full Text] [PDF]  
Serum osteocalcin was inversely associated with markers of metabolic dysfunction including fasting hyperglycemia, insulin resistance and systemic inflammation as well as measures of adiposity, suggesting that osteocalcin may contribute to the dysmetabolic phenotype in humans.

Allan Carlé, Inge Bülow Pedersen, Nils Knudsen, Hans Perrild, Lars Ovesen, Torben Jørgensen, and Peter Laurberg

Thyroid Volume in Hypothyroidism due to Autoimmune Disease Follows a Unimodal Distribution: Evidence against Primary Thyroid Atrophy and Autoimmune Thyroiditis Being Distinct Diseases
J Clin Endocrinol Metab 2009 94: 833-839 , doi:10.1210/jc.2008-1370 [Abstract] [Full Text] [PDF]  
In patients with primary autoimmune hypothyroidism, thyroid atrophy and goiter do not represent separate disorders.

Ravi Retnakaran, Ying Qi, Mathew Sermer, Philip W. Connelly, Anthony J. G. Hanley, and Bernard Zinman

The Antepartum Glucose Values that Predict Neonatal Macrosomia Differ from Those that Predict Postpartum Prediabetes or Diabetes: Implications for the Diagnostic Criteria for Gestational Diabetes
J Clin Endocrinol Metab 2009 94: 840-845 , doi:10.1210/jc.2008-2434 [Abstract] [Full Text] [PDF] [Supplemental Data]  
On the antepartum oral glucose tolerance test, the fasting glucose value best predicts macrosomic risk, whereas post-load glucose values predict postpartum pre-diabetes/diabetes.

Michael Boschmann, Stefan Engeli, Kerstin Dobberstein, Petra Budziarek, Anke Strauss, Jana Boehnke, Fred C. G. J. Sweep, Friedrich C. Luft, YanLing He, James E. Foley, and Jens Jordan

Dipeptidyl-Peptidase-IV Inhibition Augments Postprandial Lipid Mobilization and Oxidation in Type 2 Diabetic Patients
J Clin Endocrinol Metab 2009 94: 846-852 , doi:10.1210/jc.2008-1400 [Abstract] [Full Text] [PDF]  
Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation, presumably through sympathetic nervous system activation.

Thomas G. Travison, Andre B. Araujo, Thomas J. Beck, Rachel E. Williams, Richard V. Clark, Benjamin Z. Leder, and John B. McKinlay

Relation between Serum Testosterone, Serum Estradiol, Sex Hormone-Binding Globulin, and Geometrical Measures of Adult Male Proximal Femur Strength
J Clin Endocrinol Metab 2009 94: 853-860 , doi:10.1210/jc.2008-0668 [Abstract] [Full Text] [PDF]  
Circulating estradiol is strongly associated with proximal femur strength, an association that is partially mediated by body composition.

Alicia Algeciras-Schimnich, Carol M. Preissner, J. Paul Theobald, Mary S. Finseth, and Stefan K. G. Grebe

Procalcitonin: A Marker for the Diagnosis and Follow-Up of Patients with Medullary Thyroid Carcinoma
J Clin Endocrinol Metab 2009 94: 861-868 , doi:10.1210/jc.2008-1862 [Abstract] [Full Text] [PDF]  
Procalcitonin is a complementary tumor marker to calcitonin in patients with medullary thyroid carcinoma.

Martin Reincke, Lars Christian Rump, Marcus Quinkler, Stephanie Hahner, Sven Diederich, Reinhard Lorenz, Jochen Seufert, Caroline Schirpenbach, Felix Beuschlein, Martin Bidlingmaier, Christa Meisinger, Rolf Holle, Stephan Endres for the Participants of the German Conn’s Registry

Risk Factors Associated with a Low Glomerular Filtration Rate in Primary Aldosteronism
J Clin Endocrinol Metab 2009 94: 869-875 , doi:10.1210/jc.2008-1851 [Abstract] [Full Text] [PDF]  
Age, male sex, low plasma potassium levels, and high plasma aldosterone concentrations are independent risk factors associated with a lower glomerular filtration rate in primary aldosteronism.

Bert Delvoux, Patrick Groothuis, Thomas D'Hooghe, Cleophas Kyama, Gerard Dunselman, and Andrea Romano

Increased Production of 17β-Estradiol in Endometriosis Lesions Is the Result of Impaired Metabolism
J Clin Endocrinol Metab 2009 94: 876-883 , doi:10.1210/jc.2008-2218 [Abstract] [Full Text] [PDF]  
Endometriosis lesions have increased activity of 17β-hydroxysteroid dehydrogenases synthesizing active 17β-estradiol compared to the eutopic endometrium.

Josep Vidal, Joana Nicolau, Fabiola Romero, Roser Casamitjana, Dulce Momblan, Ignacio Conget, Rosa Morínigo, and Antonio M. Lacy

Long-Term Effects of Roux-en-Y Gastric Bypass Surgery on Plasma Glucagon-Like Peptide-1 and Islet Function in Morbidly Obese Subjects
J Clin Endocrinol Metab 2009 94: 884-891 , doi:10.1210/jc.2008-1620 [Abstract] [Full Text] [PDF]  
Although the GLP-1 response to meal intake is steadily elevated after Roux-en-y gastric bypass, this does not necessarily result over time in an inappropriate insulin secretion.

Shali Mazaki-Tovi, Hannah Kanety, Clara Pariente, Rina Hemi, Yoav Yinon, Amir Wiser, Eyal Schiff, and Eyal Sivan

Adiponectin and Leptin Concentrations in Dichorionic Twins with Discordant and Concordant Growth
J Clin Endocrinol Metab 2009 94: 892-898 , doi:10.1210/jc.2008-2118 [Abstract] [Full Text] [PDF]  
Low cord blood adiponectin concentrations characterize fetuses with growth restriction and are independently associated with birth weight.

M. Hatch, A. Brenner, T. Bogdanova, A. Derevyanko, N. Kuptsova, I. Likhtarev, A. Bouville, V. Tereshchenko, L. Kovgan, V. Shpak, E. Ostroumova, E. Greenebaum, L. Zablotska, E. Ron, and M. Tronko

A Screening Study of Thyroid Cancer and Other Thyroid Diseases among Individuals Exposed in Utero to Iodine-131 from Chernobyl Fallout
J Clin Endocrinol Metab 2009 94: 899-906 , doi:10.1210/jc.2008-2049 [Abstract] [Full Text] [PDF]  
In utero exposure to radioiodines from Chornobyl fallout showed a substantial, nonsignificant increased risk for thyroid cancer, reinforcing concern about I-131exposure of pregnant women.

Donald J. Brambilla, Alvin M. Matsumoto, Andre B. Araujo, and John B. McKinlay

The Effect of Diurnal Variation on Clinical Measurement of Serum Testosterone and Other Sex Hormone Levels in Men
J Clin Endocrinol Metab 2009 94: 907-913 , doi:10.1210/jc.2008-1902 [Abstract] [Full Text] [PDF]  
Although diurnal variation of testosterone declines with age, testosterone measurements should be restricted to morning hours at all ages.

Kristian Løvås, Ian McFarlane, Huy-Hoang Nguyen, Suzanne Curran, John Schwabe, David Halsall, Rita Bernhardt, A. Michael Wallace, and V. Krishna K. Chatterjee

A Novel CYP11B2 Gene Mutation in an Asian Family with Aldosterone Synthase Deficiency
J Clin Endocrinol Metab 2009 94: 914-919 , doi:10.1210/jc.2008-1524 [Abstract] [Full Text] [PDF]  
A novel mutation in the CYP11B2 gene and the biochemical phenotype of aldosterone synthase deficiency in a family of Asian origin are described.

Peter E. H. Schwarz, Jiang Li, Manja Reimann, Alta E. Schutte, Antje Bergmann, Markolf Hanefeld, Stefan R. Bornstein, Jan Schulze, Jaakko Tuomilehto, and Jaana Lindström

The Finnish Diabetes Risk Score Is Associated with Insulin Resistance and Progression towards Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 920-926 , doi:10.1210/jc.2007-2427 [Abstract] [Full Text] [PDF]  
The Finnish Diabetes Risk Score questionnaire helps health care professionals identify people with insulin resistance and progression towards type 2 diabetes, which helps to implement successful preventive intervention.

Yumiko Mizutori, Chun-Rong Chen, Francesco Latrofa, Sandra M. McLachlan, and Basil Rapoport

Evidence that Shed Thyrotropin Receptor A Subunits Drive Affinity Maturation of Autoantibodies Causing Graves’ Disease
J Clin Endocrinol Metab 2009 94: 927-935 , doi:10.1210/jc.2008-2134 [Abstract] [Full Text] [PDF]  
Strong evidence is provided that the shed ectodomain (primarily the A-subunit) is the primary antigen driving affinity maturation of thyroid stimulating antibody-producing B-cells.

Petr Rubtsov, Maksim Karmanov, Polina Sverdlova, Pavel Spirin, and Anatoly Tiulpakov

BRIEF REPORT:A Novel Homozygous Mutation in CYP11A1 Gene Is Associated with Late-Onset Adrenal Insufficiency and Hypospadias in a 46,XY Patient
J Clin Endocrinol Metab 2009 94: 936-939 , doi:10.1210/jc.2008-1118 [Abstract] [Full Text] [PDF]  
A non-classical P450scc deficiency presenting with late-onset adrenal insufficiency in a male with hypospadias.

Anne Merewood, Supriya D. Mehta, Tai C. Chen, Howard Bauchner, and Michael F. Holick

BRIEF REPORT:Association between Vitamin D Deficiency and Primary Cesarean Section
J Clin Endocrinol Metab 2009 94: 940-945 , doi:10.1210/jc.2008-1217 [Abstract] [Full Text] [PDF]  
Vitamin D deficiency is common in pregnant women. A multivariate logistic regression analysis revealed women who were vitamin D deficient were more likely to have a caesarian section than women who were vitamin D sufficient.

Endocrine Research:

Eiji Kawasaki, Takuya Awata, Hiroshi Ikegami, Tetsuro Kobayashi, Taro Maruyama, Koji Nakanishi, Akira Shimada, Miho Uga, Susumu Kurihara, Yumiko Kawabata, Shoichiro Tanaka, Yasuhiko Kanazawa, Katsumi Eguchi the Japanese Study Group on Type 1 Diabetes Genetics

Genetic Association between the Interleukin-2 Receptor- Gene and Mode of Onset of Type 1 Diabetes in the Japanese Population
J Clin Endocrinol Metab 2009 94: 947-952 , doi:10.1210/jc.2008-1596 [Abstract] [Full Text] [PDF]  
Genetic association of the IL2RA with Japanese type 1 diabetes differs according to the mode of disease onset.

Erik Ingelsson, Johan Ärnlöv, Björn Zethelius, Ramachandran S. Vasan, Allan Flyvbjerg, Jan Frystyk, Christian Berne, Arvo Hänni, Lars Lind, and Johan Sundström

Associations of Serum Adiponectin with Skeletal Muscle Morphology and Insulin Sensitivity
J Clin Endocrinol Metab 2009 94: 953-957 , doi:10.1210/jc.2008-1772 [Abstract] [Full Text] [PDF]  
Circulating adiponectin concentrations are associated with skeletal muscle morphology and could be involved in the relations between muscle morphology and insulin sensitivity.

Leif Wide, Karin Eriksson, Patrick M. Sluss, and Janet E. Hall

Serum Half-Life of Pituitary Gonadotropins Is Decreased by Sulfonation and Increased by Sialylation in Women
J Clin Endocrinol Metab 2009 94: 958-964 , doi:10.1210/jc.2008-2070 [Abstract] [Full Text] [PDF]  
Modifications of the oligosaccharides on LH and FSH determine their half-life in the circulation: sulfonation decreases and sialylation increases as estimated during GnRH receptor blockade.

Louise Moller, Lisa Dalman, Helene Norrelund, Nils Billestrup, Jan Frystyk, Niels Moller, and Jens Otto Lunde Jorgensen

Impact of Fasting on Growth Hormone Signaling and Action in Muscle and Fat
J Clin Endocrinol Metab 2009 94: 965-972 , doi:10.1210/jc.2008-1385 [Abstract] [Full Text] [PDF]  
Combination of fasting and GH exposure is associated with enhanced lipolysis, reduced IGF-I bioactivity, and accompanied by reduced activation of the JAK-STAT pathway.

Johannes D. Veldhuis, Kristi L. Mielke, Mihaela Cosma, Cacia Soares-Welch, Remberto Paulo, John M. Miles, and Cyril Y. Bowers

Aromatase and 5-Reductase Inhibition during an Exogenous Testosterone Clamp Unveils Selective Sex Steroid Modulation of Somatostatin and Growth Hormone Secretagogue Actions in Healthy Older Men
J Clin Endocrinol Metab 2009 94: 973-981 , doi:10.1210/jc.2008-2108 [Abstract] [Full Text] [PDF]  
Systemic concentrations of androgenic and estrogenic sex steroids along with abdominal visceral-fat mass jointly determine GH responses to peptidyl secretagogues and (exogenous) somatostatin.

José Manuel Fernández-Real, Francesco Equitani, José María Moreno, Melania Manco, Francisco Ortega, and Wifredo Ricart

Study of Circulating Prohepcidin in Association with Insulin Sensitivity and Changing Iron Stores
J Clin Endocrinol Metab 2009 94: 982-988 , doi:10.1210/jc.2008-1211 [Abstract] [Full Text] [PDF]  
Circulating prohepcidin, which is synthesized in the liver in response to iron overload, was associated with parameters of iron and glucose metabolism.

Dick C. Chan, P. Hugh R. Barrett, Esther M. M. Ooi, Juying Ji, Doris T. Chan, and Gerald F. Watts

Very Low Density Lipoprotein Metabolism and Plasma Adiponectin as Predictors of High-Density Lipoprotein Apolipoprotein A-I Kinetics in Obese and Nonobese Men
J Clin Endocrinol Metab 2009 94: 989-997 , doi:10.1210/jc.2008-1457 [Abstract] [Full Text] [PDF]  
Variation in VLDL-apoB production determines HDL-apoA-I catabolism, whereas insulin resistance and adiponectin contributes to the variation in HDL-apoA-I catabolism in obese and non-obese subjects, respectively.

F. Lavoie, F. Frisch, P. Brassard, F. Normand-Lauzière, D. Cyr, R. Gagnon, R. Drouin, J. -P. Baillargeon, and A. C. Carpentier

Relationship between Total and High Molecular Weight Adiponectin Levels and Plasma Nonesterified Fatty Acid Tolerance during Enhanced Intravascular Triacylglycerol Lipolysis in Men
J Clin Endocrinol Metab 2009 94: 998-1004 , doi:10.1210/jc.2008-1021 [Abstract] [Full Text] [PDF]  
Adiponectin level is a marker of non-esterified fatty acid tolerance and triglyceride lipolytic activity during intravenous triglyceride infusion in healthy men.

A. Juul, K. Sørensen, L. Aksglaede, I. Garn, E. Rajpert-De Meyts, I. Hullstein, P. Hemmersbach, and A. M. Ottesen

A Common Deletion in the Uridine Diphosphate Glucuronyltransferase (UGT) 2B17 Gene Is a Strong Determinant of Androgen Excretion in Healthy Pubertal Boys
J Clin Endocrinol Metab 2009 94: 1005-1011 , doi:10.1210/jc.2008-1984 [Abstract] [Full Text] [PDF]  
Pubertal androgen excretion is strongly dependent on a very common deletion of the gene encoding uridine diphosphate glucuronyltransferase 2B17.

Raffaele Napoli, Valentina Apuzzi, Giorgio Bosso, Carolina D'Anna, Antonietta De Sena, Concetta Pirozzi, Aldo Marano, Gelsy Arianna Lupoli, Giuseppe Cudemo, Ugo Oliviero, Margherita Matarazzo, Giovanni Lupoli, and Luigi Saccá

Recombinant Human Thyrotropin Enhances Endothelial-Mediated Vasodilation of Conduit Arteries
J Clin Endocrinol Metab 2009 94: 1012-1016 , doi:10.1210/jc.2008-2298 [Abstract] [Full Text] [PDF]  
rhTSH causes marked and persistent activation of endothelial-mediated vasodilation of human conduit arteries, independent of systemic hemodynamic changes.

En-Pei Isabel Chiang, Yi-Cheng Wang, Wei-Wen Chen, and Feng-Yao Tang

Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation, S-Adenosylmethionine Synthesis, and Global Deoxyribonucleic Acid Methylation
J Clin Endocrinol Metab 2009 94: 1017-1025 , doi:10.1210/jc.2008-2038 [Abstract] [Full Text] [PDF]  
High cellular insulin or glucose exposure promotes homocysteine re-methylation, adoMet synthase activity, adoMet synthesis, and global DNA methylation in HepG2 cells.

Anoma Nellore, Karolina Paziana, Changqing Ma, Oxana M. Tsygankova, Yan Wang, Kanchan Puttaswamy, Ammarah U. Iqbal, Susanna R. Franks, Yu Lv, Andrea B. Troxel, Michael D. Feldman, Judy L. Meinkoth, and Marcia S. Brose

Loss of Rap1GAP in Papillary Thyroid Cancer
J Clin Endocrinol Metab 2009 94: 1026-1032 , doi:10.1210/jc.2008-1042 [Abstract] [Full Text] [PDF]  
Rap1GAP is lost in papillary thyroid cancer.

Anna L. Eriksson, Mattias Lorentzon, Liesbeth Vandenput, Fernand Labrie, Marie Lindersson, Ann-Christine Syvänen, Eric S. Orwoll, Steven R. Cummings, Joseph M. Zmuda, Östen Ljunggren, Magnus K. Karlsson, Dan Mellström, and Claes Ohlsson

Genetic Variations in Sex Steroid-Related Genes as Predictors of Serum Estrogen Levels in Men
J Clin Endocrinol Metab 2009 94: 1033-1041 , doi:10.1210/jc.2008-1283 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The single nucleotide polymorphisms rs2470152 of the CYP19 gene are strongly associated with serum estradiol 2 and estradol 1 levels in men.

Jeesun Jung, Tatiana M. Foroud, George J. Eckert, Leah Flury-Wetherill, Howard J. Edenberg, Xiaoling Xuei, Syed-Adeel Zaidi, and J. Howard Pratt

Association of the Calcium-Sensing Receptor Gene with Blood Pressure and Urinary Calcium in African-Americans
J Clin Endocrinol Metab 2009 94: 1042-1048 , doi:10.1210/jc.2008-1861 [Abstract] [Full Text] [PDF]  
This study suggests that common variants in the calcium-sensing receptor affect blood pressure.

Lourdes Ibáñez, Abel López-Bermejo, Marta Díaz, Maria Victoria Marcos, Paula Casano, and Francis de Zegher

BRIEF REPORT:Abdominal Fat Partitioning and High-Molecular-Weight Adiponectin in Short Children Born Small for Gestational Age
J Clin Endocrinol Metab 2009 94: 1049-1052 , doi:10.1210/jc.2008-2176 [Abstract] [Full Text] [PDF]  
Short small-for-gestational-age children have a normal amount of visceral fat, and strikingly reduced subcutaneous fat. This combination results in a markedly elevated ratio of visceral-over-subcutaneous fat.

Translational Highlights from Endocrinology:

Elodie Riant, Aurélie Waget, Haude Cogo, Jean-François Arnal, Rémy Burcelin, and Pierre Gourdy

Abstracts:Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice
J Clin Endocrinol Metab 2009 94: 1053 [Full Text] [PDF]  

Sam John, Thomas A. Johnson, Myong-Hee Sung, Simon C. Biddie, Saskia Trump, Christine A. Koch-Paiz, Sean R. Davis, Robert Walker, Paul S. Meltzer, and Gordon L. Hager

Abstracts:Kinetic Complexity of the Global Response to Glucocorticoid Receptor Action
J Clin Endocrinol Metab 2009 94: 1053-a [Full Text] [PDF]  

Michelle Welsh, Richard M Sharpe, Marion Walker, Lee B Smith, and Philippa T. K. Saunders

Abstracts:New Insights into the Role of Androgens in Wolffian Duct Stabilization in Male and Female Rodents
J Clin Endocrinol Metab 2009 94: 1054 [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Maree Bilandzic, Simon Chu, Paul G. Farnworth, Craig Harrison, Peter Nicholls, Yao Wang, Ruth M. Escalona, Peter J. Fuller, Jock K. Findlay, and Kaye L. Stenvers

Abstracts:Loss of Betaglycan Contributes to the Malignant Properties of Human Granulosa Tumor Cells
J Clin Endocrinol Metab 2009 94: 1055 [Full Text] [PDF]  

Saleh Altuwaijri, Kuang-Hsiang Chuang, Kuo-Pao Lai, Jiann-Jyh Lai, Hung-Yun Lin, Faith M. Young, Andrea Bottaro, Meng-Yin Tsai, Wei-Ping Zeng, Hong-Chiang Chang, Shuyuan Yeh, and Chawnshang Chang

Abstracts:Susceptibility to Autoimmunity and B Cell Resistance to Apoptosis in Mice Lacking Androgen Receptor in B Cells
J Clin Endocrinol Metab 2009 94: 1055-a [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Shalender Bhasin, Philip E. Cryer, and Robert Vigersky

Patient Information Page from The Hormone Foundation:Patient Guide on the Diagnosis and Management of Hypoglycemic Disorders (Low Blood Sugar) in Adults
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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