The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

The Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism:

Aliya A. Khan, John P. Bilezikian, John T. Potts, Jr Guest Editors for the Third International Workshop on Asymptomatic Primary Hyperparathyroidism

EDITORIAL:The Diagnosis and Management of Asymptomatic Primary Hyperparathyroidism Revisited
J Clin Endocrinol Metab 2009 94: 333-334 doi:10.1210/jc.2008-1757 [Full Text] [PDF]  

John P. Bilezikian, Aliya A. Khan, John T. Potts, Jr on behalf of the Third International Workshop on the Management of Asymptomatic Primary Hyperthyroidism

SUMMARY STATEMENT:Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Third International Workshop
J Clin Endocrinol Metab 2009 94: 335-339 doi:10.1210/jc.2008-1763 [Abstract] [Full Text] [PDF]  

R. Eastell, A. Arnold, M. L. Brandi, E. M. Brown, P. D'Amour, D. A. Hanley, D. Sudhaker Rao, M. R. Rubin, D. Goltzman, S. J. Silverberg, S. J. Marx, M. Peacock, L. Mosekilde, R. Bouillon, and E. M. Lewiecki

PROCEEDINGS:Diagnosis of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop
J Clin Endocrinol Metab 2009 94: 340-350 doi:10.1210/jc.2008-1758 [Abstract] [Full Text] [PDF]  
Responses to key questions about the diagnosis of asymptomatic primary hyperparathyroidism are provided based on the Third International Workshop on primary hyperparathyroidism.

Shonni J. Silverberg, E. Michael Lewiecki, Leif Mosekilde, Munro Peacock, and Mishaela R. Rubin

PROCEEDINGS:Presentation of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop
J Clin Endocrinol Metab 2009 94: 351-365 doi:10.1210/jc.2008-1760 [Abstract] [Full Text] [PDF]  
This paper focuses on issues arising from the clinical presentation and natural history of asymptomatic primary hyperparathyroidism.

Robert Udelsman, Janice L. Pasieka, Cord Sturgeon, J. E. M. Young, and Orlo H. Clark

PROCEEDINGS:Surgery for Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop
J Clin Endocrinol Metab 2009 94: 366-372 doi:10.1210/jc.2008-1761 [Abstract] [Full Text] [PDF]  
Patients with "asymptomatic" disease often have neurocognitive symptoms and bone disease that improve following parathyroidectomy. When performed by expert surgeons, parathyroid surgery is safe and cost-effective.

Aliya Khan, Andrew Grey, and Dolores Shoback

PROCEEDINGS:Medical Management of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop
J Clin Endocrinol Metab 2009 94: 373-381 doi:10.1210/jc.2008-1762 [Abstract] [Full Text] [PDF]  
This literature review addresses advances in the medical management of asymptomatic primary hyperparathyroidism as well as the consensus statements from the Third International Workshop on primary hyperparathyroidism.

Special Features:

Mario Rotondi, Gerardo Amabile, Paola Leporati, Bruno Di Filippo, and Luca Chiovato

IMAGE IN ENDOCRINOLOGY:Repeated Laser Thermal Ablation of a Large Functioning Thyroid Nodule Restores Euthyroidism and Ameliorates Constrictive Symptoms
J Clin Endocrinol Metab 2009 94: 382-383 doi:10.1210/jc.2008-1782 [Full Text] [PDF]  

Mihaela Trulea, Martine Patey, Brigitte Chaufour-Higel, François Bouquigny, Alain Longuebray, Pascal Rousseaux, Catherine Pasqual, Antoine Tabarin, and Brigitte Delemer

IMAGE IN ENDOCRINOLOGY:An Unusual Case of Ectopic Adrenocorticotropin Secretion
J Clin Endocrinol Metab 2009 94: 384-385 doi:10.1210/jc.2008-1634 [Full Text] [PDF]  

Camilo Jimenez, Maria E. Cabanillas, Libero Santarpia, Eric Jonasch, Karen L. Kyle, Elizabeth A. Lano, Surena F. Matin, Rodolfo F. Nunez, Nancy D. Perrier, Alexandria Phan, Thereasa A. Rich, Beejal Shah, Michelle D. Williams, and Steven G. Waguespack

CLINICAL CASE SEMINAR:Use of the Tyrosine Kinase Inhibitor Sunitinib in a Patient with von Hippel-Lindau Disease: Targeting Angiogenic Factors in Pheochromocytoma and Other von Hippel-Lindau Disease-Related Tumors
J Clin Endocrinol Metab 2009 94: 386-391 , doi:10.1210/jc.2008-1972 [Abstract] [Full Text] [PDF]  
Antagonism of vascular endothelial growth factor and platelet derived growth factor receptors may help to treat von Hippel-Lindau-related tumors, including malignant pheochromocytomas.

Susan M. Webb, Christian J. Strasburger, Daojun Mo, Mark L. Hartman, Shlomo Melmed, Heike Jung, Werner F. Blum, Andrea F. Attanasio on behalf of the HypoCCS International Advisory Board

EXTENSIVE CLINICAL EXPERIENCE:Changing Patterns of the Adult Growth Hormone Deficiency Diagnosis Documented in a Decade-Long Global Surveillance Database
J Clin Endocrinol Metab 2009 94: 392-399 , doi:10.1210/jc.2008-0713 [Abstract] [Full Text] [PDF]  
Significant shifts in diagnostic patterns have occurred since approval of the adult GH deficiency (GHD) indication, with a trend to less severe forms of GHD.

Laura K. Bachrach and Leanne M. Ward

CLINICAL REVIEW:Clinical Review: Bisphosphonate Use in Childhood Osteoporosis
J Clin Endocrinol Metab 2009 94: 400-409 , doi:10.1210/jc.2008-1531 [Abstract] [Full Text] [PDF]  
Data related to safety and efficacy of bisphosphonate use in children remains inadequate, and therapy with these agents should be limited to compassionate use.

Antonio Ceriello, Michael A. Ihnat, and Jessica E. Thorpe

CLINICAL REVIEW:The "Metabolic Memory": Is More Than Just Tight Glucose Control Necessary to Prevent Diabetic Complications?
J Clin Endocrinol Metab 2009 94: 410-415 , doi:10.1210/jc.2008-1824 [Abstract] [Full Text] [PDF]  
The "metabolic memory" of vascular stress persistence after glucose normalization is multifactorial in nature and likely involves oxidative and glycative alterations in cellular macromolecules.

Editorials:

Ashok Balasubramanyam

EDITORIAL:Intensive Glycemic Control in the Intensive Care Unit: Promises and Pitfalls
J Clin Endocrinol Metab 2009 94: 416-417 doi:10.1210/jc.2008-2620 [Full Text] [PDF]  

Edward Giovannucci

EDITORIAL:Expanding Roles of Vitamin D
J Clin Endocrinol Metab 2009 94: 418-420 doi:10.1210/jc.2008-2695 [Full Text] [PDF]  

Endocrine Care:

James T. Sharkey, Roopashri Puttaramu, R. Ann Word, and James Olcese

Melatonin Synergizes with Oxytocin to Enhance Contractility of Human Myometrial Smooth Muscle Cells
J Clin Endocrinol Metab 2009 94: 421-427 , doi:10.1210/jc.2008-1723 [Abstract] [Full Text] [PDF]  
Melatonin synergizes with oxytocin to enhance myometrial cell contractions via increased activation of myosin light chain and elevated gap junction activity.

M. van Hoek, L. J. Hofland, Y. B. de Rijke, F. H. van Nederveen, R. R. de Krijger, P. M. van Koetsveld, S. W. J. Lamberts, A. J. van der Lely, W. W. de Herder, and R. A. Feelders

Effects of Somatostatin Analogs on a Growth Hormone-Releasing Hormone Secreting Bronchial Carcinoid, in Vivo and in Vitro Studies
J Clin Endocrinol Metab 2009 94: 428-433 , doi:10.1210/jc.2008-1712 [Abstract] [Full Text] [PDF]  
In vitro studies on a GHRH secreting bronchial carcinoid show that SOM-230 is at least equally potent compared to octreotide at inhibiting GHRH production.

Viive M. Howell, Anthony Gill, Adele Clarkson, Anne E. Nelson, Robert Dunne, Leigh W. Delbridge, Bruce G. Robinson, Bin T. Teh, Oliver Gimm, and Deborah J. Marsh

Accuracy of Combined Protein Gene Product 9.5 and Parafibromin Markers for Immunohistochemical Diagnosis of Parathyroid Carcinoma
J Clin Endocrinol Metab 2009 94: 434-441 , doi:10.1210/jc.2008-1740 [Abstract] [Full Text] [PDF]  
Strong evidence is provided that PGP9.5 positivity complements parafibromin negativity as a marker of malignancy and the hyperparathyroidism-jaw tumor adenoma phenotype in parathyroid tumors.

Akio Yoshida, Ichiro Hisatome, Shinichi Taniguchi, Yasuaki Shirayoshi, Yasutaka Yamamoto, Junichiro Miake, Tsuyoshi Ohkura, Takeshi Akama, Osamu Igawa, Chiaki Shigemasa, Keiichi Kamijo, Shoichiro Ikuyama, Patrizio Caturegli, and Koichi Suzuki

Pendrin Is a Novel Autoantigen Recognized by Patients with Autoimmune Thyroid Diseases
J Clin Endocrinol Metab 2009 94: 442-448 , doi:10.1210/jc.2008-1732 [Abstract] [Full Text] [PDF]  
Pendrin is a novel auto-antigen recognized by patients with autoimmune thyroid diseases, and anti-pendrin antibody is an accurate diagnostic tool.

Allan F. Moore, Kathleen A. Jablonski, Clinton C. Mason, Jarred B. McAteer, Richard F. Arakaki, Barry J. Goldstein, Steven E. Kahn, Abbas E. Kitabchi, Robert L. Hanson, William C. Knowler, Jose C. Florez for the Diabetes Prevention Program Research Group

The Association of ENPP1 K121Q with Diabetes Incidence Is Abolished by Lifestyle Modification in the Diabetes Prevention Program
J Clin Endocrinol Metab 2009 94: 449-455 , doi:10.1210/jc.2008-1583 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The ectoenzyme nucleotide pyrophosphate phosphodiesterase (ENPP1) gene K121Q polymorphism is associated with diabetes incidence in the placebo arm of the Diabetes Prevention Program, but the lifestyle intervention eliminates this risk.

Marie-Laure Nunes, Stéphanie Vattaut, Jean-Benoît Corcuff, Alexandre Rault, Hugues Loiseau, Blandine Gatta, Nathalie Valli, Luc Letenneur, and Antoine Tabarin

Late-Night Salivary Cortisol for Diagnosis of Overt and Subclinical Cushing’s Syndrome in Hospitalized and Ambulatory Patients
J Clin Endocrinol Metab 2009 94: 456-462 , doi:10.1210/jc.2008-1542 [Abstract] [Full Text] [PDF]  
This study validates outpatient sampling strategy for night salivary cortisol. In subclinical Cushing’s syndrome, night salivary cortisol is helpful to detect recurrence of Cushing’s disease, but not for the evaluation of adrenal incidentalomas.

Saskia N. van der Crabben, Regje M. E. Blümer, Michiel E. Stegenga, Mariëtte T. Ackermans, Erik Endert, Michael W. T. Tanck, Mireille J. Serlie, Tom van der Poll, and Hans P. Sauerwein

Early Endotoxemia Increases Peripheral and Hepatic Insulin Sensitivity in Healthy Humans
J Clin Endocrinol Metab 2009 94: 463-468 , doi:10.1210/jc.2008-0761 [Abstract] [Full Text] [PDF]  
The increased peripheral and hepatic insulin sensitivity seen after administration of lipopolysaccharide may contribute to the hypoglycemia occurring in some patients with critical illness.

Vanita R. Aroda, Theodore P. Ciaraldi, Paivi Burke, Sunder Mudaliar, Paul Clopton, Susan Phillips, R. Jeffrey Chang, and Robert R. Henry

Metabolic and Hormonal Changes Induced by Pioglitazone in Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Clinical Trial
J Clin Endocrinol Metab 2009 94: 469-476 , doi:10.1210/jc.2008-1133 [Abstract] [Full Text] [PDF]  
Improvements in insulin sensitivity in overweight/obese women with polycystic ovary syndrome following pioglitazone treatment are associated with reduced ovarian androgen responsiveness to gonadotropin stimulation.

Ingrid Hansen-Pupp, Eva Engström, Aimon Niklasson, Ann-Cathrine Berg, Vineta Fellman, Chatarina Löfqvist, Ann Hellström, and David Ley

Fresh-Frozen Plasma as a Source of Exogenous Insulin-Like Growth Factor-I in the Extremely Preterm Infant
J Clin Endocrinol Metab 2009 94: 477-482 , doi:10.1210/jc.2008-1293 [Abstract] [Full Text] [PDF]  
Transfusion of fresh frozen plasma to extremely preterm infants during the first postnatal week elevates levels of IGF-I and IGF binding protein-3.

Berit Kriström, A. Stefan Aronson, Jovanna Dahlgren, Jan Gustafsson, Maria Halldin, Sten A. Ivarsson, Nils-Östen Nilsson, Johan Svensson, Torsten Tuvemo, and Kerstin Albertsson-Wikland

Growth Hormone (GH) Dosing during Catch-Up Growth Guided by Individual Responsiveness Decreases Growth Response Variability in Prepubertal Children with GH Deficiency or Idiopathic Short Stature
J Clin Endocrinol Metab 2009 94: 483-490 , doi:10.1210/jc.2008-1503 [Abstract] [Full Text] [PDF]  
Individualized GH dosing according to responsiveness makes children with GH deficiency or idiopathic short stature respond equally and reach a predefined goal in height in a randomized trial.

Carrie M. Nielson, Mary L. Bouxsein, Sinara S. Freitas, Kristine E. Ensrud, Eric S. Orwoll for the Osteoporotic Fractures in Men (MrOS) Research Group

Trochanteric Soft Tissue Thickness and Hip Fracture in Older Men
J Clin Endocrinol Metab 2009 94: 491-496 , doi:10.1210/jc.2008-1640 [Abstract] [Full Text] [PDF]  
In older men, an increase in trochanteric soft tissue thickness does not appear to reduce the risk of hip fracture.

Emily Oken, Lewis E. Braverman, Deborah Platek, Marvin L. Mitchell, Stephanie L. Lee, and Elizabeth N. Pearce

Neonatal Thyroxine, Maternal Thyroid Function, and Child Cognition
J Clin Endocrinol Metab 2009 94: 497-503 , doi:10.1210/jc.2008-0936 [Abstract] [Full Text] [PDF]  
Newborn T₄ concentrations within a normal physiological reference range are not associated with maternal thyroid function and do not predict cognitive outcomes in a population living in an iodine-sufficient area.

Jeesuk Yu, Andrea K. Steck, Sunanda Babu, Liping Yu, Dongmei Miao, Kim McFann, John Hutton, George S. Eisenbarth, and Georgeanna Klingensmith

Single Nucleotide Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphisms in Antiislet Autoantibody-Negative Patients at Onset of Diabetes
J Clin Endocrinol Metab 2009 94: 504-510 , doi:10.1210/jc.2007-2694 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Transcription factor 7-like 2 (TCF7L2) type 2 diabetes susceptibility alleles are associated with islet autoantibody negative, but not autoantibody positive, new onset diabetes in young patients.

Katherine Wesseling-Perry, Renata C. Pereira, Hejing Wang, Robert M. Elashoff, Shobha Sahney, Barbara Gales, Harald Jüppner, and Isidro B. Salusky

Relationship between Plasma Fibroblast Growth Factor-23 Concentration and Bone Mineralization in Children with Renal Failure on Peritoneal Dialysis
J Clin Endocrinol Metab 2009 94: 511-517 , doi:10.1210/jc.2008-0326 [Abstract] [Full Text] [PDF]  
High levels of fibroblast growth factor-23 are associated with improved indices of skeletal mineralization in dialyzed pediatric patients with high turnover renal osteodystrophy.

Marcello Maggio, Gian Paolo Ceda, Fulvio Lauretani, Stefania Bandinelli, E. Jeffrey Metter, Andrea Artoni, Elisa Gatti, Carmelinda Ruggiero, Jack M. Guralnik, Giorgio Valenti, Shari M. Ling, Shehzad Basaria, and Luigi Ferrucci

Estradiol and Inflammatory Markers in Older Men
J Clin Endocrinol Metab 2009 94: 518-522 , doi:10.1210/jc.2008-0940 [Abstract] [Full Text] [PDF]  
In a population of older men, total estradiol is positively associated with IL-6, independent of testosterone and other confounders, including body mass index.

John D. Carmichael, Vivien S. Bonert, James M. Mirocha, and Shlomo Melmed

The Utility of Oral Glucose Tolerance Testing for Diagnosis and Assessment of Treatment Outcomes in 166 Patients with Acromegaly
J Clin Endocrinol Metab 2009 94: 523-527 , doi:10.1210/jc.2008-1371 [Abstract] [Full Text] [PDF]  
Both basal GH and GH nadir after oral glucose load are frequently discordant with serum IGF-I levels in patients with acromegaly receiving treatment with somatostatin analogs.

Annamaria Colao, Renata S. Auriemma, Mariano Galdiero, Paolo Cappabianca, Luigi M. Cavallo, Felice Esposito, Ludovica F. S. Grasso, Gaetano Lombardi, and Rosario Pivonello

Impact of Somatostatin Analogs Versus Surgery on Glucose Metabolism in Acromegaly: Results of a 5-Year Observational, Open, Prospective Study
J Clin Endocrinol Metab 2009 94: 528-537 , doi:10.1210/jc.2008-1546 [Abstract] [Full Text] [PDF]  
This 5-year, observational, prospective study demonstrates that deterioration of glucose tolerance occurs in a similar proportion of patients controlled with surgery and somatostatin analogues or cured with surgery. Body mass index increase was found to be the major predictor of deterioration of glucose tolerance.

Andrew Grey, Mark J. Bolland, Diana Wattie, Anne Horne, Greg Gamble, and Ian R. Reid

The Antiresorptive Effects of a Single Dose of Zoledronate Persist for Two Years: A Randomized, Placebo-Controlled Trial in Osteopenic Postmenopausal Women
J Clin Endocrinol Metab 2009 94: 538-544 , doi:10.1210/jc.2008-2241 [Abstract] [Full Text] [PDF]  
The anti-resorptive effects of a single intravenous dose of 5 mg zoledronate persist for at least 2 years.

R. Scott Struthers, Andrew J. Nicholls, John Grundy, Takung Chen, Roland Jimenez, Samuel S. C. Yen, and Haig P. Bozigian

Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix
J Clin Endocrinol Metab 2009 94: 545-551 , doi:10.1210/jc.2008-1695 [Abstract] [Full Text] [PDF]  
Oral administration of the nonpeptide GnRH antagonist, elagolix, to premenopausal women results in transient suppression of gonadotropins and more sustained suppression of estradiol.

Paola Villa, Barbara Costantini, Rosanna Suriano, Concetta Perri, Francesca Macrì, Luigi Ricciardi, Simona Panunzi, and Antonio Lanzone

The Differential Effect of the Phytoestrogen Genistein on Cardiovascular Risk Factors in Postmenopausal Women: Relationship with the Metabolic Status
J Clin Endocrinol Metab 2009 94: 552-558 , doi:10.1210/jc.2008-0735 [Abstract] [Full Text] [PDF]  
Genistein significantly influences glycoinsulinemic metabolism and endothelial function. Normoinsulinmeic patients show an improvement in glycemic and vascular reactivity indexes, while the insulin sensitivity indexes improve in hyperinsulinemic patients.

Kate A. Ward, Geeta Das, Jacqueline L. Berry, Stephen A. Roberts, Rainer Rawer, Judith E. Adams, and Zulf Mughal

Vitamin D Status and Muscle Function in Post-Menarchal Adolescent Girls
J Clin Endocrinol Metab 2009 94: 559-563 , doi:10.1210/jc.2008-1284 [Abstract] [Full Text] [PDF]  
Low 25-hydroxy-vitamin D levels in adolescent girls are significantly associated with impaired muscle function, yielding potentially important implications for skeletal development.

Guillermo E. Umpierrez, Tiffany Hor, Dawn Smiley, Angel Temponi, Denise Umpierrez, Miguel Ceron, Christina Munoz, Christopher Newton, Limin Peng, and David Baldwin

Comparison of Inpatient Insulin Regimens with Detemir plus Aspart Versus Neutral Protamine Hagedorn plus Regular in Medical Patients with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 564-569 , doi:10.1210/jc.2008-1441 [Abstract] [Full Text] [PDF]  
The investigation of in-patient hyperglycemia management shows that detemir daily with mealtime aspart offers equivalent glycemic control compared to neutral protamine Hagedorn and regular insulin in patients with type 2 diabetes.

Beverley Shields, Anita Hill, Mary Bilous, Beatrice Knight, Andrew T. Hattersley, Rudy W. Bilous, and Bijay Vaidya

BRIEF REPORT:Cigarette Smoking during Pregnancy Is Associated with Alterations in Maternal and Fetal Thyroid Function
J Clin Endocrinol Metab 2009 94: 570-574 , doi:10.1210/jc.2008-0380 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Maternal cigarette smoking during pregnancy is associated with alterations in maternal thyroid function and in fetal thyroid function, as measured in cord blood samples.

Thomas Remer, Friedrich Manz, Michaela F. Hartmann, Eckhard Schoenau, and Stefan A. Wudy

BRIEF REPORT:Prepubertal Healthy Children’s Urinary Androstenediol Predicts Diaphyseal Bone Strength in Late Puberty
J Clin Endocrinol Metab 2009 94: 575-578 , doi:10.1210/jc.2008-1375 [Abstract] [Full Text] [PDF]  
Androstenediol excretion in 24-h urine samples collected approximately 2 years before puberty onset predicts diaphyseal bone strength in late puberty.

Endocrine Research:

Sara Bruce, Katariina Hannula-Jouppi, Jari Peltonen, Juha Kere, and Marita Lipsanen-Nyman

Clinically Distinct Epigenetic Subgroups in Silver-Russell Syndrome: The Degree of H19 Hypomethylation Associates with Phenotype Severity and Genital and Skeletal Anomalies
J Clin Endocrinol Metab 2009 94: 579-587 , doi:10.1210/jc.2008-1805 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A "dose-response" relationship is shown between the degree of H19 imprinting control region methylation and the severity of the Silver-Russell syndrome (SRS) phenotype; also reported is the high incidence of genital and skeletal abnormalities in SRS patients with severe hypomethylation.

Everlayny Fiorot Costalonga, Sonir R. Antonini, Gil Guerra-Junior, Berenice Bilharinho Mendonca, Ivo J. P. Arnhold, and Alexander A. L. Jorge

The –202 A Allele of Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Promoter Polymorphism Is Associated with Higher IGFBP-3 Serum Levels and Better Growth Response to Growth Hormone Treatment in Patients with Severe Growth Hormone Deficiency
J Clin Endocrinol Metab 2009 94: 588-595 , doi:10.1210/jc.2008-1608 [Abstract] [Full Text] [PDF]  
A direct relation between genetic variability in insulin-like growth factor binding protein-3 (IGFBP3) gene and growth velocity after treatment with human recombinant GH in GH-deficient children is demonstrated.

Louise G. Grunnet, Charlotte Brøns, Stine Jacobsen, Emma Nilsson, Arne Astrup, Torben Hansen, Oluf Pedersen, Pernille Poulsen, Bjørn Quistorff, and Allan Vaag

Increased Recovery Rates of Phosphocreatine and Inorganic Phosphate after Isometric Contraction in Oxidative Muscle Fibers and Elevated Hepatic Insulin Resistance in Homozygous Carriers of the A-allele of FTO rs9939609
J Clin Endocrinol Metab 2009 94: 596-602 , doi:10.1210/jc.2008-1592 [Abstract] [Full Text] [PDF]  
The rs9939609 polymorphism of the fat mass and obesity-associated gene is associated with muscle energy efficiency and hepatic insulin resistance.

Kasper Aaboe, Filip Krag Knop, Tina Vilsboll, Aage Vølund, Ulf Simonsen, Carolyn Fiona Deacon, Sten Madsbad, Jens Juul Holst, and Thure Krarup

K_ATP Channel Closure Ameliorates the Impaired Insulinotropic Effect of Glucose-Dependent Insulinotropic Polypeptide in Patients with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 603-608 , doi:10.1210/jc.2008-1731 [Abstract] [Full Text] [PDF]  
Closing the K_ATP channels of the β-cell using acute administration of a sulfonylurea compound ameliorates the reduced insulinotropic effect of glucose-dependent insulinotropic polypeptide.

Guillermo E. Umpierrez, Dawn Smiley, Gonzalo Robalino, Limin Peng, Abbas E. Kitabchi, Bobby Khan, Ahn Le, Arshed Quyyumi, Virgil Brown, and Lawrence S. Phillips

Intravenous Intralipid-Induced Blood Pressure Elevation and Endothelial Dysfunction in Obese African-Americans with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 609-614 , doi:10.1210/jc.2008-1590 [Abstract] [Full Text] [PDF]  
Elevated levels of free fatty acids may be important in the development of hypertension and vascular dysfunction in obese African-Americans.

Elena Trukhacheva, Zhihong Lin, Scott Reierstad, You-Hong Cheng, Magdy Milad, and Serdar E. Bulun

Estrogen Receptor (ER) β Regulates ER Expression in Stromal Cells Derived from Ovarian Endometriosis
J Clin Endocrinol Metab 2009 94: 615-622 , doi:10.1210/jc.2008-1466 [Abstract] [Full Text] [PDF]  
Estrogen receptor β (ERβ) acts as a suppressor of ER in endometrial and endometriotic stromal cells via binding to classical and non-classical DNA motifs in specific ER promoters.

Erkut Attar, Hideki Tokunaga, Gonca Imir, M. Bertan Yilmaz, David Redwine, Michael Putman, Bilgin Gurates, Rukset Attar, Nobuo Yaegashi, Dale B. Hales, and Serdar E. Bulun

Prostaglandin E₂ Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis
J Clin Endocrinol Metab 2009 94: 623-631 , doi:10.1210/jc.2008-1180 [Abstract] [Full Text] [PDF]  
In stromal cells of endometriosis, steroidogenic factor-1 coordinately orchestrates prostaglandin-E₂ induction of the key genes responsible for the biosynthesis of estradiol from cholesterol.

V. Saroja Voruganti, Subrata D. Nath, Shelley A. Cole, Farook Thameem, Jeremy B. Jowett, Richard Bauer, Jean W. MacCluer, John Blangero, Anthony G. Comuzzie, Hanna E. Abboud, and Nedal H. Arar

Genetics of Variation in Serum Uric Acid and Cardiovascular Risk Factors in Mexican Americans
J Clin Endocrinol Metab 2009 94: 632-638 , doi:10.1210/jc.2008-0682 [Abstract] [Full Text] [PDF]  
There is a significant genetic component in the variation in serum uric acid and evidence of pleiotropy between serum uric acid and other cardiovascular risk factors.

Edna J. L. Barbosa, Jenny Palming, Camilla A. M. Glad, Helena Filipsson, Josef Koranyi, Bengt-Åke Bengtsson, Lena M. S. Carlsson, Cesar L. Boguszewski, and Gudmundur Johannsson

Influence of the Exon 3-Deleted/Full-Length Growth Hormone (GH) Receptor Polymorphism on the Response to GH Replacement Therapy in Adults with Severe GH Deficiency
J Clin Endocrinol Metab 2009 94: 639-644 , doi:10.1210/jc.2008-0323 [Abstract] [Full Text] [PDF]  
The exon 3-deleted/full-length GHR polymorphisms are not associated with the 1-year changes in IGF-I levels and body fat, which were taken as the GH response markers in this adult cohort affected by severe GH deficiency.

Lisa Ceglia, Susan S. Harris, Steven A. Abrams, Helen M. Rasmussen, Gerard E. Dallal, and Bess Dawson-Hughes

Potassium Bicarbonate Attenuates the Urinary Nitrogen Excretion That Accompanies an Increase in Dietary Protein and May Promote Calcium Absorption
J Clin Endocrinol Metab 2009 94: 645-653 , doi:10.1210/jc.2008-1796 [Abstract] [Full Text] [PDF]  
Supplementation of older adults with potassium bicarbonate attenuates the urinary nitrogen excretion that accompanies an increase in dietary protein, suggesting that the net effect of dietary protein on muscle may be enhanced by reducing its accompanying acid load.

Sarah Lesche, Diana Lehmann, Falko Nagel, Herbert A. Schmid, and Stefan Schulz

Differential Effects of Octreotide and Pasireotide on Somatostatin Receptor Internalization and Trafficking in Vitro
J Clin Endocrinol Metab 2009 94: 654-661 , doi:10.1210/jc.2008-1919 [Abstract] [Full Text] [PDF]  
Pasireotide modulates somatostatin receptor trafficking in a manner clearly distinct from somatostatin or octreotide.

Tzung-Dau Wang, Wen-Jeng Lee, Fuh-Yuan Shih, Chien-Hua Huang, Yeun-Chung Chang, Wen-Jone Chen, Yuan-Teh Lee, and Ming-Fong Chen

Relations of Epicardial Adipose Tissue Measured by Multidetector Computed Tomography to Components of the Metabolic Syndrome Are Region-Specific and Independent of Anthropometric Indexes and Intraabdominal Visceral Fat
J Clin Endocrinol Metab 2009 94: 662-669 , doi:10.1210/jc.2008-0834 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Thickness of epicardial adipose tissue in the left atrioventricular groove best reflects its metabolic risk, which is independent of anthropometric indexes and intra-abdominal visceral fat.

Malcolm C. Richardson, Susan Ingamells, Chantal D. Simonis, Iain T. Cameron, Rajiv Sreekumar, Ananth Vijendren, Luckni Sellahewa, Stephanie Coakley, and Christopher D. Byrne

Stimulation of Lactate Production in Human Granulosa Cells by Metformin and Potential Involvement of Adenosine 5' Monophosphate-Activated Protein Kinase
J Clin Endocrinol Metab 2009 94: 670-677 , doi:10.1210/jc.2008-2025 [Abstract] [Full Text] [PDF]  
Metformin stimulates lactate production by human granulosa cells through a mechanism involving activation of AMP-activated protein kinase.

Bruno Ferraz-de-Souza, Franziska Martin, Delphine Mallet, Rebecca E. Hudson-Davies, Patricia Cogram, Lin Lin, Dianne Gerrelli, Felix Beuschlein, Yves Morel, Angela Huebner, and John C. Achermann

CBP/p300-Interacting Transactivator, with Glu/Asp-Rich C-Terminal Domain, 2, and Pre-B-Cell Leukemia Transcription Factor 1 in Human Adrenal Development and Disease
J Clin Endocrinol Metab 2009 94: 678-683 , doi:10.1210/jc.2008-1064 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The transcriptional regulators CITED2 and PBX1 are expressed during adrenal development and are regulated by steroidogenic factor-1, but are not frequently disrupted in adrenal failure.

Luisa Giuliani, Livia Lenzini, Michele Antonello, Enrico Aldighieri, Anna S. Belloni, Ambrogio Fassina, Celso Gomez-Sanchez, and Gian Paolo Rossi

Expression and Functional Role of Urotensin-II and Its Receptor in the Adrenal Cortex and Medulla: Novel Insights for the Pathophysiology of Primary Aldosteronism
J Clin Endocrinol Metab 2009 94: 684-690 , doi:10.1210/jc.2008-1131 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Urotensin II is implicated in the interactions between the adrenal medulla and cortex and in the patho-physiology of pheochromocytoma presenting as aldosteronism.

Brya G. Matthews, Dorit Naot, Usha Bava, Karen E. Callon, Rocco P. Pitto, Stuart A. McCowan, Diana Wattie, Tim Cundy, Jill Cornish, and Ian R. Reid

BRIEF REPORT:Absence of Somatic SQSTM1 Mutations in Paget’s Disease of Bone
J Clin Endocrinol Metab 2009 94: 691-694 , doi:10.1210/jc.2008-1140 [Abstract] [Full Text] [PDF]  
Analysis of the SQSTM1 gene sequence in bone cells derived from lesions of 23 patients with Paget’s disease shows no evidence of somatic mutations in this gene.

Angela Dardano, Simonetta Falzoni, Nadia Caraccio, Antonio Polini, Sara Tognini, Anna Solini, Piero Berti, Francesco Di Virgilio, and Fabio Monzani

BRIEF REPORT:1513A>C Polymorphism in the P2X₇ Receptor Gene in Patients with Papillary Thyroid Cancer: Correlation with Histological Variants and Clinical Parameters
J Clin Endocrinol Metab 2009 94: 695-698 , doi:10.1210/jc.2008-1322 [Abstract] [Full Text] [PDF]  
A strong association is seen between 1513A>C polymorphism of P2X₇R gene and the follicular variant of papillary thyroid carcinoma.

Translational Highlights from Endocrinology:

Leslie M. Jackson, Kathleen M. Timmer, and and Douglas L. Foster

Abstracts:Organizational Actions of Postnatal Estradiol in Female Sheep Treated Prenatally with Testosterone: Programming of Prepubertal Neuroendocrine Function and the Onset of Puberty
J Clin Endocrinol Metab 2009 94: 699 [Full Text] [PDF]  

Michelle T Foster, James P Warne, Abigail B Ginsberg, Hart F Horneman, Norman C Pecoraro, Susan F Akana, and Mary F Dallman

Abstracts:Palatable Foods, Stress, and Energy Stores Sculpt Corticotropin-Releasing Factor, Adrenocorticotropin, and Corticosterone Concentrations after Restraint
J Clin Endocrinol Metab 2009 94: 699-a [Full Text] [PDF]  

Magnus Johansson, Johan Olerud, Leif Jansson, and Per-Ola Carlsson

Abstracts:Prolactin Treatment Improves Engraftment and Function of Transplanted Pancreatic Islets
J Clin Endocrinol Metab 2009 94: 700 [Full Text] [PDF]  

Sudipan Karmakar, Estrella A. Foster, and Carolyn L. Smith

Abstracts:Unique Roles of p160 Coactivators for Regulation of Breast Cancer Cell Proliferation and Estrogen Receptor- Transcriptional Activity
J Clin Endocrinol Metab 2009 94: 700-a [Full Text] [PDF]  

Bryan J. Peano, Judy S. Crabtree, Barry S. Komm, Richard C. Winneker, and Heather A. Harris

Abstracts:Effects of Various SERMs with or without Conjugated Estrogens on Mouse Mammary Gland
J Clin Endocrinol Metab 2009 94: 700-b-701 [Full Text] [PDF]  

Translational Highlights from Molecular Endocrinology:

Mayoura Keophiphath, Vincent Achard, Corneliu Henegar, Christine Rouault, Karine Clément, and Danièle Lacasa

Abstracts:Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes
J Clin Endocrinol Metab 2009 94: 702 [Full Text] [PDF]  

Tatyana A. Souza, Xuan Chen, Yongjing Guo, Parid Sava, Jimin Zhang, Jennifer J. Hill, Paul J. Yaworsky, and Yongchang Qiu

Abstracts:Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators
J Clin Endocrinol Metab 2009 94: 702-a [Full Text] [PDF]  

Laura A. Crawford, Michelle A. Guney, Young Ah Oh, R. Andrea DeYoung, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Karen M. Lyons, David R. Brigstock, Aris Economides, and Maureen Gannon

Abstracts:Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and Cell Proliferation During Embryogenesis
J Clin Endocrinol Metab 2009 94: 703 [Full Text] [PDF]  

Suzanne E. Wardell, Olga R. Ilkayeva, Heather L. Wieman, Daniel E. Frigo, Jeffrey C. Rathmell, Christopher B. Newgard, and Donald P. McDonnell

Abstracts:Glucose Metabolism as a Target of Histone Deacetylase Inhibitors
J Clin Endocrinol Metab 2009 94: 703-a [Full Text] [PDF]  

Anat Ben-Shlomo, Cuiqi Zhou, Oxana Pichurin, Vera Chesnokova, Ning-Ai Liu, Michael D Culler, and Shlomo Melmed

Abstracts:Constitutive Somatostatin Receptor Activity Determines Tonic Pituitary Cell Response
J Clin Endocrinol Metab 2009 94: 703-b [Full Text] [PDF]  

Announcements and Resources:

Erratum
J Clin Endocrinol Metab 2009 94: 704 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Michael Draper, Steven T. Harris, Benjamin Leder, and Dolores Shoback

Patient Information Page from The Hormone Foundation:Vitamin D, Calcium, and Bone Health
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Michael Draper, Steven T. Harris, Benjamin Leder, and Dolores Shoback

Patient Information Page from The Hormone Foundation:La vitamina D, el calcio y la salud de los huesos
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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