The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

Special Features:

Michael Stowasser

UPDATE:Update in Primary Aldosteronism
J Clin Endocrinol Metab 2009 94: 3623-3630 , doi:10.1210/jc.2009-1399 [Abstract] [Full Text] [PDF]  
New data support case detection of primary aldosteronism for specific treatment and prevention of aldosterone-associated cardiovascular morbidity.

Rossella Libé, Frédérique Tissier, Marie Bienvenu, Lionel Groussin, Sylvie Joannidis, Chantal Hignette, Bertrand Dousset, Paul Legmann, Marc Faraggi, Bruno Richard, Xavier Bertagna, and Florence Tenenbaum

IMAGE IN ENDOCRINOLOGY:Adrenocortical Tumor with Two Distinct Elements Revealed by Combined ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography and ¹³¹I Nor-Cholesterol Scintigraphy
J Clin Endocrinol Metab 2009 94: 3631-3632 doi:10.1210/jc.2009-1025 [Full Text] [PDF]  

Tulay Guran, Gwen Tolhurst, Abdullah Bereket, Nuno Rocha, Keith Porter, Serap Turan, Fiona M. Gribble, L. Damla Kotan, Teoman Akcay, Zeynep Atay, Husniye Canan, Ayse Serin, Stephen O'Rahilly, Frank Reimann, Robert K. Semple, and A. Kemal Topaloglu

CLINICAL CASE SEMINAR:Hypogonadotropic Hypogonadism due to a Novel Missense Mutation in the First Extracellular Loop of the Neurokinin B Receptor
J Clin Endocrinol Metab 2009 94: 3633-3639 , doi:10.1210/jc.2009-0551 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Congenital gonadotropin-releasing hormone deficiency (idiopathic hypogonadotropic hypogonadism)]
Hypogonadism due to a novel TACR3 mutation.

Paul J. Newey, Jeshmi Jeyabalan, Gerard V. Walls, Paul T. Christie, Fergus V. Gleeson, Steve Gould, Paul R. V. Johnson, Rachel R. Phillips, Fiona J. Ryan, Brian Shine, Michael R. Bowl, and Rajesh V. Thakker

CLINICAL CASE SEMINAR:Asymptomatic Children with Multiple Endocrine Neoplasia Type 1 Mutations May Harbor Nonfunctioning Pancreatic Neuroendocrine Tumors
J Clin Endocrinol Metab 2009 94: 3640-3646 , doi:10.1210/jc.2009-0564 [Abstract] [Full Text] [PDF]  
Pancreatic triglyceride content as measured by Magnetic Resonance Spectroscopy in humans is elevated prior to development of type 2 diabetes, early in the natural history of the disease.

Hershel Raff

CLINICAL REVIEW:Utility of Salivary Cortisol Measurements in Cushing’s Syndrome and Adrenal Insufficiency
J Clin Endocrinol Metab 2009 94: 3647-3655 , doi:10.1210/jc.2009-1166 [Abstract] [Full Text] [PDF]  
Late-night salivary cortisol is an excellent measurement for diagnosis of Cushing’s syndrome, and follow-up of patients after surgical treatment of Cushing’s disease.

J. Aidan Carney

REVIEW:Carney Triad: A Syndrome Featuring Paraganglionic, Adrenocortical, and Possibly Other Endocrine Tumors
J Clin Endocrinol Metab 2009 94: 3656-3662 , doi:10.1210/jc.2009-1156 [Abstract] [Full Text] [PDF]  
Carney triad is a rare non-familial multitumoral syndrome that features multifocal gastric, pulmonary, and endocrine tumors (paraganglioma and adrenal adenoma), and affects mainly young women.

Elaine M. Kaptein, Elizabeth Beale, and Linda S. Chan

REVIEW:Thyroid Hormone Therapy for Obesity and Nonthyroidal Illnesses: A Systematic Review
J Clin Endocrinol Metab 2009 94: 3663-3675 , doi:10.1210/jc.2009-0899 [Abstract] [Full Text] [PDF]  
Available data are inconclusive regarding effectiveness of thyroid hormone therapy in treating obesity or non-thyroidal illnesses, whereas it is clear that such therapy induces subclinical hyperthyroidism.

Aziz A. Alkatib, Mihaela Cosma, Mohamed B. Elamin, Dana Erickson, Brian A. Swiglo, Patricia J. Erwin, and Victor M. Montori

REVIEW:A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials of DHEA Treatment Effects on Quality of Life in Women with Adrenal Insufficiency
J Clin Endocrinol Metab 2009 94: 3676-3681 , doi:10.1210/jc.2009-0672 [Abstract] [Full Text] [PDF]  
Data from randomized placebo-controlled trials show that DHEA may improve, in a small and perhaps trivial manner, the quality of life in women with adrenal insufficiency.

Editorials:

Francis de Zegher and Lourdes Ibáñez

EDITORIAL:Early Origins of Polycystic Ovary Syndrome: Hypotheses May Change without Notice
J Clin Endocrinol Metab 2009 94: 3682-3685 doi:10.1210/jc.2009-1608 [Full Text] [PDF]  

Endocrine Care:

Kristen J. Nadeau, Phillip S. Zeitler, Timothy A. Bauer, Mark S. Brown, Jennifer L. Dorosz, Boris Draznin, Jane E. B. Reusch, and Judith G. Regensteiner

Insulin Resistance in Adolescents with Type 2 Diabetes Is Associated with Impaired Exercise Capacity
J Clin Endocrinol Metab 2009 94: 3687-3695 , doi:10.1210/jc.2008-2844 [Abstract] [Full Text] [PDF]  
Adolescents with type 2 diabetes have abnormal exercise function, vascular reactivity, and increased left ventricular mass.

Lourdes Ibáñez, Abel Lopez-Bermejo, Marta Díaz, Larisa Suárez, and Francis de Zegher

Low-Birth Weight Children Develop Lower Sex Hormone Binding Globulin and Higher Dehydroepiandrosterone Sulfate Levels and Aggravate their Visceral Adiposity and Hypoadiponectinemia between Six and Eight Years of Age
J Clin Endocrinol Metab 2009 94: 3696-3699 , doi:10.1210/jc.2009-0789 [Abstract] [Full Text] [PDF]  
Small-for-gestational-age children with spontaneous catch-up growth develop high dehydroepiandrosterone sulfate and low sex hormone binding globulin levels, and become high-molecular-weight hypoadiponectinemic and viscerally adipose between 6 and 8 years of age.

Frank Träisk, Leif Tallstedt, Mirna Abraham-Nordling, Tommy Andersson, Gertrud Berg, Jan Calissendorff, Bengt Hallengren, Pavo Hedner, Mikael Lantz, Ernst Nyström, Vesna Ponjavic, Adam Taube, Ove Törring, Göran Wallin, Peter Åsman, Göran Lundell the Thyroid Study Group of TT 96

Thyroid-Associated Ophthalmopathy after Treatment for Graves’ Hyperthyroidism with Antithyroid Drugs or Iodine-131
J Clin Endocrinol Metab 2009 94: 3700-3707 , doi:10.1210/jc.2009-0747 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Treatment of Graves'ophthalmopathy (orbitopathy)]
Radioiodine treatment for Graves’ hyperthyroidism (when compared to anti-thyroid drug treatment),and smoking increase the risk for the development of thyroid associated ophthalmopathy.

Kathryn Beardsall, Ken K. Ong, Nuala Murphy, M. Lynn Ahmed, Jing Hua Zhao, Maarten W. Peeters, and David B. Dunger

Heritability of Childhood Weight Gain from Birth and Risk Markers for Adult Metabolic Disease in Prepubertal Twins
J Clin Endocrinol Metab 2009 94: 3708-3713 , doi:10.1210/jc.2009-0757 [Abstract] [Full Text] [PDF]  
Postnatal weight gain is highly heritable and associated with markers of adult metabolic disease risk.

M. Hickey, D. M. Sloboda, H. C. Atkinson, D. A. Doherty, S. Franks, R. J. Norman, J. P. Newnham, and R. Hart

The Relationship between Maternal and Umbilical Cord Androgen Levels and Polycystic Ovary Syndrome in Adolescence: A Prospective Cohort Study
J Clin Endocrinol Metab 2009 94: 3714-3720 , doi:10.1210/jc.2009-0544 [Abstract] [Full Text] [PDF]  
This large prospective study of maternal and umbilical cord androgen levels failed to demonstrate a relationship between early life androgen exposure and PCOS in adolescence.

M. J. E. Wassenaar, O. M. Dekkers, A. M. Pereira, J. M. Wit, J. W. Smit, N. R. Biermasz, and J. A. Romijn

Impact of the Exon 3-Deleted Growth Hormone (GH) Receptor Polymorphism on Baseline Height and the Growth Response to Recombinant Human GH Therapy in GH-Deficient (GHD) and Non-GHD Children with Short Stature: A Systematic Review and Meta-Analysis
J Clin Endocrinol Metab 2009 94: 3721-3730 , doi:10.1210/jc.2009-0425 [Abstract] [Full Text] [PDF]  
GHRd3 stimulates growth velocity by an additional effect of 0.5 cm during the first year of rhGH treatment.

Virginie Ribault, Mireille Castanet, Anne-Marie Bertrand, Jean Guibourdenche, Edith Vuillard, Dominique Luton, Michel Polak the French Fetal Goiter Study Group

Experience with Intraamniotic Thyroxine Treatment in Nonimmune Fetal Goitrous Hypothyroidism in 12 Cases
J Clin Endocrinol Metab 2009 94: 3731-3739 , doi:10.1210/jc.2008-2681 [Abstract] [Full Text] [PDF]  
Retrospective study of 12 cases shows the feasibility and safety for L-T4 intra-amniotic injections to treat non-immune fetal goitrous hypothyroidism, which led to goiter size reduction in the majority of cases.

Amy S. Shah, Lawrence M. Dolan, Thomas R. Kimball, Zhiqian Gao, Philip R. Khoury, Stephen R. Daniels, and Elaine M. Urbina

Influence of Duration of Diabetes, Glycemic Control, and Traditional Cardiovascular Risk Factors on Early Atherosclerotic Vascular Changes in Adolescents and Young Adults with Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 2009 94: 3740-3745 , doi:10.1210/jc.2008-2039 [Abstract] [Full Text] [PDF]  
Poor glucose control, longer duration of diabetes, and traditional cardiovascular risk factors are associated with increased carotid intimal wall thickness in adolescents with type 2 diabetes mellitus.

Annamaria Colao, Renata S. Auriemma, Mariano Galdiero, Gaetano Lombardi, and Rosario Pivonello

Effects of Initial Therapy for Five Years with Somatostatin Analogs for Acromegaly on Growth Hormone and Insulin-Like Growth Factor-I Levels, Tumor Shrinkage, and Cardiovascular Disease: A Prospective Study
J Clin Endocrinol Metab 2009 94: 3746-3756 , doi:10.1210/jc.2009-0941 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A significant decrease in prevalence of hypertension, arrhythmias, left ventricular hypertrophy, diastolic and systolic dysfunction, and hypertriglyceridemia was found in 45 patients with acromegaly treated exclusively with depot somatostatin analogues for 5 years.

Fausto Bogazzi, Luca Tomisti, Giuseppe Rossi, Enrica Dell'Unto, Pasquale Pepe, Luigi Bartalena, and Enio Martino

Glucocorticoids Are Preferable to Thionamides as First-Line Treatment for Amiodarone-Induced Thyrotoxicosis due to Destructive Thyroiditis: A Matched Retrospective Cohort Study
J Clin Endocrinol Metab 2009 94: 3757-3762 , doi:10.1210/jc.2009-0940 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Amiodarone and thyroid dysfunction]
Glucocorticoids are the first-line treatment in type 2 amiodarone-induced thyrotoxicosis while thionamides play no role in this destructive thyroiditis.

Roderick F. A. de Lind van Wijngaarden, Dederieke A. M. Festen, Barto J. Otten, Edgar G. A. H. van Mil, Joost Rotteveel, Roelof J. Odink, Mariëtte van Leeuwen, Danny A. J. P. Haring, Gianni Bocca, E. C. A. Mieke Houdijk, and Anita C. S. Hokken-Koelega

Bone Mineral Density and Effects of Growth Hormone Treatment in Prepubertal Children with Prader-Willi Syndrome: A Randomized Controlled Trial
J Clin Endocrinol Metab 2009 94: 3763-3771 , doi:10.1210/jc.2009-0270 [Abstract] [Full Text] [PDF]  
Prepubertal children with Prader-Willi syndrome have a normal bone mineral density; GH treatment has no effect on bone mineral density after 24 months of study compared to randomized controls.

Felicia Cosman, Robert A. Wermers, Christopher Recknor, Karen F. Mauck, Li Xie, Emmett V. Glass, and John H. Krege

Effects of Teriparatide in Postmenopausal Women with Osteoporosis on Prior Alendronate or Raloxifene: Differences between Stopping and Continuing the Antiresorptive Agent
J Clin Endocrinol Metab 2009 94: 3772-3780 , doi:10.1210/jc.2008-2719 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Parathyroid hormone therapy for osteoporosis]
In patients treated with alendronate or raloxifene, adding teriparatide results in a greater bone mineral density response, and appears to be at least as safe as switching to teriparatide.

Fernando Gerchman, Jenny Tong, Kristina M. Utzschneider, Sakeneh Zraika, Jayalakshmi Udayasankar, Marguerite J. McNeely, Darcy B. Carr, Donna L. Leonetti, Bessie A. Young, Ian H. de Boer, Edward J. Boyko, Wilfred Y. Fujimoto, and Steven E. Kahn

Body Mass Index Is Associated with Increased Creatinine Clearance by a Mechanism Independent of Body Fat Distribution
J Clin Endocrinol Metab 2009 94: 3781-3788 , doi:10.1210/jc.2008-2508 [Abstract] [Full Text] [PDF]  
Body mass index, rather than body fat distribution, is an independent determinant of creatinine clearance, suggesting a role for lean rather than fat mass on this relationship.

Neuman Correia, Sinead Mullally, Gillian Cooke, Tommy Kyaw Tun, Niamh Phelan, Joanne Feeney, Maria Fitzgibbon, Gerard Boran, Shane O'Mara, and James Gibney

Evidence for a Specific Defect in Hippocampal Memory in Overt and Subclinical Hypothyroidism
J Clin Endocrinol Metab 2009 94: 3789-3797 , doi:10.1210/jc.2008-2702 [Abstract] [Full Text] [PDF]  
Memory deficits in subclinical and overt hypothyroidism are indicative of an underlying hippocampal deficit, although the exact underlying neuronal deficits will require further elucidation.

C. M. Weaver, B. R. Martin, G. S. Jackson, G. P. McCabe, J. R. Nolan, L. D. McCabe, S. Barnes, S. Reinwald, M. E. Boris, and M. Peacock

Antiresorptive Effects of Phytoestrogen Supplements Compared with Estradiol or Risedronate in Postmenopausal Women Using ⁴¹Ca Methodology
J Clin Endocrinol Metab 2009 94: 3798-3805 , doi:10.1210/jc.2009-0332 [Abstract] [Full Text] [PDF]  
Commercial phytoestogen supplement preparations have modest ability to reduce bone resorption in postmenopausal women compared to traditional therapies.

Peggy M. Cawthon, Kristine E. Ensrud, Gail A. Laughlin, Jane A. Cauley, Thuy-Tien L. Dam, Elizabeth Barrett-Connor, Howard A. Fink, Andrew R. Hoffman, Edith Lau, Nancy E. Lane, Marcia L. Stefanick, Steven R. Cummings, Eric S. Orwoll for the Osteoporotic Fractures in Men (MrOS) Research Group

Sex Hormones and Frailty in Older Men: The Osteoporotic Fractures in Men (MrOS) Study
J Clin Endocrinol Metab 2009 94: 3806-3815 , doi:10.1210/jc.2009-0417 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Low levels of bioavailable testosterone are associated with worse frailty status in older men. Neither total testosterone nor estradiol is related to frailty status.

Antonio La Marca, Stefania Marzotti, Annalisa Brozzetti, Gaspare Stabile, Alfredo Carducci Artenisio, Vittorio Bini, Roberta Giordano, Annamaria De Bellis, Annibale Volpe, Alberto Falorni on behalf of the Italian Addison Network

Primary Ovarian Insufficiency due to Steroidogenic Cell Autoimmunity Is Associated with a Preserved Pool of Functioning Follicles
J Clin Endocrinol Metab 2009 94: 3816-3823 , doi:10.1210/jc.2009-0817 [Abstract] [Full Text] [PDF]  
Most women with autoimmune primary ovarian insufficiency (positive for 21-hydroxylase autoantibodies) have normal serum concentrations of anti-müllerian hormone, and a preserved pool of functioning follicles.

Anthony J. G. Hanley, Ravi Retnakaran, Ying Qi, Hertzel C. Gerstein, Bruce Perkins, Janet Raboud, Stewart B. Harris, and Bernard Zinman

Association of Hematological Parameters with Insulin Resistance and β-Cell Dysfunction in Nondiabetic Subjects
J Clin Endocrinol Metab 2009 94: 3824-3832 , doi:10.1210/jc.2009-0719 [Abstract] [Full Text] [PDF]  
In a large sample of non-diabetic subjects with metabolic risk factors, hematological parameters were significantly associated with insulin sensitivity and β-cell dysfunction, the main physiological disorders underlying type 2 diabetes.

Thomas Münzer, S. Mitchell Harman, John D. Sorkin, and Marc R. Blackman

Growth Hormone and Sex Steroid Effects on Serum Glucose, Insulin, and Lipid Concentrations in Healthy Older Women and Men
J Clin Endocrinol Metab 2009 94: 3833-3841 , doi:10.1210/jc.2009-1275 [Abstract] [Full Text] [PDF]  
Chronic GH administration to healthy older individuals increases insulin resistance with moderately beneficial effects on lipids.

Andrea J. Cussons, Gerald F. Watts, Trevor A. Mori, and Bronwyn G. A. Stuckey

Omega-3 Fatty Acid Supplementation Decreases Liver Fat Content in Polycystic Ovary Syndrome: A Randomized Controlled Trial Employing Proton Magnetic Resonance Spectroscopy
J Clin Endocrinol Metab 2009 94: 3842-3848 , doi:10.1210/jc.2009-0870 [Abstract] [Full Text] [PDF]  
Omega-3 fatty acid supplementation has a beneficial effect on liver fat content and other cardiovascular risk factors in women with PCOS.

M. D. Walker, J. Fleischer, T. Rundek, D. J. McMahon, S. Homma, R. Sacco, and S. J. Silverberg

Carotid Vascular Abnormalities in Primary Hyperparathyroidism
J Clin Endocrinol Metab 2009 94: 3849-3856 , doi:10.1210/jc.2009-1086 [Abstract] [Full Text] [PDF]  
In mild primary hyperparathyroidism, carotid intima-media thickness—a subclinical marker of cardiovascular disease—is increased and PTH level is an independent predictor of carotid vascular compliance.

Smita K. Baid, Domenica Rubino, Ninet Sinaii, Sheila Ramsey, Arthur Frank, and Lynnette K. Nieman

Specificity of Screening Tests for Cushing’s Syndrome in an Overweight and Obese Population
J Clin Endocrinol Metab 2009 94: 3857-3864 , doi:10.1210/jc.2008-2766 [Abstract] [Full Text] [PDF]  
Data from this study does not support widespread screening of overweight and obese subjects for Cushing’s syndrome.

Louise A. Metherell, Danielle Naville, George Halaby, Martine Begeot, Angela Huebner, Gudrun Nürnberg, Peter Nürnberg, Jane Green, Jeremy W. Tomlinson, Nils P. Krone, Lin Lin, Michael Racine, Dan M. Berney, John C. Achermann, Wiebke Arlt, and Adrian J. L. Clark

Nonclassic Lipoid Congenital Adrenal Hyperplasia Masquerading as Familial Glucocorticoid Deficiency
J Clin Endocrinol Metab 2009 94: 3865-3871 , doi:10.1210/jc.2009-0467 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Partial loss-of-function mutations in StAR can present with glucocorticoid deficiency alone; genetic diagnosis in familial glucocorticoid deficiency is therefore important for correct replacement therapy and genetic counseling.

Christian Denzer, Dorothee Thiere, Rainer Muche, Wolfgang Koenig, Hermann Mayer, Wolfgang Kratzer, and Martin Wabitsch

Gender-Specific Prevalences of Fatty Liver in Obese Children and Adolescents: Roles of Body Fat Distribution, Sex Steroids, and Insulin Resistance
J Clin Endocrinol Metab 2009 94: 3872-3881 , doi:10.1210/jc.2009-1125 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Non-alcoholic fatty liver disease in obese children shows significant associations with visceral obesity and insulin resistance, and gender-specific associations with parameters of body fat distribution and sex steroids.

Walter Bonfig, Susanne Bechtold Dalla Pozza, Heinrich Schmidt, Philipp Pagel, Dietrich Knorr, and Hans Peter Schwarz

Hydrocortisone Dosing during Puberty in Patients with Classical Congenital Adrenal Hyperplasia: An Evidence-Based Recommendation
J Clin Endocrinol Metab 2009 94: 3882-3888 , doi:10.1210/jc.2009-0942 [Abstract] [Full Text] [PDF]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Treatment of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency in infants and children]
To optimize the final height outcome in patients with classical adrenal hyperplasia, the hydrocortisone dose during puberty should not exceed 17 mg/m².

Nuria Sucunza, M. José Barahona, Eugenia Resmini, Jose-Manuel Fernández-Real, Wifredo Ricart, Jordi Farrerons, José Rodríguez Espinosa, Ana-María Marin, Teresa Puig, and Susan M. Webb

A Link between Bone Mineral Density and Serum Adiponectin and Visfatin Levels in Acromegaly
J Clin Endocrinol Metab 2009 94: 3889-3896 , doi:10.1210/jc.2009-0474 [Abstract] [Full Text] [PDF]  
Bone mineral density is correlated negatively with, and is a predictor for, adiponectin and visfatin in patients with acromegaly.

Katherine U. Gaynor, Irina V. Grigorieva, M. Andrew Nesbit, Treena Cranston, Thushari Gomes, Ludwig Gortner, and Rajesh V. Thakker

A Missense GATA3 Mutation, Thr272Ile, Causes the Hypoparathyroidism, Deafness, and Renal Dysplasia Syndrome
J Clin Endocrinol Metab 2009 94: 3897-3904 , doi:10.1210/jc.2009-0717 [Abstract] [Full Text] [PDF]  
Hypoparathyroidism, Deafness, and Renal Dysplasia syndrome can result from the missense mutation Thr272Il3 in the transcription factor GATA3, which results in reduced DNA binding, partial loss of interaction with the protein cofactor FOG2, and a decrease in transcriptional activity.

Thien-Giang Bach-Huynh, Bindu Nayak, Jennifer Loh, Steven Soldin, and Jacqueline Jonklaas

Timing of Levothyroxine Administration Affects Serum Thyrotropin Concentration
J Clin Endocrinol Metab 2009 94: 3905-3912 , doi:10.1210/jc.2009-0860 [Abstract] [Full Text] [PDF] [Supplemental Data]  

        A general review of the topic discussed in this article is available through UpToDate in Endocrinology.

[Treatment of hypothyroidism]
The timing of levothyroxine administration has a significant effect on the serum thyrotropin concentration.

Irène Netchine, Salah Azzi, Muriel Houang, Danielle Seurin, Laurence Perin, Jean-Marc Ricort, Claudine Daubas, Christine Legay, Jan Mester, Robert Herich, François Godeau, and Yves Le Bouc

Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated with IGF1 Mutation Demonstrates Its Critical Role in Growth and Brain Development
J Clin Endocrinol Metab 2009 94: 3913-3921 , doi:10.1210/jc.2009-0452 [Abstract] [Full Text] [PDF] [Supplemental Data]  
IGF-I mild deficiency due to a novel homozygous mutation demonstrates that the integrity of IGF-I binding to its receptor is crucial for growth and brain development.

Helle-Brit Fiebrich, Adrienne H. Brouwers, Michiel N. Kerstens, Milan E. J. Pijl, Ido P. Kema, Johan R. de Jong, Pieter L. Jager, Philip H. Elsinga, Rudi A. J. O. Dierckx, Jacqueline E. van der Wal, Wim J. Sluiter, Elisabeth G. E. de Vries, and Thera P. Links

6-[F-18]Fluoro-L-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to Conventional Imaging with ¹²³I-Metaiodobenzylguanidine Scintigraphy, Computer Tomography, and Magnetic Resonance Imaging in Localizing Tumors Causing Catecholamine Excess
J Clin Endocrinol Metab 2009 94: 3922-3930 , doi:10.1210/jc.2009-1054 [Abstract] [Full Text] [PDF]  
18F-DOPA PET is superior to conventional imaging with 12316 I-MIBG scintigraphy and CT/MRI in localizing tumors causing catecholamine excess.

Maria Chiara Zatelli, Mariella Minoia, Daniela Molè, Valentina Cason, Federico Tagliati, Angelo Margutti, Marta Bondanelli, Maria Rosaria Ambrosio, and Ettore degli Uberti

Growth Hormone Excess Promotes Breast Cancer Chemoresistance
J Clin Endocrinol Metab 2009 94: 3931-3938 , doi:10.1210/jc.2009-1026 [Abstract] [Full Text] [PDF]  
Growth hormone (GH) can directly induce chemoresistance, likely involving GH-induced early gene transcription. GH excess can hamper breast cancer treatment, possibly resulting in an increased mortality.

Michela Godi, Simona Mellone, Antonella Petri, Teresa Arrigo, Claudio Bardelli, Lucia Corrado, Simonetta Bellone, Flavia Prodam, Patricia Momigliano-Richiardi, Gianni Bona, and Mara Giordano

A Recurrent Signal Peptide Mutation in the Growth Hormone Releasing Hormone Receptor with Defective Translocation to the Cell Surface and Isolated Growth Hormone Deficiency
J Clin Endocrinol Metab 2009 94: 3939-3947 , doi:10.1210/jc.2009-0833 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A heterozygous Val10Gly mutation in growth hormone releasing hormone receptor signal peptide causes a novel form of isolated growth hormone deficiency.

Markus Luster, Daria Handkiewicz-Junak, Armando Grossi, Margaret Zacharin, David Taïeb, Ofelia Cruz, Anne Hitzel, Juan Antonio Vallejo Casas, Uwe Mäder, Massimo E. Dottorini for the Pediatric rhTSH Investigators Group

BRIEF REPORT:Recombinant Thyrotropin Use in Children and Adolescents with Differentiated Thyroid Cancer: A Multicenter Retrospective Study
J Clin Endocrinol Metab 2009 94: 3948-3953 , doi:10.1210/jc.2009-0593 [Abstract] [Full Text] [PDF]  
A 100-patient multicenter, multinational retrospective study confirms that recombinant human thyroid-stimulating hormone is safe, well-tolerated, and almost always achieves sufficient TSH elevation in children and adolescents with differentiated thyroid carcinoma.

S. Kleinle, R. Lang, G. F. Fischer, H. Vierhapper, F. Waldhauser, M. Födinger, and S. M. Baumgartner-Parzer

BRIEF REPORT:Duplications of the Functional CYP21A2 Gene Are Primarily Restricted to Q318X Alleles: Evidence for a Founder Effect
J Clin Endocrinol Metab 2009 94: 3954-3958 , doi:10.1210/jc.2009-0487 [Abstract] [Full Text] [PDF]  
To avoid false positive genotyping, it is of utmost importance to be aware of the high frequency of duplicated CYP21A2-genes in association with Q318X-aberrations.

Kyriaki S. Alatzoglou, Peter C. Hindmarsh, Caroline Brain, John Torpiano, and Mehul T. Dattani

BRIEF REPORT:Acanthosis Nigricans and Insulin Sensitivity in Patients with Achondroplasia and Hypochodroplasia due to FGFR3 Mutations
J Clin Endocrinol Metab 2009 94: 3959-3963 , doi:10.1210/jc.2009-0322 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The development of acanthosis nigricans in patients with achondroplasia/hypochondroplasia is not due to reduced insulin sensitivity.

Ferdinand Roelfsema, Alberto M. Pereira, Johannes D. Veldhuis, Ria Adriaanse, Erik Endert, Eric Fliers, and Johannes A. Romijn

BRIEF REPORT:Thyrotropin Secretion Profiles Are Not Different in Men and Women
J Clin Endocrinol Metab 2009 94: 3964-3967 , doi:10.1210/jc.2009-1155 [Abstract] [Full Text] [PDF]  
The 24-hour thyrotropin secretion rate is similar in men and women, and depends on age only in women.

Endocrine Research:

Murielle Bochud, Fabienne Marquant, Pedro-Manuel Marques-Vidal, Peter Vollenweider, Jacques S. Beckmann, Vincent Mooser, Fred Paccaud, and Valentin Rousson

Association between C-Reactive Protein and Adiposity in Women
J Clin Endocrinol Metab 2009 94: 3969-3977 , doi:10.1210/jc.2008-2428 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Results in this study suggest that C-reactive protein is causally related to body mass index in women, and that this is mainly due to fat mass.

Peter Y. Liu, Paul Y. Takahashi, Pamela D. Roebuck, Joy N. Bailey, Daniel M. Keenan, and Johannes D. Veldhuis

Testosterone’s Short-Term Positive Effect on Luteinizing-Hormone Secretory-Burst Mass and Its Negative Effect on Secretory-Burst Frequency Are Attenuated in Middle-Aged Men
J Clin Endocrinol Metab 2009 94: 3978-3986 , doi:10.1210/jc.2009-0135 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Aging attenuates the positive action of testosterone on the mass of LH secreted per burst, and also diminishes the negative-feedback effect of testosterone on LH secretory-burst frequency; specialized models are required to ascertain such complex changes.

Atsuhito Saiki, Maja Olsson, Margareta Jernås, Anders Gummesson, Philip G. McTernan, Johanna Andersson, Peter Jacobson, Kajsa Sjöholm, Bob Olsson, Shigeo Yamamura, Andrew Walley, Philippe Froguel, Björn Carlsson, Lars Sjöström, Per-Arne Svensson, and Lena M. S. Carlsson

Tenomodulin Is Highly Expressed in Adipose Tissue, Increased in Obesity, and Down-Regulated during Diet-Induced Weight Loss
J Clin Endocrinol Metab 2009 94: 3987-3994 , doi:10.1210/jc.2009-0292 [Abstract] [Full Text] [PDF]  
Adipose tissue tenomodulin (TNMD) expression is highly affected by obesity, adipose tissue location and weight loss, indicating that TNMD plays a role in adipose tissue function.

Miriam A. Bredella, Martin Torriani, Bijoy J. Thomas, Reza Hosseini Ghomi, Danielle J. Brick, Anu V. Gerweck, and Karen K. Miller

Peak Growth Hormone-Releasing Hormone-Arginine-Stimulated Growth Hormone Is Inversely Associated with Intramyocellular and Intrahepatic Lipid Content in Premenopausal Women with Obesity
J Clin Endocrinol Metab 2009 94: 3995-4002 , doi:10.1210/jc.2009-0438 [Abstract] [Full Text] [PDF]  
Peak growth hormone after GHRH-arginine stimulation is inversely associated with intramyocellular and intrahepatic lipids in premenopausal women with obesity.

Caterina Di Cosmo, Neil McLellan, Xiao-Hui Liao, Kum Kum Khanna, Roy E. Weiss, Laura Papp, and Samuel Refetoff

Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X)
J Clin Endocrinol Metab 2009 94: 4003-4009 , doi:10.1210/jc.2009-0686 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The mild phenotype associated with a novel SBP2 gene mutation that produces an early stop codon is due to the synthesis of SBP2 isoforms from downstream ATGs that contain all of the protein’s functional domains.

L. Frederiksen, T. L. Nielsen, K. Wraae, C. Hagen, J. Frystyk, A. Flyvbjerg, K. Brixen, and M. Andersen

Subcutaneous Rather than Visceral Adipose Tissue Is Associated with Adiponectin Levels and Insulin Resistance in Young Men
J Clin Endocrinol Metab 2009 94: 4010-4015 , doi:10.1210/jc.2009-0980 [Abstract] [Full Text] [PDF]  
Subcutaneous adipose tissue, rather than visceral adipose tissue, is inversely associated with adiponectin; however, fat on the lower extremities is positively associated with adiponectin.

Claudia Giachini, Francesca Nuti, Daniel J. Turner, Ilaria Laface, Yali Xue, Fabrice Daguin, Gianni Forti, Chris Tyler-Smith, and Csilla Krausz

TSPY1 Copy Number Variation Influences Spermatogenesis and Shows Differences among Y Lineages
J Clin Endocrinol Metab 2009 94: 4016-4022 , doi:10.1210/jc.2009-1029 [Abstract] [Full Text] [PDF]  
Low TSPY1 copy number reduces the efficiency of spermatogenesis and represents a potential new genetic risk factor for male infertility.

Ozlem Tarcin, Dilek Gogas Yavuz, Beste Ozben, Ahu Telli, Ayliz Velioglu Ogunc, Meral Yuksel, Ahmet Toprak, Dilek Yazici, Seda Sancak, Oguzhan Deyneli, and Sema Akalin

Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects
J Clin Endocrinol Metab 2009 94: 4023-4030 , doi:10.1210/jc.2008-1212 [Abstract] [Full Text] [PDF]  
Endothelial dysfunction by flow mediated dilatation (FMD) in asymptomatic vitamin D deficient subjects improves significantly after vitamin D replacement.

Malene Boas, Laszlo Hegedüs, Ulla Feldt-Rasmussen, Niels E. Skakkebæk, Linda Hilsted, and Katharina M. Main

Association of Thyroid Gland Volume, Serum Insulin-Like Growth Factor-I, and Anthropometric Variables in Euthyroid Prepubertal Children
J Clin Endocrinol Metab 2009 94: 4031-4035 , doi:10.1210/jc.2009-0939 [Abstract] [Full Text] [PDF]  
In prepubertal children, IGF-I and anthropometric variables are positively associated with thyroid gland volume.

J. M. Moreno-Navarrete, F. J. Ortega, J. Bassols, W. Ricart, and J. M. Fernández-Real

Decreased Circulating Lactoferrin in Insulin Resistance and Altered Glucose Tolerance as a Possible Marker of Neutrophil Dysfunction in Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 4036-4044 , doi:10.1210/jc.2009-0215 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Reduced lactoferrin production in neutrophils of patients with type 2 diabetes is associated with insulin resistance and central obesity.

Johannes D. Veldhuis, Ferdinand Roelfsema, Ali Iranmanesh, Bernard J. Carroll, Daniel M. Keenan, and Steven M. Pincus

Basal, Pulsatile, Entropic (Patterned), and Spiky (Staccato-like) Properties of ACTH Secretion: Impact of Age, Gender, and Body Mass Index
J Clin Endocrinol Metab 2009 94: 4045-4052 , doi:10.1210/jc.2009-1143 [Abstract] [Full Text] [PDF]  
ACTH secretion dynamics are jointly determined by age, gender, and body mass index. Future studies must match control and interventional groups for these primary covariates.

Rosemary A. L. Bayne, Sharon L. Eddie, Craig S. Collins, Andrew J. Childs, Henry N. Jabbour, and Richard A. Anderson

Prostaglandin E₂ as a Regulator of Germ Cells during Ovarian Development
J Clin Endocrinol Metab 2009 94: 4053-4060 , doi:10.1210/jc.2009-0755 [Abstract] [Full Text] [PDF]  
PGE2 has a novel role in regulating expression of important ovarian factors during germ cell development in the human fetal ovary.

Audrey J. Robinson-White, Ioannis Bossis, Hui-Pin Hsiao, Maria Nesterova, Wolfgang W. Leitner, and Constantine A. Stratakis

8-Cl-Adenosine Inhibits Proliferation and Causes Apoptosis in B-Lymphocytes via Protein Kinase A-Dependent and Independent Effects: Implications for Treatment of Carney Complex-Associated Tumors
J Clin Endocrinol Metab 2009 94: 4061-4069 , doi:10.1210/jc.2009-0759 [Abstract] [Full Text] [PDF] [Supplemental Data]  
8-Cl-adenosine inhibits cancer cell proliferation, and induces apoptosis in B lymphocytes of Carney complex patients by PKA-independent and dependent effects that are unmasked by a mutant PRKAR1A.

Ildiko Lingvay, Victoria Esser, Jaime L. Legendre, Angela L. Price, Kristen M. Wertz, Beverley Adams-Huet, Song Zhang, Roger H. Unger, and Lidia S. Szczepaniak

Noninvasive Quantification of Pancreatic Fat in Humans
J Clin Endocrinol Metab 2009 94: 4070-4076 , doi:10.1210/jc.2009-0584 [Abstract] [Full Text] [PDF]  
Pancreatic triglyceride content as measured by Magnetic Resonance Spectroscopy in humans is elevated prior to development of type 2 diabetes, early in the natural history of the disease.

Ronnie Minnaard, Patrick Schrauwen, Gert Schaart, Johanna A. Jorgensen, Ellen Lenaers, Marco Mensink, and Matthijs K.C. Hesselink

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 2009 94: 4077-4085 , doi:10.1210/jc.2009-0352 [Abstract] [Full Text] [PDF]  
ADRP and OXPAT proteins show fiber type-specific distribution in rat and human skeletal muscle, and are involved in lipid accumulation and type 2 diabetes mellitus.

Beate Skinningsrud, Eystein S. Husebye, Gregor D. Gilfillan, Eirik Frengen, Aage Erichsen, Kristina Gervin, Eli Ormerod, Thore Egeland, and Dag E. Undlien

X-Linked Congenital Adrenal Hypoplasia with Hypogonadotropic Hypogonadism Caused by an Inversion Disrupting a Conserved Noncoding Element Upstream of the NR0B1 (DAX1) Gene
J Clin Endocrinol Metab 2009 94: 4086-4093 , doi:10.1210/jc.2009-0923 [Abstract] [Full Text] [PDF]  
The 60 Mb X-chromosome inversion causes a phenotype similar to NR0B1 null mutations by disrupting regulatory sites upstream of this gene.

Yu-Hsiang Shu, Jaana Hartiala, Anny H. Xiang, Enrique Trigo, Jean M. Lawrence, Hooman Allayee, Thomas A. Buchanan, Nunzio Bottini, and Richard M. Watanabe

Evidence for Sex-Specific Associations between Variation in Acid Phosphatase Locus 1 (ACP1) and Insulin Sensitivity in Mexican-Americans
J Clin Endocrinol Metab 2009 94: 4094-4102 , doi:10.1210/jc.2008-2751 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Variation in acid phosphatase locus 1 is associated with fasting insulin and insulin sensitivity in Mexican American males, but not Mexican American females.

Jean Michel Petit, Boris Guiu, Beatrice Terriat, Romaric Loffroy, Isabelle Robin, Vincent Petit, Benjamin Bouillet, Marie-Claude Brindisi, Laurence Duvillard, Patrick Hillon, Jean-Pierre Cercueil, and Bruno Verges

BRIEF REPORT:Nonalcoholic Fatty Liver Is Not Associated with Carotid Intima-Media Thickness in Type 2 Diabetic Patients
J Clin Endocrinol Metab 2009 94: 4103-4106 , doi:10.1210/jc.2009-0541 [Abstract] [Full Text] [PDF]  
In type 2 diabetic patients, fatty liver is not a determinant factor associated with carotid intima media thickness.

Ning Jin, Tianyun Jiang, D. Marc Rosen, Barry D. Nelkin, and Douglas W. Ball

BRIEF REPORT:Dual Inhibition of Mitogen-Activated Protein Kinase Kinase and Mammalian Target of Rapamycin in Differentiated and Anaplastic Thyroid Cancer
J Clin Endocrinol Metab 2009 94: 4107-4112 , doi:10.1210/jc.2009-0662 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Combined treatment with a MEK inhibitor (AZD6244/ARRY-142886) plus an mTOR inhibitor (Rapamycin) inhibited growth of thyroid cancer cells in vitro, and in a xenograft model, more potently than either agent alone.

Christiane Winkler, Thomas Illig, Kerstin Koczwara, Ezio Bonifacio, and Anette-Gabriele Ziegler

BRIEF REPORT:HHEX-IDE Polymorphism Is Associated with Low Birth Weight in Offspring with a Family History of Type 1 Diabetes
J Clin Endocrinol Metab 2009 94: 4113-4115 , doi:10.1210/jc.2009-0970 [Abstract] [Full Text] [PDF]  
The association of low birth weight and type 2 diabetes risk alleles of the HHEX-IDE locus is demonstrated in children of mothers with type 1 diabetes.

TRANSLATIONAL HIGHLIGHTS FROM ENDOCRINOLOGY:

Andreas Stengel, David Keire, Miriam Goebel, Lena Evilevitch, Brian Wiggins, Yvette Taché, and Joseph R. Reeve, Jr.

Abstracts:The RAPID Method for Blood Processing Yields New Insight in Plasma Concentrations and Molecular Forms of Circulating Gut Peptides
J Clin Endocrinol Metab 2009 94: 4116 [Full Text] [PDF]  

Ichiro Horie, Norio Abiru, Yuji Nagayama, Genpei Kuriya, Ohki Saitoh, Tatsuki Ichikawa, Yoichiro Iwakura, and Katsumi Eguchi

Abstracts:T Helper Type 17 Immune Response Plays an Indispensable Role for Development of Iodine-Induced Autoimmune Thyroiditis in Nonobese Diabetic-H2^h4 Mice
J Clin Endocrinol Metab 2009 94: 4116-a [Full Text] [PDF]  

V. Yechoor, V. Liu, A. Paul, J. Lee, E. Buras, K. Ozer, S. Samson, and L. Chan

Abstracts:Gene Therapy with Neurogenin 3 and Betacellulin Reverses Major Metabolic Problems in Insulin-Deficient Diabetic Mice
J Clin Endocrinol Metab 2009 94: 4117 [Full Text] [PDF]  

Sheri A. Berenbaum, Kristina Korman Bryk, Nicole Nowak, Charmian A. Quigley, and Scott Moffat

Abstracts:Fingers as a Marker of Prenatal Androgen Exposure
J Clin Endocrinol Metab 2009 94: 4117-a [Full Text] [PDF]  

TRANSLATIONAL HIGHLIGHTS FROM MOLECULAR ENDOCRINOLOGY:

Yau-Sheng Tsai, Pei-Jane Tsai, Man-Jin Jiang, Ting-Yu Chou, Avani Pendse, Hyung-Suk Kim, and Nobuyo Maeda

Abstracts:Decreased PPAR Expression Compromises Perigonadal-Specific Fat Deposition and Insulin Sensitivity
J Clin Endocrinol Metab 2009 94: 4118 [Full Text] [PDF]  

Mei Jiang, Yunsheng Ma, Congcong Chen, Xuping Fu, Shu Yang, Xia Li, Guohua Yu, Yumin Mao, Yi Xie, and Yao Li

Abstracts:Androgen-Responsive Gene Database: Integrated Knowledge on Androgen-Responsive Genes
J Clin Endocrinol Metab 2009 94: 4118-a [Full Text] [PDF]  

Fabrizio Barbetti, Nadia Cobo-Vuilleumier, Carlo Dionisi-Vici, Sonia Toni, Paolo Ciampalini, Ornella Massa, Pablo Rodriguez-Bada, Carlo Colombo, Lorenzo Lenzi, María A. Garcia-Gimeno, Francisco J. Bermudez, Fernando Rodriguez de Fonseca, Patrizia Banin, Juan C. Aledo, Elena Baixeras, Pascual Sanz, and Antonio L. Cuesta-Muñoz

Abstracts:Opposite Clinical Phenotypes of "Glucokinase Disease": Description of a Novel Activating Mutation and Contiguous Inactivating Mutations in Human Glucokinase Gene
J Clin Endocrinol Metab 2009 94: 4119 [Full Text] [PDF]  

Fiona O'Mahony, Rodrigo Alzamora, Ho-Lam Chung, Warren Thomas, and Brian J. Harvey

Abstracts:Genomic Priming of the Antisecretory Response to Estrogen in Rat Distal Colon throughout the Estrous Cycle
J Clin Endocrinol Metab 2009 94: 4119-a [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Kathryn Martin, JoAnn Pinkerton, and Richard Santen

Patient Information Page from The Hormone Foundation:Medicina complementaria y alternativa (CAM) para síntomas de la menopausia
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Kathryn Martin, JoAnn Pinkerton, and Richard Santen

Patient Information Page from The Hormone Foundation:Complementary and Alternative Medicine (CAM) for Menopausal Symptoms
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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