The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2009 94: 17a-20a [Full Text] [PDF]  

Special Features:

Jil Huong Nguyen, Maya B. Lodish, Nicholas J. Patronas, Figen Ugrasbul, Margaret F. Keil, Mary D. Roberts, Jadranka Popovic, and Constantine A. Stratakis

IMAGE IN ENDOCRINOLOGY:Extensive and Largely Reversible Ischemic Cerebral Infarctions in a Prepubertal Child with Hypertension and Cushing Disease
J Clin Endocrinol Metab 2009 94: 1-2 doi:10.1210/jc.2008-1346 [Full Text] [PDF]  

Hernan Valdes-Socin, Roberto Salvi, Albert Thiry, Adrian F. Daly, François P. Pralong, Rolf Gaillard, and Albert Beckers

IMAGE IN ENDOCRINOLOGY:Testicular Effects of Isolated Luteinizing Hormone Deficiency and Reversal by Long-Term Human Chorionic Gonadotropin Treatment
J Clin Endocrinol Metab 2009 94: 3-4 doi:10.1210/jc.2008-1584 [Full Text] [PDF]  

Anthony M. Joshua, Shereen Ezzat, Sylvia L. Asa, Andrew Evans, Reuben Broom, Marc Freeman, and Jennifer J. Knox

CLINICAL CASE SEMINAR:Rationale and Evidence for Sunitinib in the Treatment of Malignant Paraganglioma/Pheochromocytoma
J Clin Endocrinol Metab 2009 94: 5-9 , doi:10.1210/jc.2008-1836 [Abstract] [Full Text] [PDF]  
Clinical evidence and a correlative molecular explanation are presented to show the effectiveness of sunitinib in metastatic paraganglioma.

David B. Savage, Robert K. Semple, Menna R. Clatworthy, Paul A. Lyons, B. Paul Morgan, Elaine K. Cochran, Phillip Gorden, Philippa Raymond-Barker, Peter R. Murgatroyd, Claire Adams, Ian Scobie, Ghulam J. Mufti, Graeme J. M. Alexander, Sathia Thiru, Incoronata Murano, Saverio Cinti, Afzal N. Chaudhry, Kenneth G. C. Smith, and Stephen O'Rahilly

CLINICAL CASE SEMINAR:Complement Abnormalities in Acquired Lipodystrophy Revisited
J Clin Endocrinol Metab 2009 94: 10-16 , doi:10.1210/jc.2008-1703 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A novel subtype of acquired generalized lipodystrophy associated with activation of the classical complement pathway and low C4 complement levels is described.

Whitney W. Brown, Harald Jüppner, Craig B. Langman, Heather Price, Emily G. Farrow, Kenneth E. White, and Kenneth L. McCormick

CLINICAL CASE SEMINAR:Hypophosphatemia with Elevations in Serum Fibroblast Growth Factor 23 in a Child with Jansen’s Metaphyseal Chondrodysplasia
J Clin Endocrinol Metab 2009 94: 17-20 , doi:10.1210/jc.2008-0220 [Abstract] [Full Text] [PDF]  
Serum fibroblast growth factor 23 could be governed by factor(s) other than serum phosphorus, potentially by activation of the PTH/PTHrP receptor in bone.

Alex Stagnaro-Green

CLINICAL REVIEW:Maternal Thyroid Disease and Preterm Delivery
J Clin Endocrinol Metab 2009 94: 21-25 , doi:10.1210/jc.2008-1288 [Abstract] [Full Text] [PDF]  
A literature review reveals that hypothyroidism and autoimmune thyroid disease are associated with preterm delivery.

Daniel Bikle

REVIEW:Nonclassic Actions of Vitamin D
J Clin Endocrinol Metab 2009 94: 26-34 , doi:10.1210/jc.2008-1454 [Abstract] [Full Text] [PDF]  
Vitamin D, via its active metabolite 1,25(OH)₂ D, regulates numerous biologic functions in addition to bone mineral homeostasis, including hormone secretion, immune response, and cellular proliferation and differentiation.

Editorials:

Kathleen M. Hoeger

EDITORIAL:Polycystic Ovary Syndrome, Inflammation, and Statins: Do We Have the Right Target?
J Clin Endocrinol Metab 2009 94: 35-37 doi:10.1210/jc.2008-2376 [Full Text] [PDF]  

Endocrine Care:

Andrew A. Palladino, Samir Sayed, Lorraine E. Levitt Katz, Paul R. Gallagher, and Diva D. De León

Increased Glucagon-Like Peptide-1 Secretion and Postprandial Hypoglycemia in Children after Nissen Fundoplication
J Clin Endocrinol Metab 2009 94: 39-44 , doi:10.1210/jc.2008-1263 [Abstract] [Full Text] [PDF]  
Children with post-prandial hypoglycemia after Nissen fundoplication have abnormally exaggerated secretion of glucagon-like peptide-1, which may contribute to the amplified insulin surge and resultant hypoglycemia.

Ippei Kanazawa, Toru Yamaguchi, Masahiro Yamamoto, Mika Yamauchi, Soichi Kurioka, Shozo Yano, and Toshitsugu Sugimoto

Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 2009 94: 45-49 , doi:10.1210/jc.2008-1455 [Abstract] [Full Text] [PDF]  
Serum osteocalcin is associated with glucose and serum adiponectin levels, fat mass, and atherosclerosis parameters in patients with type 2 diabetes. Thus, osteocalcin is important for not only bone metabolism, but also glucose and fat metabolism.

Antti P. M. Viljanen, Patricia Iozzo, Ronald Borra, Mikko Kankaanpää, Anna Karmi, Riikka Lautamäki, Mikko Järvisalo, Riitta Parkkola, Tapani Rönnemaa, Letizia Guiducci, Terho Lehtimäki, Olli T. Raitakari, Andrea Mari, and Pirjo Nuutila

Effect of Weight Loss on Liver Free Fatty Acid Uptake and Hepatic Insulin Resistance
J Clin Endocrinol Metab 2009 94: 50-55 , doi:10.1210/jc.2008-1689 [Abstract] [Full Text] [PDF]  
Liver responds to a 6-week period of calorie restriction with a parallel reduction in lipid uptake and storage, accompanied by enhancement of hepatic insulin sensitivity and clearance.

Christopher R. McCartney, Kathleen A. Prendergast, Susan K. Blank, Kristin D. Helm, Sandhya Chhabra, and John C. Marshall

Maturation of Luteinizing Hormone (Gonadotropin-Releasing Hormone) Secretion across Puberty: Evidence for Altered Regulation in Obese Peripubertal Girls
J Clin Endocrinol Metab 2009 94: 56-66 , doi:10.1210/jc.2008-1252 [Abstract] [Full Text] [PDF]  
Obesity in pre- and early pubertal girls is associated with reduced LH secretion and dampened nocturnal changes of LH. In later pubertal girls, obesity is linked with reduced LH amplitude and elevated LH frequency, with the latter possibly reflecting hyperandrogenemia.

Richard Kremer, Patricia P. Campbell, Timothy Reinhardt, and Vicente Gilsanz

Vitamin D Status and Its Relationship to Body Fat, Final Height, and Peak Bone Mass in Young Women
J Clin Endocrinol Metab 2009 94: 67-73 , doi:10.1210/jc.2008-1575 [Abstract] [Full Text] [PDF]  
Vitamin D insufficiency in young women is associated with increased body fat and decreased height.

Borgström Birgit, Hreinsson Julius, Rasmussen Carsten, Sheikhi Maryam, Fried Gabriel, Keros Victoria, Fridström Margareta, and Hovatta Outi

Fertility Preservation in Girls with Turner Syndrome: Prognostic Signs of the Presence of Ovarian Follicles
J Clin Endocrinol Metab 2009 94: 74-80 , doi:10.1210/jc.2008-0708 [Abstract] [Full Text] [PDF]  
Ovarian biopsy and cryopreservation is a possibility for girls with Turner syndrome. In selected cases, this is a way to overcome the expected permanent infertility.

David A. D'Alessio, Amanda M. Denney, Linda M. Hermiller, Ronald L. Prigeon, Julie M. Martin, William G. Tharp, Monica Liqueros Saylan, YanLing He, Beth E. Dunning, James E. Foley, and Richard E. Pratley

Treatment with the Dipeptidyl Peptidase-4 Inhibitor Vildagliptin Improves Fasting Islet-Cell Function in Subjects with Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 81-88 , doi:10.1210/jc.2008-1135 [Abstract] [Full Text] [PDF]  
Three months of vildagliptin treatment in subjects with well-controlled type 2 diabetes improves fasting β-cell function, with only minor effects on plasma glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1.

Larissa G. Gomes, Ningwu Huang, Vishal Agrawal, Berenice B. Mendonça, Tania A. S. S. Bachega, and Walter L. Miller

Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency
J Clin Endocrinol Metab 2009 94: 89-95 , doi:10.1210/jc.2008-1174 [Abstract] [Full Text] [PDF]  
Hepatic CYP2C19 and CYP3A4 can 21-hydroxylate progesterone with 17% and 10% of the activity of P450c21, but have no activity with 17-hydroxyprogesterone. These enzymes may ameliorate salt loss in congenital adrenal hyperplasia.

Bess Dawson-Hughes, Susan S. Harris, Nancy J. Palermo, Carmen Castaneda-Sceppa, Helen M. Rasmussen, and Gerard E. Dallal

Treatment with Potassium Bicarbonate Lowers Calcium Excretion and Bone Resorption in Older Men and Women
J Clin Endocrinol Metab 2009 94: 96-102 , doi:10.1210/jc.2008-1662 [Abstract] [Full Text] [PDF]  
Treatment with bicarbonate lowers bone resorption and calcium excretion in healthy older men and women.

Thozhukat Sathyapalan, Eric S. Kilpatrick, Anne-Marie Coady, and Stephen L. Atkin

The Effect of Atorvastatin in Patients with Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Study
J Clin Endocrinol Metab 2009 94: 103-108 , doi:10.1210/jc.2008-1750 [Abstract] [Full Text] [PDF]  
Atorvastatin improves high sensitivity C-reactive protein, insulin resistance, and biochemical hyperandrogenemia in patients with polycystic ovary syndrome compared to placebo.

Kai-Hang Yiu, Man-Hong Jim, Chung-Wah Siu, Chi-Ho Lee, Michele Yuen, Maggie Mok, Yet-Fung Shea, Katherine Fan, Hung-Fat Tse, and Wing-Hing Chow

Amiodarone-Induced Thyrotoxicosis Is a Predictor of Adverse Cardiovascular Outcome
J Clin Endocrinol Metab 2009 94: 109-114 , doi:10.1210/jc.2008-1907 [Abstract] [Full Text] [PDF]  
Patients who develop amiodarone-induced thyrotoxicosis are associated with a higher risk of adverse cardiovascular events when compared to those without.

M. Boscaro, W. H. Ludlam, B. Atkinson, J. E. Glusman, S. Petersenn, M. Reincke, P. Snyder, A. Tabarin, B. M. K. Biller, J. Findling, S. Melmed, C. H. Darby, K. Hu, Y. Wang, P. U. Freda, A. B. Grossman, L. A. Frohman, and J. Bertherat

Treatment of Pituitary-Dependent Cushing’s Disease with the Multireceptor Ligand Somatostatin Analog Pasireotide (SOM230): A Multicenter, Phase II Trial
J Clin Endocrinol Metab 2009 94: 115-122 , doi:10.1210/jc.2008-1008 [Abstract] [Full Text] [PDF]  
Results from this phase II study show pasireotide to be a promising pituitary-directed medical therapy for patients with Cushing’s disease.

Wiebke Fenske, Stefan Störk, Anne Blechschmidt, Sebastian G. K. Maier, Nils G. Morgenthaler, and Bruno Allolio

Copeptin in the Differential Diagnosis of Hyponatremia
J Clin Endocrinol Metab 2009 94: 123-129 , doi:10.1210/jc.2008-1426 [Abstract] [Full Text] [PDF]  
Plasma copeptin is a useful tool in differentiating special hyponatremic disorders and in improving the pathophysiological understanding of vasopressin-dependent hyponatremia.

Kavya C. Mekala and Nicholas A. Tritos

Effects of Recombinant Human Growth Hormone Therapy in Obesity in Adults: A Metaanalysis
J Clin Endocrinol Metab 2009 94: 130-137 , doi:10.1210/jc.2008-1357 [Abstract] [Full Text] [PDF]  
Recombinant human GH therapy decreases visceral adiposity, increases lean body mass, and improves lipid profile in obese adults, without inducing weight loss.

David M. Robertson, Georgina E. Hale, Damien Jolley, Ian S. Fraser, Claude L. Hughes, and Henry G. Burger

Interrelationships between Ovarian and Pituitary Hormones in Ovulatory Menstrual Cycles across Reproductive Age
J Clin Endocrinol Metab 2009 94: 138-144 , doi:10.1210/jc.2008-1684 [Abstract] [Full Text] [PDF]  
Using multiple linear regression analysis exploring associations between ovarian and pituitary hormones across ovulatory cycles of normal human menstrual cycles, it was concluded that inhibin B but not inhibin A, estradiol, progesterone, and anti-Müllerian hormone were the major negative feedback regulators of follicle stimulating hormone while inhibin B may be a negative regulator of LH.

Jeannet Lauenborg, Niels Grarup, Peter Damm, Knut Borch-Johnsen, Torben Jørgensen, Oluf Pedersen, and Torben Hansen

Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes
J Clin Endocrinol Metab 2009 94: 145-150 , doi:10.1210/jc.2008-1336 [Abstract] [Full Text] [PDF]  
The association among several type 2 diabetes risk variants with gestational diabetes mellitus points to identical geneticbackground for the two diseases.

Hakan Cinemre, Cemil Bilir, Feyzi Gokosmanoglu, and Talat Bahcebasi

Hematologic Effects of Levothyroxine in Iron-Deficient Subclinical Hypothyroid Patients: A Randomized, Double-Blind, Controlled Study
J Clin Endocrinol Metab 2009 94: 151-156 , doi:10.1210/jc.2008-1440 [Abstract] [Full Text] [PDF]  
Iron-deficiency anemia might be an indication for treating subclinical hypothyroidism.

Theodore P. Ciaraldi, Vanita Aroda, Sunder Mudaliar, R. Jeffrey Chang, and Robert R. Henry

Polycystic Ovary Syndrome Is Associated with Tissue-Specific Differences in Insulin Resistance
J Clin Endocrinol Metab 2009 94: 157-163 , doi:10.1210/jc.2008-1492 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Insulin resistance in polycystic ovary syndrome involves unique contributions from adipocytes (impaired sensitivity) and skeletal muscle (impaired responsiveness) as well as communication between tissues.

Jennifer A. Woyach, Richard T. Kloos, Matthew D. Ringel, Daria Arbogast, Minden Collamore, James A. Zwiebel, Michael Grever, Miguel Villalona-Calero, and Manisha H. Shah

Lack of Therapeutic Effect of the Histone Deacetylase Inhibitor Vorinostat in Patients with Metastatic Radioiodine-Refractory Thyroid Carcinoma
J Clin Endocrinol Metab 2009 94: 164-170 , doi:10.1210/jc.2008-1631 [Abstract] [Full Text] [PDF]  
This phase II study of the histone deacetylase inhibitor vorinostat shows that at the dosing schedule used, this drug is not aneffective treatment for advanced radioiodine-refractory thyroid cancer.

E. Michael Lewiecki, Tony M. Keaveny, David L. Kopperdahl, Harry K. Genant, Klaus Engelke, Thomas Fuerst, Alan Kivitz, Richard Y. Davies, and Lorraine A. Fitzpatrick

Once-Monthly Oral Ibandronate Improves Biomechanical Determinants of Bone Strength in Women with Postmenopausal Osteoporosis
J Clin Endocrinol Metab 2009 94: 171-180 , doi:10.1210/jc.2008-1807 [Abstract] [Full Text] [PDF]  
Once-monthly oral ibandronate for 12 months in postmenopausal osteoporosis improves hip and spine bone mineral density, as measured by quantitative computed tomography, dual-energy x-ray absorptiometry, and finite element analysis.

Michael R. Rickels, Rebecca Mueller, James F. Markmann, and Ali Naji

Effect of Glucagon-Like Peptide-1 on β- and -Cell Function in Isolated Islet and Whole Pancreas Transplant Recipients
J Clin Endocrinol Metab 2009 94: 181-189 , doi:10.1210/jc.2008-1806 [Abstract] [Full Text] [PDF]  
Glucagon-like peptide 1 infusion significantly increases second-phase insulin secretion in islet and pancreas transplant recipients, an effect that is dependent on the β-cell secretory capacity.

Sabrina Prudente, Daniela Scarpelli, Manisha Chandalia, Yuan-Yuan Zhang, Eleonora Morini, Silvia Del Guerra, Francesco Perticone, Rong Li, Christine Powers, Francesco Andreozzi, Piero Marchetti, Bruno Dallapiccola, Nicola Abate, Alessandro Doria, Giorgio Sesti, and Vincenzo Trischitta

The TRIB3 Q84R Polymorphism and Risk of Early-Onset Type 2 Diabetes
J Clin Endocrinol Metab 2009 94: 190-196 , doi:10.1210/jc.2008-1365 [Abstract] [Full Text] [PDF]  
Tribbles homolog 3 (TRIB3) Q84R polymorphism is associated with type 2 diabetes as a likely consequence of altered interplay between insulin secretion and action.

Emilie Maquet, Sabine Costagliola, Jasmine Parma, Christiane Christophe-Hobertus, Luc L. Oligny, Jean-Christophe Fournet, Yves Robitaille, Jean-Marc Vuissoz, Antoine Payot, Sophie Laberge, Gilbert Vassart, Guy Van Vliet, and Johnny Deladoëy

Lethal Respiratory Failure and Mild Primary Hypothyroidism in a Term Girl with a de Novo Heterozygous Mutation in the TITF1/NKX2.1 Gene
J Clin Endocrinol Metab 2009 94: 197-203 , doi:10.1210/jc.2008-1402 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A heterozygous mutation for thyroid transcription factor 1 (TITF1/NKX2.1) accounts for elevated thyrotropin levels associated with unexplained lethal respiratory failure in a term neonate.

Ferdous M. Barlaskar, Aaron C. Spalding, Joanne H. Heaton, Rork Kuick, Alex C. Kim, Dafydd G. Thomas, Thomas J. Giordano, Edgar Ben-Josef, and Gary D. Hammer

Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma
J Clin Endocrinol Metab 2009 94: 204-212 , doi:10.1210/jc.2008-1456 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Targeted pharmacologic blockade of IGF signaling in adrenocortical cancer xenografts results in marked growth inhibition that is enhanced with mitotane, providing rationale for future clinical trials.

Tobias Henopp, Martin Anlauf, Anja Schmitt, Regina Schlenger, Attila Zalatnai, Anne Couvelard, Philippe Ruszniewski, Klaus-Peter Schaps, Yvonne M. H. Jonkers, Ernst-Jan M. Speel, Natalia S. Pellegata, Philipp U. Heitz, Paul Komminoth, Aurel Perren, and Günter Klöppel

BRIEF REPORT:Glucagon Cell Adenomatosis: A Newly Recognized Disease of the Endocrine Pancreas
J Clin Endocrinol Metab 2009 94: 213-217 , doi:10.1210/jc.2008-1300 [Abstract] [Full Text] [PDF]  
Multiple pancreatic neoplasms exclusively producing glucagon, associated with glucagon cell hyperplasia of the islets and unrelated to multiple endocrine neoplasia type 1, VHL, and the p27 multiple endocrine neoplasia syndrome, suggest using the term "glucagon cell adenomatosis".

Eugenia Resmini, Alberto Tagliafico, Lorenzo Bacigalupo, Giorgia Giordano, Enrico Melani, Alberto Rebora, Francesco Minuto, Gian Andrea Rollandi, and Diego Ferone

BRIEF REPORT:Computed Tomography Colonography in Acromegaly
J Clin Endocrinol Metab 2009 94: 218-222 , doi:10.1210/jc.2008-1479 [Abstract] [Full Text] [PDF]  
Computed tomography colonography has the ability to parallel traditional colonoscopy in acromegaly, to improve patient’s acceptability, and to screen for colon cancer in acromegaly.

Rosario Pivonello, Maria Cristina De Martino, Paolo Cappabianca, Monica De Leo, Antongiulio Faggiano, Gaetano Lombardi, Leo J. Hofland, Steven W. J. Lamberts, and Annamaria Colao

BRIEF REPORT:The Medical Treatment of Cushing’s Disease: Effectiveness of Chronic Treatment with the Dopamine Agonist Cabergoline in Patients Unsuccessfully Treated by Surgery
J Clin Endocrinol Metab 2009 94: 223-230 , doi:10.1210/jc.2008-1533 [Abstract] [Full Text] [PDF]  
Cabergoline is effective in controlling cortisol secretion in more than one third of patients with Cushing’s disease during chronic treatment, without major side effects, thus representing medical treatment of the disease.

Takuya Awata, Eiji Kawasaki, Shoichiro Tanaka, Hiroshi Ikegami, Taro Maruyama, Akira Shimada, Koji Nakanishi, Tetsuro Kobayashi, Hiroyuki Iizuka, Miho Uga, Yumiko Kawabata, Yasuhiko Kanazawa, Susumu Kurihara, Masataka Osaki, Shigehiro Katayama on behalf of the Japanese Study Group on Type 1 Diabetes Genetics

BRIEF REPORT:Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese
J Clin Endocrinol Metab 2009 94: 231-235 , doi:10.1210/jc.2008-0718 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Two loci on 12q13 and 16p13 are associated with type 1 diabetes in Japan. In addition, these loci may also contribute to the co-occurrence of thyroid autoimmunity in type 1 diabetes.

Endocrine Research:

Jose Manuel Fernández-Real, Mikel Izquierdo, Francisco Ortega, Esteban Gorostiaga, Javier Gómez-Ambrosi, Jose Maria Moreno-Navarrete, Gema Frühbeck, Cristina Martínez, Fernando Idoate, Javier Salvador, Lluis Forga, Wifredo Ricart, and Javier Ibañez

The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training
J Clin Endocrinol Metab 2009 94: 237-245 , doi:10.1210/jc.2008-0270 [Abstract] [Full Text] [PDF]  
Bone recently exhibited properties of an endocrine organ in animal models. In humans, osteocalcin might also be an active regulator of insulin sensitivity by bone.

Johannes D. Veldhuis, Daniel M. Keenan, Joy N. Bailey, Adenborduin Adeniji, John M. Miles, Remberto Paulo, Mihaela Cosma, and Cacia Soares-Welch

Testosterone Supplementation in Older Men Restrains Insulin-Like Growth Factor’s Dose-Dependent Feedback Inhibition of Pulsatile Growth Hormone Secretion
J Clin Endocrinol Metab 2009 94: 246-254 , doi:10.1210/jc.2008-1516 [Abstract] [Full Text] [PDF]  
In healthy older men, testosterone stimulates GH secretion in part by limiting negative feedback.

Ziad Mallat, Tabassome Simon, Joelle Benessiano, Karine Clément, Soraya Taleb, Nicholas J. Wareham, Robert Luben, Kay-Tee Khaw, Alain Tedgui, and S. Matthijs Boekholdt

Retinol-Binding Protein 4 and Prediction of Incident Coronary Events in Healthy Men and Women
J Clin Endocrinol Metab 2009 94: 255-260 , doi:10.1210/jc.2008-0253 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Measurement of serum retinol binding protein 4 provides no additive value over traditional risk factors for assessing the risk of future cardiovascular disease.

A. R. Baker, A. L. Harte, N. Howell, D. C. Pritlove, A. M. Ranasinghe, N. F. da Silva, E. M. Youssef, K. Khunti, M. J. Davies, R. S. Bonser, S. Kumar, D. Pagano, and P. G. McTernan

Epicardial Adipose Tissue as a Source of Nuclear Factor-B and c-Jun N-Terminal Kinase Mediated Inflammation in Patients with Coronary Artery Disease
J Clin Endocrinol Metab 2009 94: 261-267 , doi:10.1210/jc.2007-2579 [Abstract] [Full Text] [PDF]  
NF-B and JNK pathways are implicated in the inflammatory profile of epicardial adipose tissue. The role of macrophage in this inflammation is discussed.

Charles C. Chung, Lawrence Shimmin, Sivamani Natarajan, Craig L. Hanis, Eric Boerwinkle, and James E. Hixson

Glucocorticoid Receptor Gene Variant in the 3' Untranslated Region Is Associated with Multiple Measures of Blood Pressure
J Clin Endocrinol Metab 2009 94: 268-276 , doi:10.1210/jc.2008-1089 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Resequencing of the glucocorticoid receptor gene identified extensive variability, but limited haplotype diversity among three American ethnic groups. Family-based studies identified associations between a functional polymorphism in the 3’ untranslated region with multiple measures of blood pressure.

Ilpo T. Huhtaniemi, Stephen R. Pye, Kate L. Limer, Wendy Thomson, Terence W. O'Neill, Hazel Platt, Debbie Payne, Sally L. John, Min Jiang, Steven Boonen, Herman Borghs, Dirk Vanderschueren, Judith E. Adams, Kate A. Ward, György Bartfai, Felipe Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Krzysztof Kula, Michael E. J. Lean, Neil Pendleton, Margus Punab, Alan J. Silman, Frederick C. W. Wu the European Male Ageing Study Group

Increased Estrogen Rather Than Decreased Androgen Action Is Associated with Longer Androgen Receptor CAG Repeats
J Clin Endocrinol Metab 2009 94: 277-284 , doi:10.1210/jc.2008-0848 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The androgen receptor CAG repeat length correlates with male serum testosterone and estradiol. The phenotypic correlations may reflect differences in estrogen rather than androgen action.

Salama A. Salama, Marwa W. Kamel, Concepcion R. Diaz-Arrastia, Xia Xu, Timothy D. Veenstra, Sana Salih, Shaleen K. Botting, and Raj Kumar

Effect of Tumor Necrosis Factor- on Estrogen Metabolism and Endometrial Cells: Potential Physiological and Pathological Relevance
J Clin Endocrinol Metab 2009 94: 285-293 , doi:10.1210/jc.2008-1389 [Abstract] [Full Text] [PDF] [Supplemental Data]  
TNF- increases the local estrogen biosynthesis in endometrial glandular cells and directs estrogen metabolism into more hormonally active and carcinogenic metabolites.

Anne Marie Petersen, Peter Plomgaard, Christian P. Fischer, Tobias Ibfelt, Bente Klarlund Pedersen, and Gerrit van Hall

Acute Moderate Elevation of TNF- Does Not Affect Systemic and Skeletal Muscle Protein Turnover in Healthy Humans
J Clin Endocrinol Metab 2009 94: 294-299 , doi:10.1210/jc.2008-1110 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Acute, moderately elevated levels of TNF- (from 0.7 to 16.7 pg/ml) do not affect systemic and skeletal muscle protein synthesis and degradation.

Nicola Santoro, Grazia Cirillo, Maria Grazia Lepore, Alfonsina Palma, Alessandra Amato, Piera Savarese, Pierluigi Marzuillo, Anna Grandone, Laura Perrone, and Emanuele Miraglia del Giudice

Effect of the rs997509 Polymorphism on the Association between Ectonucleotide Pyrophosphatase Phosphodiesterase 1 and Metabolic Syndrome and Impaired Glucose Tolerance in Childhood Obesity
J Clin Endocrinol Metab 2009 94: 300-305 , doi:10.1210/jc.2008-1659 [Abstract] [Full Text] [PDF]  
The nucleotide pyrophosphatase/phosphodiesterase 1(ENPP1) rs997509 variant is strongly associated with insulin resistance, metabolic syndrome, and impaired glucose tolerance in obese children and adolescents. This variant also drives the known association between the ENPP1 121Q variant and insulin resistance.

Zhen Yang, Ping Zhu, Chunming Guo, Xiaoou Zhu, and Kang Sun

Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Human Fetal Lung and Regulation of Its Expression by Interleukin-1β and Cortisol
J Clin Endocrinol Metab 2009 94: 306-313 , doi:10.1210/jc.2008-1534 [Abstract] [Full Text] [PDF]  
11β-Hydroxysteroid dehydrogenase type 1 is expressed in human fetal lung, with cortisol and IL-1β synergistically inducing its expression.

Toshihiro Tajima, Akira Ohtake, Masaya Hoshino, Shin Amemiya, Nozomu Sasaki, Katsura Ishizu, and Kenji Fujieda

BRIEF REPORT:OTX2 Loss of Function Mutation Causes Anophthalmia and Combined Pituitary Hormone Deficiency with a Small Anterior and Ectopic Posterior Pituitary
J Clin Endocrinol Metab 2009 94: 314-319 , doi:10.1210/jc.2008-1219 [Abstract] [Full Text] [PDF]  
Orthodenticle homeobox 2 is a transcription factor necessary for ocular and forebrain development. In humans, a novel mutation of this gene is one of the causes of combined pituitary hormone deficiency.

Fernando Colbari Amaral, Natalia Torres, Fabiano Saggioro, Luciano Neder, Hélio Rubens Machado, Wilson Araújo Silva, Jr, Ayrton Custódio Moreira, and Margaret Castro

BRIEF REPORT:MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors
J Clin Endocrinol Metab 2009 94: 320-323 , doi:10.1210/jc.2008-1451 [Abstract] [Full Text] [PDF]  
MicroRNAs (miRNAs) are underexpressed in corticotropinomas without association with tumor size; however, lower miR-141 expression was associated with a better chance of Cushing’s disease remission.

Announcements and Resources:

Corrigendum
J Clin Endocrinol Metab 2009 94: 324 [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2009 94: 325 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Camila M. Manrique, James L. Rosenzweig, and Guillermo E. Umpierrez

Patient Information Page from The Hormone Foundation:Diabetes, Dyslipidemia, and Heart Protection
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

Camila M. Manrique, James L. Rosenzweig, and Guillermo E. Umpiérrez

Patient Information Page from The Hormone Foundation:Diabetes, Dislipidemia y Protección del Corazón
J Clin Endocrinol Metab 2009 94 [Full Text] [PDF]  

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