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Spatial distribution of the pyr/deH-DHLNL collagen cross-link ratio (blue-lowest, red-highest) in the trabecular bone of a patient with primary hyperparathyroidism before (left panel) and 3 years after parathyroidectomy (right panel), as determined by Fourier Transform Infrared Imaging analysis. The changes reflect recovery of normal bone turnover following treatment. From the article by Zoehrer et al., in this issue, pages 3484–3489.