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Marked facial lipoatrophy in a 45-yr-old female with well-controlled HIV infection and an 8-yr history of antiretroviral therapy. The loss of fat is most notable in malar area bilaterally, giving prominence to the nasolabial folds, with extension to buccal and temporal areas. The underlying facial musculature (zygomaticus major) and bony landmarks are visible through the skin. From the article by Brown, in this issue, pages 2937–2945.