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Formation of caveloae and lipid droplets containing caveolin-1 (CAV1) in adipocytes (left panel); 20-year-old Brazilian woman with congenital generalized lipodystrophy due to homozygous null mutation in CAV1 gene (middle panel); and Western-blot analysis of skin fibroblast cell lysates demonstrating absence of the CAV1 protein and its associated partner, CAV2 (right panel). From the articles by Garg and Agarwal and Kim et al., in this issue, pages 1183–1185 and 1129–1134, respectively.