The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2008 93: 17a-20a [Full Text] [PDF]  

Special Features:

Kathryn Ann Martin and JoAnn E. Manson

APPROACH TO THE PATIENT:Approach to the Patient with Menopausal Symptoms
J Clin Endocrinol Metab 2008 93: 4567-4575 doi:10.1210/jc.2008-1272 [Abstract] [Full Text] [PDF]  
Short-term estrogen therapy, using the lowest effective estrogen dose, is a reasonable option for recently menopausal women with moderate to severe symptoms who are in good cardiovascular health.

Gilbert P. August, Sonia Caprio, Ilene Fennoy, Michael Freemark, Francine R. Kaufman, Robert H. Lustig, Janet H. Silverstein, Phyllis W. Speiser, Dennis M. Styne, and Victor M. Montori

CLINICAL PRACTICE GUIDELINE:Prevention and Treatment of Pediatric Obesity: An Endocrine Society Clinical Practice Guideline Based on Expert Opinion
J Clin Endocrinol Metab 2008 93: 4576-4599 , doi:10.1210/jc.2007-2458 [Abstract] [Full Text] [PDF]  
Pediatric obesity can lead to concurrent co-morbidities. Intensive lifestyle modification remains the primary treatment. Carefully selected patients with severe co-morbidities may benefit from the addition of pharmacotherapy and/or bariatric surgery. Because treatment is difficult, prevention is the ultimate goal.

Lauren McGovern, Jonathan N. Johnson, Remberto Paulo, Allison Hettinger, Vibha Singhal, Celia Kamath, Patricia J. Erwin, and Victor M. Montori

CLINICAL REVIEW:Treatment of Pediatric Obesity: A Systematic Review and Meta-Analysis of Randomized Trials
J Clin Endocrinol Metab 2008 93: 4600-4605 , doi:10.1210/jc.2006-2409 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Meta-analyses of randomized trials describe the short-term efficacy of medications and lifestyle treatments for pediatric obesity, but their long-term efficacy and safety remain unclear.

Celia C. Kamath, Kristin S. Vickers, Angela Ehrlich, Lauren McGovern, Jonathan Johnson, Vibha Singhal, Remberto Paulo, Allison Hettinger, Patricia J. Erwin, and Victor M. Montori

CLINICAL REVIEW:Behavioral Interventions to Prevent Childhood Obesity: A Systematic Review and Metaanalyses of Randomized Trials
J Clin Endocrinol Metab 2008 93: 4606-4615 , doi:10.1210/jc.2006-2411 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Meta-analyses show that programs to prevent pediatric obesity cause small changes in target behaviors and no significant effect on body mass index.

Elizabeth A. Lawson, Bradley R. Buchbinder, and Gilbert H. Daniels

IMAGE IN ENDOCRINOLOGY:Hypopituitarism Associated with a Giant Aneurysm of the Internal Carotid Artery
J Clin Endocrinol Metab 2008 93: 4616 doi:10.1210/jc.2008-0596 [Full Text] [PDF]  

Anil K. Agarwal, Irina Kazachkova, Svetlana Ten, and Abhimanyu Garg

CLINICAL CASE SEMINAR:Severe Mandibuloacral Dysplasia-Associated Lipodystrophy and Progeria in a Young Girl with a Novel Homozygous Arg527Cys LMNA Mutation
J Clin Endocrinol Metab 2008 93: 4617-4623 , doi:10.1210/jc.2008-0123 [Abstract] [Full Text] [PDF]  
We report a 7-year-old girl with mandibuloacral dysplasia, severe progeroid features, and lipodystrophy due to a novel homozygous missense mutation Arg527Cys in the lamin A/C gene.

Sigrid Jehle, Jane E. Walsh, Pamela U. Freda, and Kalmon D. Post

EXTENSIVE CLINICAL EXPERIENCE:Selective Use of Bilateral Inferior Petrosal Sinus Sampling in Patients with Adrenocorticotropin-Dependent Cushing’s Syndrome Prior to Transsphenoidal Surgery
J Clin Endocrinol Metab 2008 93: 4624-4632 , doi:10.1210/jc.2008-0979 [Abstract] [Full Text] [PDF]  
Outcome is not adversely affected when bilateral inferior petrosal sinus sampling is performed only in those patients with ACTH-dependent Cushing’s syndrome without a clear adenoma on MRI and/or inconsistent testing.

Jose C. Florez

CLINICAL REVIEW:The Genetics of Type 2 Diabetes: A Realistic Appraisal in 2008
J Clin Endocrinol Metab 2008 93: 4633-4642 , doi:10.1210/jc.2008-1345 [Abstract] [Full Text] [PDF]  
New genetic discoveries in type 2 diabetes are described; the review places these discoveries in context, answers some common misconceptions, and outlines avenues for future research.

Editorials:

Mark E. Molitch

EDITORIAL:The Cabergoline-Resistant Prolactinoma Patient: New Challenges
J Clin Endocrinol Metab 2008 93: 4643-4645 doi:10.1210/jc.2008-2244 [Full Text] [PDF]  

Jeffrey L. Ecker

EDITORIAL:Gestational Diabetes: An Opportunity for Improvement
J Clin Endocrinol Metab 2008 93: 4646-4647 doi:10.1210/jc.2008-2204 [Full Text] [PDF]  

Endocrine Care:

Gherardo Mazziotti, Antonio Bianchi, Stefania Bonadonna, Vincenzo Cimino, Ilaria Patelli, Alessandra Fusco, Alfredo Pontecorvi, Laura De Marinis, and Andrea Giustina

Prevalence of Vertebral Fractures in Men with Acromegaly
J Clin Endocrinol Metab 2008 93: 4649-4655 , doi:10.1210/jc.2008-0791 [Abstract] [Full Text] [PDF]  
This review reports the high prevalence of osteoporotic vertebral fractures assessed with the morphometric approach in an unselected acromegalic male population.

Benjamin T. Bikman, Donghai Zheng, Walter J. Pories, William Chapman, John R. Pender, Rita C. Bowden, Melissa A. Reed, Ronald N. Cortright, Edward B. Tapscott, Joseph A. Houmard, Charles J. Tanner, Jihyun Lee, and G. Lynis Dohm

Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
J Clin Endocrinol Metab 2008 93: 4656-4663 , doi:10.1210/jc.2008-1030 [Abstract] [Full Text] [PDF]  
Insulin sensitivity is greater than expected in regards to body mass index in patients following gastric bypass surgery, suggesting improved skeletal muscle insulin signaling as a likely mechanism.

Julia Wilkens, Kristof Chwalisz, Cong Han, Jane Walker, Iain T. Cameron, Susan Ingamells, Alexandra C. Lawrence, Mary Ann Lumsden, Dharani Hapangama, Alistair R. W. Williams, and Hilary O. D. Critchley

Effects of the Selective Progesterone Receptor Modulator Asoprisnil on Uterine Artery Blood Flow, Ovarian Activity, and Clinical Symptoms in Patients with Uterine Leiomyomata Scheduled for Hysterectomy
J Clin Endocrinol Metab 2008 93: 4664-4671 , doi:10.1210/jc.2008-1104 [Abstract] [Full Text] [PDF]  
Selective progesterone receptor modulator, Asoprisnil, moderately reduces uterine artery blood flow and decreases menstrual bleeding mostly with continued ovarian follicular activity in patients with uterine fibroids.

Frédéric Jehan, Céline Gaucher, Thi Minh Nguyen, Odile Walrant-Debray, Najiba Lahlou, Christiane Sinding, Michèle Déchaux, and Michèle Garabédian

Vitamin D Receptor Genotype in Hypophosphatemic Rickets as a Predictor of Growth and Response to Treatment
J Clin Endocrinol Metab 2008 93: 4672-4682 , doi:10.1210/jc.2007-2553 [Abstract] [Full Text] [PDF]  
Short stature is often observed in patients with hypophosphatemic rickets despite treatment with phosphates and 1alpha-hydroxylated derivatives of vitamin D3. Vitamine D receptor promoter genotype is a major contributor in the variability of growth and urinary calcium excretion in treated patients.

Won Gu Kim, Jong Ho Yoon, Won Bae Kim, Tae Yong Kim, Eui Young Kim, Jung Min Kim, Jin-Sook Ryu, Gyungyub Gong, Suck Joon Hong, and Young Kee Shong

Change of Serum Antithyroglobulin Antibody Levels Is Useful for Prediction of Clinical Recurrence in Thyroglobulin-Negative Patients with Differentiated Thyroid Carcinoma
J Clin Endocrinol Metab 2008 93: 4683-4689 , doi:10.1210/jc.2008-0962 [Abstract] [Full Text] [PDF]  
In thyroid cancer patients treated with surgery and radioiodine ablation, not only the presence of Tg-antibody at 1 year after ablation, but changing patterns, can predict recurrences.

Liang Sun, Oscar H. Franco, Frank B. Hu, Lu Cai, Zhijie Yu, Huaixing Li, Xingwang Ye, Qibin Qi, Jing Wang, An Pan, Yong Liu, and Xu Lin

Ferritin Concentrations, Metabolic Syndrome, and Type 2 Diabetes in Middle-Aged and Elderly Chinese
J Clin Endocrinol Metab 2008 93: 4690-4696 , doi:10.1210/jc.2008-1159 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In middle-aged and elderly Chinese, elevated plasma ferritin is independently associated with higher risk of type 2 diabetes and metabolic syndrome, suggesting the crucial role of iron overload in developing countries.

Kristiina Rull, Liina Nagirnaja, Veli-Matti Ulander, Piret Kelgo, Tõnu Margus, Milja Kaare, Kristiina Aittomäki, and Maris Laan

Chorionic Gonadotropin β-Gene Variants Are Associated with Recurrent Miscarriage in Two European Populations
J Clin Endocrinol Metab 2008 93: 4697-4706 , doi:10.1210/jc.2008-1101 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The genetic analysis of HCG β genes reveals common polymorphisms protective towards recurrent miscarriage in two populations and rare variants identified only in these patients.

Alina German, Suheir Suraiya, Yardena Tenenbaum-Rakover, Ilana Koren, Giora Pillar, and Ze'ev Hochberg

Control of Childhood Congenital Adrenal Hyperplasia and Sleep Activity and Quality with Morning or Evening Glucocorticoid Therapy
J Clin Endocrinol Metab 2008 93: 4707-4710 , doi:10.1210/jc.2008-0519 [Abstract] [Full Text] [PDF]  
Children with classical congenital adrenal hyperplasia on a high morning hydrocortisone dose versus a high evening dose show comparable disease control, sleep quality, and daytime activity.

Arthur Weltman, Judy Y. Weltman, Dee Dee Watson Winfield, Kirsten Frick, James Patrie, Petra Kok, Daniel M. Keenan, Glenn A. Gaesser, and Johannes D. Veldhuis

Effects of Continuous Versus Intermittent Exercise, Obesity, and Gender on Growth Hormone Secretion
J Clin Endocrinol Metab 2008 93: 4711-4720 , doi:10.1210/jc.2008-0998 [Abstract] [Full Text] [PDF]  
Although the response is attenuated in obese adults, one 30-min vs three 10-min bouts of exercise are equally effective for augmenting 24-h spontaneous GH secretion.

Masami Ono, Nobuhiro Miki, Takakazu Kawamata, Rena Makino, Kosaku Amano, Toshiro Seki, Osami Kubo, Tomokatsu Hori, and Kazue Takano

Prospective Study of High-Dose Cabergoline Treatment of Prolactinomas in 150 Patients
J Clin Endocrinol Metab 2008 93: 4721-4727 , doi:10.1210/jc.2007-2758 [Abstract] [Full Text] [PDF]  
Some prolactinomas respond poorly to dopamine agonists. But cabergoline normalizes hyperprolactinemia and hypogonadism in nearly all prolactinomas with treatment appropriately individualized based on post-treatment prolactin.

Carmen A. Carrasco, Joël Coste, Laurence Guignat, Lionel Groussin, Marie Annick Dugué, Stéphane Gaillard, Xavier Bertagna, and Jérôme Bertherat

Midnight Salivary Cortisol Determination for Assessing the Outcome of Transsphenoidal Surgery in Cushing’s Disease
J Clin Endocrinol Metab 2008 93: 4728-4734 , doi:10.1210/jc.2008-1171 [Abstract] [Full Text] [PDF]  
Midnight salivary cortisol can be a simple and robust marker of remission after transsphenoidal surgery for Cushing’s disease.

Minouk J. Schoemaker, Anthony J. Swerdlow, Craig D. Higgins, Alan F. Wright, Patricia A. Jacobs on behalf of the United Kingdom Clinical Cytogenetics Group

Mortality in Women with Turner Syndrome in Great Britain: A National Cohort Study
J Clin Endocrinol Metab 2008 93: 4735-4742 , doi:10.1210/jc.2008-1049 [Abstract] [Full Text] [PDF]  
Women with Turner syndrome are subject to raised mortality from almost all major causes of death, with the greatest excess mortality in older adulthood.

Kathleen M. Hill, Michelle Braun, Mark Kern, Berdine R. Martin, James W. Navalta, Darlene A. Sedlock, Linda McCabe, George P. McCabe, Munro Peacock, and Connie M. Weaver

Predictors of Calcium Retention in Adolescent Boys
J Clin Endocrinol Metab 2008 93: 4743-4748 , doi:10.1210/jc.2008-0957 [Abstract] [Full Text] [PDF]  
A metabolic balance study in adolescent boys shows that calcium intake and serum IGF-1 predict calcium retention.

Giorgio Radetti, Wolfgang Kleon, Fabio Buzi, Claudio Crivellaro, Lucia Pappalardo, Natascia di Iorgi, and Mohamad Maghnie

Thyroid Function and Structure Are Affected in Childhood Obesity
J Clin Endocrinol Metab 2008 93: 4749-4754 , doi:10.1210/jc.2008-0823 [Abstract] [Full Text] [PDF]  
Obese children frequently show changes of thyroid function and structure, suggestive of Hashimoto’s thyroiditis, but without any evidence of thyroid autoimmunity.

Kari Hemminki, Xiaochen Shu, Xinjun Li, Jianguang Ji, Jan Sundquist, and Kristina Sundquist

Familial Risks for Hospitalization with Endocrine Diseases
J Clin Endocrinol Metab 2008 93: 4755-4758 , doi:10.1210/jc.2008-1210 [Abstract] [Full Text] [PDF]  
Familial clustering of hospitalized endocrine disease is high presently, whereas the reason, bias, or possible recessive effects calls for further studies.

Koji Nakanishi and Chizuru Watanabe

Rate of β-Cell Destruction in Type 1 Diabetes Influences the Development of Diabetic Retinopathy: Protective Effect of Residual β-Cell Function for More Than 10 Years
J Clin Endocrinol Metab 2008 93: 4759-4766 , doi:10.1210/jc.2008-1209 [Abstract] [Full Text] [PDF]  
Undetectable β-cell function within 10 years of the onset of type 1 diabetes is associated with the earlier occurrence of diabetic retinopathy.

Catherine M. Jankowski, Wendolyn S. Gozansky, John M. Kittelson, Rachael E. Van Pelt, Robert S. Schwartz, and Wendy M. Kohrt

Increases in Bone Mineral Density in Response to Oral Dehydroepiandrosterone Replacement in Older Adults Appear to Be Mediated by Serum Estrogens
J Clin Endocrinol Metab 2008 93: 4767-4773 , doi:10.1210/jc.2007-2614 [Abstract] [Full Text] [PDF]  
The effects of DHEA treatment to increase bone mineral density of the total hip and trochanteric/shaft subregions in older adults are mediated by increases in serum estradiol, but not testosterone or IGF-1.

Robert E. Ratner, Costas A. Christophi, Boyd E. Metzger, Dana Dabelea, Peter H. Bennett, Xavier Pi-Sunyer, Sarah Fowler, Steven E. Kahn The Diabetes Prevention Program Research Group

Prevention of Diabetes in Women with a History of Gestational Diabetes: Effects of Metformin and Lifestyle Interventions
J Clin Endocrinol Metab 2008 93: 4774-4779 , doi:10.1210/jc.2008-0772 [Abstract] [Full Text] [PDF]  
Diabetes development is more common in women with gestational diabetes mellitus histories compared to those without, despite similar degrees of impaired glucose tolerance; lifestyle and metformin equivalently delay diabetes.

Brooke Rossi, Sara Sukalich, Jennifer Droz, Adam Griffin, Stephen Cook, Aaron Blumkin, David S. Guzick, and Kathleen M. Hoeger

Prevalence of Metabolic Syndrome and Related Characteristics in Obese Adolescents with and without Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2008 93: 4780-4786 , doi:10.1210/jc.2008-1198 [Abstract] [Full Text] [PDF]  
Obese adolescent women have a high prevalence of metabolic syndrome irrespective of polycystic ovary syndrome status, which is associated with the amount of visceral adiposity.

Herbert Marini, Alessandra Bitto, Domenica Altavilla, Bruce P. Burnett, Francesca Polito, Vincenzo Di Stefano, Letteria Minutoli, Marco Atteritano, Robert M. Levy, Rosario D'Anna, Nicola Frisina, Susanna Mazzaferro, Francesco Cancellieri, Maria Letizia Cannata, Francesco Corrado, Alessia Frisina, Vincenzo Adamo, Carla Lubrano, Carlo Sansotta, Rolando Marini, Elena Bianca Adamo, and Francesco Squadrito

Breast Safety and Efficacy of Genistein Aglycone for Postmenopausal Bone Loss: A Follow-Up Study
J Clin Endocrinol Metab 2008 93: 4787-4796 , doi:10.1210/jc.2008-1087 [Abstract] [Full Text] [PDF]  
Genistein aglycone is a phytoestrogen that exhibits a promising safety profile with positive effects on bone formation in a subcohort of osteopenic, postmenopausal women.

Ramona Rus, Christine Haag, Christiane Bumke-Vogt, Volker Bähr, Bernhard Mayr, Matthias Möhlig, Egbert Schulze, Karin Frank-Raue, Friedhelm Raue, and Christof Schöfl

Novel Inactivating Mutations of the Calcium-Sensing Receptor: The Calcimimetic NPS R-568 Improves Signal Transduction of Mutant Receptors
J Clin Endocrinol Metab 2008 93: 4797-4803 , doi:10.1210/jc.2008-1076 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Novel inactivating mutations of the calcium-sensing receptor are functionally characterized. Rescue of receptor signaling by calcimimetics may offer medical treatment for symptomatic patients with familial hypocalciuric hypercalcemia or neonatal severe hyperparathyroidism.

L. Joseph Melton, III, B. Lawrence Riggs, Cynthia L. Leibson, Sara J. Achenbach, Jon J. Camp, Mary L. Bouxsein, Elizabeth J. Atkinson, Richard A. Robb, and Sundeep Khosla

A Bone Structural Basis for Fracture Risk in Diabetes
J Clin Endocrinol Metab 2008 93: 4804-4809 , doi:10.1210/jc.2008-0639 [Abstract] [Full Text] [PDF]  
Patients with type 2 diabetes mellitus have greater trabecular volumetric bone mineral density, but overall bone load to bone strength ratios are not improved compared to non-diabetic controls.

Jessica E. Matthews, Murray W. Stewart, Erika H. De Boever, Robert L. Dobbins, Rebecca J. Hodge, Susan E. Walker, M. Claire Holland, Mark A. Bush for the Albiglutide Study Group

Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Albiglutide, a Long-Acting Glucagon-Like Peptide-1 Mimetic, in Patients with Type 2 Diabetes
J Clin Endocrinol Metab 2008 93: 4810-4817 , doi:10.1210/jc.2008-1518 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Albiglutide improves glycemic control in subjects with type 2 diabetes, with a favorable safety profile and the potential for once-weekly or less-frequent dosing.

Mariola Peczkowska, Zoran Erlic, Michael M. Hoffmann, Mariusz Furmanek, Jaroslaw Cwikla, Agata Kubaszek, Aleksander Prejbisz, Zbigniew Szutkowski, Andrzej Kawecki, Krzysztof Chojnowski, Anna Lewczuk, Mieczyslaw Litwin, Witold Szyfter, Martin A. Walter, Maren Sullivan, Charis Eng, Andrzej Januszewicz, and Hartmut P. H. Neumann

Impact of Screening Kindreds for SDHD p.Cys11X as a Common Mutation Associated with Paraganglioma Syndrome Type 1
J Clin Endocrinol Metab 2008 93: 4818-4825 , doi:10.1210/jc.2008-1290 [Abstract] [Full Text] [PDF]  
The p.Cys11X mutation of the succinate dehydrogenase D subunit is a founding mutation associated with a high penetrance for paraganglial tumors of the skull base, neck, thorax, and retroperitoneum in the first four decades of life and rarely with malignancy.

Henri J. L. M. Timmers, Karel Pacak, Thanh T. Huynh, Mones Abu-Asab, Maria Tsokos, Maria J. Merino, Bora E. Baysal, Karen T. Adams, and Graeme Eisenhofer

Biochemically Silent Abdominal Paragangliomas in Patients with Mutations in the Succinate Dehydrogenase Subunit B Gene
J Clin Endocrinol Metab 2008 93: 4826-4832 , doi:10.1210/jc.2008-1093 [Abstract] [Full Text] [PDF]  
Succinate dehydrogenase subunit B-related paragangliomas may be biochemically silent as a result of defective catecholamine synthesis due to absence of tyrosine hydroxylase.

Karoliina Wehkalampi, Elisabeth Widén, Tiina Laine, Aarno Palotie, and Leo Dunkel

Association of the Timing of Puberty with a Chromosome 2 Locus
J Clin Endocrinol Metab 2008 93: 4833-4839 , doi:10.1210/jc.2008-0882 [Abstract] [Full Text] [PDF]  
A locus on chromosome 2 associates with constitutional delay of puberty (CDGP) in extended multiply affected Finnish families.

Enrico Brignardello, Andrea Corrias, Giuseppe Isolato, Nicola Palestini, Luca Cordero di Montezemolo, Franca Fagioli, and Giuseppe Boccuzzi

BRIEF REPORT:Ultrasound Screening for Thyroid Carcinoma in Childhood Cancer Survivors: A Case Series
J Clin Endocrinol Metab 2008 93: 4840-4843 , doi:10.1210/jc.2008-1528 [Abstract] [Full Text] [PDF]  
Ultrasound screening for thyroid carcinoma in childhood cancer survivors is worthy because it detects unpalpable thyroid cancers, some of which contain nodal metastases.

Kathleen Freson, Benedetta Izzi, Jaak Jaeken, Monique Van Helvoirt, Chantal Thys, Christine Wittevrongel, Francis de Zegher, and Chris Van Geet

BRIEF REPORT:Compound Heterozygous Mutations in the GNAS Gene of a Boy with Morbid Obesity, Thyroid-Stimulating Hormone Resistance, Pseudohypoparathyroidism, and a Prothrombotic State
J Clin Endocrinol Metab 2008 93: 4844-4849 , doi:10.1210/jc.2008-0233 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A patient with severe pseudohypoparathyroidism type Ia and a thrombotic tendency carries a de novo missense mutation on his paternal stimulatory guanine nucleotide binding protein (GNAS) allele, maternally inherited single nucleotide polymorphisms linked to alternative GNAS splicing, and reduced platelet expression of the alpha subunit of the stimulatory G protein of adenylyl cylcase, Gs.

Endocrine Research:

Kathleen Freson, Benedetta Izzi, Veerle Labarque, Monique Van Helvoirt, Chantal Thys, Christine Wittevrongel, Marie Bex, Roger Bouillon, Nathalie Godefroid, Willem Proesmans, Francis de Zegher, Jaak Jaeken, and Chris Van Geet

GNAS Defects Identified by Stimulatory G Protein -Subunit Signalling Studies in Platelets
J Clin Endocrinol Metab 2008 93: 4851-4859 , doi:10.1210/jc.2008-0883 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Functional studies of the stimulatory G protein subunit (GNAS) in platelets from pseudohypoparathyroidism (PHP) patients show hypofunction in PHPIa, mild hypofunction in PHPIb with an overall epigenetic defect, and normal GNAS function in PHPIb with an exon 1A-only epigenetic defect.

Robin P. F. Dullaart, Frank Perton, Wim J. Sluiter, Rindert de Vries, and Arie van Tol

Plasma Lecithin: Cholesterol Acyltransferase Activity Is Elevated in Metabolic Syndrome and Is an Independent Marker of Increased Carotid Artery Intima Media Thickness
J Clin Endocrinol Metab 2008 93: 4860-4866 , doi:10.1210/jc.2008-1213 [Abstract] [Full Text] [PDF]  
Plasma lecithin:cholesterol acyltransferase activity is elevated in metabolic syndrome and may be a marker of subclinical atherosclerosis, as suggested by its association with intima media thickness.

Anna Kotronen, Moira Lewitt, Kerstin Hall, Kerstin Brismar, and Hannele Yki-Järvinen

Insulin-Like Growth Factor Binding Protein 1 as a Novel Specific Marker of Hepatic Insulin Sensitivity
J Clin Endocrinol Metab 2008 93: 4867-4872 , doi:10.1210/jc.2008-1245 [Abstract] [Full Text] [PDF]  
In non-diabetic subjects, fasting serum insulin-like growth factor binding protein 1 is inversely correlated with liver fat content and is an obesity-independent and liver-specific circulating marker of hepatic insulin sensitivity.

Taru Tervo, Peter Nordström, Martin Neovius, and Anna Nordström

Constant Adaptation of Bone to Current Physical Activity Level in Men: A 12-Year Longitudinal Study
J Clin Endocrinol Metab 2008 93: 4873-4879 , doi:10.1210/jc.2008-1313 [Abstract] [Full Text] [PDF]  
Bone mineral density at the neck and spine constantly adapts to the present physical activity level in men during 12 years of follow up.

Louise E. Olofsson, Marju Orho-Melander, Lena William-Olsson, Kajsa Sjöholm, Lars Sjöström, Leif Groop, Björn Carlsson, Lena M. S. Carlsson, and Bob Olsson

CCAAT/Enhancer Binding Protein (C/EBP) in Adipose Tissue Regulates Genes in Lipid and Glucose Metabolism and a Genetic Variation in C/EBP Is Associated with Serum Levels of Triglycerides
J Clin Endocrinol Metab 2008 93: 4880-4886 , doi:10.1210/jc.2008-0574 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Adipose tissue C/EBP regulates several genes involved in glucose and lipid metabolism. A genetic variation in C/EBP is associated with triglycerides in two independent populations.

Renée F. Johnson, Natascha Rennie, Vanessa Murphy, Tamas Zakar, Vicki Clifton, and Roger Smith

Expression of Glucocorticoid Receptor Messenger Ribonucleic Acid Transcripts in the Human Placenta at Term
J Clin Endocrinol Metab 2008 93: 4887-4893 , doi:10.1210/jc.2008-1077 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Alterations in glucocorticoid receptor (GR) mRNA transcript expression and promoter usage, particularly for GR-P and GR-1A3, respectively, may alter the cortisol responsiveness in human placenta at term.

Gijs Afink, Willem Kulik, Henk Overmars, Janine de Randamie, Truus Veenboer, Arno van Cruchten, Margarita Craen, and Carrie Ris-Stalpers

Molecular Characterization of Iodotyrosine Dehalogenase Deficiency in Patients with Hypothyroidism
J Clin Endocrinol Metab 2008 93: 4894-4901 , doi:10.1210/jc.2008-0865 [Abstract] [Full Text] [PDF] [Supplemental Data]  
The molecular basis of congenital hypothyroidism due to iodine wasting is a functional iodotyrosine dehalogenase (IYD) gene mutation with a dominant pattern of inheritance and incomplete penetrance.

Kristel C. M. C. Koeijvoets, Jeroen B. van der Net, Elisabeth F. C. van Rossum, Ewout W. Steyerberg, Joep C. Defesche, John J. P. Kastelein, Steven W. J. Lamberts, and Eric J. G. Sijbrands

Two Common Haplotypes of the Glucocorticoid Receptor Gene Are Associated with Increased Susceptibility to Cardiovascular Disease in Men with Familial Hypercholesterolemia
J Clin Endocrinol Metab 2008 93: 4902-4908 , doi:10.1210/jc.2008-0813 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In men but not in women with familial hypercholesterolemia, variation of the glucocorticoid receptor gene influences the risk of cardiovascular disease independent of other risk factors.

Marzieh Salehi, Torsten P. Vahl, and David A. D'Alessio

Regulation of Islet Hormone Release and Gastric Emptying by Endogenous Glucagon-Like Peptide 1 after Glucose Ingestion
J Clin Endocrinol Metab 2008 93: 4909-4916 , doi:10.1210/jc.2008-0605 [Abstract] [Full Text] [PDF]  
In healthy humans, endogenous glucagon-like peptide-1 regulates glucose tolerance by increasing insulin release and inhibiting glucagon secretion, but not by affecting gastric emptying.

Krista Casazza, Paul B. Higgins, José R. Fernández, Michael I. Goran, and Barbara A. Gower

Longitudinal Analysis of the Insulin-Like Growth Factor System in African-American and European American Children and Adolescents
J Clin Endocrinol Metab 2008 93: 4917-4923 , doi:10.1210/jc.2008-0999 [Abstract] [Full Text] [PDF]  
African Americans have higher IGF-I concentrations than European Americans only in pre-puberty and lower concentrations of insulin-like growth factor binding protein 3 (IGFBP-3) and IGFBP-1 throughout the pubertal transition; the lower IGFBP-1 of African Americans is due in part to the higher acute insulin response to glucose (AIGg), suggesting physiological relevance for the frequently reported higher AIRg among African Americans.

Maria Beatrice Morelli, Marzia Barberi, Alessia Gambardella, Andrea Borini, Sandra Cecconi, Giovanni Coticchio, and Rita Canipari

Characterization, Expression, and Functional Activity of Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors in Human Granulosa-Luteal Cells
J Clin Endocrinol Metab 2008 93: 4924-4932 , doi:10.1210/jc.2007-2621 [Abstract] [Full Text] [PDF]  
Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide receptors are found in human granulosa-luteal cells, suggesting their possible role in maintaining follicle viability.

Sophie Deram, Christiane Y. Nicolau, Pablo Perez-Martinez, Isabel Guazzelli, Alfredo Halpern, Bernardo L. Wajchenberg, Jose M. Ordovas, and Sandra M. Villares

Effects of Perilipin (PLIN) Gene Variation on Metabolic Syndrome Risk and Weight Loss in Obese Children and Adolescents
J Clin Endocrinol Metab 2008 93: 4933-4940 , doi:10.1210/jc.2008-0947 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Perilipin single nucleotide polymorphisms are associated with higher risk of metabolic syndrome (A carriers at PLIN4 11482GA) and better weight-loss during lifestyle intervention (T carriers at PLIN6 14995AT) on obese children and adolescents.

L. Damaj, M. le Lorch, V. Verkarre, C. Werl, L. Hubert, C. Nihoul-Fékété, Y. Aigrain, Y. de Keyzer, S. P. Romana, C. Bellanne-Chantelot, P. de Lonlay, and F. Jaubert

Chromosome 11p15 Paternal Isodisomy in Focal Forms of Neonatal Hyperinsulinism
J Clin Endocrinol Metab 2008 93: 4941-4947 , doi:10.1210/jc.2008-0673 [Abstract] [Full Text] [PDF]  
The authors report chromosome 11p15 isodisomy of paternal origin in focal forms of congenital hyperinsulinism, explaining the numerous β cells in the lesion.

T. T. Chung, T. R. Webb, L. F. Chan, S. N. Cooray, L. A. Metherell, P. J. King, J. P. Chapple, and A. J. L. Clark

The Majority of Adrenocorticotropin Receptor (Melanocortin 2 Receptor) Mutations Found in Familial Glucocorticoid Deficiency Type 1 Lead to Defective Trafficking of the Receptor to the Cell Surface
J Clin Endocrinol Metab 2008 93: 4948-4954 , doi:10.1210/jc.2008-1744 [Abstract] [Full Text] [PDF]  
The majority of ACTH receptor mutations found in familial glucocorticoid deficiency do not function because they fail to traffic to the cell surface.

Karine Clément, Béatrice Dubern, Monica Mencarelli, Paul Czernichow, Shosuke Ito, Kazumasa Wakamatsu, Gregory S. Barsh, Christian Vaisse, and Juliane Leger

Unexpected Endocrine Features and Normal Pigmentation in a Young Adult Patient Carrying a Novel Homozygous Mutation in the POMC Gene
J Clin Endocrinol Metab 2008 93: 4955-4962 , doi:10.1210/jc.2008-1164 [Abstract] [Full Text] [PDF]  
The absence of a pigmentary phenotype and/or the presence of multiple pituitary hormone anomalies do not exclude a pro-opiomelanocortin mutation in patients with adrenal insufficiency and obesity.

Evangelia Charmandari, Takamasa Ichijo, William Jubiz, Smita Baid, Keith Zachman, George P. Chrousos, and Tomoshige Kino

BRIEF REPORT:A Novel Point Mutation in the Amino Terminal Domain of the Human Glucocorticoid Receptor (hGR) Gene Enhancing hGR-Mediated Gene Expression
J Clin Endocrinol Metab 2008 93: 4963-4968 , doi:10.1210/jc.2008-0892 [Abstract] [Full Text] [PDF]  
A novel mutation of the human glucocorticoid receptor (hGR) gene enhances its gene expression and may predispose subjects to obesity, hypertension, and metabolic syndrome-related atherosclerotic cardiovascular disease.

Blerina Kola, Mirjam Christ-Crain, Francesca Lolli, Giorgio Arnaldi, Gilberta Giacchetti, Marco Boscaro, Ashley B. Grossman, and Márta Korbonits

BRIEF REPORT:Changes in Adenosine 5'-Monophosphate-Activated Protein Kinase as a Mechanism of Visceral Obesity in Cushing’s Syndrome
J Clin Endocrinol Metab 2008 93: 4969-4973 , doi:10.1210/jc.2008-1297 [Abstract] [Full Text] [PDF]  
Glucocorticoid excess reduces adenosine monophosphate-activated protein kinase activity in visceral fat tissue of patients with Cushing’s syndrome, suggesting a novel mechanism for the increased central obesity and for the deleterious metabolic effects of hypercortisolemia.

Jens Tank, Karsten Heusser, Andre Diedrich, Dagmara Hering, Friedrich C. Luft, Andreas Busjahn, Krzysztof Narkiewicz, and Jens Jordan

BRIEF REPORT:Influences of Gender on the Interaction between Sympathetic Nerve Traffic and Central Adiposity
J Clin Endocrinol Metab 2008 93: 4974-4978 , doi:10.1210/jc.2007-2820 [Abstract] [Full Text] [PDF]  
A microneurography study in 111 healthy subjects demonstrates that muscle sympathetic nerve activity relates to waist-to-hip ratio in men but not in women.

Nicholette D. Palmer, Carl D. Langefeld, Michael Bryer-Ash, Jerome I. Rotter, Kent D. Taylor, and Donald W. Bowden

BRIEF REPORT:Association of the Kir6.2 E23K Variant with Reduced Acute Insulin Response in African-Americans
J Clin Endocrinol Metab 2008 93: 4979-4983 , doi:10.1210/jc.2008-0543 [Abstract] [Full Text] [PDF]  
In African Americans, Kir6.2 E23K and SUR1 A1369S mutations are associated with a significant reduction in insulin secretion in glucose-tolerant carriers of the minor alleles.

Announcements and Resources:

Erratum
J Clin Endocrinol Metab 2008 93: 4984 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Francine R. Kaufman, Robert H. Lustig, and Robert Vigersky

Patient Information Page from The Hormone Foundation:Patient Guide to the Prevention and Management of Pediatric Obesity
J Clin Endocrinol Metab 2008 93 [Full Text] [PDF]  

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