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The biological connections among human endometrial delayed genes at the day of embryonic implantation in controlled ovarian stimulated cycles compared to natural cycles by String (http://string.embl.de/) reveal that VEGF is a central target. In comparing the endometrial transcriptomics in natural versus controlled ovarian stimulated cycles during the early-mid secretory phase with microarray technology, we have observed a two-day functional genomic delay in the activation and/or repression of two clusters composed by 218 and 133 endometrial genes on the day that the embryo implants. From the article by Horcajadas et al., in this issue, pages 4500–4510.