The Endocrine Society:

Endocrinology & Metabolism News
J Clin Endocrinol Metab 2008 93: 17a-20a [Full Text] [PDF]  

Special Features:

Erik K. Alexander

APPROACH TO THE PATIENT:Approach to the Patient with a Cytologically Indeterminate Thyroid Nodule
J Clin Endocrinol Metab 2008 93: 4175-4182 doi:10.1210/jc.2008-1328 [Abstract] [Full Text] [PDF]  
This article examines the diagnostic and therapeutic approach to patients with cytologically indeterminate thyroid nodules.

A. P. Goldstone, A. J. Holland, B. P. Hauffa, A. C. Hokken-Koelega, M. Tauber on behalf of speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS

CLINICAL PRACTICE GUIDELINE:Recommendations for the Diagnosis and Management of Prader-Willi Syndrome
J Clin Endocrinol Metab 2008 93: 4183-4197 , doi:10.1210/jc.2008-0649 [Abstract] [Full Text] [PDF]  
Recommendations are provided for diagnosis and management of Prader-Willi syndrome to guide clinical practice throughout these patients' lifespans.

Pedro Iglesias, Roberto Olmos-García, Bernardo Riva, and Juan J. Díez

IMAGE IN ENDOCRINOLOGY:Iodine 131 and Lingual Thyroid
J Clin Endocrinol Metab 2008 93: 4198-4199 , doi:10.1210/jc.2008-0909 [Full Text] [PDF]  

Peter O. Kwiterovich, Jr.

CLINICAL REVIEW:Recognition and Management of Dyslipidemia in Children and Adolescents
J Clin Endocrinol Metab 2008 93: 4200-4209 , doi:10.1210/jc.2008-1270 [Abstract] [Full Text] [PDF]  
Early identification and treatment of youth at risk for early atherosclerosis requires an integrated assessment of predisposing cardiovascular disease risk factors and a comprehensive screening and treatment program.

P. Cohen, A. D. Rogol, C. L. Deal, P. Saenger, E. O. Reiter, J. L. Ross, S. D. Chernausek, M. O. Savage, J. M. Wit on behalf of the 2007 ISS Consensus Workshop participants

CONSENSUS STATEMENTS:Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop
J Clin Endocrinol Metab 2008 93: 4210-4217 , doi:10.1210/jc.2008-0509 [Abstract] [Full Text] [PDF]  
This multi-society consensus statement offers advice on the diagnosis and management of patients with idiopathic short stature.

Editorials:

Richard S. Legro

EDITORIAL:Impact of Metformin, Oral Contraceptives, and Lifestyle Modification on Polycystic Ovary Syndrome in Obese Adolescent Women: Do We Need a New Drug?
J Clin Endocrinol Metab 2008 93: 4218-4220 doi:10.1210/jc.2008-1994 [Full Text] [PDF]  

Gudmundur Johannsson

EDITORIAL:Central Adiposity as an Important Confounder in the Diagnosis of Adult Growth Hormone Deficiency
J Clin Endocrinol Metab 2008 93: 4221-4223 doi:10.1210/jc.2008-2020 [Full Text] [PDF]  

Stephanie B. Seminara

EDITORIAL:Lack of Association of Hypogonadotropic Genes with Age at Menarche: Prospects for the Future
J Clin Endocrinol Metab 2008 93: 4224-4225 doi:10.1210/jc.2008-2010 [Full Text] [PDF]  

Matthew D. Ringel

EDITORIAL:"Thyroid Cancer" Cell Line Misidentification: A Time for Proactive Change
J Clin Endocrinol Metab 2008 93: 4226-4227 doi:10.1210/jc.2008-2008 [Full Text] [PDF]  

Rosanna Roman and Philip S. Zeitler

EDITORIAL:Oral Glucose Tolerance Testing in Asymptomatic Obese Children: More Questions than Answers
J Clin Endocrinol Metab 2008 93: 4228-4230 doi:10.1210/jc.2008-1993 [Full Text] [PDF]  

Endocrine Care:

I. M. Libman, E. Barinas-Mitchell, A. Bartucci, R. Robertson, and S. Arslanian

Reproducibility of the Oral Glucose Tolerance Test in Overweight Children
J Clin Endocrinol Metab 2008 93: 4231-4237 , doi:10.1210/jc.2008-0801 [Abstract] [Full Text] [PDF]  
Poor reproducibility of the oral glucose tolerance test is seen in obese youth, in particular for the 2-hour plasma glucose.

Deborah J. Wexler, David M. Nathan, Richard W. Grant, Susan Regan, Allison L. Van Leuvan, and Enrico Cagliero

Prevalence of Elevated Hemoglobin A1c among Patients Admitted to the Hospital without a Diagnosis of Diabetes
J Clin Endocrinol Metab 2008 93: 4238-4244 , doi:10.1210/jc.2008-1090 [Abstract] [Full Text] [PDF]  
Eighteen percent of patients admitted to a general hospital had undiagnosed diabetes, but only 15% of these patients with follow-up data available had evaluation for, or diagnosis of, diabetes within the year following admission.

Rasa Kazlauskaite, Arthur T. Evans, Carmen V. Villabona, Tariq A. M. Abdu, Bruno Ambrosi, A. Brew Atkinson, Cheung Hei Choi, Richard N. Clayton, C. Hamish Courtney, E. Nazli Gonc, Mohamad Maghnie, Susan R. Rose, Steven G. Soule, Karen Tordjman Consortium for Evaluation of Corticotropin Test in Hypothalamic-Pituitary Adrenal Insufficiency

Corticotropin Tests for Hypothalamic-Pituitary- Adrenal Insufficiency: A Metaanalysis
J Clin Endocrinol Metab 2008 93: 4245-4253 , doi:10.1210/jc.2008-0710 [Abstract] [Full Text] [PDF]  
A meta-analysis of data from 13 studies with 679 subjects determines that the low-dose corticotropin stimulation test is superior to the standard-dose test for diagnosing hypothalamic-pituitary-adrenal insufficiency. However, the low-dose test has some technical limitations.

Hideo Makimura, Takara Stanley, David Mun, Sung Min You, and Steven Grinspoon

The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men
J Clin Endocrinol Metab 2008 93: 4254-4260 , doi:10.1210/jc.2008-1333 [Abstract] [Full Text] [PDF]  
This study demonstrates an independent association between peak GH response to GHRH arginine and waist circumference, controlling for body mass index. Waist circumference should be considered in addition to body mass index in interpreting results of the GHRH-arginine stimulation test.

Yoshihiro Maruo, Hiroko Takahashi, Ikumi Soeda, Noriko Nishikura, Katsuyuki Matsui, Yoriko Ota, Yu Mimura, Asami Mori, Hiroshi Sato, and Yoshihiro Takeuchi

Transient Congenital Hypothyroidism Caused by Biallelic Mutations of the Dual Oxidase 2 Gene in Japanese Patients Detected by a Neonatal Screening Program
J Clin Endocrinol Metab 2008 93: 4261-4267 , doi:10.1210/jc.2008-0856 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Biallelic mutations of the dual oxidase 2 (DUOX2) gene cause transient congenital hypothyroidism.

Glenn D. Braunstein, B. Delia Johnson, Frank Z. Stanczyk, Vera Bittner, Sarah L. Berga, Leslee Shaw, T. Keta Hodgson, Maura Paul-Labrador, Ricardo Azziz, and C. Noel Bairey Merz

Relations between Endogenous Androgens and Estrogens in Postmenopausal Women with Suspected Ischemic Heart Disease
J Clin Endocrinol Metab 2008 93: 4268-4275 , doi:10.1210/jc.2008-0792 [Abstract] [Full Text] [PDF]  
Epidemiologic studies that relate sex steroid hormones to pathological processes should control for the independent effect of both estrogens and androgens as they track together.

Nuria García de la Torre, Miguel A. Rubio, Elena Bordiú, Lucio Cabrerizo, Eugenio Aparicio, Carmen Hernández, Andrés Sánchez-Pernaute, Luis Díez-Valladares, Antonio J. Torres, Montserrat Puente, and Aniceto L. Charro

Effects of Weight Loss after Bariatric Surgery for Morbid Obesity on Vascular Endothelial Growth Factor-A, Adipocytokines, and Insulin
J Clin Endocrinol Metab 2008 93: 4276-4281 , doi:10.1210/jc.2007-1370 [Abstract] [Full Text] [PDF]  
Insulin, leptin, and serum vascular endothelial growth factor A levels are significantly higher in obese patients than in lean controls, and decrease after weight loss with bariatric surgery, suggesting the possibility of using anti-angiogenic drugs to treat obesity.

Dalal Alkazemi, Grace Egeland, Jacob Vaya, Sara Meltzer, and Stan Kubow

Oxysterol as a Marker of Atherogenic Dyslipidemia in Adolescence
J Clin Endocrinol Metab 2008 93: 4282-4289 , doi:10.1210/jc.2008-0586 [Abstract] [Full Text] [PDF]  
In a healthy cohort of adolescent women, serum oxysterol concentrations are positively associated with apolipoprotein B and insulin, early metabolic risk markers of cardiovascular dysfunction.

Zofia K. Z. Gajdos, Johannah L. Butler, Katherine DeLellis Henderson, Chunyan He, Pamela J. Supelak, Matthew Egyud, Alkes Price, David Reich, Peter E. Clayton, Loic Le Marchand, David J. Hunter, Brian E. Henderson, Mark R. Palmert, and Joel N. Hirschhorn

Association Studies of Common Variants in 10 Hypogonadotropic Hypogonadism Genes with Age at Menarche
J Clin Endocrinol Metab 2008 93: 4290-4298 , doi:10.1210/jc.2008-0981 [Abstract] [Full Text] [PDF] [Supplemental Data]  
A genetic study in a large, multiethnic cohort finds no association between age at menarche and common variants in 10 genes related to hypogonadotropic hypogonadism.

Kathleen Hoeger, Kristen Davidson, Lynda Kochman, Tracy Cherry, Laurie Kopin, and David S. Guzick

The Impact of Metformin, Oral Contraceptives, and Lifestyle Modification on Polycystic Ovary Syndrome in Obese Adolescent Women in Two Randomized, Placebo-Controlled Clinical Trials
J Clin Endocrinol Metab 2008 93: 4299-4306 , doi:10.1210/jc.2008-0461 [Abstract] [Full Text] [PDF]  
Preliminary data from two small clinical trials indicate lifestyle modification with or without metformin therapy improved androgen, lipoprotein, and inflammatory marker levels in obese adolescent women with polycystic ovary syndrome.

R. W. J. Leunissen, G. F. Kerkhof, T. Stijnen, and A. C. S. Hokken-Koelega

Fat Mass and Apolipoprotein E Genotype Influence Serum Lipoprotein Levels in Early Adulthood, whereas Birth Size Does Not
J Clin Endocrinol Metab 2008 93: 4307-4314 , doi:10.1210/jc.2008-0621 [Abstract] [Full Text] [PDF]  
Fat accumulation during childhood and apoE genotype, but not birth size, are significant determinants of serum lipid levels in young adulthood, underlining the importance of preventing excess fat accumulation in children.

Frédéric Capel, Nathalie Viguerie, Nathalie Vega, Sébastien Dejean, Peter Arner, Eva Klimcakova, J. Alfredo Martinez, Wim H. M. Saris, Claus Holst, Moira Taylor, Jean M. Oppert, Thorkild I. A. Sørensen, Karine Clément, Hubert Vidal, and Dominique Langin

Contribution of Energy Restriction and Macronutrient Composition to Changes in Adipose Tissue Gene Expression during Dietary Weight-Loss Programs in Obese Women
J Clin Endocrinol Metab 2008 93: 4315-4322 , doi:10.1210/jc.2008-0814 [Abstract] [Full Text] [PDF] [Supplemental Data]  
In women following a weight-reducing hypocaloric diet, energy restriction has a more pronounced impact on human adipose tissue gene expression than its fat and carbohydrate composition.

Dalia L. Batista, Nikos Courcoutsakis, Jehan Riar, Margaret F. Keil, and Constantine A. Stratakis

Severe Obesity Confounds the Interpretation of Low-Dose Dexamethasone Test Combined with the Administration of Ovine Corticotrophin-Releasing Hormone in Childhood Cushing Syndrome
J Clin Endocrinol Metab 2008 93: 4323-4330 , doi:10.1210/jc.2008-0985 [Abstract] [Full Text] [PDF]  
The combined administration of low dose dexamethasone and ovine CRH testing is not as good a test for the differential diagnosis of Cushing's versus pseudo-Cushing's syndrome in pediatric patients.

Rebecca E. Schweppe, Joshua P. Klopper, Christopher Korch, Umarani Pugazhenthi, Miriam Benezra, Jeffrey A. Knauf, James A. Fagin, Laura A. Marlow, John A. Copland, Robert C. Smallridge, and Bryan R. Haugen

Deoxyribonucleic Acid Profiling Analysis of 40 Human Thyroid Cancer Cell Lines Reveals Cross-Contamination Resulting in Cell Line Redundancy and Misidentification
J Clin Endocrinol Metab 2008 93: 4331-4341 , doi:10.1210/jc.2008-1102 [Abstract] [Full Text] [PDF]  
Genetic profiling shows that only 23 of 40 presumed thyroid cancer cell lines are unique, 6 are redundant, and 13 are not of thyroid origin.

Kerstin Albertsson-Wikland, A. Stefan Aronson, Jan Gustafsson, Lars Hagenäs, Sten A. Ivarsson, Björn Jonsson, Berit Kriström, Claude Marcus, Karl Olof Nilsson, E. Martin Ritzén, Torsten Tuvemo, Otto Westphal, and Jan Åman

Dose-Dependent Effect of Growth Hormone on Final Height in Children with Short Stature without Growth Hormone Deficiency
J Clin Endocrinol Metab 2008 93: 4342-4350 , doi:10.1210/jc.2008-0707 [Abstract] [Full Text] [PDF]  
GH-treatment of short children from peripuberty until the time of final height showed a dose-dependent height gain leading to a 1 standard deviation-increase in final height compared to randomized untreated controls.

Daniel Diaczok, Christopher Romero, Janice Zunich, Ian Marshall, and Sally Radovick

A Novel Dominant Negative Mutation of OTX2 Associated with Combined Pituitary Hormone Deficiency
J Clin Endocrinol Metab 2008 93: 4351-4359 , doi:10.1210/jc.2008-1189 [Abstract] [Full Text] [PDF]  
A novel heterozygous mutation in OTX2 was found in two patients with combined pituitary hormone deficiency. The mutant protein binds normally to target sequences, but functions as a dominant negative inhibitor of HESX1 expression, resulting in hypopituitarism.

Peder Wiklund, Fredrik Toss, Lars Weinehall, Göran Hallmans, Paul W. Franks, Anna Nordström, and Peter Nordström

Abdominal and Gynoid Fat Mass Are Associated with Cardiovascular Risk Factors in Men and Women
J Clin Endocrinol Metab 2008 93: 4360-4366 , doi:10.1210/jc.2008-0804 [Abstract] [Full Text] [PDF]  
Abdominal fat mass measured by dual energy X-ray absorptiometry is generally the best predictor of multiple risk factors for cardiovascular disease.

Lei Ye, Libero Santarpia, Gilbert J. Cote, Adel K. El-Naggar, and Robert F. Gagel

High Resolution Array-Comparative Genomic Hybridization Profiling Reveals Deoxyribonucleic Acid Copy Number Alterations Associated with Medullary Thyroid Carcinoma
J Clin Endocrinol Metab 2008 93: 4367-4372 , doi:10.1210/jc.2008-0912 [Abstract] [Full Text] [PDF]  
A high density array comparative genomic hybridization study defining genomic chromosomal alterations associated with medullary thyroid carcinoma reveals partial similar gene profiles in different medullary thyroid carcinomas subgroups, and supports the importance of candidate tumor suppressor genes in medullary thyroid carcinoma tumorigenesis.

R. Murphy, J. Baptista, J. Holly, A. M. Umpleby, S. Ellard, L. W. Harries, J. Crolla, T. Cundy, and A. T. Hattersley

Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 Gene
J Clin Endocrinol Metab 2008 93: 4373-4380 , doi:10.1210/jc.2008-0819 [Abstract] [Full Text] [PDF] [Supplemental Data]  
IGF2 gene dysregulation results in severe IGF-2 deficiency, short stature lactation failure, and diabetes of young adult onset with excess abdominal subcutaneous fat, despite normal BMI.

Nina van Beek, Eniko Bodó, Arno Kromminga, Erzsébet Gáspár, Katja Meyer, Michal A. Zmijewski, Andrzej Slominski, Björn E. Wenzel, and Ralf Paus

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation
J Clin Endocrinol Metab 2008 93: 4381-4388 , doi:10.1210/jc.2008-0283 [Abstract] [Full Text] [PDF]  
Human hair follicles are direct targets of thyroid hormones, which modulate a number of their physiological parameters, including hair follicle cycling and pigmentation.

Antonella Meloni, Maria Furcas, Filomena Cetani, Claudio Marcocci, Alberto Falorni, Roberto Perniola, Mikulás Pura, Anette S. Bøe Wolff, Eystein S. Husebye, Desa Lilic, Kelli R. Ryan, Andrew R. Gennery, Andrew J. Cant, Mario Abinun, Gavin P. Spickett, Peter D. Arkwright, David Denning, Colm Costigan, Maria Dominguez, Vivienne McConnell, Nick Willcox, and Anthony Meager

Autoantibodies against Type I Interferons as an Additional Diagnostic Criterion for Autoimmune Polyendocrine Syndrome Type I
J Clin Endocrinol Metab 2008 93: 4389-4397 , doi:10.1210/jc.2008-0935 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Autoantibodies against interferon-{alpha} and-{omega} have very high diagnostic sensitivities and specificities for autoimmune polyendocrine syndrome type-I, regardless of the exact AIRE mutation, clinical picture, or duration.

Valentina De Falco, Riccardo Giannini, Anna Tamburrino, Clara Ugolini, Cristiana Lupi, Efisio Puxeddu, Massimo Santoro, and Fulvio Basolo

BRIEF REPORT:Functional Characterization of the Novel T599I-VKSRdel BRAF Mutation in a Follicular Variant Papillary Thyroid Carcinoma
J Clin Endocrinol Metab 2008 93: 4398-4402 , doi:10.1210/jc.2008-0887 [Abstract] [Full Text] [PDF]  
A novel T599I-VKSR(600-603)del BRAF mutation is identified in a follicular-variant papillary thyroid cancer patient.

Shu-Fu Lin, Daniel L. Price, Chun-Hao Chen, Peter Brader, Sen Li, Lorena Gonzalez, Qian Zhang, Yong A. Yu, Nanhai Chen, Aladar A. Szalay, Yuman Fong, and Richard J. Wong

BRIEF REPORT:Oncolytic Vaccinia Virotherapy of Anaplastic Thyroid Cancer in Vivo
J Clin Endocrinol Metab 2008 93: 4403-4407 , doi:10.1210/jc.2008-0316 [Abstract] [Full Text] [PDF]  
A recombinant, replication-competent, oncolytic vaccinia virus effectively infects, expresses transgenes within, and impedes tumor growth of a murine model of human anaplastic thyroid cancer.

Héctor E. Chemes, Rodolfo A. Rey, Manuel Nistal, Javier Regadera, Mariana Musse, Pilar González-Peramato, and Álvaro Serrano

BRIEF REPORT:Physiological Androgen Insensitivity of the Fetal, Neonatal, and Early Infantile Testis Is Explained by the Ontogeny of the Androgen Receptor Expression in Sertoli Cells
J Clin Endocrinol Metab 2008 93: 4408-4412 , doi:10.1210/jc.2008-0915 [Abstract] [Full Text] [PDF]  
Absence of androgen receptor in fetal and neonatal Sertoli cells represents a transient, physiological state of cell-specific androgen insensitivity, which prevents precocious Sertoli cell maturation and spermatogenic development.

W. Matthew Widdowson and James Gibney

BRIEF REPORT:The Effect of Growth Hormone Replacement on Exercise Capacity in Patients with GH Deficiency: A Metaanalysis
J Clin Endocrinol Metab 2008 93: 4413-4417 , doi:10.1210/jc.2008-1239 [Abstract] [Full Text] [PDF]  
This meta-analysis provides the strongest evidence to date for a beneficial effect of GH replacement on exercise performance in GH-deficient adults.

Palmiero Monteleone, Cristina Serritella, Vassilis Martiadis, Pasquale Scognamiglio, and Mario Maj

BRIEF REPORT:Plasma Obestatin, Ghrelin, and Ghrelin/Obestatin Ratio Are Increased in Underweight Patients with Anorexia Nervosa But Not in Symptomatic Patients with Bulimia Nervosa
J Clin Endocrinol Metab 2008 93: 4418-4421 , doi:10.1210/jc.2008-1138 [Abstract] [Full Text] [PDF]  
Anorexia nervosa, but not bulimia nervosa, is characterized by increased circulating ghrelin and obestatin levels and a higher ghrelin/obestatin ratio, which may contribute to disordered eating.

Anastasios Papadimitriou, Soula Pantsiotou, Konstandinos Douros, Dimitrios T. Papadimitriou, Polyxeni Nicolaidou, and Andreas Fretzayas

BRIEF REPORT:Timing of Pubertal Onset in Girls: Evidence for Non-Gaussian Distribution
J Clin Endocrinol Metab 2008 93: 4422-4425 , doi:10.1210/jc.2008-0661 [Abstract] [Full Text] [PDF]  
A non-Gaussian distribution of the age at pubertal onset in girls is documented. The currently used cut-off ages for precocious and delayed puberty may not be applicable to modern children.

Branca M. Cavaco, Pedro F. Batista, Luís G. Sobrinho, and Valeriano Leite

BRIEF REPORT:Mapping a New Familial Thyroid Epithelial Neoplasia Susceptibility Locus to Chromosome 8p23.1-p22 by High-Density Single-Nucleotide Polymorphism Genome-Wide Linkage Analysis
J Clin Endocrinol Metab 2008 93: 4426-4430 , doi:10.1210/jc.2008-0449 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Genome-wide linkage analysis using high-density single nucleotide polymorphism arrays, in a large Portuguese family with familial thyroid epithelial neoplasia, identifies a novel predisposition locus on chromosome 8p23.1-p22.

Endocrine Research:

Aiwei Yao-Borengasser, Negah Rassouli, Vijayalakshmi Varma, Angela M. Bodles, Neda Rasouli, Resat Unal, Bounleut Phanavanh, Gouri Ranganathan, Robert E. McGehee, Jr., and Philip A. Kern

Stearoyl-Coenzyme A Desaturase 1 Gene Expression Increases after Pioglitazone Treatment and Is Associated with Peroxisomal Proliferator-Activated Receptor- Responsiveness
J Clin Endocrinol Metab 2008 93: 4431-4439 , doi:10.1210/jc.2008-0782 [Abstract] [Full Text] [PDF]  
Pioglitazone treatment increased stearoyl-Co-A desaturase (SCD1). There were also significant positive correlations between SCD1 and peroxisome proliferator-activated receptor-{gamma} (PPAR{gamma}), as well as other PPAR{gamma}-responsive genes, suggesting that SCD1 is closely linked to PPAR{gamma} expression and downstream signaling.

Remberto C. Paulo, Richard Brundage, Mihaela Cosma, Kristi L. Mielke, Cyril Y. Bowers, and Johannes D. Veldhuis

Estrogen Elevates the Peak Overnight Production Rate of Acylated Ghrelin
J Clin Endocrinol Metab 2008 93: 4440-4447 , doi:10.1210/jc.2008-0783 [Abstract] [Full Text] [PDF]  
Estradiol stimulates ghrelin acylation in postmenopausal women without affecting its metabolic clearance rate.

Ching-Lung Cheung, Pak C. Sham, Vivian Chan, Andrew D. Paterson, Keith D. K. Luk, and Annie W. C. Kung

Identification of LTBP2 on Chromosome 14q as a Novel Candidate Gene for Bone Mineral Density Variation and Fracture Risk Association
J Clin Endocrinol Metab 2008 93: 4448-4455 , doi:10.1210/jc.2007-2836 [Abstract] [Full Text] [PDF]  
Using case-control subject pairs, LTBP2 is a novel positional candidate gene in chromosome 14q quantitative trait loci for bone mineral density variation and fracture.

Sophie Catteau-Jonard, Soazik P. Jamin, Arnaud Leclerc, Jacques Gonzalès, Didier Dewailly, and Nathalie di Clemente

Anti-Mullerian Hormone, Its Receptor, FSH Receptor, and Androgen Receptor Genes Are Overexpressed by Granulosa Cells from Stimulated Follicles in Women with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 2008 93: 4456-4461 , doi:10.1210/jc.2008-1231 [Abstract] [Full Text] [PDF]  
Using quantitative reverse transcriptase polymerase chain reaction, it is shown that anti-Mullerian hormone (AMH), AMH receptor type II, FSH receptor, and androgen receptor genes are overexpressed by granulosa cells from stimulated follicles in women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation.

Garry D. Tan, David B. Savage, Barbara A. Fielding, Jenny Collins, Leanne Hodson, Sandy M. Humphreys, Stephen O'Rahilly, Krishna Chatterjee, Keith N. Frayn, and Fredrik Karpe

Fatty Acid Metabolism in Patients with PPAR Mutations
J Clin Endocrinol Metab 2008 93: 4462-4470 , doi:10.1210/jc.2007-2356 [Abstract] [Full Text] [PDF]  
A detailed description of fatty acid metabolism in two rare cases carrying disruptive mutations in the PPARG gene is provided. The PPARG P467L carrier, who is severely insulin resistant and lipodystrophic, show signs of substantial generation of non-esterified fatty acids directly from triglyceride-rich lipoproteins.

Johannes D. Veldhuis, Daniel M. Keenan, Joy N. Bailey, Adenborduin Adeniji, John M. Miles, Remberto Paulo, Mihaela Cosma, and Cacia Soares-Welch

Estradiol Supplementation in Postmenopausal Women Attenuates Suppression of Pulsatile Growth Hormone Secretion by Recombinant Human Insulin-like Growth Factor Type I
J Clin Endocrinol Metab 2008 93: 4471-4478 , doi:10.1210/jc.2008-1493 [Abstract] [Full Text] [PDF]  
Estrogen supplementation often stimulates GH secretion. An additional mechanism for this effect is feedback inhibition by IGF-1.

Thomas Reinehr and Christian L. Roth

Fetuin-A and Its Relation to Metabolic Syndrome and Fatty Liver Disease in Obese Children Before and After Weight Loss
J Clin Endocrinol Metab 2008 93: 4479-4485 , doi:10.1210/jc.2008-1505 [Abstract] [Full Text] [PDF]  
Fetuin-A levels are a new promising link between non-alcoholic fatty liver disease, insulin resistance, and other features of the metabolic syndrome in obese children.

Anders Rinnov Nielsen, Pernille Hojman, Christian Erikstrup, Christian Philip Fischer, Peter Plomgaard, Remi Mounier, Ole Hartvig Mortensen, Christa Broholm, Sarah Taudorf, Rikke Krogh-Madsen, Birgitte Lindegaard, Anne Marie Winther Petersen, Julie Gehl, and Bente Klarlund Pedersen

Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass
J Clin Endocrinol Metab 2008 93: 4486-4493 , doi:10.1210/jc.2007-2561 [Abstract] [Full Text] [PDF]  
Interleukin 15 is negatively associated with body fat mass, independent of the diagnosis of type 2 diabetes, suggesting involvement of this cytokine in fat mass regulation.

John W. M. Creemers, Yung Seng Lee, Robert L. Oliver, Mithat Bahceci, Alpaslan Tuzcu, Deniz Gokalp, Julia Keogh, Stefan Herber, Anne White, Stephen O'Rahilly, and I. Sadaf Farooqi

Mutations in the Amino-Terminal Region of Proopiomelanocortin (POMC) in Patients with Early-Onset Obesity Impair POMC Sorting to the Regulated Secretory Pathway
J Clin Endocrinol Metab 2008 93: 4494-4499 , doi:10.1210/jc.2008-0954 [Abstract] [Full Text] [PDF]  
Two novel mutations in the pro-opiomelanocortin (POMC) gene have been identified in patients with severe early-onset obesity. Both mutations lie in a region of the N-terminus of POMC gene and result in impaired sorting to the regulated secretory pathway.

José A. Horcajadas, Pablo Mínguez, Joaquín Dopazo, Francisco J. Esteban, Francisco Domínguez, Linda C. Giudice, Antonio Pellicer, and Carlos Simón

Controlled Ovarian Stimulation Induces a Functional Genomic Delay of the Endometrium with Potential Clinical Implications
J Clin Endocrinol Metab 2008 93: 4500-4510 , doi:10.1210/jc.2008-0588 [Abstract] [Full Text] [PDF]  
This study reports differences between controlled ovarian stimulation and natural cycles at the functional genomic level.

Xiumei Hong, Hui-Ju Tsai, Xin Liu, Zhiping Li, Xue Liu, Genfu Tang, Houxun Xing, Jianhua Yang, Binyan Wang, Yan Feng, Xin Xu, Xiping Xu, and Xiaobin Wang

A Large-Scale Genome-Wide Linkage Analysis to Map Loci Linked to Stature in Chinese Population
J Clin Endocrinol Metab 2008 93: 4511-4518 , doi:10.1210/jc.2008-0262 [Abstract] [Full Text] [PDF] [Supplemental Data]  
There is a strong linkage of chromosome 17q24 to stature in the Chinese population. It is informative to consider age and gender effects in the genetic dissection of stature.

Thomas Fischer, Christian Doll, Stefan Jacobs, Angela Kolodziej, Ralf Stumm, and Stefan Schulz

Reassessment of sst₂ Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-1
J Clin Endocrinol Metab 2008 93: 4519-4524 , doi:10.1210/jc.2008-1063 [Abstract] [Full Text] [PDF]  
Immunocytochemical evaluation of the somatostatin 2A receptor status is of value for predicting response to octreotide therapy and disease prognosis.

S. Ravet, C. Munaut, S. Blacher, G. Brichant, S. Labied, A. Beliard, N. Chabbert-Buffet, P. Bouchard, J.-M. Foidart, and A. Pintiaux

Persistence of an Intact Endometrial Matrix and Vessels Structure in Women Exposed to VA-2914, a Selective Progesterone Receptor Modulator
J Clin Endocrinol Metab 2008 93: 4525-4531 , doi:10.1210/jc.2008-0731 [Abstract] [Full Text] [PDF]  
The progesterone receptor modulator VA-2914 maintains a stable vascular network that closely resembles that observed during the secretory phase of spontaneous ovulatory cycle.

Neeraj K. Sharma, Swapan K. Das, Ashis K. Mondal, Oksana G. Hackney, Winston S. Chu, Philip A. Kern, Neda Rasouli, Horace J. Spencer, Aiwei Yao-Borengasser, and Steven C. Elbein

Endoplasmic Reticulum Stress Markers Are Associated with Obesity in Nondiabetic Subjects
J Clin Endocrinol Metab 2008 93: 4532-4541 , doi:10.1210/jc.2008-1001 [Abstract] [Full Text] [PDF] [Supplemental Data]  
Studies of subcutaneous adipose tissue endoplasmic reticulum stress in healthy individuals shows marked elevation of chaperone gene expression and increased phosphorylation of initiation factor EIF2{alpha} with increasing obesity.

Jeniel Parmar, Rebecca E. Key, and William E. Rainey

BRIEF REPORT:Development of an Adrenocorticotropin-Responsive Human Adrenocortical Carcinoma Cell Line
J Clin Endocrinol Metab 2008 93: 4542-4546 , doi:10.1210/jc.2008-0903 [Abstract] [Full Text] [PDF]  
The development and characterization of an ACTH- and angiotensin II-responsive human adrenal cell line, human adrenocortical carcinoma clone 15 (HAC15), is described.

SoJung Lee and Silva A. Arslanian

BRIEF REPORT:Fat Oxidation in Black and White Youth: A Metabolic Phenotype Potentially Predisposing Black Girls to Obesity
J Clin Endocrinol Metab 2008 93: 4547-4551 , doi:10.1210/jc.2008-1024 [Abstract] [Full Text] [PDF]  
Resting metabolic rate and postabsorptive fat oxidation are substantially lower in black versus white girls. This racial difference is more pronounced in the pubertal group.

Announcements and Resources:

Announcement
J Clin Endocrinol Metab 2008 93: 4197 [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2008 93: 4552 [Full Text] [PDF]  

Erratum
J Clin Endocrinol Metab 2008 93: 4553 [Full Text] [PDF]  

Endocrine-Related Resources from the National Institutes of Health
J Clin Endocrinol Metab 2008 93: 4554-4557 [Full Text] [PDF]  

National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available
J Clin Endocrinol Metab 2008 93: 4558-4560 [Full Text] [PDF]  

Patient Information Page from The Hormone Foundation:

Guillermo Umpierrez and Lawrence S. Phillips

Patient Information Page from The Hormone Foundation:Type 2 Diabetes Screening
J Clin Endocrinol Metab 2008 93 [Full Text] [PDF]  

Guillermo Umpierrez and Lawrence S. Phillips

Patient Information Page from The Hormone Foundation:Detección de la Diabetes Tipo 2
J Clin Endocrinol Metab 2008 93 [Full Text] [PDF]  

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