Articles listed in blue may be of special interest to clinicians.

Special Articles:

Seymour Reichlin

EDITORIAL:Is Leptin a Secretion of the Brain?
J Clin Endocrinol Metab 1999 84: 2267-2269 doi:10.1210/jc.84.7.2267 [Full Text] [PDF]  

Shonni J. Silverberg, John P. Bilezikian, Henry G. Bone, Gary B. Talpos, Mara J. Horwitz, and Andrew F. Stewart

THERAPEUTIC CONTROVERSY:To Treat or Not To Treat: Conclusions from the NIH Consensus Conference^a
J Clin Endocrinol Metab 1999 84: 2275-2278 doi:10.1210/jc.84.7.2275 [Full Text] [PDF]  

Henry G. Bone

THERAPEUTIC CONTROVERSY:Who Needs Parathyroid Surgery? The Case for Parathyroidectomy in Nonclassical Primary Hyperparathyroidism^b
J Clin Endocrinol Metab 1999 84: 2278-2282 doi:10.1210/jc.84.7.2278 [Full Text] [PDF]  

Mara J. Horwitz and Andrew F. Stewart

THERAPEUTIC CONTROVERSY:Overview and Summary^c
J Clin Endocrinol Metab 1999 84: 2283-2285 doi:10.1210/jc.84.7.2283 [Full Text] [PDF]  

Yujin Shuto, Tadasumi Nakano, Naoko Sanno, Hideharu Domoto, Hitoshi Sugihara, and Ichiji Wakabayashi

CLINICAL CASE SEMINAR:Reduced Growth Hormone Receptor Messenger Ribonucleic Acid in an Aged Man with Chronic Malnutrition and Growth Hormone Resistance
J Clin Endocrinol Metab 1999 84: 2320-2323 doi:10.1210/jc.84.7.2320 [Abstract] [Full Text] [PDF]  

Original Studies:

Glen Wiesner, Mario Vaz, Greg Collier, Douglas Seals, David Kaye, Gary Jennings, Gavin Lambert, Dominic Wilkinson, and Murray Esler

Leptin Is Released from the Human Brain: Influence of Adiposity and Gender
J Clin Endocrinol Metab 1999 84: 2270-2274 doi:10.1210/jc.84.7.2270 [Abstract] [Full Text] [PDF]  

Peter Vestergaard, Anne Pernille Hermann, Hans Ørskov, and Leif Mosekilde

Effect of Sex Hormone Replacement on the Insulin-Like Growth Factor System and Bone Mineral: A Cross-Sectional and Longitudinal Study in 595 Perimenopausal Women Participating in the Danish Osteoporosis Prevention Study
J Clin Endocrinol Metab 1999 84: 2286-2290 doi:10.1210/jc.84.7.2286 [Abstract] [Full Text] [PDF]  

Weiping Wang, Homer Macapinlac, Steven M. Larson, Samuel D. J. Yeh, Timothy Akhurst, Ronald D. Finn, Juan Rosai, and Richard J. Robbins

[¹⁸F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Localizes Residual Thyroid Cancer in Patients with Negative Diagnostic ¹³¹I Whole Body Scans and Elevated Serum Thyroglobulin Levels
J Clin Endocrinol Metab 1999 84: 2291-2302 doi:10.1210/jc.84.7.2291 [Abstract] [Full Text] [PDF]  

Marco Zaccaria, Maurizio Varnier, Paolo Piazza, Donatella Noventa, and Andrea Ermolao

Blunted Growth Hormone Response to Maximal Exercise in Middle-Aged Versus Young Subjects and No Effect of Endurance Training
J Clin Endocrinol Metab 1999 84: 2303-2307 doi:10.1210/jc.84.7.2303 [Abstract] [Full Text] [PDF]  

George J. Kahaly, Stephan Wagner, Jana Nieswandt, Susanne Mohr-Kahaly, and Thomas J. Ryan

Stress Echocardiography in Hyperthyroidism
J Clin Endocrinol Metab 1999 84: 2308-2313 doi:10.1210/jc.84.7.2308 [Abstract] [Full Text] [PDF]  

N. D. Quinton, R. F. Smith, P. E. Clayton, M. S. Gill, S. Shalet, S. K. Justice, S. A. Simon, S. Walters, M.-C. Postel-Vinay, A. I. F. Blakemore, and R. J. M. Ross

Leptin Binding Activity Changes with Age: The Link between Leptin and Puberty
J Clin Endocrinol Metab 1999 84: 2336-2341 doi:10.1210/jc.84.7.2336 [Abstract] [Full Text] [PDF]  

Karin M. Ferber, Elisabeth Keller, Ekkehard D. Albert, and Anette-G. Ziegler

Predictive Value of Human Leukocyte Antigen Class II Typing for the Development of Islet Autoantibodies and Insulin-Dependent Diabetes Postpartum in Women with Gestational Diabetes
J Clin Endocrinol Metab 1999 84: 2342-2348 doi:10.1210/jc.84.7.2342 [Abstract] [Full Text] [PDF]  

Rosario Pivonello, Antongiulio Faggiano, Carolina Di Somma, Michele Klain, Mariagiovanna Filippella, Marco Salvatore, Gaetano Lombardi, and Annamaria Colao

Effect of a Short-Term Treatment with Alendronate on Bone Density and Bone Markers in Patients with Central Diabetes Insipidus
J Clin Endocrinol Metab 1999 84: 2349-2352 doi:10.1210/jc.84.7.2349 [Abstract] [Full Text] [PDF]  

Yutaka Yano, Akira Katsuki, Esteban C. Gabazza, Kuninobu Ito, Masashi Fujii, Masahiko Furuta, Ken Tuchihashi, Hiroyuki Goto, Kaname Nakatani, Yasuko Hori, Yasuhiro Sumida, and Yukihiko Adachi

Plasma Brain Natriuretic Peptide Levels in Normotensive Noninsulin-Dependent Diabetic Patients with Microalbuminuria
J Clin Endocrinol Metab 1999 84: 2353-2356 doi:10.1210/jc.84.7.2353 [Abstract] [Full Text] [PDF]  

Georg Stacher, Guntram Schernthaner, Mario Francesconi, Hans-Peter Kopp, Helmar Bergmann, Giselheid Stacher-Janotta, and Ute Weber

Cisapride Versus Placebo for 8 Weeks on Glycemic Control and Gastric Emptying in Insulin-Dependent Diabetes: A Double Blind Cross-Over Trial
J Clin Endocrinol Metab 1999 84: 2357-2362 doi:10.1210/jc.84.7.2357 [Abstract] [Full Text] [PDF]  

P. Ravn, D. Hosking, D. Thompson, G. Cizza, R. D. Wasnich, M. McClung, A. J. Yates, N. H. Bjarnason, and C. Christiansen

Monitoring of Alendronate Treatment and Prediction of Effect on Bone Mass by Biochemical Markers in the Early Postmenopausal Intervention Cohort Study
J Clin Endocrinol Metab 1999 84: 2363-2368 doi:10.1210/jc.84.7.2363 [Abstract] [Full Text] [PDF]  

Anna Ferenczi, Miklós Garami, Eszter Kiss, Mónika Pék, Mária Sasvári-Székely, Csaba Barta, Mária Staub, János Sólyom, and György Fekete

COMMENTS:Screening for Mutations of 21-Hydroxylase Gene in Hungarian Patients with Congenital Adrenal Hyperplasia
J Clin Endocrinol Metab 1999 84: 2369-2372 doi:10.1210/jc.84.7.2369 [Abstract] [Full Text] [PDF]  

Jan C. ter Maaten, Hans de Boer, Otto Kamp, Lotte Stuurman, and Eduard A. van der Veen

Long-Term Effects of Growth Hormone (GH) Replacement in Men with Childhood-Onset GH Deficiency
J Clin Endocrinol Metab 1999 84: 2373-2380 doi:10.1210/jc.84.7.2373 [Abstract] [Full Text] [PDF]  

M. Torlontano, I. Chiodini, M. Pileri, G. Guglielmi, M. Cammisa, S. Modoni, V. Carnevale, V. Trischitta, and A. Scillitani

Altered Bone Mass and Turnover in Female Patients with Adrenal Incidentaloma: The Effect of Subclinical Hypercortisolism
J Clin Endocrinol Metab 1999 84: 2381-2385 doi:10.1210/jc.84.7.2381 [Abstract] [Full Text] [PDF]  

L. De Marinis, A. Mancini, D. Valle, A. Bianchi, D. Milardi, A. Proto, A. Lanzone, and R. Tacchino

Plasma Leptin Levels after Biliopancreatic Diversion: Dissociation with Body Mass Index
J Clin Endocrinol Metab 1999 84: 2386-2389 doi:10.1210/jc.84.7.2386 [Abstract] [Full Text] [PDF]  

Patrick Garnero, Yannis Tsouderos, Istvan Marton, Clara Pelissier, Claire Varin, and Pierre D. Delmas

Effects of Intranasal 17ß-Estradiol on Bone Turnover and Serum Insulin-Like Growth Factor I in Postmenopausal Women
J Clin Endocrinol Metab 1999 84: 2390-2397 doi:10.1210/jc.84.7.2390 [Abstract] [Full Text] [PDF]  

Joanne M. Heward, Amit Allahabadia, Mary Armitage, Andrew Hattersley, Paul M. Dodson, Ken Macleod, Jackie Carr-Smith, Jacquie Daykin, Angela Daly, Michael C. Sheppard, Roger L. Holder, Anthony H. Barnett, Jayne A. Franklyn, and Stephen C. L. Gough

The Development of Graves’ Disease and the CTLA-4 Gene on Chromosome 2q33
J Clin Endocrinol Metab 1999 84: 2398-2401 doi:10.1210/jc.84.7.2398 [Abstract] [Full Text] [PDF]  

A. C. Duncan, H. Lyall, R.N. Roberts, J. R. Petrie, M. J. Perera, S. Monaghan, D. M. Hart, J. M. C. Connell, and M. A. Lumsden

The Effect of Estradiol and a Combined Estradiol/Progestagen Preparation on Insulin Sensitivity in Healthy Postmenopausal Women
J Clin Endocrinol Metab 1999 84: 2402-2407 doi:10.1210/jc.84.7.2402 [Abstract] [Full Text] [PDF]  

Stéphanie Chen, Juliane Léger, Catherine Garel, Max Hassan, and Paul Czernichow

Growth Hormone Deficiency with Ectopic Neurohypophysis: Anatomical Variations and Relationship between the Visibility of the Pituitary Stalk Asserted by Magnetic Resonance Imaging and Anterior Pituitary Function
J Clin Endocrinol Metab 1999 84: 2408-2413 doi:10.1210/jc.84.7.2408 [Abstract] [Full Text] [PDF]  

Artur J. Jakimiuk, Stacy R. Weitsman, and Denis A. Magoffin

5-Reductase Activity in Women with Polycystic Ovary Syndrome
J Clin Endocrinol Metab 1999 84: 2414-2418 doi:10.1210/jc.84.7.2414 [Abstract] [Full Text] [PDF]  

A. Mayer, F. Rharbaoui, C. Thivolet, J. Orgiazzi, and A. M. Madec

The Relationship between Peripheral T Cell Reactivity to Insulin, Clinical Remissions and Cytokine Production in Type 1 (Insulin-Dependent) Diabetes Mellitus
J Clin Endocrinol Metab 1999 84: 2419-2424 doi:10.1210/jc.84.7.2419 [Abstract] [Full Text] [PDF]  

Yuji Yoshitomi, Shunichi Kojima, Takuya Umemoto, Kiyokage Kubo, Yuji Matsumoto, Michiko Yano, Toshihiko Sugi, and Morio Kuramochi

Serum Hepatocyte Growth Factor in Patients with Peripheral Arterial Occlusive Disease
J Clin Endocrinol Metab 1999 84: 2425-2428 doi:10.1210/jc.84.7.2425 [Abstract] [Full Text] [PDF]  

Paula Heinonen, Markku Koulu, Ullamari Pesonen, Matti K. Karvonen, Aila Rissanen, Markku Laakso, Raisa Valve, Matti Uusitupa, and Mika Scheinin

Identification of a Three-Amino Acid Deletion in the _2B-Adrenergic Receptor That Is Associated with Reduced Basal Metabolic Rate in Obese Subjects
J Clin Endocrinol Metab 1999 84: 2429-2433 doi:10.1210/jc.84.7.2429 [Abstract] [Full Text] [PDF]  

Keiko Arai, Keith Zachman, Tamotsu Shibasaki, and George P. Chrousos

Polymorphisms of Amiloride-Sensitive Sodium Channel Subunits in Five Sporadic Cases of Pseudohypoaldosteronism: Do They Have Pathologic Potential?
J Clin Endocrinol Metab 1999 84: 2434-2437 doi:10.1210/jc.84.7.2434 [Abstract] [Full Text] [PDF]  

Zeev N. Kain, Zoran Zimolo, and George Heninger

Leptin and the Perioperative Neuroendocrinological Stress Response
J Clin Endocrinol Metab 1999 84: 2438-2442 doi:10.1210/jc.84.7.2438 [Abstract] [Full Text] [PDF]  

Sam Mesiano, Steven L. Katz, Janet Y. Lee, and Robert B. Jaffe

Phytoestrogens Alter Adrenocortical Function: Genistein and Daidzein Suppress Glucocorticoid and Stimulate Androgen Production by Cultured Adrenal Cortical Cells
J Clin Endocrinol Metab 1999 84: 2443-2448 doi:10.1210/jc.84.7.2443 [Abstract] [Full Text] [PDF]  

Gopalakrishnan M. Venkataraman, Mustafa Yatin, Regina Marcinek, and Kenneth B. Ain

Restoration of Iodide Uptake in Dedifferentiated Thyroid Carcinoma: Relationship to Human Na⁺/I^- Symporter Gene Methylation Status
J Clin Endocrinol Metab 1999 84: 2449-2457 doi:10.1210/jc.84.7.2449 [Abstract] [Full Text] [PDF]  

Marta Bondanelli, Maria Rosaria Ambrosio, Paola Franceschetti, Angelo Margutti, Giorgio Trasforini, and Ettore C. degli Uberti

Diurnal Rhythm of Plasma Catecholamines in Acromegaly
J Clin Endocrinol Metab 1999 84: 2458-2467 doi:10.1210/jc.84.7.2458 [Abstract] [Full Text] [PDF]  

Masato Nishimura, Masaji Ushiyama, Ken Ohtsuka, Masashi Nishida, Naoto Inoue, Akiyoshi Matsumuro, Toru Mineo, and Manabu Yoshimura

Serum Hepatocyte Growth Factor as a Possible Indicator of Vascular Lesions
J Clin Endocrinol Metab 1999 84: 2475-2480 doi:10.1210/jc.84.7.2475 [Abstract] [Full Text] [PDF]  

Shemina S. Kanji, Wendy Kuohung, David C. Labaree, and Richard B. Hochberg

Regiospecific Esterification of Estrogens by Lecithin:Cholesterol Acyltransferase
J Clin Endocrinol Metab 1999 84: 2481-2488 doi:10.1210/jc.84.7.2481 [Abstract] [Full Text] [PDF]  

Márta Korbonits, Gregory Kaltsas, Leslie A. Perry, Piero Putignano, Ashley B. Grossman, G. Michael Besser, and Peter J. Trainer

The Growth Hormone Secretagogue Hexarelin Stimulates the Hypothalamo-Pituitary-Adrenal Axis via Arginine Vasopressin
J Clin Endocrinol Metab 1999 84: 2489-2495 doi:10.1210/jc.84.7.2489 [Abstract] [Full Text] [PDF]  

Sigrid von Eckardstein, Manuela Simoni, Martin Bergmann, Gerhard F. Weinbauer, Paul Gassner, Andreas G. Schepers, and Eberhard Nieschlag

Serum Inhibin B in Combination with Serum Follicle-Stimulating Hormone (FSH) Is a More Sensitive Marker Than Serum FSH Alone for Impaired Spermatogenesis in Men, But Cannot Predict the Presence of Sperm in Testicular Tissue Samples
J Clin Endocrinol Metab 1999 84: 2496-2501 doi:10.1210/jc.84.7.2496 [Abstract] [Full Text] [PDF]  

Heidi Devos, Celia Rodd, Nancy Gagné, Rachel Laframboise, and Guy Van Vliet

A Search for the Possible Molecular Mechanisms of Thyroid Dysgenesis: Sex Ratios and Associated Malformations
J Clin Endocrinol Metab 1999 84: 2502-2506 doi:10.1210/jc.84.7.2502 [Abstract] [Full Text] [PDF]  

Rosanna Apa, Fiorella Miceli, Emilia Pierro, Francesca Minici, Pierluigi Navarra, Alessandro Caruso, Maddalena Napolitano, Salvatore Mancuso, and Antonio Lanzone

Paracrine Regulation of Insulin-Like Growth Factor I (IGF-I) and IGF-II on Prostaglandins F₂ and E₂ Synthesis by Human Corpus Luteum in Vitro: A Possible Balance of Luteotropic and Luteolytic Effects
J Clin Endocrinol Metab 1999 84: 2507-2512 doi:10.1210/jc.84.7.2507 [Abstract] [Full Text] [PDF]  

Morten Wøjdemann, Andre Wettergren, Bolette Hartmann, Linda Hilsted, and Jens J. Holst

Inhibition of Sham Feeding-Stimulated Human Gastric Acid Secretion by Glucagon-Like Peptide-2
J Clin Endocrinol Metab 1999 84: 2513-2517 doi:10.1210/jc.84.7.2513 [Abstract] [Full Text] [PDF]  

Johan Verhelst, Roger Abs, Dominique Maiter, Annick van den Bruel, Mark Vandeweghe, Brigitte Velkeniers, Jean Mockel, Gerard Lamberigts, Patrick Petrossians, Peter Coremans, Charles Mahler, Achille Stevenaert, Jan Verlooy, Christian Raftopoulos, and Albert Beckers

Cabergoline in the Treatment of Hyperprolactinemia: A Study in 455 Patients
J Clin Endocrinol Metab 1999 84: 2518-2522 doi:10.1210/jc.84.7.2518 [Abstract] [Full Text] [PDF]  

David S. Goldstein, Kathryn J. Swoboda, John M. Miles, Simon W. Coppack, Anders Aneman, Courtney Holmes, Isaac Lamensdorf, and Graeme Eisenhofer

Sources and Physiological Significance of Plasma Dopamine Sulfate
J Clin Endocrinol Metab 1999 84: 2523-2531 doi:10.1210/jc.84.7.2523 [Abstract] [Full Text] [PDF]  

Moshe Weintraub, Itamar Grosskopf, Yana Trostanesky, Gideon Charach, Ardon Rubinstein, and Naftali Stern

Thyroxine Replacement Therapy Enhances Clearance of Chylomicron Remnants in Patients with Hypothyroidism
J Clin Endocrinol Metab 1999 84: 2532-2536 doi:10.1210/jc.84.7.2532 [Abstract] [Full Text] [PDF]  

Simone A. R. van de Graaf, Carrie Ris-Stalpers, Geertruda J. M. Veenboer, Marianne Cammenga, Cécilia Santos, Héctor M. Targovnik, Jan J. M. de Vijlder, and Geraldo Medeiros-Neto

A Premature Stopcodon in Thyroglobulin Messenger RNA Results in Familial Goiter and Moderate Hypothyroidism
J Clin Endocrinol Metab 1999 84: 2537-2542 doi:10.1210/jc.84.7.2537 [Abstract] [Full Text] [PDF]  

Hui H. Zhang, Sudhesh Kumar, Anthony H. Barnett, and Margaret C. Eggo

Intrinsic Site-Specific Differences in the Expression of Leptin in Human Adipocytes and Its Autocrine Effects on Glucose Uptake
J Clin Endocrinol Metab 1999 84: 2550-2556 doi:10.1210/jc.84.7.2550 [Abstract] [Full Text] [PDF]  

Rosanee W. Valyasevi, Dana Z. Erickson, Debra A. Harteneck, Charyl M. Dutton, Armin E. Heufelder, Soma C. Jyonouchi, and Rebecca S. Bahn

Differentiation of Human Orbital Preadipocyte Fibroblasts Induces Expression of Functional Thyrotropin Receptor
J Clin Endocrinol Metab 1999 84: 2557-2562 doi:10.1210/jc.84.7.2557 [Abstract] [Full Text] [PDF]  

S. A. Milne, H. O. D. Critchley, T. A. Drudy, R. W. Kelly, and D. T. Baird

Perivascular Interleukin-8 Messenger Ribonucleic Acid Expression in Human Endometrium Varies across the Menstrual Cycle and in Early Pregnancy Decidua
J Clin Endocrinol Metab 1999 84: 2563-2567 doi:10.1210/jc.84.7.2563 [Abstract] [Full Text] [PDF]  

Katsuaki Kato, Hironobu Sasano, Shuichi Ohara, Hitoshi Sekine, Shizue Mochizuki, Tomoatsu Mune, Keigo Yasuda, Hiroshi Nagura, Tooru Shimosegawa, Takayoshi Toyota, and Zygmunt Krozowski

Coexpression of Mineralocorticoid Receptors and 11ß-Hydroxysteroid Dehydrogenase 2 in Human Gastric Mucosa
J Clin Endocrinol Metab 1999 84: 2568-2573 doi:10.1210/jc.84.7.2568 [Abstract] [Full Text] [PDF]  

From the Clinical Research Centers:

Rita Basu, Ananda Basu, Michael Nielsen, Pankaj Shah, and Robert A. Rizza

Effect of Overnight Restoration of Euglycemia on Glucose Effectiveness in Type 2 Diabetes Mellitus
J Clin Endocrinol Metab 1999 84: 2314-2319 doi:10.1210/jc.84.7.2314 [Abstract] [Full Text] [PDF]  

Najya Attia, Sonia Caprio, Timothy W. Jones, Rubina Heptulla, John Holcombe, David Silver, Robert S. Sherwin, and William V. Tamborlane

Changes in Free Insulin-Like Growth Factor-1 and Leptin Concentrations during Acute Metabolic Decompensation in Insulin Withdrawn Patients with Type 1 Diabetes
J Clin Endocrinol Metab 1999 84: 2324-2328 doi:10.1210/jc.84.7.2324 [Abstract] [Full Text] [PDF]  

Manisha Chandalia, Nicola Abate, Abhimanyu Garg, James Stray-Gundersen, and Scott M. Grundy

Relationship between Generalized and Upper Body Obesity to Insulin Resistance in Asian Indian Men
J Clin Endocrinol Metab 1999 84: 2329-2335 doi:10.1210/jc.84.7.2329 [Abstract] [Full Text] [PDF]  

Michele Marinò, Luca Chiovato, Joel A. Friedlander, Francesco Latrofa, Aldo Pinchera, and Robert T. McCluskey

Serum Antibodies against Megalin (GP330) in Patients with Autoimmune Thyroiditis
J Clin Endocrinol Metab 1999 84: 2468-2474 doi:10.1210/jc.84.7.2468 [Abstract] [Full Text] [PDF]  

Michael C. Henson, V. Daniel Castracane, Jennifer S. O’Neil, Terry Gimpel, Kenneth F. Swan, Amy E. Green, and Wenliang Shi

COMMENTS:Serum Leptin Concentrations and Expression of Leptin Transcripts in Placental Trophoblast with Advancing Baboon Pregnancy
J Clin Endocrinol Metab 1999 84: 2543-2549 doi:10.1210/jc.84.7.2543 [Abstract] [Full Text] [PDF]  

Rapid Communications:

Z. Kraiem, R. Heinrich, O. Sadeh, E. Shiloni, E. Nassir, E. Hazani, and B. Glaser

Sulfate Transport Is Not Impaired in Pendred Syndrome Thyrocytes
J Clin Endocrinol Metab 1999 84: 2574-2576 doi:10.1210/jc.84.7.2574 [Abstract] [Full Text] [PDF]  

M. H. A. Kester, C. H. van Dijk, D. Tibboel, A. M. Hood, N. J. M. Rose, W. Meinl, U. Pabel, H. Glatt, C. N. Falany, M. W. H. Coughtrie, and T. J. Visser

Sulfation of Thyroid Hormone by Estrogen Sulfotransferase
J Clin Endocrinol Metab 1999 84: 2577-2580 doi:10.1210/jc.84.7.2577 [Abstract] [Full Text] [PDF]  

S. Nakamura, A. Ohtsuru, N. Takamura, G. Kitange, Y. Tokunaga, A. Yasunaga, S. Shibata, and S. Yamashita

PROP-1 Gene Expression in Human Pituitary Tumors
J Clin Endocrinol Metab 1999 84: 2581-2584 doi:10.1210/jc.84.7.2581 [Abstract] [Full Text] [PDF]  

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