Articles listed in blue may be of special interest to clinicians.

Special Articles:

Michael Derwahl, Martina Broecker, and Zaki Kraiem

CLINICAL REVIEW 101:Thyrotropin May Not Be the Dominant Growth Factor in Benign and Malignant Thyroid Tumors
J Clin Endocrinol Metab 1999 84: 829-834 doi:10.1210/jc.84.3.829 [Full Text] [PDF]  

David H. P. Streeten

EDITORIAL:Shortcomings in the Low-Dose (1 µg) ACTH Test for the Diagnosis of ACTH Deficiency States
J Clin Endocrinol Metab 1999 84: 835-837 doi:10.1210/jc.84.3.835 [Full Text] [PDF]  

Original Studies:

T. A. M. Abdu, T. A. Elhadd, R. Neary, and R. N. Clayton

Comparison of the Low Dose Short Synacthen Test (1 µg), the Conventional Dose Short Synacthen Test (250 µg), and the Insulin Tolerance Test for Assessment of the Hypothalamo-Pituitary-Adrenal Axis in Patients with Pituitary Disease
J Clin Endocrinol Metab 1999 84: 838-843 doi:10.1210/jc.84.3.838 [Abstract] [Full Text] [PDF]  

Leanne Ward, Jean Paquette, Ernest Seidman, Céline Huot, Fernando Alvarez, Patricia Crock, Edgard Delvin, Olle Kämpe, and Cheri Deal

Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy in an Adolescent Girl with a Novel AIRE Mutation: Response to Immunosuppressive Therapy
J Clin Endocrinol Metab 1999 84: 844-852 doi:10.1210/jc.84.3.844 [Abstract] [Full Text] [PDF]  

Jesus Sainz, Jan M. Van Tornout, James Sayre, Francine Kaufman, and Vicente Gilsanz

Association of Collagen Type 1 1 Gene Polymorphism with Bone Density in Early Childhood
J Clin Endocrinol Metab 1999 84: 853-855 doi:10.1210/jc.84.3.853 [Abstract] [Full Text] [PDF]  

Julien Mendlewicz, Paul Linkowski, Myriam Kerkhofs, Rachel Leproult, Georges Copinschi, and Eve Van Cauter

Genetic Control of 24-Hour Growth Hormone Secretion in Man: A Twin Study
J Clin Endocrinol Metab 1999 84: 856-862 doi:10.1210/jc.84.3.856 [Abstract] [Full Text] [PDF]  

Patricia Iozzo, Henning Beck-Nielsen, Markku Laakso, Ulf Smith, Hannele Yki-Järvinen, and Ele Ferrannini

Independent Influence of Age on Basal Insulin Secretion in Nondiabetic Humans
J Clin Endocrinol Metab 1999 84: 863-868 doi:10.1210/jc.84.3.863 [Abstract] [Full Text] [PDF]  

Marcello Carantoni, Fahim Abbasi, Salman Azhar, Patricia Schaaf, and Gerald M. Reaven

Can Changes in Plasma Insulin Concentration Explain the Variability in Leptin Response to Weight Loss in Obese Women with Normal Glucose Tolerance?
J Clin Endocrinol Metab 1999 84: 869-872 doi:10.1210/jc.84.3.869 [Abstract] [Full Text] [PDF]  

M. P. Warren, F. Voussoughian, E. B. Geer, E. P. Hyle, C. L. Adberg, and R. H. Ramos

Functional Hypothalamic Amenorrhea: Hypoleptinemia and Disordered Eating
J Clin Endocrinol Metab 1999 84: 873-877 doi:10.1210/jc.84.3.873 [Abstract] [Full Text] [PDF]  

Margaret Castro, Paula C. L. Elias, Ana R. P. Quidute, Fernanda P. B. Halah, and Ayrton C. Moreira

Out-Patient Screening for Cushing’s Syndrome: The Sensitivity of the Combination of Circadian Rhythm and Overnight Dexamethasone Suppression Salivary Cortisol Tests
J Clin Endocrinol Metab 1999 84: 878-882 doi:10.1210/jc.84.3.878 [Abstract] [Full Text] [PDF]  

M. Bergendahl, W. S. Evans, C. Pastor, A. Patel, A. Iranmanesh, and J. D. Veldhuis

Short-Term Fasting Suppresses Leptin and (Conversely) Activates Disorderly Growth Hormone Secretion in Midluteal Phase Women—A Clinical Research Center Study
J Clin Endocrinol Metab 1999 84: 883-894 doi:10.1210/jc.84.3.883 [Abstract] [Full Text] [PDF]  

Paul J. Nestel, Sylvia Pomeroy, Sally Kay, Paul Komesaroff, Julie Behrsing, James D. Cameron, and Leanne West

Isoflavones from Red Clover Improve Systemic Arterial Compliance But Not Plasma Lipids in Menopausal Women
J Clin Endocrinol Metab 1999 84: 895-898 doi:10.1210/jc.84.3.895 [Abstract] [Full Text] [PDF]  

Marion Lynn Ahmed, Ken K. L. Ong, David J. Morrell, Les Cox, Nick Drayer, Leslie Perry, Michael A. Preece, and David B. Dunger

Longitudinal Study of Leptin Concentrations during Puberty: Sex Differences and Relationship to Changes in Body Composition
J Clin Endocrinol Metab 1999 84: 899-905 doi:10.1210/jc.84.3.899 [Abstract] [Full Text] [PDF]  

William W. Wong, Nancy F. Butte, Kenneth J. Ellis, Albert C. Hergenroeder, Rebecca B. Hill, Janice E. Stuff, and E. O’Brian Smith

Pubertal African-American Girls Expend Less Energy at Rest and During Physical Activity than Caucasian Girls
J Clin Endocrinol Metab 1999 84: 906-911 doi:10.1210/jc.84.3.906 [Abstract] [Full Text] [PDF]  

Sung-Soo Koong, James C. Reynolds, Edward G. Movius, Andrew M. Keenan, Kenneth B. Ain, Mark C. Lakshmanan, and Jacob Robbins

Lithium as a Potential Adjuvant to ¹³¹I Therapy of Metastatic, Well Differentiated Thyroid Carcinoma
J Clin Endocrinol Metab 1999 84: 912-916 doi:10.1210/jc.84.3.912 [Abstract] [Full Text] [PDF]  

Roberto Salvatori, César Y. Hayashida, Manuel H. Aguiar-Oliveira, John A. Phillips, III, Anita H. O. Souza, Rogério G. Gondo, Sergio P. A. Toledo, Maria M. Conceicão, Melissa Prince, Hiralal G. Maheshwari, Gerhard Baumann, and Michael A. Levine

Familial Dwarfism due to a Novel Mutation of the Growth Hormone-Releasing Hormone Receptor Gene
J Clin Endocrinol Metab 1999 84: 917-923 doi:10.1210/jc.84.3.917 [Abstract] [Full Text] [PDF]  

Elisabetta Ferretti, Luca Persani, Marie-Lise Jaffrain-Rea, Salvatore Giambona, Guido Tamburrano, and Paolo Beck-Peccoz

Evaluation of the Adequacy of Levothyroxine Replacement Therapy in Patients with Central Hypothyroidism
J Clin Endocrinol Metab 1999 84: 924-929 doi:10.1210/jc.84.3.924 [Abstract] [Full Text] [PDF]  

Berenice B. Mendonca, Maria G. F. Osorio, Ana Claudia Latronico, Vivian Estefan, Leonard Su Sih Lo, and Ivo J. P. Arnhold

Longitudinal Hormonal and Pituitary Imaging Changes in Two Females with Combined Pituitary Hormone Deficiency due to Deletion of A301,G302 in the PROP1 Gene
J Clin Endocrinol Metab 1999 84: 942-945 doi:10.1210/jc.84.3.942 [Abstract] [Full Text] [PDF]  

R. Azziz, V. Y. Black, E. S. Knochenhauer, G. A. Hines, and L. R. Boots

Ovulation After Glucocorticoid Suppression of Adrenal Androgens in the Polycystic Ovary Syndrome Is Not Predicted by the Basal Dehydroepiandrosterone Sulfate Level
J Clin Endocrinol Metab 1999 84: 946-950 doi:10.1210/jc.84.3.946 [Abstract] [Full Text] [PDF]  

Toru Takano, Akira Miyauchi, Fumio Matsuzuka, Gang Liu, Takuya Higashiyama, Tamotsu Yokozawa, Kanji Kuma, and Nobuyuki Amino

Preoperative Diagnosis of Medullary Thyroid Carcinoma by RT-PCR Using RNA Extracted from Leftover Cells within a Needle Used for Fine Needle Aspiration Biopsy
J Clin Endocrinol Metab 1999 84: 951-955 doi:10.1210/jc.84.3.951 [Abstract] [Full Text] [PDF]  

Hiralal G. Maheshwari, Asad Rahim, Stephen M. Shalet, and Gerhard Baumann

Selective Lack of Growth Hormone (GH) Response to the GH-Releasing Peptide Hexarelin in Patients with GH-Releasing Hormone Receptor Deficiency
J Clin Endocrinol Metab 1999 84: 956-959 doi:10.1210/jc.84.3.956 [Abstract] [Full Text] [PDF]  

Jodene Fitness, Naznin Dixit, Dianne Webster, Toni Torresani, Robert Pergolizzi, Phyllis W. Speiser, and Darren J. Day

Genotyping of CYP21, Linked Chromosome 6p Markers, and a Sex-Specific Gene in Neonatal Screening for Congenital Adrenal Hyperplasia
J Clin Endocrinol Metab 1999 84: 960-966 doi:10.1210/jc.84.3.960 [Abstract] [Full Text] [PDF]  

U. Querfeld, S. Döpper, A. Gradehand, P. Kiencke, F. Wahn, and H.-J. Zeisel

Long-Term Treatment with Growth Hormone Has No Persisting Effect on Lipoprotein(a) in Patients with Turner’s Syndrome
J Clin Endocrinol Metab 1999 84: 967-970 doi:10.1210/jc.84.3.967 [Abstract] [Full Text] [PDF]  

Cosimo Massafra, Claudio De Felice, Donato Pompeo Agnusdei, Dino Gioia, and Franco Bagnoli

Androgens and Osteocalcin during the Menstrual Cycle
J Clin Endocrinol Metab 1999 84: 971-974 doi:10.1210/jc.84.3.971 [Abstract] [Full Text] [PDF]  

Carina Ankarberg and Ensio Norjavaara

Diurnal Rhythm of Testosterone Secretion before and throughout Puberty in Healthy Girls: Correlation with 17ß-Estradiol and Dehydroepiandrosterone Sulfate
J Clin Endocrinol Metab 1999 84: 975-984 doi:10.1210/jc.84.3.975 [Abstract] [Full Text] [PDF]  

Brian W. Walsh, Donna Spiegelman, Mary Morrissey, and Frank M. Sacks

Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol
J Clin Endocrinol Metab 1999 84: 985-989 doi:10.1210/jc.84.3.985 [Abstract] [Full Text] [PDF]  

Philippe Caron, Stéphanie Chauvin, Sophie Christin-Maitre, Antoine Bennet, Najiba Lahlou, Raymond Counis, Philippe Bouchard, and Marie-Laure Kottler

Resistance of Hypogonadic Patients with Mutated GnRH Receptor Genes to Pulsatile GnRH Administration
J Clin Endocrinol Metab 1999 84: 990-996 doi:10.1210/jc.84.3.990 [Abstract] [Full Text] [PDF]  

Stephen J. Winters, Jun Takahashi, and Philip Troen

Secretion of Testosterone and Its ⁴ Precursor Steroids into Spermatic Vein Blood in Men with Varicocele-Associated Infertility
J Clin Endocrinol Metab 1999 84: 997-1001 doi:10.1210/jc.84.3.997 [Abstract] [Full Text] [PDF]  

Leen M. 't Hart, Ronald P. Stolk, Jacqueline M. Dekker, Giel Nijpels, Diederick E. Grobbee, Robert J. Heine, and J. Antonie Maassen

Prevalence of Variants in Candidate Genes for Type 2 Diabetes Mellitus in The Netherlands: The Rotterdam Study and the Hoorn Study
J Clin Endocrinol Metab 1999 84: 1002-1006 doi:10.1210/jc.84.3.1002 [Abstract] [Full Text] [PDF]  

Keiji Iida, Yutaka Takahashi, Hidesuke Kaji, Michiko Okazaki Takahashi, Yasuhiko Okimura, Osamu Nose, Hiromi Abe, and Kazuo Chihara

Functional Characterization of Truncated Growth Hormone (GH) Receptor-(1–277) Causing Partial GH Insensitivity Syndrome with High GH-Binding Protein
J Clin Endocrinol Metab 1999 84: 1011-1016 doi:10.1210/jc.84.3.1011 [Abstract] [Full Text] [PDF]  

Gene A. Hines and Ricardo Azziz

Impact of Architectural Disruption on Adrenocortical Steroidogenesis In Vitro
J Clin Endocrinol Metab 1999 84: 1017-1021 doi:10.1210/jc.84.3.1017 [Abstract] [Full Text] [PDF]  

Paul M. Stewart, Abigail Boulton, Sudhesh Kumar, Penny M. S. Clark, and Cedric H. L. Shackleton

Cortisol Metabolism in Human Obesity: Impaired CortisoneCortisol Conversion in Subjects with Central Adiposity
J Clin Endocrinol Metab 1999 84: 1022-1027 doi:10.1210/jc.84.3.1022 [Abstract] [Full Text] [PDF]  

Gary F. Lewis, André Carpentier, Debra Bilinski, Adria Giacca, and Mladen Vranic

Counterregulatory Response to Hypoglycemia Differs According to the Insulin Delivery Route, But Does Not Affect Glucose Production in Normal Humans
J Clin Endocrinol Metab 1999 84: 1037-1046 doi:10.1210/jc.84.3.1037 [Abstract] [Full Text] [PDF]  

Kenneth E. White, Daniel L. Koller, Istvan Takacs, Kenneth A. Buckwalter, Tatiana Foroud, and Michael J. Econs

Locus Heterogeneity of Autosomal Dominant Osteopetrosis (ADO)
J Clin Endocrinol Metab 1999 84: 1047-1051 doi:10.1210/jc.84.3.1047 [Abstract] [Full Text] [PDF]  

Jane E. Kerstetter, MaryAnn E. Mitnick, Caren M. Gundberg, Donna M. Caseria, Alice F. Ellison, Thomas O. Carpenter, and Karl L. Insogna

Changes in Bone Turnover in Young Women Consuming Different Levels of Dietary Protein
J Clin Endocrinol Metab 1999 84: 1052-1055 doi:10.1210/jc.84.3.1052 [Abstract] [Full Text] [PDF]  

Sefina Arif, James A. Underhill, Peter Donaldson, Gerard S. Conway, and Mark Peakman

Human Leukocyte Antigen-DQB1* Genotypes Encoding Aspartate at Position 57 Are Associated with 3ß-Hydroxysteroid Dehydrogenase Autoimmunity in Premature Ovarian Failure
J Clin Endocrinol Metab 1999 84: 1056-1060 doi:10.1210/jc.84.3.1056 [Abstract] [Full Text] [PDF]  

Silvana Pannain, Roy E. Weiss, Charles E. Jackson, Donald Dian, John C. Beck, Val C. Sheffield, Nancy Cox, and Samuel Refetoff

Two Different Mutations in the Thyroid Peroxidase Gene of a Large Inbred Amish Kindred: Power and Limits of Homozygosity Mapping
J Clin Endocrinol Metab 1999 84: 1061-1071 doi:10.1210/jc.84.3.1061 [Abstract] [Full Text] [PDF]  

Sanjay K. Agarwal, Klara Vogel, Stacy R. Weitsman, and Denis A. Magoffin

Leptin Antagonizes the Insulin-Like Growth Factor-I Augmentation of Steroidogenesis in Granulosa and Theca Cells of the Human Ovary
J Clin Endocrinol Metab 1999 84: 1072-1076 doi:10.1210/jc.84.3.1072 [Abstract] [Full Text] [PDF]  

Robert A. Hegele, Henian Cao, Stewart B. Harris, Anthony J. G. Hanley, and Bernard Zinman

The Hepatic Nuclear Factor-1 G319S Variant Is Associated with Early-Onset Type 2 Diabetes in Canadian Oji-Cree
J Clin Endocrinol Metab 1999 84: 1077-1082 doi:10.1210/jc.84.3.1077 [Abstract] [Full Text] [PDF]  

Alessandra Vottero, Constantine A. Stratakis, Lucia Ghizzoni, Carlos A. Longui, Michael Karl, and George P. Chrousos

Androgen Receptor-Mediated Hypersensitivity to Androgens in Women with Nonhyperandrogenic Hirsutism: Skewing of X-Chromosome Inactivation
J Clin Endocrinol Metab 1999 84: 1091-1095 doi:10.1210/jc.84.3.1091 [Abstract] [Full Text] [PDF]  

Christine P. Burren, Elisabeth M. Wilson, Vivian Hwa, Youngman Oh, and Ron G. Rosenfeld

Binding Properties and Distribution of Insulin-Like Growth Factor Binding Protein-Related Protein 3 (IGFBP-rP3/NovH), an Additional Member of the IGFBP Superfamily
J Clin Endocrinol Metab 1999 84: 1096-1103 doi:10.1210/jc.84.3.1096 [Abstract] [Full Text] [PDF]  

Cuong Hoang-Vu, Kerstin Bull, Irene Schwarz, Gabriele Krause, Cornelia Schmutzler, Gabriela Aust, Josef Köhrle, and Henning Dralle

Regulation of CD97 Protein in Thyroid Carcinoma
J Clin Endocrinol Metab 1999 84: 1104-1109 doi:10.1210/jc.84.3.1104 [Abstract] [Full Text] [PDF]  

Susan J. Spencer, Sam Mesiano, Janet Y. Lee, and Robert B. Jaffe

Proliferation and Apoptosis in the Human Adrenal Cortex during the Fetal and Perinatal Periods: Implications for Growth and Remodeling
J Clin Endocrinol Metab 1999 84: 1110-1115 doi:10.1210/jc.84.3.1110 [Abstract] [Full Text] [PDF]  

Bonald C. Figueiredo, Constantine A. Stratakis, Romolo Sandrini, Luiz DeLacerda, Mara A. D. Pianovsky, Christoforos Giatzakis, Hannah M. Young, and Bassem R. Haddad

Comparative Genomic Hybridization Analysis of Adrenocortical Tumors of Childhood
J Clin Endocrinol Metab 1999 84: 1116-1121 doi:10.1210/jc.84.3.1116 [Abstract] [Full Text] [PDF]  

Constantine A. Stratakis, J. Aidan Carney, Lawrence S. Kirschner, Holger S. Willenberg, Silke Brauer, Monika Ehrhart-Bornstein, and Stefan R. Bornstein

Synaptophysin Immunoreactivity in Primary Pigmented Nodular Adrenocortical Disease: Neuroendocrine Properties of Tumors Associated with Carney Complex
J Clin Endocrinol Metab 1999 84: 1122-1128 doi:10.1210/jc.84.3.1122 [Abstract] [Full Text] [PDF]  

Hugh S. Taylor, Peter Igarashi, David L. Olive, and Aydin Arici

Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium
J Clin Endocrinol Metab 1999 84: 1129-1135 doi:10.1210/jc.84.3.1129 [Abstract] [Full Text] [PDF]  

H. Kremer, J. W. M. Martens, M. van Reen, M. Verhoef-Post, J. M. Wit, B. J. Otten, S. L. S. Drop, H. A. Delemarre-van de Waal, M. Pombo-Arias, F. De Luca, N. Potau, J. M. H. Buckler, M. Jansen, J. S. Parks, H. A. Latif, G. W. Moll, W. Epping, G. Saggese, E. C. M. Mariman, A. P. N. Themmen, and H. G. Brunner

COMMENTS:A Limited Repertoire of Mutations of the Luteinizing Hormone (LH) Receptor Gene in Familial and Sporadic Patients with Male LH-Independent Precocious Puberty
J Clin Endocrinol Metab 1999 84: 1136-1140 doi:10.1210/jc.84.3.1136 [Abstract] [Full Text] [PDF]  

From the Clinical Research Centers:

Joan C. Lo, Valerie M. Schwitzgebel, J. Blake Tyrrell, Paul A. Fitzgerald, Selna L. Kaplan, Felix A. Conte, and Melvin M. Grumbach

Normal Female Infants Born of Mothers with Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
J Clin Endocrinol Metab 1999 84: 930-936 doi:10.1210/jc.84.3.930 [Abstract] [Full Text] [PDF]  

C. Prasad, M. Imamura, C. Debata, F. Svec, N. Sumar, and J. Hermon-Taylor

Hyperenterostatinemia in Premenopausal Obese Women
J Clin Endocrinol Metab 1999 84: 937-941 doi:10.1210/jc.84.3.937 [Abstract] [Full Text] [PDF]  

Linda A. Jahn, Eugene J. Barrett, Michael L. Genco, Liping Wei, Thomas A. Spraggins, and David A. Fryburg

Tissue Composition Affects Measures of Postabsorptive Human Skeletal Muscle Metabolism: Comparison across Genders
J Clin Endocrinol Metab 1999 84: 1007-1010 doi:10.1210/jc.84.3.1007 [Abstract] [Full Text] [PDF]  

Frances J. Hayes, Dennis J. McNicholl, David Schoenfeld, Erica E. Marsh, and Janet E. Hall

Free -Subunit Is Superior to Luteinizing Hormone as a Marker of Gonadotropin-Releasing Hormone Despite Desensitization at Fast Pulse Frequencies
J Clin Endocrinol Metab 1999 84: 1028-1036 doi:10.1210/jc.84.3.1028 [Abstract] [Full Text] [PDF]  

A. Iranmanesh, T. Mulligan, and J. D. Veldhuis

Mechanisms Subserving the Physiological Nocturnal Relative Hypoprolactinemia of Healthy Older Men: Dual Decline in Prolactin Secretory Burst Mass and Basal Release with Preservation of Pulse Duration, Frequency, and Interpulse Interval—A General Clinical Research Center Study
J Clin Endocrinol Metab 1999 84: 1083-1090 doi:10.1210/jc.84.3.1083 [Abstract] [Full Text] [PDF]  

Rapid Communications:

Paresh Dandona, Ahmad Aljada, Rajesh Garg, and Priya Mohanty

Increase in Plasma Interleukin-10 Following Hydrocortisone Injection
J Clin Endocrinol Metab 1999 84: 1141-1144 doi:10.1210/jc.84.3.1141 [Abstract] [Full Text] [PDF]  

Ken K. L. Ong, Marion L. Ahmed, Andrea Sherriff, Katie A. Woods, Angie Watts, Jean Golding, and David B. Dunger

Cord Blood Leptin Is Associated with Size at Birth and Predicts Infancy Weight Gain in Humans
J Clin Endocrinol Metab 1999 84: 1145-1148 doi:10.1210/jc.84.3.1145 [Abstract] [Full Text] [PDF]  

Toni R. Prezant, Pinar Kadioglu, and Shlomo Melmed

An Intronless Homolog of Human Proto-Oncogene hPTTG Is Expressed in Pituitary Tumors: Evidence for hPTTG Family
J Clin Endocrinol Metab 1999 84: 1149-1152 doi:10.1210/jc.84.3.1149 [Abstract] [Full Text] [PDF]  

Zhang-Zhi Hu, Li Zhuang, Jianping Meng, Mark Leondires, and Maria L. Dufau

The Human Prolactin Receptor Gene Structure and Alternative Promoter Utilization: The Generic Promoter hPII and a Novel Human Promoter hP_N
J Clin Endocrinol Metab 1999 84: 1153-1156 doi:10.1210/jc.84.3.1153 [Abstract] [Full Text] [PDF]  

Cedric H.L. Shackleton, Esther Roitman, Lisa E. Kratz, and Richard I. Kelley

Equine Type Estrogens Produced by a Pregnant Woman Carrying a Smith-Lemli-Opitz Syndrome Fetus
J Clin Endocrinol Metab 1999 84: 1157-1159 doi:10.1210/jc.84.3.1157 [Abstract] [Full Text] [PDF]  

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