Articles listed in blue may be of special interest to clinicians.

Special Articles:

Nicholas A. Tritos and Christos S. Mantzoros

CLINICAL REVIEW 97: Syndromes of Severe Insulin Resistance
J Clin Endocrinol Metab 1998 83: 3025-3030. [Full Text]  

Pamela U. Freda and Sharon L. Wardlaw

EDITORIAL: Primary Medical Therapy for Acromegaly
J Clin Endocrinol Metab 1998 83: 3031-3033. [Full Text]  

Samuel A. Wells, Jr.

THERAPEUTIC CONTROVERSY: The Role of Laparoscopic Surgery in Adrenal Disease
J Clin Endocrinol Metab 1998 83: 3041-3043. [Full Text]  

André Lacroix

THERAPEUTIC CONTROVERSY: Five-Year Experience with Laparoscopic Adrenalectomy at Hôtel-Dieu in Montréal: Endocrinologist’s Perspective
J Clin Endocrinol Metab 1998 83: 3043-3046. [Full Text]  

Deborah P. Merke

THERAPEUTIC CONTROVERSY: The Role of Laparoscopic Surgery in Adrenal Disease: A Pediatric Perspective
J Clin Endocrinol Metab 1998 83: 3046-3048. [Full Text]  

Jeffrey A. Norton

THERAPEUTIC CONTROVERSY: Laparoscopic versus Open Adrenalectomy
J Clin Endocrinol Metab 1998 83: 3048-3049. [Full Text]  

From the Clinical Research Centers:

Shalender Bhasin, Thomas W. Storer, Nancy Asbel-Sethi, Amy Kilbourne, Ron Hays, Indrani Sinha-Hikim, Ruoquing Shen, Stefan Arver, and Gildon Beall

Effects of Testosterone Replacement with a Nongenital, Transdermal System, Androderm, in Human Immunodeficiency Virus-Infected Men with Low Testosterone Levels
J Clin Endocrinol Metab 1998 83: 3155-3162. [Abstract] [Full Text]  

Howard B. A. Baum, Laurence Katznelson, Janet C. Sherman, Beverly M. K. Biller, Douglas L. Hayden, David A. Schoenfeld, Kristin E. Cannistraro, and Anne Klibanski

Effects of Physiological Growth Hormone (GH) Therapy on Cognition and Quality of Life in Patients with Adult-Onset GH Deficiency
J Clin Endocrinol Metab 1998 83: 3184-3189. [Abstract] [Full Text]  

Caren M. Gundberg, Sherril D. Nieman, Steven Abrams, and Harold Rosen

Vitamin K Status and Bone Health: An Analysis of Methods for Determination of Undercarboxylated Osteocalcin
J Clin Endocrinol Metab 1998 83: 3258-3266. [Abstract] [Full Text]  

Elizabeth A. Young, Juan F. Lopez, Virginia Murphy-Weinberg, Stanley J. Watson, and Huda Akil

The Role of Mineralocorticoid Receptors in Hypothalamic-Pituitary-Adrenal Axis Regulation in Humans
J Clin Endocrinol Metab 1998 83: 3339-3345. [Abstract] [Full Text]  

Original Studies:

Connie B. Newman, Shlomo Melmed, Ajax George, Drew Torigian, Michael Duhaney, Peter Snyder, William Young, Anne Klibanski, Mark E. Molitch, Robert Gagel, Leslie Sheeler, David Cook, William Malarkey, Ivor Jackson, Mary Lee Vance, Ariel Barkan, Lawrence Frohman, and David L. Kleinberg

Octreotide as Primary Therapy for Acromegaly
J Clin Endocrinol Metab 1998 83: 3034-3040. [Abstract] [Full Text]  

Margaret A. McNurlan, Peter J. Garlick, Robert A. Frost, Kim A. DeCristofaro, Charles H. Lang, Roy T. Steigbigel, Jack Fuhrer, and Marie Gelato

Albumin Synthesis and Bone Collagen Formation in Human Immunodeficiency Virus-Positive Subjects: Differential Effects of Growth Hormone Administration
J Clin Endocrinol Metab 1998 83: 3050-3055. [Abstract] [Full Text]  

E. Stacey, P. Korkia, M. V. J. Hukkanen, J. M. Polak, and O. M. Rutherford

Decreased Nitric Oxide Levels and Bone Turnover in Amenorrheic Athletes with Spinal Osteopenia
J Clin Endocrinol Metab 1998 83: 3056-3061. [Abstract] [Full Text]  

Greet Van den Berghe, Pieter Wouters, Lena Carlsson, Robert C. Baxter, Roger Bouillon, and Cyril Y. Bowers

Leptin Levels in Protracted Critical Illness: Effects of Growth Hormone-Secretagogues and Thyrotropin-Releasing Hormone
J Clin Endocrinol Metab 1998 83: 3062-3070. [Abstract] [Full Text]  

Graziano Pinna, Luis Hiedra, Harald Meinhold, Murat Eravci, Hans Prengel, Oliver Brödel, Klaus-Jürgen Gräf, Gisela Stoltenburg-Didinger, Michael Bauer, and Andreas Baumgartner

3,3'-Diiodothyronine Concentrations in the Sera of Patients with Nonthyroidal Illnesses and Brain Tumors and of Healthy Subjects during Acute Stress
J Clin Endocrinol Metab 1998 83: 3071-3077. [Abstract] [Full Text]  

E. S. Knochenhauer, T. J. Key, M. Kahsar-Miller, W. Waggoner, L. R. Boots, and R. Azziz

Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study
J Clin Endocrinol Metab 1998 83: 3078-3082. [Abstract] [Full Text]  

J. Lado-Abeal, J. Rodriguez-Arnao, J. D. C. Newell-Price, L. A. Perry, A. B. Grossman, G. M. Besser, and P. J. Trainer

Menstrual Abnormalities in Women with Cushing’s Disease Are Correlated with Hypercortisolemia Rather Than Raised Circulating Androgen Levels
J Clin Endocrinol Metab 1998 83: 3083-3088. [Abstract] [Full Text]  

Mohamad Maghnie, Grazia Bossi, Catherine Klersy, Gianluca Cosi, Eugenio Genovese, and Maurizio Aricò

Dynamic Endocrine Testing and Magnetic Resonance Imaging in the Long Term Follow-Up of Childhood Langerhans Cell Histiocytosis
J Clin Endocrinol Metab 1998 83: 3089-3094. [Abstract] [Full Text]  

Rong Wang, Jerald C. Nelson, and R. Bruce Wilcox

Salsalate Administration—A Potential Pharmacological Model of the Sick Euthyroid Syndrome
J Clin Endocrinol Metab 1998 83: 3095-3099. [Abstract] [Full Text]  

Gabriel Dickstein, Carmela Shechner, Eldad Arad, Lael-Anson Best, and Ofer Nativ

Is There a Role for Low Doses of Mitotane (o,p'-DDD) as Adjuvant Therapy in Adrenocortical Carcinoma?
J Clin Endocrinol Metab 1998 83: 3100-3103. [Abstract] [Full Text]  

Marlys R. Drange and Shlomo Melmed

Long-Acting Lanreotide Induces Clinical and Biochemical Remission of Acromegaly Caused by Disseminated Growth Hormone-Releasing Hormone-Secreting Carcinoid
J Clin Endocrinol Metab 1998 83: 3104-3109. [Abstract] [Full Text]  

Frank H. Pierik, Jan T. M. Vreeburg, Theo Stijnen, Frank H. de Jong, and Robertus F. A. Weber

Serum Inhibin B as a Marker of Spermatogenesis
J Clin Endocrinol Metab 1998 83: 3110-3114. [Abstract] [Full Text]  

Paul Saenger, Kenneth M. Attie, Joan DiMartino-Nardi, Raymond Hintz, Lindley Frahm, and James W. Frane

Metabolic Consequences of 5-Year Growth Hormone (GH) Therapy in Children Treated with GH for Idiopathic Short Stature
J Clin Endocrinol Metab 1998 83: 3115-3120. [Abstract] [Full Text]  

P. M. Crofton, S. F. Ahmed, J. C. Wade, R. Stephen, M. W. Elmlinger, M. B. Ranke, C. J. H. Kelnar, and W. H. B. Wallace

Effects of Intensive Chemotherapy on Bone and Collagen Turnover and the Growth Hormone Axis in Children with Acute Lymphoblastic Leukemia
J Clin Endocrinol Metab 1998 83: 3121-3129. [Abstract] [Full Text]  

Isabella Heuser, Michael Deuschle, Peter Luppa, Ulrich Schweiger, Harald Standhardt, and Bettina Weber

Increased Diurnal Plasma Concentrations of Dehydroepiandrosterone in Depressed Patients
J Clin Endocrinol Metab 1998 83: 3130-3133. [Abstract] [Full Text]  

Olivier Chabre, Panagiotis Liakos, Josiane Vivier, Philippe Chaffanjon, Françoise Labat-Moleur, Monique Martinie, Serge P. Bottari, Ivan Bachelot, Edmond M. Chambaz, Geneviève Defaye, and Jean-Jacques Feige

Cushing’s Syndrome due to a Gastric Inhibitory Polypeptide-Dependent Adrenal Adenoma: Insights into Hormonal Control of Adrenocortical Tumorigenesis
J Clin Endocrinol Metab 1998 83: 3134-3143. [Abstract] [Full Text]  

J. Sundgot-Borgen, R. Bahr, J. A. Falch, and L. Sundgot Schneider

Normal Bone Mass in Bulimic Women
J Clin Endocrinol Metab 1998 83: 3144-3149. [Abstract] [Full Text]  

Giampiero Igli Baroncelli, Silvano Bertelloni, Cinzia Ceccarelli, and Giuseppe Saggese

Measurement of Volumetric Bone Mineral Density Accurately Determines Degree of Lumbar Undermineralization in Children with Growth Hormone Deficiency
J Clin Endocrinol Metab 1998 83: 3150-3154. [Abstract] [Full Text]  

Stefano Laureti, Patrick Aubourg, Filippo Calcinaro, Francis Rocchiccioli, Giovanni Casucci, Gabriella Angeletti, Paolo Brunetti, Åke Lernmark, Fausto Santeusanio, and Alberto Falorni

Etiological Diagnosis of Primary Adrenal Insufficiency Using an Original Flowchart of Immune and Biochemical Markers
J Clin Endocrinol Metab 1998 83: 3163-3168. [Abstract] [Full Text]  

Vivian A. Fonseca, Thomas R. Valiquett, Saling M. Huang, Mahmoud N. Ghazzi, and Randall W. Whitcomb

Troglitazone Monotherapy Improves Glycemic Control in Patients With Type 2 Diabetes Mellitus: A Randomized, Controlled Study
J Clin Endocrinol Metab 1998 83: 3169-3176. [Abstract] [Full Text]  

Marc Y. Donath, Gabor Sütsch, Xia-Wei Yan, Bruno Piva, Hans-Peter Brunner, Yvonne Glatz, Jürgen Zapf, Ferenc Follath, E. Rudolf Froesch, and Wolfgang Kiowski

Acute Cardiovascular Effects of Insulin-Like Growth Factor I in Patients with Chronic Heart Failure
J Clin Endocrinol Metab 1998 83: 3177-3183. [Abstract] [Full Text]  

Sami T. Azar and Adel Birbari

Nocturnal Blood Pressure Elevation in Patients with Type 1 Diabetes Receiving Intensive Insulin Therapy Compared with that in Patients Receiving Conventional Insulin Therapy
J Clin Endocrinol Metab 1998 83: 3190-3193. [Abstract] [Full Text]  

Victor J. Pop, Luc H. Maartens, Geraline Leusink, Maarten J. van Son, Andre A. Knottnerus, Anthony M. Ward, Russell Metcalfe, and Anthony P. Weetman

Are Autoimmune Thyroid Dysfunction and Depression Related?
J Clin Endocrinol Metab 1998 83: 3194-3197. [Abstract] [Full Text]  

Judith L. Ross, David Roeltgen, Penelope Feuillan, Harvey Kushner, and Gordon B. Cutler, Jr.

Effects of Estrogen on Nonverbal Processing Speed and Motor Function in Girls with Turner’s Syndrome
J Clin Endocrinol Metab 1998 83: 3198-3204. [Abstract] [Full Text]  

Katsumi Goji, Michio Kuwahara, Yong Gu, Masafumi Matsuo, Fumiaki Marumo, and Sei Sasaki

Novel Mutations in Aquaporin-2 Gene in Female Siblings with Nephrogenic Diabetes Insipidus: Evidence of Disrupted Water Channel Function
J Clin Endocrinol Metab 1998 83: 3205-3209. [Abstract] [Full Text]  

Sylvia L. Asa, Katia Somers, and Shereen Ezzat

The MEN-1 Gene Is Rarely Down-Regulated in Pituitary Adenomas
J Clin Endocrinol Metab 1998 83: 3210-3212. [Abstract] [Full Text]  

R. C. Baxter, M. A. Binoux, D. R. Clemmons, C. A. Conover, S. L. S. Drop, J. M. P. Holly, S. Mohan, Y. Oh, and R. G. Rosenfeld

Recommendations for Nomenclature of the Insulin-Like Growth Factor Binding Protein Superfamily
J Clin Endocrinol Metab 1998 83: 3213. [Full Text]  

David J. Torpy, Richard D. Gordon, Jing Ping Lin, Phillip R. Huggard, Susan E. Taymans, Michael Stowasser, George P. Chrousos, and Constantine A. Stratakis

Familial Hyperaldosteronism Type II: Description of a Large Kindred and Exclusion of the Aldosterone Synthase (CYP11B2) Gene
J Clin Endocrinol Metab 1998 83: 3214-3218. [Abstract] [Full Text]  

R. P. Buyalos, R. V. Jackson, G. I. Grice, G. I. Hockings, D. J. Torpy, L. M. Fox, L. R. Boots, and R. Azziz

Androgen Response to Hypothalamic-Pituitary-Adrenal Stimulation with Naloxone in Women with Myotonic Muscular Dystrophy
J Clin Endocrinol Metab 1998 83: 3219-3224. [Abstract] [Full Text]  

Hiroko Mise, Norimasa Sagawa, Tsunekazu Matsumoto, Shigeo Yura, Hidetaka Nanno, Hiroaki Itoh, Takahide Mori, Hiroaki Masuzaki, Kiminori Hosoda, Yoshihiro Ogawa, and Kazuwa Nakao

Augmented Placental Production of Leptin in Preeclampsia: Possible Involvement of Placental Hypoxia
J Clin Endocrinol Metab 1998 83: 3225-3229. [Abstract] [Full Text]  

Jon J. Ramsey, Joseph W. Kemnitz, Ricki J. Colman, David Cunningham, and Andrew G. Swick

Different Central and Peripheral Responses to Leptin in Rhesus Monkeys: Brain Transport May Be Limited
J Clin Endocrinol Metab 1998 83: 3230-3235. [Abstract] [Full Text]  

Agneta Nordenskjöld and Sten-Anders Ivarsson

Molecular Characterization of 5-Reductase Type 2 Deficiency and Fertility in a Swedish Family
J Clin Endocrinol Metab 1998 83: 3236-3238. [Abstract] [Full Text]  

Matti K. Karvonen, Ullamari Pesonen, Paula Heinonen, Markku Laakso, Aila Rissanen, Hannu Naukkarinen, Raisa Valve, Matti I. J. Uusitupa, and Markku Koulu

Identification of New Sequence Variants in the Leptin Gene
J Clin Endocrinol Metab 1998 83: 3239-3242. [Abstract] [Full Text]  

Virve Luukkaa, Ullamari Pesonen, Ilpo Huhtaniemi, Aapo Lehtonen, Reijo Tilvis, Jaakko Tuomilehto, Markku Koulu, and Risto Huupponen

Inverse Correlation between Serum Testosterone and Leptin in Men
J Clin Endocrinol Metab 1998 83: 3243-3246. [Abstract] [Full Text]  

Kwon-Yul Ryu, Qiang Tong, and Sissy M. Jhiang

Promoter Characterization of the Human Na⁺/I^- Symporter
J Clin Endocrinol Metab 1998 83: 3247-3251. [Abstract] [Full Text]  

Ewan S. Grant, Margaret B. Ross, Stephen Ballard, Alasdair Naylor, and Fouad K. Habib

The Insulin-Like Growth Factor Type I Receptor Stimulates Growth and Suppresses Apoptosis in Prostatic Stromal Cells
J Clin Endocrinol Metab 1998 83: 3252-3257. [Abstract] [Full Text]  

Wanfang Su, Hannia Campos, Helena Judge, Brian W. Walsh, and Frank M. Sacks

Metabolism of Apo(a) and ApoB100 of Lipoprotein(a) in Women: Effect of Postmenopausal Estrogen Replacement
J Clin Endocrinol Metab 1998 83: 3267-3276. [Abstract] [Full Text]  

Janet Pritchard, Jean-Pierre Després, Jacques Gagnon, André Tchernof, André Nadeau, Angelo Tremblay, and Claude Bouchard

Plasma Adrenal, Gonadal, and Conjugated Steroids before and after Long Term Overfeeding in Identical Twins
J Clin Endocrinol Metab 1998 83: 3277-3284. [Abstract] [Full Text]  

Anders Frost, Kenneth B. Jonsson, Helena Brändström, Claes Ohlsson, Sverker Ljunghall, and Östen Ljunggren

Interleukin-13 Inhibits Cell Proliferation and Stimulates Interleukin-6 Formation in Isolated Human Osteoblasts
J Clin Endocrinol Metab 1998 83: 3285-3289. [Abstract] [Full Text]  

Giuseppe Barbesino, Yaron Tomer, Erlinda S. Concepcion, Terry F. Davies, and David A. Greenberg

Linkage Analysis of Candidate Genes in Autoimmune Thyroid Disease. II. Selected Gender-Related Genes and the X-Chromosome
J Clin Endocrinol Metab 1998 83: 3290-3295. [Abstract] [Full Text]  

Kevin T. Whang, Paul M. Steinwald, Jon C. White, Eric S. Nylen, Richard H. Snider, Gary L. Simon, Robin L. Goldberg, and Kenneth L. Becker

Serum Calcitonin Precursors in Sepsis and Systemic Inflammation
J Clin Endocrinol Metab 1998 83: 3296-3301. [Abstract] [Full Text]  

Nancy E. Reame, Tammy L. Wyman, David J. Phillips, David M. de Kretser, and Vasantha Padmanabhan

Net Increase in Stimulatory Input Resulting from a Decrease in Inhibin B and an Increase in Activin A May Contribute in Part to the Rise in Follicular Phase Follicle-Stimulating Hormone of Aging Cycling Women
J Clin Endocrinol Metab 1998 83: 3302-3307. [Abstract] [Full Text]  

Sushela S. Chaidarun, Brooke Swearingen, and Joseph M. Alexander

Differential Expression of Estrogen Receptor-ß (ERß) in Human Pituitary Tumors: Functional Interactions with ER and a Tumor-Specific Splice Variant
J Clin Endocrinol Metab 1998 83: 3308-3315. [Abstract] [Full Text]  

Mohamed Shaarawy, Mohamed Amin Fikry, Baher Aly Massoud, and Samar Lotfy

Insulin-Like Growth Factor Binding Protein-3: A Novel Biomarker for the Assessment of the Synthetic Capacity of Hepatocytes in Liver Cirrhosis
J Clin Endocrinol Metab 1998 83: 3316-3319. [Abstract] [Full Text]  

Keith M. Godfrey, Nina Matthews, Jocelyn Glazier, Alan Jackson, Clare Wilman, and Colin P. Sibley

Neutral Amino Acid Uptake by the Microvillous Plasma Membrane of the Human Placenta Is Inversely Related to Fetal Size at Birth in Normal Pregnancy
J Clin Endocrinol Metab 1998 83: 3320-3326. [Abstract] [Full Text]  

K. D. Dieterich, E. D. Gundelfinger, D. K. Lüdecke, and H. Lehnert

Mutation and Expression Analysis of Corticotropin-Releasing Factor 1 Receptor in Adrenocorticotropin-Secreting Pituitary Adenomas
J Clin Endocrinol Metab 1998 83: 3327-3331. [Abstract] [Full Text]  

Patricia A. Deuster, John S. Petrides, Anita Singh, Edward B. Lucci, George P. Chrousos, and Philip W. Gold

High Intensity Exercise Promotes Escape of Adrenocorticotropin and Cortisol from Suppression by Dexamethasone: Sexually Dimorphic Responses
J Clin Endocrinol Metab 1998 83: 3332-3338. [Abstract] [Full Text]  

Joy D. Cogan, Wei Wu, John A. Phillips, III, Ivo J. P. Arnhold, Ana Agapito, Olga V. Fofanova, Maria Geralda F. Osorio, Iffet Bircan, Adolfo Moreno, and Berenice B. Mendonca

The PROP1 2-Base Pair Deletion Is a Common Cause of Combined Pituitary Hormone Deficiency
J Clin Endocrinol Metab 1998 83: 3346-3349. [Abstract] [Full Text]  

Bo Ahrén and Giovanni Pacini

Age-Related Reduction in Glucose Elimination Is Accompanied by Reduced Glucose Effectiveness and Increased Hepatic Insulin Extraction in Man
J Clin Endocrinol Metab 1998 83: 3350-3356. [Abstract] [Full Text]  

Carlos E. Fardella, Helena Poggi, Pedro Pineda, Julia Soto, Isabel Torrealba, AndreÍna Cattani, Eveline Oestreicher, and Arnaldo Foradori

COMMENTS: Salt-Wasting Congenital Adrenal Hyperplasia: Detection of Mutations in CYP21B Gene in a Chilean Population
J Clin Endocrinol Metab 1998 83: 3357-3360. [Abstract] [Full Text]  

Salud Borrego, Charis Eng, Beatriz Sánchez, María-Eugenia Sáez, Elena Navarro, and Guillermo Antiñolo

COMMENTS: Molecular Analysis of the ret and GDNF Genes in a Family with Multiple Endocrine Neoplasia Type 2A and Hirschsprung Disease
J Clin Endocrinol Metab 1998 83: 3361-3364. [Abstract] [Full Text]  

Rapid Communications:

Shinji Kosugi, Shinobu Inoue, Akira Matsuda, and Sissy M. Jhiang

Novel, Missense, and Loss-of-Function Mutations in the Sodium/Iodide Symporter Gene Causing Iodide Transport Defect in Three Japanese Patients
J Clin Endocrinol Metab 1998 83: 3365-3368. [Abstract] [Full Text]  

Steven W. Lockley, Debra J. Skene, Kavita Thapan, Judie English, David Ribeiro, Iris Haimov, Shelagh Hampton, Benita Middleton, Malcolm von Schantz, and Josephine Arendt

Extraocular Light Exposure Does Not Suppress Plasma Melatonin in Humans
J Clin Endocrinol Metab 1998 83: 3369-3372. [Abstract] [Full Text]  

Ping Zhang, Anne-Sixtine Jobert, Alain Couvineau, and Carline Silve

A Homozygous Inactivating Mutation in the Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Causing Blomstrand Chondrodysplasia
J Clin Endocrinol Metab 1998 83: 3373-3376. [Abstract] [Full Text]  

Letters to the Editor:

Salvatore Benvenga

Effect of Thyroxine on Low Density Lipoprotein Oxidation Another Thyroid Hormone Nongenomic Effect
J Clin Endocrinol Metab 1998 83: 3377-3378. [Full Text]  

James M. Falko and Vidya Sundaram

Effect of Thyroxine on Low Density Lipoprotein Oxidation—Authors’ Response
J Clin Endocrinol Metab 1998 83: 3378. [Full Text]  

Theodore C. Friedman and Dimitris A. Papanicolaou

Comment on High Urinary Free Cortisol Excretion in a Patient with Psychogenic Polydipsia
J Clin Endocrinol Metab 1998 83: 3378a. [Full Text]  

Maria Veronica Mericq

High Fluid Intake Increases Urine Free Cortisol Excretion in Normal Subjects—Authors’ Response
J Clin Endocrinol Metab 1998 83: 3378b-3379. [Full Text]  

Constantine Tsigos, Ioannis Kyrou, George P. Chrousos, and Dimitris A. Papanicolaou

Prolonged Suppression of Corticosteroid-Binding Globulin by Recombinant Human Interleukin-6 in Man
J Clin Endocrinol Metab 1998 83: 3379. [Full Text]  

A. Michael Parfitt

Comment on Therapeutic Controversy: Thyroid Surgery—The Choice
J Clin Endocrinol Metab 1998 83: 3379a-3380. [Full Text]  

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