Articles listed in blue may be of special interest to clinicians.

Special Articles:

Greet Van den Berghe, Francis de Zegher, and Roger Bouillon

CLINICAL REVIEW 95: Acute and Prolonged Critical Illness as Different Neuroendocrine Paradigms
J Clin Endocrinol Metab 1998 83: 1827-1834. [Full Text]  

Frances J. Hayes, Janet E. Hall, Paul A. Boepple, and William F. Crowley, Jr.

CLINICAL REVIEW 96: Differential Control of Gonadotropin Secretion in the Human: Endocrine Role of Inhibin
J Clin Endocrinol Metab 1998 83: 1835-1841. [Full Text]  

George P. Chrousos and Philip W. Gold

EDITORIAL: A Healthy Body in a Healthy Mind—and Vice Versa—The Damaging Power of "Uncontrollable" Stress
J Clin Endocrinol Metab 1998 83: 1842-1845. [Full Text]  

Ian R. Reid

EDITORIAL: Glucocorticoid Effects on Bone
J Clin Endocrinol Metab 1998 83: 1860-1862. [Full Text]  

CONSENSUS: Treatment of Estrogen Deficiency Symptoms in Women Surviving Breast Cancer
J Clin Endocrinol Metab 1998 83: 1993-2000. [Full Text]  

From the Clinical Research Centers:

Nelly Mauras, Valerie Hayes, Susan Welch, Annie Rini, Kevin Helgeson, Maryanne Dokler, Johannes D. Veldhuis, and Randall J. Urban

Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity
J Clin Endocrinol Metab 1998 83: 1886-1892. [Abstract] [Full Text]  

Hassan M. Heshmati, Sundeep Khosla, Mary F. Burritt, W. Michael O’Fallon, and B. Lawrence Riggs

A Defect in Renal Calcium Conservation May Contribute to the Pathogenesis of Postmenopausal Osteoporosis
J Clin Endocrinol Metab 1998 83: 1916-1920. [Abstract] [Full Text]  

Sharon H. Travers, Jose I. Labarta, Sharron E. Gargosky, Ron G. Rosenfeld, Barrett W. Jeffers, and Robert H. Eckel

Insulin-Like Growth Factor Binding Protein-I Levels Are Strongly Associated with Insulin Sensitivity and Obesity in Early Pubertal Children
J Clin Endocrinol Metab 1998 83: 1935-1939. [Abstract] [Full Text]  

Matti Bergendahl, Joseph A. Aloi, Ali Iranmanesh, Thomas M. Mulligan, and Johannes D. Veldhuis

Fasting Suppresses Pulsatile Luteinizing Hormone (LH) Secretion and Enhances Orderliness of LH Release in Young but Not Older Men
J Clin Endocrinol Metab 1998 83: 1967-1975. [Abstract] [Full Text]  

Original Studies:

Maurizio Panarelli, Christine D. Holloway, Robert Fraser, John M. C. Connell, Mary C. Ingram, Niall H. Anderson, and Christopher J. Kenyon

Glucocorticoid Receptor Polymorphism, Skin Vasoconstriction, and Other Metabolic Intermediate Phenotypes in Normal Human Subjects
J Clin Endocrinol Metab 1998 83: 1846-1852. [Abstract] [Full Text]  

Roland Rosmond, Mary F. Dallman, and Per Björntorp

Stress-Related Cortisol Secretion in Men: Relationships with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities
J Clin Endocrinol Metab 1998 83: 1853-1859. [Abstract] [Full Text]  

I. Chiodini, V. Carnevale, M. Torlontano, S. Fusilli, G. Guglielmi, M. Pileri, S. Modoni, A. Di Giorgio, A. Liuzzi, S. Minisola, M. Cammisa, V. Trischitta, and A. Scillitani

Alterations of Bone Turnover and Bone Mass at Different Skeletal Sites due to Pure Glucocorticoid Excess: Study in Eumenorrheic Patients with Cushing’s Syndrome
J Clin Endocrinol Metab 1998 83: 1863-1867. [Abstract] [Full Text]  

Harold Snieder, Alex J. MacGregor, and Tim D. Spector

Genes Control the Cessation of a Woman’s Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause
J Clin Endocrinol Metab 1998 83: 1875-1880. [Abstract] [Full Text]  

Yrsa Bergmann Sverrisdóttir, Mikael Elam, Hans Herlitz, Bengt-Åke Bengtsson, and Gudmundur Johannsson

Intense Sympathetic Nerve Activity in Adults with Hypopituitarism and Untreated Growth Hormone Deficiency
J Clin Endocrinol Metab 1998 83: 1881-1885. [Abstract] [Full Text]  

C. Simon, C. Gronfier, J. L. Schlienger, and G. Brandenberger

Circadian and Ultradian Variations of Leptin in Normal Man under Continuous Enteral Nutrition: Relationship to Sleep and Body Temperature
J Clin Endocrinol Metab 1998 83: 1893-1899. [Abstract] [Full Text]  

Nelly Mauras, Susan Welch, Annie Rini, and Morey W. Haymond

Ovarian Hyperandrogenism Is Associated with Insulin Resistance to Both Peripheral Carbohydrate and Whole-Body Protein Metabolism in Postpubertal Young Females: A Metabolic Study
J Clin Endocrinol Metab 1998 83: 1900-1905. [Abstract] [Full Text]  

Frederick R. Singer, Thomas L. Clemens, Rachelle A. Eusebio, and Pirow J. Bekker

Risedronate, a Highly Effective Oral Agent in the Treatment of Patients with Severe Paget’s Disease
J Clin Endocrinol Metab 1998 83: 1906-1910. [Abstract] [Full Text]  

Ramin Alemzadeh, Gina Langley, Lori Upchurch, Pam Smith, and Alfred E. Slonim

Beneficial Effect of Diazoxide in Obese Hyperinsulinemic Adults
J Clin Endocrinol Metab 1998 83: 1911-1915. [Abstract] [Full Text]  

Kristina Åkesson, K.-H. William Lau, Patricia Johnston, Ellen Imperio, and David J. Baylink

Effects of Short-Term Calcium Depletion and Repletion on Biochemical Markers of Bone Turnover in Young Adult Women
J Clin Endocrinol Metab 1998 83: 1921-1927. [Abstract] [Full Text]  

Wiebke Arlt, Hans-Georg Justl, Frank Callies, Martin Reincke, Doris Hübler, Michael Oettel, Michael Ernst, Heinrich Maria Schulte, and Bruno Allolio

Oral Dehydroepiandrosterone for Adrenal Androgen Replacement: Pharmacokinetics and Peripheral Conversion to Androgens and Estrogens in Young Healthy Females after Dexamethasone Suppression
J Clin Endocrinol Metab 1998 83: 1928-1934. [Abstract] [Full Text]  

Daisy Chin, Phyllis W. Speiser, Julianne Imperato-McGinley, Naznin Dixit, Naveen Uli, Raphael David, and Sharon E. Oberfield

Study of a Kindred with Classic Congenital Adrenal Hyperplasia: Diagnostic Challenge due to Phenotypic Variance
J Clin Endocrinol Metab 1998 83: 1940-1945. [Abstract] [Full Text]  

Robert V. Hogikyan, Andrzej T. Galecki, Bertram Pitt, Jeffrey B. Halter, Douglas A. Greene, and Mark A. Supiano

Specific Impairment of Endothelium-Dependent Vasodilation in Subjects with Type 2 Diabetes Independent of Obesity
J Clin Endocrinol Metab 1998 83: 1946-1952. [Abstract] [Full Text]  

John H. Kranzler, Arlan L. Rosenbloom, Victor Martinez, and Jaime Guevara-Aguirre

Normal Intelligence with Severe Insulin-Like Growth Factor I Deficiency due to Growth Hormone Receptor Deficiency: A Controlled Study in a Genetically Homogeneous Population
J Clin Endocrinol Metab 1998 83: 1953-1958. [Abstract] [Full Text]  

Johannes L. Kuijpens, Meeny de Haan-Meulman, Huib L. Vader, Victor J. Pop, Wilmar M. Wiersinga, and Hemmo A. Drexhage

Cell-Mediated Immunity and Postpartum Thyroid Dysfunction: A Possibility for the Prediction of Disease?
J Clin Endocrinol Metab 1998 83: 1959-1966. [Abstract] [Full Text]  

L. Cronin, G. Guyatt, L. Griffith, E. Wong, R. Azziz, W. Futterweit, D. Cook, and A. Dunaif

Development of a Health-Related Quality-of-Life Questionnaire (PCOSQ) for Women with Polycystic Ovary Syndrome (PCOS)
J Clin Endocrinol Metab 1998 83: 1976-1987. [Abstract] [Full Text]  

Lena Seippel and Torbjörn Bäckström

Luteal-Phase Estradiol Relates to Symptom Severity in Patients with Premenstrual Syndrome
J Clin Endocrinol Metab 1998 83: 1988-1992. [Abstract] [Full Text]  

John E. Nestler, Daniela J. Jakubowicz, Aida Falcon de Vargas, Carlos Brik, Nitza Quintero, and Francisco Medina

Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System
J Clin Endocrinol Metab 1998 83: 2001-2005. [Abstract] [Full Text]  

M. A. Llopis, M. L. Granada, G. Cuatrecasas, X. Formiguera, L. Sánchez-Planell, A. SanmartÍ, A. Alastrué, M. Rull, A. Corominas, and M. Foz

Growth Hormone-Binding Protein Directly Depends on Serum Leptin Levels in Adults with Different Nutritional Status
J Clin Endocrinol Metab 1998 83: 2006-2011. [Abstract] [Full Text]  

R. H. Straub, L. Konecna, S. Hrach, G. Rothe, M. Kreutz, J. Schölmerich, W. Falk, and B. Lang

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence
J Clin Endocrinol Metab 1998 83: 2012-2017. [Abstract] [Full Text]  

M. E. Wilson

Regulation of the Growth Hormone-Insulin-Like Growth Factor I Axis in Developing and Adult Monkeys Is Affected by Estradiol Replacement and Supplementation with Insulin-Like Growth Factor I
J Clin Endocrinol Metab 1998 83: 2018-2028. [Abstract] [Full Text]  

Giorgio Arnaldi, Jean-Marie Gasc, Yves de Keyzer, Marie-Laure Raffin-Sanson, Véronique Perraudin, Jean-Marc Kuhn, Marie-Charles Raux-Demay, Jean-Pierre Luton, Eric Clauser, and Xavier Bertagna

Variable Expression of the V1 Vasopressin Receptor Modulates the Phenotypic Response of Steroid-Secreting Adrenocortical Tumors
J Clin Endocrinol Metab 1998 83: 2029-2035. [Abstract] [Full Text]  

Dorry L. Segev, Motoyasu Saji, Grace S. Phillips, William H. Westra, Yumi Takiyama, Steven Piantadosi, Robert C. Smallridge, Ronald H. Nishiyama, Robert Udelsman, and Martha A. Zeiger

Polymerase Chain Reaction-Based Microsatellite Polymorphism Analysis of Follicular and Hürthle Cell Neoplasms of the Thyroid
J Clin Endocrinol Metab 1998 83: 2036-2042. [Abstract] [Full Text]  

Domingo Cheleuitte, Shuichi Mizuno, and Julie Glowacki

In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status
J Clin Endocrinol Metab 1998 83: 2043-2051. [Abstract] [Full Text]  

A. Forbes Howie, John R. Arthur, Fergus Nicol, Simon W. Walker, Stuart G. Beech, and Geoffrey J. Beckett

Identification of a 57-Kilodalton Selenoprotein in Human Thyrocytes as Thioredoxin Reductase and Evidence That Its Expression Is Regulated through the Calcium-Phosphoinositol Signaling Pathway
J Clin Endocrinol Metab 1998 83: 2052-2058. [Abstract] [Full Text]  

Steven C. Elbein, Kui Teng, Phaedra Yount, and Eric Scroggin

Linkage and Molecular Scanning Analyses of MODY3/Hepatocyte Nuclear Factor-1 Gene in Typical Familial Type 2 Diabetes: Evidence for Novel Mutations in Exons 8 and 10
J Clin Endocrinol Metab 1998 83: 2059-2065. [Abstract] [Full Text]  

Zeynel A. Erkut, Chris Pool, and Dick F. Swaab

Glucocorticoids Suppress Corticotropin-Releasing Hormone and Vasopressin Expression in Human Hypothalamic Neurons
J Clin Endocrinol Metab 1998 83: 2066-2073. [Abstract] [Full Text]  

Maria Candida B. Villares Fragoso, Ana Claudia Latronico, Filomena Marino Carvalho, Maria Claudia N. Zerbini, Jose Antonio Miguel Marcondes, Leila M. B. Araujo, Valeria S. Lando, Eliana T. Frazzatto, Berenice B. Mendonca, and Sandra Mara F. Villares

Activating Mutation of the Stimulatory G Protein (gsp) as a Putative Cause of Ovarian and Testicular Human Stromal Leydig Cell Tumors
J Clin Endocrinol Metab 1998 83: 2074-2078. [Abstract] [Full Text]  

Flavia Pernasetti, Robert D. G. Milner, Abdullah A. Z. Al Ashwal, Francis de Zegher, Viviana M. Chavez, Marc Muller, and Joseph A. Martial

Pro239Ser: A Novel Recessive Mutation of the Pit-1 Gene in Seven Middle Eastern Children with Growth Hormone, Prolactin, and Thyrotropin Deficiency
J Clin Endocrinol Metab 1998 83: 2079-2083. [Abstract] [Full Text]  

Elza Muscelli, Michele Emdin, Andrea Natali, Lorenza Pratali, Stefania Camastra, Amalia Gastaldelli, Simona Baldi, Clara Carpeggiani, and Ele Ferrannini

Autonomic and Hemodynamic Responses to Insulin in Lean and Obese Humans
J Clin Endocrinol Metab 1998 83: 2084-2090. [Abstract] [Full Text]  

Stavros S. Stavrou, Yuan-Shan Zhu, Li-Qun Cai, Melissa D. Katz, Cecilia Herrera, Mariano DeFillo-Ricart, and Julianne Imperato-McGinley

A Novel Mutation of the Human Luteinizing Hormone Receptor in 46XY and 46XX Sisters
J Clin Endocrinol Metab 1998 83: 2091-2098. [Abstract] [Full Text]  

A. R. Genazzani, F. Petraglia, F. Bernardi, E. Casarosa, C. Salvestroni, A. Tonetti, R. E. Nappi, S. Luisi, M. Palumbo, R. H. Purdy, and M. Luisi

Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences
J Clin Endocrinol Metab 1998 83: 2099-2103. [Abstract] [Full Text]  

Steven J. Santner, Bradley Albertson, Gui-yuan Zhang, Guang-hua Zhang, Michael Santulli, Christina Wang, Laurence M. Demers, Cedric Shackleton, and Richard J. Santen

Comparative Rates of Androgen Production and Metabolism in Caucasian and Chinese Subjects
J Clin Endocrinol Metab 1998 83: 2104-2109. [Abstract] [Full Text]  

Ana A. Murphy, Nalini Santanam, Arlene J. Morales, and Sampath Parthasarathy

Lysophosphatidyl Choline, a Chemotactic Factor for Monocytes/T-Lymphocytes Is Elevated in Endometriosis
J Clin Endocrinol Metab 1998 83: 2110-2113. [Abstract] [Full Text]  

Bin Tean Teh, Filip Farnebo, Stephen Twigg, Anders Höög, Soili Kytölä, Eeva Korpi-Hyövälti, Fung Ki Wong, Jörgen Nordenström, Lars Grimelius, Kerstin Sandelin, Bruce Robinson, Lars-Ove Farnebo, and Catharina Larsson

Familial Isolated Hyperparathyroidism Maps to the Hyperparathyroidism-Jaw Tumor Locus in 1q21-q32 in a Subset of Families
J Clin Endocrinol Metab 1998 83: 2114-2120. [Abstract] [Full Text]  

Annamaria Colao, Paolo Marzullo, Gianfranco Vallone, Valeria Marinò, Massimo Annecchino, Diego Ferone, Davide de Brasi, Raffaele Scarpa, Pasquale Oriente, and Gaetano Lombardi

Reversibility of Joint Thickening in Acromegalic Patients: An Ultrasonography Study
J Clin Endocrinol Metab 1998 83: 2121-2125. [Abstract] [Full Text]  

Shinichiro Ueda, John R. Petrie, Stephen J. Cleland, Henry L. Elliott, and John M. C. Connell

The Vasodilating Effect of Insulin Is Dependent on Local Glucose Uptake: A Double Blind, Placebo-Controlled Study
J Clin Endocrinol Metab 1998 83: 2126-2131. [Abstract] [Full Text]  

Thomas Remer, Klaus Pietrzik, and Friedrich Manz

Short-Term Impact of a Lactovegetarian Diet on Adrenocortical Activity and Adrenal Androgens
J Clin Endocrinol Metab 1998 83: 2132-2137. [Abstract] [Full Text]  

Gary S. Wand and Henry Schumann

Relationship between Plasma Adrenocorticotropin, Hypothalamic Opioid Tone, and Plasma Leptin
J Clin Endocrinol Metab 1998 83: 2138-2142. [Abstract] [Full Text]  

Y. J. H. Janssen, N. A. T. Hamdy, M. Frölich, and F. Roelfsema

Skeletal Effects of Two Years of Treatment with Low Physiological Doses of Recombinant Human Growth Hormone (GH) in Patients with Adult-Onset GH Deficiency
J Clin Endocrinol Metab 1998 83: 2143-2148. [Abstract] [Full Text]  

Xesús Casabiell, Verónica Piñeiro, Roberto Peino, Mary Lage, Jesús Camiña, Rosalía Gallego, Luis Garcia Vallejo, Carlos Dieguez, and Felipe F. Casanueva

Gender Differences in Both Spontaneous and Stimulated Leptin Secretion by Human Omental Adipose Tissue in Vitro: Dexamethasone and Estradiol Stimulate Leptin Release in Women, But Not in Men
J Clin Endocrinol Metab 1998 83: 2149-2155. [Abstract] [Full Text]  

E. Barbara Mawer, Glenville Jones, Michael Davies, Pamela E. Still, Valarie Byford, Neil J. Schroeder, Hugh L. J. Makin, Charles W. Bishop, and Joyce C. Knutson

Unique 24-Hydroxylated Metabolites Represent a Significant Pathway of Metabolism of Vitamin D₂ in Humans: 24-Hydroxyvitamin D₂ and 1,24-Dihydroxyvitamin D₂ Detectable in Human Serum
J Clin Endocrinol Metab 1998 83: 2156-2166. [Abstract] [Full Text]  

Hartmut H.-J. Schmidt, Manfred Stuhrmann, Robert Shamburek, C. Knud Schewe, Margit Ebhardt, Loren A. Zech, Carsten Büttner, Matthias Wendt, Ulrike Beisiegel, H. Bryan Brewer, and Michael P. Manns

Delayed Low Density Lipoprotein (LDL) Catabolism Despite a Functional Intact LDL-Apolipoprotein B Particle and LDL-Receptor in a Subject with Clinical Homozygous Familial Hypercholesterolemia
J Clin Endocrinol Metab 1998 83: 2167-2174. [Abstract] [Full Text]  

Graeme Eisenhofer, Harry Keiser, Peter Friberg, Eva Mezey, Thanh-Truc Huynh, Bhargava Hiremagalur, Todd Ellingson, Sushil Duddempudi, Agnes Eijsbouts, and Jacques W. M. Lenders

Plasma Metanephrines Are Markers of Pheochromocytoma Produced by Catechol-O-Methyltransferase Within Tumors
J Clin Endocrinol Metab 1998 83: 2175-2185. [Abstract] [Full Text]  

Alessandra De Bellis, Clara Crescioli, Cecilia Grappone, Stefano Milani, Paola Ghiandi, Gianni Forti, and Mario Serio

Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue
J Clin Endocrinol Metab 1998 83: 2186-2191. [Abstract] [Full Text]  

Yosuke Shimomura, Hiroya Matsuo, Takasi Samoto, and Takesi Maruo

Up-Regulation by Progesterone of Proliferating Cell Nuclear Antigen and Epidermal Growth Factor Expression in Human Uterine Leiomyoma
J Clin Endocrinol Metab 1998 83: 2192-2198. [Abstract] [Full Text]  

Nicholas Mitsiades, Vassiliki Poulaki, Vassiliki Kotoula, George Mastorakos, Sophia Tseleni-Balafouta, Demetrios A. Koutras, and Maria Tsokos

Fas/Fas Ligand Up-Regulation and BCL-2 Down-Regulation May Be Significant in the Pathogenesis of Hashimoto’s Thyroiditis
J Clin Endocrinol Metab 1998 83: 2199-2203. [Abstract] [Full Text]  

Alois Gessl and Werner Waldhäusl

COMMENTS: Increased CD69 and Human Leukocyte Antigen-DR Expression on T Lymphocytes in Insulin-Dependent Diabetes Mellitus of Long Standing
J Clin Endocrinol Metab 1998 83: 2204-2209. [Abstract] [Full Text]  

Rapid Communications:

Junnosuke Inoue, Taisuke Iwaoka, Hiroshi Tokunaga, Kazufumi Takamune, Shojiro Naomi, Masatake Araki, Kazuo Takahama, Kohei Yamaguchi, and Kimio Tomita

A Family with Liddle’s Syndrome Caused by a New Missense Mutation in the ß Subunit of the Epithelial Sodium Channel
J Clin Endocrinol Metab 1998 83: 2210-2213. [Abstract] [Full Text]  

Letters to the Editor:

Evan Simpson

Why Do the Clinical Sequelae of Estrogen Deficiency Affect Women More than Men?^a
J Clin Endocrinol Metab 1998 83: 2214-2215. [Full Text]  

Antonio E. Pontiroli

Is Insulin the Only Treatment for Obese NIDDM Patients Poorly Controlled By Oral Hypoglycemic Agents?^b
J Clin Endocrinol Metab 1998 83: 2215. [Full Text]  

Markus Hufnagel, Dirk Eichmann, Jürgen Stieh, and René Santer

Further Evidence for a Dominant Form of Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy: A Family with Documented Hyperinsulinemia in Two Generations^c
J Clin Endocrinol Metab 1998 83: 2215a-2216. [Full Text]  

Eric Adams and Michael Buchfelder

Comment on Human Fetal Pituitary Expresses Functional GHRP Receptors^d
J Clin Endocrinol Metab 1998 83: 2216. [Full Text]  

I. Shimon and S. Melmed

Human Fetal Pituitary Expresses Functional GHRP Receptors—Authors’ Response^e
J Clin Endocrinol Metab 1998 83: 2216a-2217. [Full Text]  

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