Articles listed in blue may be of special interest to clinicians.

Special Articles:

Gianni Forti and Csilla Krausz

CLINICAL REVIEW 100: Evaluation and Treatment of the Infertile Couple
J Clin Endocrinol Metab 1998 83: 4177-4188. [Full Text]  

Richard S. Haber

EDITORIAL: The Diagnosis of Recurrent Thyroid Cancer—A New Approach
J Clin Endocrinol Metab 1998 83: 4189-4190. [Full Text]  

Charis Eng, Debbie J. Marsh, Bruce G. Robinson, C. W. Chow, Michael A. Patton, Melissa C. Southey, Deon J. Venter, Bruce A. J. Ponder, Peter J. Milla, and Virpi V. Smith

CLINICAL CASE SEMINAR: Germline RET Codon 918 Mutation in Apparently Isolated Intestinal Ganglioneuromatosis
J Clin Endocrinol Metab 1998 83: 4191-4194. [Full Text]  

Leonard Wartofsky

THERAPEUTIC CONTROVERSY: Management of Patients with Scan Negative, Thyroglobulin Positive Differentiated Thyroid Carcinoma
J Clin Endocrinol Metab 1998 83: 4195-4199. [Full Text]  

Steven I. Sherman and Jayashree Gopal

THERAPEUTIC CONTROVERSY: Thyroglobulin Positive, RAI Negative Thyroid Cancers: The Role of Conservative Management
J Clin Endocrinol Metab 1998 83: 4199-4200. [Full Text]  

Martin Schlumberger

THERAPEUTIC CONTROVERSY: Use of Radioactive Iodine in Patients with Papillary and Follicular Thyroid Cancer: Towards A Selective Approach
J Clin Endocrinol Metab 1998 83: 4201-4203. [Full Text]  

Anne Grethe Myhre, Petra Björses, Are Dalen, and Eystein S. Husebye

CLINICAL CASE SEMINAR: Three Sisters with Addison’s Disease
J Clin Endocrinol Metab 1998 83: 4204-4206. [Full Text]  

From the Clinical Research Centers:

Yuling Hong, Treva Rice, Jacques Gagnon, Jean-Pierre Després, André Nadeau, Louis Pérusse, Claude Bouchard, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, and D. C. Rao

Familial Clustering of Insulin and Abdominal Visceral Fat: The HERITAGE Family Study
J Clin Endocrinol Metab 1998 83: 4239-4245. [Abstract] [Full Text]  

Steven Grinspoon, Colleen Corcoran, Takara Stanley, Laurence Katznelson, and Anne Klibanski

Effects of Androgen Administration on the Growth Hormone-Insulin-Like Growth Factor I Axis in Men with Acquired Immunodeficiency Syndrome Wasting
J Clin Endocrinol Metab 1998 83: 4251-4256. [Abstract] [Full Text]  

Robert A. Phillips, Lawrence R. Krakoff, Andrea Dunaif, Diane T. Finegood, Richard Gorlin, and Seiichi Shimabukuro

Relation among Left Ventricular Mass, Insulin Resistance, and Blood Pressure in Nonobese Subjects
J Clin Endocrinol Metab 1998 83: 4284-4288. [Abstract] [Full Text]  

Michael P. Diamond, David Grainger, Meredith C. Diamond, Robert S. Sherwin, and Ralph A. DeFronzo

Effects of Methyltestosterone on Insulin Secretion and Sensitivity In Women
J Clin Endocrinol Metab 1998 83: 4420-4425. [Abstract] [Full Text]  

Lorraine E. Levitt Katz, Marta S. Satin-Smith, Paulo Collett-Solberg, Lester Baker, Charles A. Stanley, and Pinchas Cohen

Dual Regulation of Insulin-Like Growth Factor Binding Protein-1 Levels by Insulin and Cortisol during Fasting
J Clin Endocrinol Metab 1998 83: 4426-4430. [Abstract] [Full Text]  

Original Studies:

E. Arvat, R. Giordano, J. Ramunni, G. Arnaldi, A. Colao, R. Deghenghi, G. Lombardi, F. Mantero, F. Camanni, and E. Ghigo

Adrenocorticotropin and Cortisol Hyperresponsiveness to Hexarelin in Patients with Cushing’s Disease Bearing a Pituitary Microadenoma, But Not in Those with Macroadenoma
J Clin Endocrinol Metab 1998 83: 4207-4211. [Abstract] [Full Text]  

David E. Cummings, Narender Kumar, C. Wayne Bardin, Kalyan Sundaram, and William J. Bremner

Prostate-Sparing Effects in Primates of the Potent Androgen 7-Methyl-19-Nortestosterone: A Potential Alternative to Testosterone for Androgen Replacement and Male Contraception
J Clin Endocrinol Metab 1998 83: 4212-4219. [Abstract] [Full Text]  

Mary Jane De Souza, B. E. Miller, A. B. Loucks, A. A. Luciano, L. S. Pescatello, C. G. Campbell, and B. L. Lasley

High Frequency of Luteal Phase Deficiency and Anovulation in Recreational Women Runners: Blunted Elevation in Follicle-Stimulating Hormone Observed during Luteal-Follicular Transition
J Clin Endocrinol Metab 1998 83: 4220-4232. [Abstract] [Full Text]  

G. A. Kaltsas, J. J. Mukherjee, P. N. Plowman, J. P. Monson, A. B. Grossman, and G. M. Besser

The Role of Cytotoxic Chemotherapy in the Management of Aggressive and Malignant Pituitary Tumors
J Clin Endocrinol Metab 1998 83: 4233-4238. [Abstract] [Full Text]  

Mikael Fogelholm, Raisa Valve, Katriina Kukkonen-Harjula, Arja Nenonen, Virpi Hakkarainen, Markku Laakso, and Matti Uusitupa

Additive Effects of the Mutations in the ß₃-Adrenergic Receptor and Uncoupling Protein-1 Genes on Weight Loss and Weight Maintenance in Finnish Women
J Clin Endocrinol Metab 1998 83: 4246-4250. [Abstract] [Full Text]  

Jean A. Langlois, Clifford J. Rosen, Marjolein Visser, Marian T. Hannan, Tamara Harris, Peter W. F. Wilson, and Douglas P. Kiel

Association Between Insulin-Like Growth Factor I and Bone Mineral Density in Older Women and Men: The Framingham Heart Study
J Clin Endocrinol Metab 1998 83: 4257-4262. [Abstract] [Full Text]  

Florian Chapotot, Claude Gronfier, Christophe Jouny, Alain Muzet, and Gabrielle Brandenberger

Cortisol Secretion Is Related to Electroencephalographic Alertness in Human Subjects during Daytime Wakefulness
J Clin Endocrinol Metab 1998 83: 4263-4268. [Abstract] [Full Text]  

Lars Lönn, Kaj Stenlöf, Malin Ottosson, Anna-Karin Lindroos, Ernst Nyström, and Lars Sjöström

Body Weight and Body Composition Changes after Treatment of Hyperthyroidism
J Clin Endocrinol Metab 1998 83: 4269-4273. [Abstract] [Full Text]  

G. Jones and T. Dwyer

Bone Mass in Prepubertal Children: Gender Differences and the Role of Physical Activity and Sunlight Exposure
J Clin Endocrinol Metab 1998 83: 4274-4279. [Abstract] [Full Text]  

Silvano Bertelloni, Giampiero I. Baroncelli, Marco Ferdeghini, Giuseppe Perri, and Giuseppe Saggese

Normal Volumetric Bone Mineral Density and Bone Turnover in Young Men with Histories of Constitutional Delay of Puberty
J Clin Endocrinol Metab 1998 83: 4280-4283. [Abstract] [Full Text]  

Stéphane Blanc, Sylvie Normand, Patrick Ritz, Christiane Pachiaudi, Laurence Vico, Claude Gharib, and Guillemette Gauquelin-Koch

Energy and Water Metabolism, Body Composition, and Hormonal Changes Induced by 42 Days of Enforced Inactivity and Simulated Weightlessness
J Clin Endocrinol Metab 1998 83: 4289-4297. [Abstract] [Full Text]  

Cynthia J. Lees, Christopher P. Jerome, Thomas C. Register, and Cathy S. Carlson

Changes in Bone Mass and Bone Biomarkers of Cynomolgus Monkeys during Pregnancy and Lactation
J Clin Endocrinol Metab 1998 83: 4298-4302. [Abstract] [Full Text]  

Qi Wang, Farid J. Ghadessy, Alan Trounson, David de Kretser, Rob McLachlan, s. C. Ng, and E. L. Yong

Azoospermia Associated with a Mutation in the Ligand-Binding Domain of an Androgen Receptor Displaying Normal Ligand Binding, but Defective Trans-Activation
J Clin Endocrinol Metab 1998 83: 4303-4309. [Abstract] [Full Text]  

Charis Eng, Gerry A. Thomas, Donna S. Neuberg, Lois M. Mulligan, Catherine S. Healey, Carol Houghton, Andrea Frilling, Friedhelm Raue, E. Dillwyn Williams, and Bruce A. J. Ponder

Mutation of the RET Proto-Oncogene Is Correlated with RET Immunostaining in Subpopulations of Cells in Sporadic Medullary Thyroid Carcinoma
J Clin Endocrinol Metab 1998 83: 4310-4313. [Abstract] [Full Text]  

Monica M. Skinner, Ralf Nass, Beatriz Lopes, Edward R. Laws, and Michael O. Thorner

Growth Hormone Secretagogue Receptor Expression in Human Pituitary Tumors
J Clin Endocrinol Metab 1998 83: 4314-4320. [Abstract] [Full Text]  

Yaron Tomer, Giuseppe Barbesino, David A. Greenberg, Erlinda Concepcion, and Terry F. Davies

Linkage Analysis of Candidate Genes in Autoimmune Thyroid Disease. III. Detailed Analysis of Chromosome 14 Localizes Graves’ Disease-1 (GD-1) Close to Multinodular Goiter-1 (MNG-1)
J Clin Endocrinol Metab 1998 83: 4321-4327. [Abstract] [Full Text]  

A. A. MacConnachie, K. F. Kelly, A. McNamara, S. Loughlin, L. J. Gates, G. C. Inglis, A. Jamieson, J. M. C. Connell, and N. E. Haites

Rapid Diagnosis and Identification of Cross-Over Sites in Patients with Glucocorticoid Remediable Aldosteronism
J Clin Endocrinol Metab 1998 83: 4328-4331. [Abstract] [Full Text]  

K. L. Simpson, J. A. Keelan, and M. D. Mitchell

Labor-Associated Changes in Interleukin-10 Production and Its Regulation by Immunomodulators in Human Choriodecidua
J Clin Endocrinol Metab 1998 83: 4332-4337. [Abstract] [Full Text]  

Min Jiang, Kristiina Aittomäki, Christel Nilsson, Pirjo Pakarinen, Antti Iitiä, Toni Torresani, Henrik Simonsen, Victor Goh, Kim Pettersson, Albert de la Chapelle, and Ilpo Huhtaniemi

The Frequency of an Inactivating Point Mutation (⁵⁶⁶CT) of the Human Follicle-Stimulating Hormone Receptor Gene in Four Populations Using Allele-Specific Hybridization and Time-Resolved Fluorometry
J Clin Endocrinol Metab 1998 83: 4338-4343. [Abstract] [Full Text]  

David M. Hoffman, Robert Pallasser, Mark Duncan, Tuan V. Nguyen, and Ken K. Y. Ho

How Is Whole Body Protein Turnover Perturbed in Growth Hormone-Deficient Adults?
J Clin Endocrinol Metab 1998 83: 4344-4349. [Abstract] [Full Text]  

Fernando Cordido, Teresa Fernandez, Teresa Martinez, Angela Peñalva, Roberto Peinó, Felipe F. Casanueva, and Carlos Dieguez

Effect of Acute Pharmacological Reduction of Plasma Free Fatty Acids on Growth Hormone (GH) Releasing Hormone-Induced GH Secretion in Obese Adults with and without Hypopituitarism
J Clin Endocrinol Metab 1998 83: 4350-4354. [Abstract] [Full Text]  

Vivian Hwa, Cindy Tomasini-Sprenger, Abel López Bermejo, Ron G. Rosenfeld, and Steven R. Plymate

Characterization of Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Prostate Cells
J Clin Endocrinol Metab 1998 83: 4355-4362. [Abstract] [Full Text]  

Elena Volpi, Paola Lucidi, Geremia B. Bolli, Fausto Santeusanio, and Pierpaolo De Feo

Gender Differences in Basal Protein Kinetics in Young Adults
J Clin Endocrinol Metab 1998 83: 4363-4367. [Abstract] [Full Text]  

X. De Deken, C. Vilain, J. Van Sande, J. E. Dumont, and F. Miot

Decrease of Telomere Length in Thyroid Adenomas without Telomerase Activity
J Clin Endocrinol Metab 1998 83: 4368-4372. [Abstract] [Full Text]  

Farhad B. Hashemi, Thomas K. Hughes, and Eric M. Smith

Human Immunodeficiency Virus Induction of Corticotropin in Lymphoid Cells
J Clin Endocrinol Metab 1998 83: 4373-4381. [Abstract] [Full Text]  

Hillevi Larsson, Sölve Elmståhl, Göran Berglund, and Bo Ahrén

Evidence for Leptin Regulation of Food Intake in Humans
J Clin Endocrinol Metab 1998 83: 4382-4385. [Abstract] [Full Text]  

Emilia Ballaré, Simona Mantovani, Andrea Lania, Anna M. Di Blasio, Lucia Vallar, and Anna Spada

Activating Mutations of the G_s Gene Are Associated with Low Levels of Gs Protein in Growth Hormone-Secreting Tumors
J Clin Endocrinol Metab 1998 83: 4386-4390. [Abstract] [Full Text]  

Daniela Rogoff, Zuzana Smolenicka, Ignacio Bergadá, Graciela Vallejo, Marta Barontini, Juan Jorge Heinrich, and Paolo Ferrari

The Codon 213 of the 11ß-Hydroxysteroid Dehydrogenase Type 2 Gene Is a Hot Spot for Mutations in Apparent Mineralocorticoid Excess
J Clin Endocrinol Metab 1998 83: 4391-4393. [Abstract] [Full Text]  

M. Ellmerer, L. Schaupp, G. Sendlhofer, A. Wutte, G. A. Brunner, Z. Trajanoski, F. Skrabal, P. Wach, and T. R. Pieber

Lactate Metabolism of Subcutaneous Adipose Tissue Studied by Open Flow Microperfusion
J Clin Endocrinol Metab 1998 83: 4394-4401. [Abstract] [Full Text]  

Ligia J. Dominguez, Mario Barbagallo, James R. Sowers, and Lawrence M. Resnick

Magnesium Responsiveness to Insulin and Insulin-Like Growth Factor I in Erythrocytes from Normotensive and Hypertensive Subjects
J Clin Endocrinol Metab 1998 83: 4402-4407. [Abstract] [Full Text]  

Anders Juul, Søren Møller, Eva Mosfeldt-Laursen, Michael Højby Rasmussen, Thomas Scheike, Søren A. Pedersen, Knud W. Kastrup, Herbert Yu, Jehangir Mistry, Susanne Rasmussen, Jørn Müller, Jens Henriksen, and Niels E. Skakkebæk

The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency
J Clin Endocrinol Metab 1998 83: 4408-4415. [Abstract] [Full Text]  

Tânia A. S. S. Bachega, Ana Elisa C. Billerbeck, Guiomar Madureira, José A. M. Marcondes, Carlos A. Longui, Maristela V. Leite, Ivo J. P. Arnhold, and Berenice B. Mendonca

Molecular Genotyping in Brazilian Patients with the Classical and Nonclassical Forms of 21-Hydroxylase Deficiency
J Clin Endocrinol Metab 1998 83: 4416-4419. [Abstract] [Full Text]  

Patrice Rodien, Filomena Cetani, Sabine Costagliola, Massimo Tonacchera, Laurence Duprez, T. Minegishi, Cedric Govaerts, and Gilbert Vassart

Evidences for an Allelic Variant of the Human LC/CG Receptor rather than a Gene Duplication: Functional Comparison of Wild-Type and Variant Receptors
J Clin Endocrinol Metab 1998 83: 4431-4434. [Abstract] [Full Text]  

Matthew D. Ringel, Paul W. Ladenson, and Michael A. Levine

Molecular Diagnosis of Residual and Recurrent Thyroid Cancer by Amplification of Thyroglobulin Messenger Ribonucleic Acid in Peripheral Blood
J Clin Endocrinol Metab 1998 83: 4435-4442. [Abstract] [Full Text]  

Sushma Kumar, Li-Ji Zhu, Mary Polihronis, Sharon T. Cameron, David T. Baird, Frederick Schatz, Anuradha Dua, Yu-Kang Ying, Milan K. Bagchi, and Indrani C. Bagchi

Progesterone Induces Calcitonin Gene Expression in Human Endometrium within the Putative Window of Implantation
J Clin Endocrinol Metab 1998 83: 4443-4450. [Abstract] [Full Text]  

Anna-Maria Andersson, Jørn Müller, and Niels E. Skakkebæk

Different Roles of Prepubertal and Postpubertal Germ Cells and Sertoli Cells in the Regulation of Serum Inhibin B Levels
J Clin Endocrinol Metab 1998 83: 4451-4458. [Abstract] [Full Text]  

A. Glasow, A. Haidan, U. Hilbers, M. Breidert, J. Gillespie, W. A. Scherbaum, G. P. Chrousos, and S. R. Bornstein

Expression of Ob Receptor in Normal Human Adrenals: Differential Regulation of Adrenocortical and Adrenomedullary Function by Leptin
J Clin Endocrinol Metab 1998 83: 4459-4466. [Abstract] [Full Text]  

Jan Tesarik, Maurizio Guido, Carmen Mendoza, and Ermanno Greco

Human Spermatogenesis in Vitro: Respective Effects of Follicle-Stimulating Hormone and Testosterone on Meiosis, Spermiogenesis, and Sertoli Cell Apoptosis
J Clin Endocrinol Metab 1998 83: 4467-4473. [Abstract] [Full Text]  

Khaled Zeitoun, Kazuto Takayama, Hironobu Sasano, Takashi Suzuki, Nabil Moghrabi, Stefan Andersson, Alan Johns, Li Meng, Michael Putman, Bruce Carr, and Serdar E. Bulun

Deficient 17ß-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17ß-Estradiol
J Clin Endocrinol Metab 1998 83: 4474-4480. [Abstract] [Full Text]  

Jérôme Wojcik, Mary Anne Berg, Nazario Esposito, Mitchell E. Geffner, Nadia Sakati, Edward O. Reiter, Steven Dower, Uta Francke, Marie-Catherine Postel-Vinay, and Joëlle Finidori

Four Contiguous Amino Acid Substitutions, Identified in Patients with Laron Syndrome, Differently Affect the Binding Affinity and Intracellular Trafficking of the Growth Hormone Receptor
J Clin Endocrinol Metab 1998 83: 4481-4489. [Abstract] [Full Text]  

Jennifer Condon, Christine Gosden, Derek Gardener, Paul Nickson, Martin Hewison, Alexander J. Howie, and Paul M. Stewart

Expression of Type 2 11ß-Hydroxysteroid Dehydrogenase and Corticosteroid Hormone Receptors in Early Human Fetal Life
J Clin Endocrinol Metab 1998 83: 4490-4497. [Abstract] [Full Text]  

Yolanda R. Smith, Jon-Kar Zubieta, Marcela G. del Carmen, Robert F. Dannals, Hayden T. Ravert, Howard A. Zacur, and J. James Frost

Brain Opioid Receptor Measurements by Positron Emission Tomography in Normal Cycling Women: Relationship to Luteinizing Hormone Pulsatility and Gonadal Steroid Hormones
J Clin Endocrinol Metab 1998 83: 4498-4505. [Abstract] [Full Text]  

Søren A. Urhammer, Torben Hansen, Claus T. Ekstrøm, Hans Eiberg, and Oluf Pedersen

COMMENTS: The Ala/Val98 Polymorphism of the Hepatocyte Nuclear Factor-1 Gene Contributes to the Interindividual Variation in Serum C-Peptide Response during an Oral Glucose Tolerance Test: Evidence from Studies of 231 Glucose-Tolerant First Degree Relatives of Type 2 Diabetic Probands
J Clin Endocrinol Metab 1998 83: 4506-4509. [Abstract] [Full Text]  

Ian M. Leitch, Alan L. A. Boura, Chiara Botti, Mark A. Read, William A. W. Walters, and Roger Smith

COMMENTS: Vasodilator Actions of Urocortin and Related Peptides in the Human Perfused Placenta in Vitro
J Clin Endocrinol Metab 1998 83: 4510-4513. [Abstract] [Full Text]  

M. C. Lebrethon, O. Avallet, Y. Reznik, F. Archambeaud, J. Combes, T. B. Usdin, G. Narboni, J. Mahoudeau, and J. M. Saez

COMMENTS: Food-Dependent Cushing’s Syndrome: Characterization and Functional Role of Gastric Inhibitory Polypeptide Receptor in the Adrenals of Three Patients
J Clin Endocrinol Metab 1998 83: 4514-4519. [Abstract] [Full Text]  

Rapid Communications:

Hirotaka Shibata, Takashi Ando, Toshihiko Suzuki, Isao Kurihara, Kouichi Hayashi, Matsuhiko Hayashi, Ikuo Saito, Masaru Murai, and Takao Saruta

COUP-TFI Expression in Human Adrenocortical Adenomas: Possible Role in Steroidogenesis
J Clin Endocrinol Metab 1998 83: 4520. [Abstract] [Full Text]  

K. Rosenkranz, A. Hinney, A. Ziegler, H. Hermann, M. Fichter, H. Mayer, W. Siegfried, JK. Young, H. Remschmidt, and J. Hebebrand

Systematic Mutation Screening of the Estrogen Receptor Beta Gene in Probands of Different Weight Extremes: Identification of Several Genetic Variants
J Clin Endocrinol Metab 1998 83: 4524. [Abstract] [Full Text]  

Letters to the Editor:

Z. Laron and A. Galatzer

A Comment on Normal Intelligence in Growth Hormone Receptor Deficiency^a
J Clin Endocrinol Metab 1998 83: 4528. [Full Text]  

John H. Kranzler and Arlan L. Rosenbloom

Normal Intelligence In Growth Hormone Receptor Deficiency—Authors’ Response^b
J Clin Endocrinol Metab 1998 83: 4528a-4530. [Full Text]  

Karen Tordjman

Comments on the Comparison of Low and High Dose Corticotropin Stimulation Tests in Patients with Pituitary Disease^c
J Clin Endocrinol Metab 1998 83: 4530. [Full Text]  

Leonard M. Thaler

Comment on The Low-Dose Corticotropin Stimulation Test Is More Sensitive than the High-Dose Test^d
J Clin Endocrinol Metab 1998 83: 4530a-4531. [Full Text]  

Gabriel Dickstein

Commentary to the Article: Comparison of Low and High Dose Corticotropin Stimulation Tests in Patients with Pituitary Disease^e
J Clin Endocrinol Metab 1998 83: 4531-4532. [Full Text]  

W. Oelkers

Comparison of Low- and High-Dose Corticotropin Stimulation Tests in Patients with Pituitary Disease—Author’s Response^f
J Clin Endocrinol Metab 1998 83: 4532-4533. [Full Text]  

Alessandro Sartorio and Silvia Saraifoger

Comments on Adults with Childhood-Onset GH Deficiency: the Psychosocial Adjustment Can Be Negatively Conditioned by a Final "Unsatisfactory" Height^g
J Clin Endocrinol Metab 1998 83: 4533-4534. [Full Text]  

David E. Sandberg and Margaret H. MacGillivray

Adult Height and Psychological Adaptation—Authors’ Response^h
J Clin Endocrinol Metab 1998 83: 4534. [Full Text]  

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