Articles listed in blue may be of special interest to clinicians.

Special Articles:

Dorothy A. Nelson and Michael Kleerekoper M.D.

EDITORIAL: The Search for the Osteoporosis Gene
J Clin Endocrinol Metab 1997 82: 989-990. [Full Text]  

Mark E. Molitch, Michael O. Thorner, Charles Wilson, Mark E. Molitch, M. D., Michael O. Thorner, and Charles Wilson

THERAPEUTIC CONTROVERSY: The Case for Initial Surgical Removal of Certain Prolactinomas
J Clin Endocrinol Metab 1997 82: 996-1000. [Full Text]  

Nicholas J. Sarlis, George P. Chrousos, John L. Doppman, J. Aidan Carney, and Constantine A. Stratakis

CLINICAL CASE SEMINAR: Primary Pigmented Nodular Adrenocortical Disease: Reevaluation of a Patient with Carney Complex 27 Years after Unilateral Adrenalectomy
J Clin Endocrinol Metab 1997 82: 1274-1278. [Abstract] [Full Text]  

Clinical Studies:

Mario Salvi, Elio Spaggiari, Fabrizio Neri, Claudio Macaluso, Eliana Gardini, Francesco Ferrozzi, Roberta Minelli, Jack R. Wall, and Elio Roti

The Study of Visual Evoked Potentials in Patients with Thyroid-Associated Ophthalmopathy Identifies Asymptomatic Optic Nerve Involvement
J Clin Endocrinol Metab 1997 82: 1027-1030. [Abstract] [Full Text]  

Rosario López-Velasco, Héctor F. Escobar-Morreale, Belén Vega, Eduardo Villa, José M. Sancho, José Luis Moya-Mur, and Rafael García-Robles

Cardiac Involvement in Acromegaly: Specific Myocardiopathy or Consequence of Systemic Hypertension?
J Clin Endocrinol Metab 1997 82: 1047-1053. [Abstract] [Full Text]  

Toshikazu Saito, San-e Ishikawa, Keishi Abe, Kyuzi Kamoi, Kenichi Yamada, Kurakazu Shimizu, Takao Saruta, and Sho Yoshida

Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
J Clin Endocrinol Metab 1997 82: 1054-1057. [Abstract] [Full Text]  

James W. Findling, Hershel Raff, Joni H. Hansson, and Richard P. Lifton

Liddle’s Syndrome: Prospective Genetic Screening and Suppressed Aldosterone Secretion in an Extended Kindred
J Clin Endocrinol Metab 1997 82: 1071-1074. [Abstract] [Full Text]  

Michael Behr, David B. Ramsden, and Ulrich Loos

Deoxyribonucleic Acid Binding and Transcriptional Silencing by a Truncated c-erbAß1 Thyroid Hormone Receptor Identified in a Severely Retarded Patient with Resistance to Thyroid Hormone
J Clin Endocrinol Metab 1997 82: 1081-1087. [Abstract] [Full Text]  

Clemens Kirschbaum, Esperanza Gonzalez Bono, Nicolas Rohleder, Claudius Gessner, Karl Martin Pirke, Alicia Salvador, and Dirk Helmut Hellhammer

Effects of Fasting and Glucose Load on Free Cortisol Responses to Stress and Nicotine
J Clin Endocrinol Metab 1997 82: 1101-1105. [Abstract] [Full Text]  

Jan Born, Dirk Steinbach, Christoph Dodt, and Horst-Lorenz Fehm

Blocking of Central Nervous Mineralocorticoid Receptors Counteracts Inhibition of Pituitary-Adrenal Activity in Human Sleep
J Clin Endocrinol Metab 1997 82: 1106-1110. [Abstract] [Full Text]  

Leah Holloway, Lynn Kohlmeier, Kyla Kent, and Robert Marcus

Skeletal Effects of Cyclic Recombinant Human Growth Hormone and Salmon Calcitonin in Osteopenic Postmenopausal Women
J Clin Endocrinol Metab 1997 82: 1111-1117. [Abstract] [Full Text]  

Hana Al-Adsani, L. John Hoffer, and J. Enrique Silva

Resting Energy Expenditure is Sensitive to Small Dose Changes in Patients on Chronic Thyroid Hormone Replacement
J Clin Endocrinol Metab 1997 82: 1118-1125. [Abstract] [Full Text]  

Kathryn Thrailkill, Teresa Quattrin, Lester Baker, Jean Litton, Karen Dwigun, Melissa Rearson, Mary Poppenheimer, Debbie Kotlovker, David Giltinan, Neil Gesundheit, and Paul Martha, Jr.

Dual Hormonal Replacement Therapy with Insulin and Recombinant Human Insulin-Like Growth Factor (IGF)-I in Insulin-Dependent Diabetes Mellitus: Effects on the Growth Hormone/IGF/IGF-Binding Protein System
J Clin Endocrinol Metab 1997 82: 1181-1187. [Abstract] [Full Text]  

J. F. Tinahones, G. Pérez-Lindón, F. J. C-Soriguer, A. Pareja, P. Sánchez-Guijo, and E. Collantes

Dietary Alterations in Plasma Very Low Density Lipoprotein Levels Modify Renal Excretion of Urates in Hyperuricemic-Hypertriglyceridemic Patients
J Clin Endocrinol Metab 1997 82: 1188-1191. [Abstract] [Full Text]  

Lucila L. K. Elias, José Antunes-Rodrigues, Paula C. L. Elias, and Ayrton C. Moreira

Effect of Plasma Osmolality on Pituitary-Adrenal Responses to Corticotropin-Releasing Hormone and Atrial Natriuretic Peptide Changes in Central Diabetes Insipidus
J Clin Endocrinol Metab 1997 82: 1243-1247. [Abstract] [Full Text]  

Kaj Stenlöf, Jan-Ove Johansson, Lars Lönn, Lars Sjöström, and Bengt-Åke Bengtsson

Diurnal Variations in Twenty-Four-Hour Energy Expenditure During Growth Hormone Treatment of Adults with Pituitary Deficiency
J Clin Endocrinol Metab 1997 82: 1255-1260. [Abstract] [Full Text]  

L. Iraki, A. Bogdan, F. Hakkou, N. Amrani, A. Abkari, and Y. Touitou

Ramadan Diet Restrictions Modify the Circadian Time Structure in Humans. A Study on Plasma Gastrin, Insulin, Glucose, and Calcium and on Gastric pH
J Clin Endocrinol Metab 1997 82: 1261-1273. [Abstract] [Full Text]  

Leslie J. Crofford, Konstantine T. Kalogeras, George Mastorakos, Maria-Alexandra Magiakou, Jana Wells, Keith S. Kanik, Philip W. Gold, George P. Chrousos, and Ronald L. Wilder

COMMENTS: Circadian Relationships between Interleukin (IL)-6 and Hypothalamic-Pituitary-Adrenal Axis Hormones: Failure of IL-6 to Cause Sustained Hypercortisolism in Patients with Early Untreated Rheumatoid Arthritis
J Clin Endocrinol Metab 1997 82: 1279-1283. [Abstract] [Full Text]  

Terumasa Nagase, Akira Aoki, Michiko Yamamoto, Hiroko Yasuda, Seijiro Kado, Miyuki Nishikawa, Nobuo Kugai, Takuhiko Akatsu, and Naokazu Nagata

COMMENTS: Lack of Association between the Trp⁶⁴Arg Mutation in the ß₃-Adrenergic Receptor Gene and Obesity in Japanese Men: A Longitudinal Analysis
J Clin Endocrinol Metab 1997 82: 1284-1287. [Abstract] [Full Text]  

Clinical Research Center Studies:

Christos S. Mantzoros, Jeffrey S. Flier, and Alan D. Rogol

A Longitudinal Assessment of Hormonal and Physical Alterations during Normal Puberty in Boys. V. Rising Leptin Levels May Signal the Onset of Puberty
J Clin Endocrinol Metab 1997 82: 1066-1070. [Abstract] [Full Text]  

Susan E. Kirk, Barry J. Gertz, Stephen H. Schneider, Mark L. Hartman, Suzan S. Pezzoli, Johanna M. Wittreich, David A. Krupa, James R. Seibold, and Michael O. Thorner

Effect of Obesity and Feeding on the Growth Hormone (GH) Response to the GH Secretagogue L-692,429 in Young Men
J Clin Endocrinol Metab 1997 82: 1154-1159. [Abstract] [Full Text]  

Endocrinological Oncology:

Sushela S. Chaidarun, Anne Klibanski, and Joseph M. Alexander

Tumor-Specific Expression of Alternatively Spliced Estrogen Receptor Messenger Ribonucleic Acid Variants in Human Pituitary Adenomas
J Clin Endocrinol Metab 1997 82: 1058-1065. [Abstract] [Full Text]  

Patricia L. M. Dahia, Jürgen Honegger, Martin Reincke, Richard A. Jacobs, Adriana Mirtella, Rudolf Fahlbusch, G. Michael Besser, Shern L. Chew, and Ashley B. Grossman

Expression of Glucocorticoid Receptor Gene Isoforms in Corticotropin-Secreting Tumors
J Clin Endocrinol Metab 1997 82: 1088-1093. [Abstract] [Full Text]  

Li-Wha Wu, Hyun Koo Yoon, David J. Baylink, Lee M. Graves, and K.-H. William Lau

Fluoride at Mitogenic Doses Induces a Sustained Activation of p44^mapk, but Not p42^mapk, in Human TE85 Osteosarcoma Cells
J Clin Endocrinol Metab 1997 82: 1126-1135. [Abstract] [Full Text]  

S. Ali Asghar Abbass, Sylvia L. Asa, and Shereen Ezzat

Altered Expression of Fibroblast Growth Factor Receptors in Human Pituitary Adenomas
J Clin Endocrinol Metab 1997 82: 1160-1166. [Abstract] [Full Text]  

Yoko Sakai, Nobuo Horiba, Ken Sakai, Fumiko Tozawa, Akio Kuwayama, Hiroshi Demura, and Toshihiro Suda

Corticotropin-Releasing Factor Up-Regulates Its Own Receptor Gene Expression in Corticotropic Adenoma Cells in Vitro
J Clin Endocrinol Metab 1997 82: 1229-1234. [Abstract] [Full Text]  

Experimental Studies:

Sung Kil Lim, Young Jun Won, Ji Hyun Lee, Suk Ho Kwon, Eun Jig Lee, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh, and Bong Chul Chung

Altered Hydroxylation of Estrogen in Patients with Postmenopausal Osteopenia
J Clin Endocrinol Metab 1997 82: 1001-1006. [Abstract] [Full Text]  

J. David Bettoun, Masanori Minagawa, Mei Yee Kwan, Han S. Lee, Toshiyuki Yasuda, Geoffrey N. Hendy, David Goltzman, and John H. White

Cloning and Characterization of the Promoter Regions of the Human Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Gene: Analysis of Deoxyribonucleic Acid from Normal Subjects and Patients with Pseudohypoparathyroidism Type 1b
J Clin Endocrinol Metab 1997 82: 1031-1040. [Abstract] [Full Text]  

A. Barreca, D. Larizza, G. Damonte, M. Arvigo, P. Ponzani, A. Cesarone, F. Lo Curto, F. Severi, G. Giordano, and F. Minuto

Insulin-Like Growth Factors (IGF-I and IGF-II) and IGF-Binding Protein-3 Production by Fibroblasts of Patients with Turner’s Syndrome in Culture
J Clin Endocrinol Metab 1997 82: 1041-1046. [Abstract] [Full Text]  

Richard Stephen McIntosh, Philip Francis Watson, and Anthony Peter Weetman

Analysis of the T Cell Receptor V Repertoire in Hashimoto’s Thyroiditis: Evidence for the Restricted Accumulation of CD8⁺ T Cells in the Absence of CD4⁺ T Cell Restriction
J Clin Endocrinol Metab 1997 82: 1140-1146. [Abstract] [Full Text]  

P. G. Andreis, G. Neri, T. Prayer-Galetti, G. P. Rossi, G. Gottardo, L. K. Malendowicz, and G. G. Nussdorfer

Effects of Adrenomedullin on the Human Adrenal Glands: An in Vitro Study
J Clin Endocrinol Metab 1997 82: 1167-1170. [Abstract] [Full Text]  

Lars Sävendahl and Louis E. Underwood

Decreased Interleukin-2 Production from Cultured Peripheral Blood Mononuclear Cells in Human Acute Starvation
J Clin Endocrinol Metab 1997 82: 1177-1180. [Abstract] [Full Text]  

D. A. Sass, C. P. Jerome, A. R. Bowman, A. Bennett-Cain, T. A. Ginn, D. LeRoith, and S. Epstein

Short-Term Effects of Growth Hormone and Insulin-Like Growth Factor I on Cancellous Bone in Rhesus Macaque Monkeys
J Clin Endocrinol Metab 1997 82: 1202-1209. [Abstract] [Full Text]  

Louise Prentice, Jane F. Sanders, Maria Perez, Ryoji Kato, Joanna Sawicka, Yasuo Oda, Donat Jaskolski, Jadwiga Furmaniak, and Bernard Rees Smith

COMMENTS: Thyrotropin (TSH) Receptor Autoantibodies Do Not Appear to Bind to the TSH Receptor Produced in an in Vitro Transcription/Translation System
J Clin Endocrinol Metab 1997 82: 1288-1292. [Abstract] [Full Text]  

Adele Kennedy, Thomas W. Gettys, Patricia Watson, Penny Wallace, Elizabeth Ganaway, Qin Pan, and W. Timothy Garvey

COMMENTS: The Metabolic Significance of Leptin in Humans: Gender-Based Differences in Relationship to Adiposity, Insulin Sensitivity, and Energy Expenditure
J Clin Endocrinol Metab 1997 82: 1293-1300. [Abstract] [Full Text]  

Pediatric Endocrinology:

Burkhard Tönshoff, Michael J. Cronin, Marcel Reichert, Dieter Haffner, Anne-Margret Wingen, Werner F. Blum, and Otto Mehls

Reduced Concentration of Serum Growth Hormone (GH)-Binding Protein in Children with Chronic Renal Failure: Correlation with GH Insensitivity
J Clin Endocrinol Metab 1997 82: 1007-1013. [Abstract] [Full Text]  

Margaret Boguszewski, Ragnar Bjarnason, Sten Rosberg, Lena M. S. Carlsson, and Kerstin Albertsson-Wikland

Growth Hormone (GH)-Binding Protein in Prepubertal Short Children Born Small for Gestational Age: Effects of Growth Hormone Treatment
J Clin Endocrinol Metab 1997 82: 1014-1019. [Abstract] [Full Text]  

R. J. Clifton-Bligh, J. W. Gregory, M. Ludgate, R. John, L. Persani, C. Asteria, P. Beck-Peccoz, and V. K. K. Chatterjee

Two Novel Mutations in the Thyrotropin (TSH) Receptor Gene in a Child with Resistance to TSH
J Clin Endocrinol Metab 1997 82: 1094-1100. [Abstract] [Full Text]  

Fabrizio Aghini-Lombardi, Lucia Antonangeli, Aldo Pinchera, Francesco Leoli, Teresa Rago, Anna M. Bartolomei, and Paolo Vitti

Effect of Iodized Salt on Thyroid Volume of Children Living in an Area Previously Characterized by Moderate Iodine Deficiency
J Clin Endocrinol Metab 1997 82: 1136-1139. [Abstract] [Full Text]  

Asterios Kukuvitis, Cheri Deal, Laura Arbour, and Constantin Polychronakos

An Autosomal Dominant Form of Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy, Not Linked to the Sulfonylurea Receptor Locus
J Clin Endocrinol Metab 1997 82: 1192-1194. [Abstract] [Full Text]  

Anders Juul, Knud W. Kastrup, Søren A. Pedersen, and Niels E. Skakkebæk

Growth Hormone (GH) Provocative Retesting of 108 Young Adults with Childhood-Onset GH Deficiency and the Diagnostic Value of Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3
J Clin Endocrinol Metab 1997 82: 1195-1201. [Abstract] [Full Text]  

Reproductive Endocrinology:

Ki Ok Han, In Gul Moon, Young Soon Kang, Ho Yeon Chung, Hun Ki Min, and In Kwon Han

Nonassociation of Estrogen Receptor Genotypes with Bone Mineral Density and Estrogen Responsiveness to Hormone Replacement Therapy in Korean Postmenopausal Women
J Clin Endocrinol Metab 1997 82: 991-995. [Abstract] [Full Text]  

T. J. Kotlar, R. H. Young, C. Albanese, W. F. Crowley, Jr., R. E. Scully, and J. L. Jameson

A Mutation in the Follicle-Stimulating Hormone Receptor Occurs Frequently in Human Ovarian Sex Cord Tumors
J Clin Endocrinol Metab 1997 82: 1020-1026. [Abstract] [Full Text]  

Carlo Foresta, Alberto Ferlin, Andrea Garolla, Marco Rossato, Sandrine Barbaux, and Angelo De Bortoli

Y-Chromosome Deletions in Idiopathic Severe Testiculopathies
J Clin Endocrinol Metab 1997 82: 1075-1080. [Abstract] [Full Text]  

Ingvar Ek, Peter Arner, Agneta Bergqvist, Kjell Carlström, and Hans Wahrenberg

Impaired Adipocyte Lipolysis in Nonobese Women with the Polycystic Ovary Syndrome: A Possible Link to Insulin Resistance?
J Clin Endocrinol Metab 1997 82: 1147-1153. [Abstract] [Full Text]  

Jaron Rabinovici, Nicholas A. Cataldo, Pramila Dandekar, Stephen M. Rosenthal, Sharron E. Gargosky, Neil Gesundheit, and Mary C. Martin

Adjunctive Growth Hormone during Ovarian Hyperstimulation Increases Levels of Insulin-Like Growth Factor Binding Proteins in Follicular Fluid: A Randomized, Placebo-Controlled, Cross-Over Study
J Clin Endocrinol Metab 1997 82: 1171-1176. [Abstract] [Full Text]  

Andrea Giustina, Tiziano Scalvini, Carla Tassi, Paolo Desenzani, Claudio Poiesi, William B. Wehrenberg, Alan D. Rogol, and Johannes D. Veldhuis

Maturation of the Regulation of Growth Hormone Secretion in Young Males with Hypogonadotropic Hypogonadism Pharmacologically Exposed to Progressive Increments in Serum Testosterone
J Clin Endocrinol Metab 1997 82: 1210-1219. [Abstract] [Full Text]  

Tung-Ping Su, Peter J. Schmidt, Merry Danaceau, Dennis L. Murphy, and David R. Rubinow

Effect of Menstrual Cycle Phase on Neuroendocrine and Behavioral Responses to the Serotonin Agonist m-Chlorophenylpiperazine in Women with Premenstrual Syndrome and Controls
J Clin Endocrinol Metab 1997 82: 1220-1228. [Abstract] [Full Text]  

Stefan Engelhardt, Wolfgang Zieger, Jan Kassubek, Martin C. Michel, Martin J. Lohse, and Otto-Erich Brodde

Tocolytic Therapy with Fenoterol Induces Selective Down-Regulation of ß-Adrenergic Receptors in Human Myometrium
J Clin Endocrinol Metab 1997 82: 1235-1242. [Abstract] [Full Text]  

Johannes D. Veldhuis, Ali Iranmanesh, Eugeniusz Samojlik, and Randall J. Urban

Differential Sex Steroid Negative Feedback Regulation of Pulsatile Follicle-Stimulating Hormone Secretion in Healthy Older Men: Deconvolution Analysis and Steady- State Sex-Steroid Hormone Infusions in Frequently Sampled Healthy Older Individuals
J Clin Endocrinol Metab 1997 82: 1248-1254. [Abstract] [Full Text]  

Rapid Communications:

Elizabeth M. Wilson, Youngman Oh, and Ron G. Rosenfeld

Generation and Characterization of an IGFBP-7 Antibody: Identification of 31kD IGFBP-7 in Human Biological Fluids and Hs578T Human Breast Cancer Conditioned Media
J Clin Endocrinol Metab 1997 82: 1301-1303. [Abstract] [Full Text]  

Letters to the Editor:

Giovanni Amato and Antonio Bellastella

Growth Hormone Therapy in GH-Deficient Adults: The Problem of the Dose
J Clin Endocrinol Metab 1997 82: 1304-1307. [Full Text]  

Selma F. Witchel, Durga Bhamidipati, Eric P. Hoffman, and Justus B. Cohen

Phenotypic Heterogeneity Associated with the Splicing Mutation in Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency—Authors’ Response
J Clin Endocrinol Metab 1997 82: 1304a. [Full Text]  

Gudmundur Johannsson, MD, Bengt-Åke Bengtsson, and Ph. D.

Growth Hormone Therapy in GH-Deficient Adults: The Problem of the Dose—Authors’ Response
J Clin Endocrinol Metab 1997 82: 1305-1306. [Full Text]  

Bernhard Mayr, M. D., Georg Brabant, M. D., Peter Goretzki, M. D, Henning Dralle, and M. D.

ret/PTC-1, -2, and -3 Oncogene Rearrangements in Human Thyroid Carcinomas: Implications for Metastatic Potential?
J Clin Endocrinol Metab 1997 82: 1306. [Full Text]  

Sonia L. Sugg, Shereen Ezzat, and Sylvia L. Asa

ref/PTC-1, -2, and -3 Oncogene Rearrangements in Human Thyroid Carcinomas: Implications for Metastatic Potential?
J Clin Endocrinol Metab 1997 82: 1306a-1307. [Full Text]  

Ismail Çelik

More Than IL-6 in Graves’ Disease?
J Clin Endocrinol Metab 1997 82: 1307. [Full Text]  

M. Salvi, G. Girasole, M. Pedrazzoni, M. Passeri, N. Giuliani, R. Minelli, and E. Roti

More Than IL-6 in Graves’ Disease?—Authors’ Response
J Clin Endocrinol Metab 1997 82: 1307a. [Full Text]  

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