Special Articles:

Shalender Bhasin and William J. Bremner

CLINICAL REVIEW 85: Emerging Issues in Androgen Replacement Therapy
J Clin Endocrinol Metab 1997 82: 3-8. [Full Text]  

Charles H. Emerson and Raffaella Colzani

EDITORIAL: Epithelial Cell Thyroid Cancer and Thyroid Stimulating Hormone—When Less is More
J Clin Endocrinol Metab 1997 82: 9-10. [Full Text]  

Amiel Z. Rudavsky and Leonard M. Freeman

CLINICAL CASE SEMINAR: Treatment of Scan-Negative, Thyroglobulin-Positive Metastatic Thyroid Cancer Using Radioiodine ¹³¹I and Recombinant Human Thyroid Stimulating Hormone
J Clin Endocrinol Metab 1997 82: 11-14. [Full Text]  

Richard J. Robbins

EDITORIAL: Depot Somatostatin Analogs—A New First Line Therapy for Acromegaly
J Clin Endocrinol Metab 1997 82: 15-17. [Full Text]  

Robert Pacifici

EDITORIAL: Idiopathic Hypercalciuria and Osteoporosis—Distinct Clinical Manifestations of Increased Cytokine-Induced Bone Resorption?
J Clin Endocrinol Metab 1997 82: 29-31. [Full Text]  

Virginia A. LiVolsi

EDITORIAL: C Cell Hyperplasia/Neoplasia
J Clin Endocrinol Metab 1997 82: 39-41. [Full Text]  

Edward G. Biglieri

A PRISMATIC CASE: 17-Hydroxylase Deficiency: 1963–1966
J Clin Endocrinol Metab 1997 82: 48-50. [Full Text]  

Laurence Duprez, Jacques Hermans, Jacqueline Van Sande, Jacques E. Dumont, Gilbert Vassart, and Jasmine Parma

CLINICAL CASE SEMINAR: Two Autonomous Nodules of a Patient with Multinodular Goiter Harbor Different Activating Mutations of the Thyrotropin Receptor Gene
J Clin Endocrinol Metab 1997 82: 306-308. [Full Text]  

Clinical Studies:

Philippe Caron, Isabelle Morange-Ramos, Muriel Cogne, and Philippe Jaquet

Three Year Follow-Up of Acromegalic Patients Treated with Intramuscular Slow-Release Lanreotide
J Clin Endocrinol Metab 1997 82: 18-22. [Abstract] [Full Text]  

Anette Kvistborg Fløgstad, Johan Halse, Søren Bakke, Ioana Lancranjan, P. Marbach, Ch. Bruns, and Jak Jervell

Sandostatin LAR in Acromegalic Patients: Long Term Treatment
J Clin Endocrinol Metab 1997 82: 23-28. [Abstract] [Full Text]  

A. Ghazali, V. Fuentès, C. Desaint, P. Bataille, A. Westeel, M. Brazier, L. Prin, and A. Fournier

Low Bone Mineral Density and Peripheral Blood Monocyte Activation Profile in Calcium Stone Formers with Idiopathic Hypercalciuria
J Clin Endocrinol Metab 1997 82: 32-38. [Abstract] [Full Text]  

David R. Repaske, Rita Medlej, Ebrû K. Gültekin, M. R. S. Krishnamani, George Halaby, James W. Findling, and John A. Phillips, III

Heterogeneity in Clinical Manifestation of Autosomal Dominant Neurohypophyseal Diabetes Insipidus Caused by a Mutation Encoding Ala^-1Val in the Signal Peptide of the Arginine Vasopressin/Neurophysin II/Copeptin Precursor
J Clin Endocrinol Metab 1997 82: 51-56. [Abstract] [Full Text]  

Peter Lakatos, Janos Foldes, Csaba Horvath, Laszlo Kiss, Agnes Tatrai, Istvan Takacs, Gabor Tarjan, and Paula H. Stern

Serum Interleukin-6 and Bone Metabolism in Patients with Thyroid Function Disorders
J Clin Endocrinol Metab 1997 82: 78-81. [Abstract] [Full Text]  

Andrea F. Attanasio, Steven W.J. Lamberts, Anna M.C. Matranga, Martin A. Birkett, Peter C. Bates, Nick K. Valk, Jannik Hilsted, Bengt-Åke Bengtsson, and Christian J. Strasburger

Adult Growth Hormone (GH)-Deficient Patients Demonstrate Heterogeneity Between Childhood Onset and Adult Onset Before and During Human GH Treatment
J Clin Endocrinol Metab 1997 82: 82-88. [Abstract] [Full Text]  

Karim Meeran, Donal O’Shea, Paul D. Upton, Caroline J. Small, Mohammad A. Ghatei, Peter H. Byfield, and Stephen R. Bloom

Circulating Adrenomedullin Does Not Regulate Systemic Blood Pressure but Increases Plasma Prolactin after Intravenous Infusion in Humans: A Pharmacokinetic Study
J Clin Endocrinol Metab 1997 82: 95-100. [Abstract] [Full Text]  

Thomas Stefenelli, Claudette Abela, Herbert Frank, Janette Koller-Strametz, Sebastian Globits, Jutta Bergler-Klein, and Bruno Niederle

Cardiac Abnormalities in Patients with Primary Hyperparathyroidism: Implications for Follow-Up
J Clin Endocrinol Metab 1997 82: 106-112. [Abstract] [Full Text]  

Sanne Fisker, Nina Vahl, Jens Otto Lunde Jørgensen, Jens Sandahl Christiansen, and Hans Ørskov

Abdominal Fat Determines Growth Hormone-Binding Protein Levels in Healthy Nonobese Adults
J Clin Endocrinol Metab 1997 82: 123-128. [Abstract] [Full Text]  

Y. J. H. Janssen, M. Frölich, and F. Roelfsema

A Low Starting Dose of Genotropin in Growth Hormone-Deficient Adults
J Clin Endocrinol Metab 1997 82: 129-135. [Abstract] [Full Text]  

Horst Donner, Harald Rau, Paul G. Walfish, Jens Braun, Thorsten Siegmund, Reinhard Finke, Jürgen Herwig, Klaus H. Usadel, and Klaus Badenhoop

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus
J Clin Endocrinol Metab 1997 82: 143-146. [Abstract] [Full Text]  

Ching-Ling Lin, Ta-Jen Wu, Dwaine A. Machacek, Nai-Siang Jiang, and Pai C. Kao

Urinary Free Cortisol and Cortisone Determined by High Performance Liquid Chromatography in the Diagnosis of Cushing’s Syndrome
J Clin Endocrinol Metab 1997 82: 151-155. [Abstract] [Full Text]  

John Newell-Price, Les Perry, Sami Medbak, John Monson, Martin Savage, Michael Besser, and Ashley Grossman

A Combined Test Using Desmopressin and Corticotropin-Releasing Hormone in the Differential Diagnosis of Cushing’s Syndrome
J Clin Endocrinol Metab 1997 82: 176-181. [Abstract] [Full Text]  

Andrej Nikoshkov, Svetlana Lajic, Mikael Holst, Anna Wedell, and Holger Luthman

Synergistic Effect of Partially Inactivating Mutations in Steroid 21-Hydroxylase Deficiency
J Clin Endocrinol Metab 1997 82: 194-199. [Abstract] [Full Text]  

Michael Davies, Sara E. Heys, Peter L. Selby, Jacqueline L. Berry, and E. Barbara Mawer

Increased Catabolism of 25-Hydroxyvitamin D in Patients with Partial Gastrectomy and Elevated 1,25-Dihydroxyvitamin D Levels. Implications for Metabolic Bone Disease
J Clin Endocrinol Metab 1997 82: 209-212. [Abstract] [Full Text]  

Marja Thorén, Agneta Hilding, Robert C. Baxter, Marie Degerblad, Inga-Lena Wivall-Helleryd, and Kerstin Hall

Serum Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit as Serum Markers of Body Composition during Growth Hormone (GH) Therapy in Adults with GH Deficiency
J Clin Endocrinol Metab 1997 82: 223-228. [Abstract] [Full Text]  

Michael Deuschle, Ulrich Schweiger, Bettina Weber, Ulrike Gotthardt, Andreas Körner, Jurgen Schmider, Harald Standhardt, Claas-Hinrich Lammers, and Isabella Heuser

Diurnal Activity and Pulsatility of the Hypothalamus-Pituitary-Adrenal System in Male Depressed Patients and Healthy Controls
J Clin Endocrinol Metab 1997 82: 234-238. [Abstract] [Full Text]  

Susan B. Bowes, Margot Umpleby, Michael H. Cummings, Nicola C. Jackson, Paul V. Carroll, Clara Lowy, Peter H. Sönksen, and David L. Russell-Jones

The Effect of Recombinant Human Growth Hormone on Glucose and Leucine Metabolism in Cushing’s Syndrome
J Clin Endocrinol Metab 1997 82: 243-246. [Abstract] [Full Text]  

Richard L. Doty, Alberto D. Fernandez, Michael A. Levine, Arnold Moses, and Donald A. McKeown

Olfactory Dysfunction in Type I Pseudohypoparathyroidism: Dissociation from G_s Protein Deficiency
J Clin Endocrinol Metab 1997 82: 247-250. [Abstract] [Full Text]  

L. Frassetto, R. Curtis Morris, Jr., and A. Sebastian

Potassium Bicarbonate Reduces Urinary Nitrogen Excretion in Postmenopausal Women
J Clin Endocrinol Metab 1997 82: 254-259. [Abstract] [Full Text]  

R. L. Prince, I. M. Dick, J. Lemmon, and D. Randell

The Pathogenesis of Age-Related Osteoporotic Fracture: Effects of Dietary Calcium Deprivation
J Clin Endocrinol Metab 1997 82: 260-264. [Abstract] [Full Text]  

Henry G. Bone, Robert W. Downs, Jr., Joseph R. Tucci, Steven T. Harris, Robert S. Weinstein, Angelo A. Licata, Michael R. McClung, Donald B. Kimmel, Barry J. Gertz, Erika Hale, and William J. Polvino

Dose-Response Relationships for Alendronate Treatment in Osteoporotic Elderly Women
J Clin Endocrinol Metab 1997 82: 265-274. [Abstract] [Full Text]  

Giorgio Iervasi, Aldo Clerico, Rita Bonini, Cristina Manfredi, Sergio Berti, Marcello Ravani, Cataldo Palmieri, Angelo Carpi, Andrea Biagini, and Inder J. Chopra

Acute Effects of Amiodarone Administration on Thyroid Function in Patients with Cardiac Arrhythmia
J Clin Endocrinol Metab 1997 82: 275-280. [Abstract] [Full Text]  

Ghada El-Hajj Fuleihan, Elizabeth B. Klerman, Emery N. Brown, Yong Choe, Edward M. Brown, and Charles A. Czeisler

The Parathyroid Hormone Circadian Rhythm Is Truly Endogenous—A General Clinical Research Center Study
J Clin Endocrinol Metab 1997 82: 281-286. [Abstract] [Full Text]  

Barbara J. Nicklas, Michael J. Toth, Andrew P. Goldberg, and Eric T. Poehlman

COMMENTS: Racial Differences in Plasma Leptin Concentrations in Obese Postmenopausal Women
J Clin Endocrinol Metab 1997 82: 315-317. [Abstract] [Full Text]  

Endocrinological Oncology:

Marie Leblond-Francillard, Agnès Picon, Xavier Bertagna, and Yves de Keyzer

High Expression of the POU Factor Brn3a in Aggressive Neuroendocrine Tumors
J Clin Endocrinol Metab 1997 82: 89-94. [Abstract] [Full Text]  

E. Barbara Mawer, Janet Walls, Anthony Howell, Michael Davies, Wendy A. Ratcliffe, and Nigel J. Bundred

Serum 1,25-Dihydroxyvitamin D May Be Related Inversely to Disease Activity in Breast Cancer Patients with Bone Metastases
J Clin Endocrinol Metab 1997 82: 118-122. [Abstract] [Full Text]  

Arthur J. Castelbaum, Lei Ying, Stephen G. Somkuti, Jinghai Sun, Abiodun O. Ilesanmi, and Bruce A. Lessey

Characterization of Integrin Expression in a Well Differentiated Endometrial Adenocarcinoma Cell Line (Ishikawa)
J Clin Endocrinol Metab 1997 82: 136-142. [Abstract] [Full Text]  

Steven J. Santner, Robert J. Pauley, Larry Tait, Jennifer Kaseta, and Richard J. Santen

Aromatase Activity and Expression in Breast Cancer and Benign Breast Tissue Stromal Cells
J Clin Endocrinol Metab 1997 82: 200-208. [Abstract] [Full Text]  

Shozo Yamada, Katsuhiko Yoshimoto, Toshiaki Sano, Kouji Takada, Mitsuo Itakura, Masaaki Usui, and Akira Teramoto

Inactivation of the Tumor Suppressor Gene on 11q13 in Brothers with Familial Acrogigantism without Multiple Endocrine Neoplasia Type 1
J Clin Endocrinol Metab 1997 82: 239-242. [Abstract] [Full Text]  

Experimental Studies:

Serge Guyétant, Marie-Christine Rousselet, Michel Durigon, Daniel Chappard, Brigitte Franc, Olivier Guerin, and Jean-Paul Saint-André

Sex-Related C Cell Hyperplasia in the Normal Human Thyroid: A Quantitative Autopsy Study
J Clin Endocrinol Metab 1997 82: 42-47. [Abstract] [Full Text]  

P. Barbe, V. Stich, J. Galitzky, M. Kunesova, V. Hainer, M. Lafontan, and M. Berlan

In Vivo Increase in ß-Adrenergic Lipolytic Response in Subcutaneous Adipose Tissue of Obese Subjects Submitted to a Hypocaloric Diet
J Clin Endocrinol Metab 1997 82: 63-69. [Abstract] [Full Text]  

Veena R. Agarwal, Christy I. Ashanullah, Evan R. Simpson, and Serdar E. Bulun

Alternatively Spliced Transcripts of the Aromatase Cytochrome P450 (CYP19) Gene in Adipose Tissue of Women
J Clin Endocrinol Metab 1997 82: 70-74. [Abstract] [Full Text]  

Paola Viganò, Barbara Gaffuri, Guido Ragni, Anna Maria Di Blasio, and Mario Vignali

Intercellular Adhesion Molecule-1 is Expressed on Human Granulosa Cells and Mediates Their Binding to Lymphoid Cells
J Clin Endocrinol Metab 1997 82: 101-105. [Abstract] [Full Text]  

Eystein S. Husebye, Gennet Gebre-Medhin, Tiinamaija Tuomi, Jaakko Perheentupa, Mona Landin-Olsson, Jan Gustafsson, Fredrik Rorsman, and Olle Kämpe

Autoantibodies against Aromatic L-Amino Acid Decarboxylase in Autoimmune Polyendocrine Syndrome Type I
J Clin Endocrinol Metab 1997 82: 147-150. [Abstract] [Full Text]  

Lena Hellström, Hans Wahrenberg, Signy Reynisdottir, and Peter Arner

Catecholamine-Induced Adipocyte Lipolysis in Human Hyperthyroidism
J Clin Endocrinol Metab 1997 82: 159-166. [Abstract] [Full Text]  

Pierre R. Provost, Bernard Lavallée, and Alain Bélanger

Transfer of Dehydroepiandrosterone- and Pregnenolone-Fatty Acid Esters between Human Lipoproteins
J Clin Endocrinol Metab 1997 82: 182-187. [Abstract] [Full Text]  

Neoklis A. Georgopoulos, François P. Pralong, Christine E. Seidman, J. G. Seidman, William F. Crowley, Jr., and Mario Vallejo

Genetic Heterogeneity Evidenced by Low Incidence of KAL-1 Gene Mutations in Sporadic Cases of Gonadotropin-Releasing Hormone Deficiency
J Clin Endocrinol Metab 1997 82: 213-217. [Abstract] [Full Text]  

Angelo Cagnacci, Elisabetta Mallus, Federica Tuveri, Rocco Cirillo, Anna Maria Setteneri, and Gian Benedetto Melis

Effect of Tibolone on Glucose and Lipid Metabolism in Postmenopausal Women
J Clin Endocrinol Metab 1997 82: 251-253. [Abstract] [Full Text]  

Pediatric Endocrinology:

Annemieke M. Boot, Maria A. J. de Ridder, Huibert A. P. Pols, Eric P. Krenning, and Sabine M. P. F. de Muinck Keizer-Schrama

Bone Mineral Density in Children and Adolescents: Relation to Puberty, Calcium Intake, and Physical Activity
J Clin Endocrinol Metab 1997 82: 57-62. [Abstract] [Full Text]  

Samu Sarna, Kalle Hoppu, Pertti J. Neuvonen, Jarmo Laine, and Christer Holmberg

Methylprednisolone Exposure, Rather than Dose, Predicts Adrenal Suppression and Growth Inhibition in Children with Liver and Renal Transplants
J Clin Endocrinol Metab 1997 82: 75-77. [Abstract] [Full Text]  

Yukihiro Hasegawa, Tomonobu Hasegawa, Katsura Fujii, Hideko Konii, Makoto Anzo, Taiji Aso, Shinobu Koto, Makoto Takada, and Yutaka Tsuchiya

High Ratios of Free to Total Insulin-Like Growth Factor-I in Early Infancy
J Clin Endocrinol Metab 1997 82: 156-158. [Abstract] [Full Text]  

L. Adan, J. C. Souberbielle, J. M. Zucker, A. Pierre-Kahn, C. Kalifa, and R. Brauner

Adult Height in 24 Patients Treated for Growth Hormone Deficiency and Early Puberty
J Clin Endocrinol Metab 1997 82: 229-233. [Abstract] [Full Text]  

Reproductive Endocrinology:

Antonio R. Gargiulo, Firyal S. Khan-Dawood, and M. Yusoff Dawood

Epidermal Growth Factor Receptors in Uteroplacental Tissues in Term Pregnancy before and after the Onset of Labor
J Clin Endocrinol Metab 1997 82: 113-117. [Abstract] [Full Text]  

M. Linette Casey and Paul C. MacDonald

Lysyl Oxidase (ras Recision Gene) Expression in Human Amnion: Ontogeny and Cellular Localization
J Clin Endocrinol Metab 1997 82: 167-172. [Abstract] [Full Text]  

Cosimo Massafra, Giuseppe Buonocore, Dino Gioia, Isa Sargentini, and Giovanni Farina

Effects of Estradiol and Medroxyprogesterone-Acetate Treatment on Erythrocyte Antioxidant Enzyme Activities and Malondialdehyde Plasma Levels in Amenorrhoic Women
J Clin Endocrinol Metab 1997 82: 173-175. [Abstract] [Full Text]  

Frederick Schatz, Csaba Papp, Stefan Aigner, Graciela Krikun, Virginia Hausknecht, and Charles J. Lockwood

Biological Mechanisms Underlying the Clinical Effects of RU 486: Modulation of Cultured Endometrial Stromal Cell Stromelysin-1 and Prolactin Expression
J Clin Endocrinol Metab 1997 82: 188-193. [Abstract] [Full Text]  

Euan M. Wallace, Simon C. Riley, Jennifer A. Crossley, Savitri C. Ritoe, Andrew Horne, Mary Shade, Patricia M. Ellis, David A. Aitken, and Nigel P. Groome

Dimeric Inhibins in Amniotic Fluid, Maternal Serum, and Fetal Serum in Human Pregnancy
J Clin Endocrinol Metab 1997 82: 218-222. [Abstract] [Full Text]  

John P. Miell, Katherine S. Langford, Jennifer S. Jones, Penny Noble, Melissa Westwood, Anne White, and Kypros H. Nicolaides

The Maternal Insulin-Like Growth Factor (IGF) and IGF-Binding Protein Response to Trisomic Pregnancy during the First Trimester: A Possible Diagnostic Tool for Trisomy 18 Pregnancies
J Clin Endocrinol Metab 1997 82: 287-292. [Abstract] [Full Text]  

Hiroya Matsuo, Takeshi Maruo, and Takashi Samoto

Increased Expression of Bcl-2 Protein in Human Uterine Leiomyoma and Its Up-Regulation by Progesterone
J Clin Endocrinol Metab 1997 82: 293-299. [Abstract] [Full Text]  

Kang Sun, Kaiping Yang, and John R. G. Challis

Differential Expression of 11ß-Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Placenta and Fetal Membranes
J Clin Endocrinol Metab 1997 82: 300-305. [Abstract] [Full Text]  

Richard Quinton, Wohaib Hasan, William Grant, Chris Thrasivoulou, Robert E. Quiney, G. Michael Besser, and Pierre-M. G. Bouloux

COMMENTS: Gonadotropin-Releasing Hormone Immunoreactivity in the Nasal Epithelia of Adults with Kallmann’s Syndrome and Isolated Hypogonadotropic Hypogonadism and in the Early Midtrimester Human Fetus
J Clin Endocrinol Metab 1997 82: 309-314. [Abstract] [Full Text]  

Rapid Communications:

G. A. Laughlin and S. S. C. Yen

Hypoleptinemia in Women Athletes: Absence of a Diurnal Rhythm with Amenorrhea
J Clin Endocrinol Metab 1997 82: 318-321. [Abstract] [Full Text]  

Letters to the Editor:

Gabriel Dickstein and Carmela Shechner

Low Dose ACTH Test—A Word of Caution to the Word of Caution: When and How to Use It
J Clin Endocrinol Metab 1997 82: 322. [Full Text]  

Frances J. Hayes, Tarek M. Fiad, and T. Joseph McKenna

Activity of the Renin-Angiotensin-Aldosterone Axis is Dependent on the Occurrence of Edema in Growth Hormone(GH)-Deficient Adults Treated with GH
J Clin Endocrinol Metab 1997 82: 322a-323. [Full Text]  

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