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Endocrine Care: Gwenaelle Abiven, Joel Coste, Lionel Groussin, Philippe Anract, Frédérique Tissier, Paul Legmann, Bertrand Dousset, Xavier Bertagna, and Jérôme Bertherat Clinical and Biological Features in the Prognosis of Adrenocortical Cancer: Poor Outcome of Cortisol-Secreting Tumors in a Series of 202 Consecutive Patients J Clin Endocrinol Metab 2006; 91: 2650-2655 [Abstract] [Full text] [PDF]

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Anjali Mishra, Bhargav PRK, and Pradeep PV   (6 October 2006)

Letter to editor 6 October 2006
Anjali Mishra, Dr assistant Professor, Bhargav PRK, and Pradeep PV Send letter to journal: Re: Letter to editor anjali{at}sgpgi.ac.in Anjali Mishra, et al.	We read with interest the impressive analysis by Abiven et al. (1) of prognostic factors for adrenocortical carcinoma. We have some queries about these patients and their tumors. Was histological grading of cortisol-producing tumors performed? What was their Weiss score (2, 3) and was it an independent predictor of disease-free survival? Were these tumors functional? What was mean tumor diameter in this subgroup, and specifically how many were more than 6 cm in diameter, which is a conventional cut- off limit for surgery in non- functioning adrenal incidentalomas (2)? How many patients in this series fell between ages of 10 and 20 years and were their outcomesl different from those of adults? References 1. Abiven G, Coste J, GroussinL, Anract P, Tissier F, Legmann P, Dousset B, Bertagna X, Bertherat J 2006 Clinical and Biological features in the prognosis of Adrenocortical cancer: Poor outcome of cortisol-secreting tumours in a series of 202 consecutive patients. J Clin Endocrinol Metab 91:2650-2655 2. Luton JP, Martinez M, Coste J, Bertherat J 2004 Outcome in patients with adrenal incidentaloma selected for surgery: an analysis of 88 cases investigated in a single clinical center. Eur J Endocrinol 143:111-117 3. Michalkiewicz E, Sandrini R, Figueiredo B, Miranda E.C.M, Caran E, Oliveira-Filho AG, Marques R, Pianovski MAD, Lacerda L, Cristofani LM, Jenkins J, Rodriguez-Galindo C, Ribeiro RC. 2004 Clinical and outcome characteristics of children with adrenocortical tumours: A report from the international pediatric adrenocortical tumor registry. J Clin Oncol 22:838