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Other Original Articles: T. Illig, F. Bongardt, A. Schöpfer, S. Müller-Scholze, W. Rathmann, W. Koenig, B. Thorand, C. Vollmert, R. Holle, H. Kolb, C. Herder Members of the Kooperative Gesundheitsforschung im Raum Augsburg/Cooperative Research in the Region of Augsburg Significant Association of the Interleukin-6 Gene Polymorphisms C-174G and A-598G with Type 2 Diabetes J Clin Endocrinol Metab 2004; 89: 5053-5058 [Abstract] [Full text] [PDF]

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Letter to the Editor

Thomas Illig, F. Bongardt, A. Schopfer, S. Muller-Scholze, W. Rathmann, W. Koenig, B. Thorand, C. Vollmert, R. Holle, H. Kolb, and C. Herder   (13 December 2005)

Letter to the Editor 13 December 2005
Thomas Illig, MD GSF-Forschungszentrum fur Umwelt und Gesundheit, F. Bongardt, A. Schopfer, S. Muller-Scholze, W. Rathmann, W. Koenig, B. Thorand, C. Vollmert, R. Holle, H. Kolb, and C. Herder Send letter to journal: Re: Letter to the Editor illig{at}gsf.de Thomas Illig, et al.	Since the submission of our manuscript (1), several articles have been published looking on associations of the IL-6 promoter genotypes with type 2 diabetes and related phenotypes. The largest data set was published in a Danish study with 7,553 individuals including 1,389 patients with type 2 diabetes (2). The authors looked for associations between three promoter polymorphisms in the IL-6 gene (C-174G, G-572C and A-597G), the metabolic syndrome and related quantitative traits. They found that the - 174G allele was associated with insulin resistance and dyslipidemia. Composite haplotype analysis of the three SNPs showed associations with type 2 diabetes, obesity and the metabolic syndrome. These results confirm the association of the C-174G polymorphism with type 2 diabetes, as suggested by our study. To further elucidate the impact of the IL-6 SNPs on type 2 diabetes and related phenotypes in a large population, we have initiated an international meta-analysis of available data sets which involves nearly 20 different research groups worldwide. References 1. T. Illig, F. Bongardt, A. Schopfer, S. Muller-Scholze, W. Rathmann, W. Koenig, B. Thorand, C. Vollmert, R. Holle, H. Kolb, C. Herder Members of the Kooperative Gesundheitsforschung im Raum Augsburg/Cooperative Research in the Region of Augsburg 2004 Significant Association of the Interleukin-6 Gene Polymorphisms C-174G and A-598G with Type 2 Diabetes J. Clin Endo Metab 88:5053-5058 2. Hamid YH, Rose CS, Urhammer SA, Glumer C, Nolsoe R, Kristiansen OP, Mandrup-Poulsen T, Borch-Johnsen K, Jorgensen T, Hansen T, Pedersen O 2005 Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia 48:251-260