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This version published online on April 1, 2008
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-2342
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Right arrow Female Endocrinology

Submitted on October 22, 2007
Accepted on March 26, 2008

Concentration of Anti-Müllerian hormone and inhibin-B in relation to steroids and age in follicular fluid from small antral human follicles

Claus Yding Andersen*, Mikkel Rosendahl, and Anne Grete Byskov

Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: yding{at}rh.dk.

Context: Ovaries surgically removed for fertility preservation served as a source of follicle fluid from human small antral follicles.

Objective: To measure intrafollicular concentrations of anti-Müllerian Hormone (AMH), inhibin-B, progesterone, androstenedione, testosterone, estradiol and IGFBP4.

Setting: University Hospital.

Patients: 43 women having one ovary removed prior to receiving gonadotoxic treatment due to malignant disease

Interventions: Fluid from 100 follicles (diameter of 3–9 mM) were included.

Main outcome measures: Intrafollicular concentrations of the measured hormones, their possible intercorrelation and correlation with age.

Results: Concentrations of AMH were unrelated to FF concentrations of androstenedione and testosterone. There was a significant negative correlation between estradiol, inhibin-B, progesterone and AMH. In four age groups spanning 11 – 37 years levels of AMH, estradiol and inhibin-B remained constant, whereas progesterone, androstenedione and testosterone showed significant variations. IGFBP4 was unrelated to any other measured hormone.

Conclusions: This study is unable to confirm a stimulatory effect of androgens on AMH secretion but does enforce a close intimate correlation between AMH and estradiol expressions in the developing human follicle. The insignificant variation of the AMH concentration with age even in prepubertal girls suggests that AMH expression is unrelated to menstrual cycle FSH cyclicity.
Key words: Follicle fluid • AMH • Inhibin-B • Steroids • small antral follicles






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