help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on September 18, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-1244
A more recent version of this article appeared on December 1, 2007
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
92/12/4623    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Misra, M.
Right arrow Articles by Klibanski, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Misra, M.
Right arrow Articles by Klibanski, A.
Related Collections
Right arrow Neuroendocrinology and Pituitary
Right arrow Pediatric Endocrinology

Submitted on June 5, 2007
Accepted on September 7, 2007

Growth Hormone Suppression Following an Oral Glucose Load in Children

Madhusmita Misra*, Jennalee Cord, Rajani Prabhakaran, Karen K. Miller, and Anne Klibanski

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114; and Pediatric Endocrine Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts 02114

* To whom correspondence should be addressed. E-mail: mmisra{at}partners.org.

Background: Growth hormone (GH) non-suppression following oral glucose is diagnostic for GH excess, but normative data are lacking in children. Adult data cannot be extrapolated to children given the pubertal rise in GH concentration. Also, because GH levels are higher in pubertal girls than boys, nadir GH may differ across gender.

Objective: To determine whether nadir GH during an oral glucose tolerance test (OGTT) is gender and pubertal stage specific. We hypothesized that nadir GH would be higher in girls, and at the pubertal stage known to correspond with peak height velocity (Tanner 2–3 in girls, and Tanner 3–4 in boys) and maximal GH concentrations.

Subjects/ Methods: A two-hour OGTT using 2.35 g/kg oral glucose (maximum 100-g) was performed in 64 girls and 43 boys 9–17 years (10th-90th percentiles for BMI). Girls were grouped as Group 1 (Tanner 1), Group 2 (Tanner 2–3), and Group 3 (Tanner 4- 5), and boys as Group 1(Tanner 1–2), Group 2 (Tanner 3–4), and Group 3 (Tanner 5).

Results: Nadir GH was higher in girls than boys, and in Group 2 girls and boys than the other two groups. The upper limit for nadir GH was highest in Group 2 girls (1.57 ng/ml), and lower for the other two groups of girls (0.64 ng/ml), and for boys (0.50 ng/ml). All but one girl, and all boys suppressed to <1.0 ng/ml. Sixteen girls and five boys had a nadir GH of >0.3 ng/ml.

Conclusion: GH suppression following oral glucose is gender and pubertal stage specific.
Key words: Growth hormone • oral glucose tolerance test • children • pubertal stage • Tanner stage






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society