help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on June 12, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-0790
A more recent version of this article appeared on September 1, 2007
This Article
Right arrow Author Manuscript (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
92/9/3660    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheng, I.
Right arrow Articles by Le Marchand, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheng, I.
Right arrow Articles by Le Marchand, L.
Related Collections
Right arrow Metabolism

Submitted on April 6, 2007
Accepted on June 4, 2007

Genetic Determinants of Circulating IGF-I, IGFBP-1 and IGFBP-3 Levels in a Multiethnic Population

Iona Cheng*, Katherine DeLellis Henderson, Christopher A. Haiman, Laurence N. Kolonel, Brian E. Henderson, Matthew L. Freedman, and Loïc Le Marchand

Department of Epidemiology and Biostatistics and Institute of Human Genetics, University of California, San Francisco, San Francisco, CA, 94143-0794, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Epidemiology Program, Cancer Research Center of Hawai'i, University of Hawai'i, Honolulu, HI 96813, USA

* To whom correspondence should be addressed. E-mail: chengi{at}humgen.ucsf.edu.

Context: Both circulating levels and genetic variation of insulin-like growth factors (IGF) have been associated with cancer risk, yet the relationship between the two is not well understood.

Objective: To investigate whether common genetic variation in IGF1, IGFBP1 and IGFBP3 influences circulating levels of IGF-I, IGFBP-1 and IGFBP-3, we conducted a cross-sectional study of African-American, Native Hawaiian, Japanese-American, Latino, and White men and women in the Multiethnic Cohort.

Design: Plasma levels of IGF-I, IGFBP-1 and IGBFP-3 were measured by ELISA in a random sample of 837 Multiethnic Cohort participants. Previously identified tag SNPs for IGF1 (29 tag SNPs) and IGFBP1/IGFBP3 (23 tag SNPs) were genotyped among the 837 participants. Analysis of covariance was conducted to test for differences in mean IGF-I, IGFBP-1 and IGFBP-3 levels across respective IGF1, IGFBP1 and IGFBP3 genotypes, adjusting for previously identified dietary and lifestyle correlates.

Results: Five highly correlated IGFBP3 SNPs (rs3110697, rs2854747, rs2854746, rs2854744 and rs2132570) demonstrated strongly significant associations with IGFBP-3 levels when conservatively adjusted for multiple hypothesis testing (Bonferroni adjusted P trends = 7.75 x 10-8 to 1.44 x 10-5). Patterns of associations were consistent across the five racial/ethnic groups.

Conclusion: In summary, our study suggests that common genetic variation in IGFBP3 influences circulating levels of IGFBP-3 among African-Americans, Native Hawaiians, Japanese-Americans, Latinos, and Whites.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society