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Submitted on March 15, 2007
Accepted on May 29, 2007
Max-Planck Institute of Psychiatry, Munich, Germany
* To whom correspondence should be addressed. E-mail: kluge{at}mpipsykl.mpg.de.
Context: Ghrelin affects the hypothalamic-pituitary-gonadal axis in various non-human mammalians, predominantly by suppressing secretion of luteinizing hormone (LH). For humans, however, no such evidence exists.
Objective: To study the effect of ghrelin on secretion of LH and testosterone in humans.
Design/Participants/Intervention: Nocturnal (2000-0700 h) secretion profiles of LH and testosterone were determined in 10 healthy males (25.3 ± 3.2 years) twice, receiving 50 µg ghrelin or placebo at 2200, 2300, 0000, and 0100 h, in this single-blind, randomized, cross-over study.
Results: Ghrelin was associated with significantly (P < 0.05) lower mean plasma levels of both LH (2340 to 0200 h) and testosterone (0040 to 0300 h) than placebo. LH peak levels of the pulse after first administration of ghrelin/placebo were significantly (P = 0.014) smaller in the ghrelin (2.98 ± 1.34 mlU/ml) than in the placebo condition (4.37 ± 1.09 mlU/ml). In addition, the interval between this and the preceding peak was significantly (p = 0.010) longer in the ghrelin (255.8 ± 79.1 minutes) than in the placebo condition (190.8 ± 51.0 minutes). Significantly (P = 0.005) more LH pulses occurred with placebo (3.2 ± 0.75) than ghrelin (2.6 ± 0.7) subsequent to ghrelin/placebo administration.
Conclusions: Ghrelin caused both a delay and a suppression of the amplitude of LH pulses. These findings are in accordance with those in non-human mammalians.
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