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This version published online on June 5, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-0209
A more recent version of this article appeared on August 1, 2007
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Submitted on January 29, 2007
Accepted on May 24, 2007

Association of Serum Retinol Binding Protein 4 and Visceral Adiposity in Chinese Subjects with and without Type 2 Diabetes

Weiping Jia*, Haiya Wu, Yuqian Bao, Chen Wang, Junxi Lu, Jiehua Zhu, and Kunsan Xiang

Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes, Shanghai, China

* To whom correspondence should be addressed. E-mail: wpjia{at}sjtu.edu.cn.

Objective Previous studies have shown that adipose-derived serum retinol binding protein 4 (RBP4) levels are increased in insulin-resistant mouse models and in subjects with insulin resistance or type 2 diabetes. However, the association of visceral fat and serum RBP4 has not been studied. The purpose of this study was to investigate the relationship between serum RBP4 and regional fat distribution in Chinese subjects with and without type 2 diabetes.

Design We measured serum RBP4 concentrations from 1033 Chinese subjects with various degree of obesity and tested the association between visceral adposity and serum RBP4. In a subgroup of this study, euglycemic hyperinsulinemic clamp was performed to measure insulin sensitivity. The association between visceral adiposity and serum RBP4 was also determined in response to rosiglitazone treatment in a subgroup of patients with diabetes.

Results Serum RBP4 level was positively correlated with visceral adipose area in male (r=0.171, p<0.001) and female (r=0.215, p<0.001) subjects. However, there was no correlation between serum RBP4 and body-mass-index. Subjects with visceral obesity had higher serum RBP4 concentrations than those without visceral obesity in both men and women. Rosiglitazone treatment in patients with diabetes resulted in a lower serum RBP4 level (35.2±10.2 vs. 24.9±5.6 µg/ml; before vs. after treatment). These changes were accompanied by improved insulin sensitivity and reductions in visceral fat area. The latter was found to be highly correlated with the decline of serum RBP4 levels (r=0.471, p=0.027).

Conclusions Serum RBP4 level is positively associated with visceral adiposity in both men and women. Our data suggest that RBP4 may contribute to the development of insulin resistance along with other adipokines.
Key words: retinol binding protein 4 • visceral fat • type 2 diabetes • obesity




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