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This version published online on March 20, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-2865
A more recent version of this article appeared on June 1, 2007
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Submitted on December 27, 2006
Accepted on March 13, 2007

Determination of the elimination half life of FGF-23

Azarmindokht Khosravi, Carolee M. Cutler, Marilyn H. Kelly, Richard Chang, Richard E. Royal, Richard M. Sherry, Felasfa M Wodajo, Neal S. Fedarko, and Michael T. Collins*

Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research; Department of Radiology, Mark O. Hatfield Clinical Center, Surgery Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland; Department of Orthopedics and Pediatrics, Georgetown University, Washington, D.C.; Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: mc247k{at}nih.gov.

Context: Tumor-induced osteomalacia (TIO) is rare paraneoplastic disease caused by mesenchymal tumors that secrete fibroblast growth factor-23 (FGF-23), a newly-described vitamin D and phosphate regulating hormone. Surgical removal of the tumor, the ectopic source of circulating FGF-23, offers the opportunity to determine the elimination half life of FGF-23.

Objective: To determine the elimination half life of FGF-23.

Patients/Methods: The tumors were removed from three patients with TIO and serum samples were taken every 30 minutes for up to 72 hours after the operation. FGF-23 was measured by both a C-terminal/intact assay and an intact assay and the elimination half life determined by one phase exponential decay methodology.

Setting: Mark O. Hatfield Clinical Research Center of the National Institutes of Health, a tertiary referral clinical research center.

Results: The elimination life of FGF-23 as determined by C-terminal/intact and intact assays was 46 ± 12 and 58 ± 34 min., respectively.

Conclusions: The plasma half life of serum FGF-23 is in the range of 46 - 58 min.




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