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This version published online on January 30, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-2794
A more recent version of this article appeared on April 1, 2007
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Submitted on December 18, 2006
Accepted on January 23, 2007

Beneficial effects of A three-month structured Exercise Training Program on the Cardiopulmonary Functional Capacity in Young Women with Polycystic Ovary Syndrome

Carlo Vigorito, Francesco Giallauria, Stefano Palomba, Teresa Cascella, Francesco Manguso, Rosa Lucci, Anna De Lorenzo, Domenico Tafuri, Gaetano Lombardi, Annamaria Colao, and Francesco Orio*

Departments of: Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit (C.V., F.G., R.L., A.D.L) and Molecular & Clinical Endocrinology and Oncology (T.C., G.L., A.C.,F.O.), University "Federico II" of Naples, 80131 Naples, Italy; Department of Obstetrics and Gynecology (S.P.), University "Magna Graecia" of Catanzaro, Catanzaro 88100, Italy; Department of Clinical and Experimental Medicine, Gastroenterology Unit (F.M.), University "Federico II" of Naples, 80131 Naples, Italy; Teaching and Methods of Sportive Activity (D.T.) and Endocrinology (F.O.), Faculty of Exercise Sciences, University "Parthenope" of Naples, Naples 80133, Italy

* To whom correspondence should be addressed. E-mail: francescoorio{at}virgilio.it.

Context: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors for cardiovascular disease. An impaired cardiopulmonary functional capacity was previously demonstrated in PCOS women. No data regarding the effects of a structured exercise training (ET) program on cardiopulmonary functional capacity in PCOS women are available.

Objective: To evaluate the effects of 3-month ET program on cardiopulmonary functional capacity in young PCOS women.

Design: Prospective baseline-randomized clinical study.

Setting: University "Federico II" of Naples, School of Medicine (Italy).

Patients: Ninety young overweight PCOS women were enrolled.

Mean Outcome Measures: Ninety young PCOS women were randomly subdivided into two groups each composed of 45 subjects: PCOS-T (trained) group underwent a 3-months structured ET programme whereas PCOS-UnT (untrained) group did not. Hormonal and metabolic profile, and cardiopulmonary and exercise parameters were evaluated.

Results: After 3-month ET, PCOS-T showed a significant improvement in peak oxygen consumption (+35.4%, P<0.001) and in maximal workload (+37.2%, P<0.001). In PCOS-T we also observed a significant reduction in Body mass index (-4.5%, P<0.001) and in C-reactive protein (-10%, P<0.001), and a significant (p<0.001) improvement in insulin sensitivity indexes. After 3 months, no changes were observed in PCOS-UnT.

Conclusions: A three-month structured ET program improves cardiopulmonary functional capacity in young PCOS women.
Key words: PCOS • exercise training • cardiopulmonary functional capacity • cardiopulmonary exercise test • cardiovascular risk • insulin resistance




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S. Palomba, F. Giallauria, A. Falbo, T. Russo, R. Oppedisano, A. Tolino, A. Colao, C. Vigorito, F. Zullo, and F. Orio
Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study
Hum. Reprod., March 1, 2008; 23(3): 642 - 650.
[Abstract] [Full Text] [PDF]


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