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Submitted on December 14, 2006
Accepted on June 14, 2007
Department of Medicine, Johns Hopkins University School of Medicine and Johns Hopkins Bayview Medical Center, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, Kronos Longevity Research Institute, Phoenix, AZ, and Laboratory of Clinical Investigation, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD
* To whom correspondence should be addressed. E-mail: arodrig5{at}jhmi.edu.
Background: Based on ATPIII criteria, we previously reported that the prevalence of the metabolic syndrome (MS) increased with aging, was higher if elevated 2 hour plasma post-glucose challenge (2hPG) values were included as a criterion, and was greater in men compared with women. The aim of this study was to evaluate the relationship between the MS and circulating androgen levels in a cohort of men in the Baltimore Longitudinal Study of Aging.
Methods and Results: Study participants were Caucasian community dwelling adult men in the Baltimore Longitudinal Study of Aging, who underwent a fasting 2 hour OGTT and had serum concentrations of total testosterone (T), dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) levels measured. The prevalence of the MS was 4%, 21%, 21% and 18% for men between the ages of 20-39, 40-59, 60-79 and 80-94 years, respectively. Total T and SHBG were inversely related to the development of the MS over a mean follow-up period of 5.8 years (range 1.5-14.0 years), while the free testosterone index and BMI were positively related to the incidence of the MS. Age alone did not predict the development of the MS nor did the inclusion of abnormal 2hPG levels in the classification of the MS. Stepwise proportional hazards regression analyses showed that among the various measurements, SHBG levels exerted the greatest influence on development of the MS.
Conclusion: The prevalence of the MS increased with aging, and this was associated with lower androgen levels. Lower total T and SHBG predicted a higher incidence of the MS.
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