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This version published online on April 10, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-2428
A more recent version of this article appeared on July 1, 2007
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*Substance via MeSH
Medline Plus Health Information
*Coronary Artery Disease
*Metabolic Syndrome
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Submitted on November 6, 2006
Accepted on April 2, 2007

The Effects of Metabolic Syndrome versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events

Dao-Fu Dai, Jou-Wei Lin, Jia-Horng Kao, Chih-Neng Hsu, Fu-Tien Chiang, Jiunn-Lee Lin, Yi-Hua Chou, Kwan-Lih Hsu, Chuen-Den Tseng, Yung-Zu Tseng, and Juey-Jen Hwang*

Cardiovascular Division, Gastroenterology Division, Department of Internal Medicine, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, and Cardiovascular Center of National Taiwan University Hospital Yun-Lin Branch

* To whom correspondence should be addressed. E-mail: juey{at}ha.mc.ntu.edu.tw.

Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors versus infectious burden with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs).

Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease (CAD). Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. Infectious burden score (0-7) was defined as the number of seropositivities to several agents. Results: Infectious burden score was not associated with plasma CRP concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (p<0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios: 1.51, p<0.001 and 1.90, p=0.002, respectively). Conclusion: Compared with infectious burden, metabolic abnormalities have more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with CAD.
Key words: Metabolic Syndrome X • Infection • Coronary Arteriosclerosis • C-Reactive Protein






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