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Submitted on November 6, 2006
Accepted on February 5, 2007
Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093
* To whom correspondence should be addressed. E-mail: rjchang{at}ucsd.edu.
Context: In the human ovary, expression of anti-mullerian hormone (AMH) is detected primarily in granulosa cells of preantral and small antral follicles. This finding is consistent with the tight correlation between circulating AMH levels and the number of small antral follicles (2-5 mm) in normal and polycystic ovary syndrome (PCOS) women. In addition, the greater follicle count in PCOS is mirrored by significantly higher serum AMH levels compared to those of normal women. Despite the utility of AMH measurements in evaluating ovarian physiology and function, the regulation of AMH remains poorly understood.
Objective: To determine whether gonadotropins acutely regulate serum AMH in women with PCOS and normal women.
Design: Prospective study to compare ovarian responses to follicle stimulating hormone (FSH) in two groups of women.
Setting: GCRC in a tertiary academic medical center.
Patients: Women with PCOS, 18-35 years (n = 16), and normal ovulatory controls, 18-35 years (n = 11), were recruited for study.
Interventions: Serum samples were measured over a 24 hour period following an intravenous injection of r-hFSH, 150IU.
Main Outcome Measure(s): Serum AMH responses following FSH administration.
Results: Basal serum AMH levels were markedly increased in women with PCOS compared to that observed in normal women. Following FSH injection, PCOS women failed to demonstrate changes in circulating AMH over 24 hours. A similar lack of alteration in serum AMH was observed in normal women.
Conclusions: These findings suggest that in PCOS and normal women, acute exposure to FSH does not appear to exert an effect on AMH production.
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