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Submitted on October 23, 2006
Accepted on January 30, 2007
The Medical Research Laboratories, Clinical Institute and the Medical Department M (Diabetes and Endocrinology), Aarhus University Hospital, DK-8000 Aarhus C, Denmark; Childrens Clinic Randers, DK-8900, Randers, Denmark; Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Skejby, Denmark
* To whom correspondence should be addressed. E-mail: allan.flyvbjerg{at}dadlnet.dk.
Context: Pubertal stages have been shown to influence total adiponectin (ADPN) levels. Further, testosterone has been shown to alter the isomer distribution of ADPN.
Objective: To investigate whether pubertal stages and testosterone levels influenced total serum ADPN levels and the distribution of ADPN isomers.
Design: Cross-sectional study.
Patients: 859 children and adolescents (396 males) aged 6 to 20 yrs.
Main Outcome Measures: Total ADPN and ADPN isomers were measured using a validated in-house immunoflurometric assay. Fractioning of the ADPN into the 3 major molecular fractions was performed in representative subgroups of pre- and post-pubertal males and females (n= 40, 10 in each group) using a validated fast protein liquid chromatomography method.
Results: Total ADPN levels before puberty were 13.4 (11.1 - 15.9) mg/l (median and inter quartile range) and 14.7 (12.3 - 18.1) mg/l (P=ns), in males and females, respectively. After puberty, ADPN levels were significantly reduced in males, 9.7 (8.2 - 12.0) mg/l, but remained unchanged in females, 12.1 (9.7 - 15.3) mg/l (P<0.0001). Concomitantly, a reduction was seen in the ratio of high molecular weight (HMW) isomers to total ADPN (HMW ratio) when comparing pre-pubertal and post-pubertal males. Also, post-pubertal males had lower HMW ratios than corresponding females (P=0.038). Finally, a negative correlation was seen between HMW ratio and testosterone (r= - 0.430, P=0.007).
Conclusion: Serum total ADPN levels decrease through puberty in males. Also, reduced HMW ratio is seen in males at the onset of puberty. We speculate that the suppression of HMW ADPN may be caused by testosterone.
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