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This version published online on February 6, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-2240
A more recent version of this article appeared on April 1, 2007
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Submitted on October 13, 2006
Accepted on January 26, 2007

HUMAN ADIPOSE TISSUE CANNABINOID RECEPTOR 1 GENE EXPRESSION IS NOT RELATED TO FAT CELL FUNCTION OR ADIPONECTIN LEVEL

Patrik Löfgren, Eva Sjölin, Kerstin Wåhlen, and Johan Hoffstedt*

Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden

* To whom correspondence should be addressed. E-mail: johan.hoffstedt{at}ki.se.

Context: The cannabinoid receptor 1 gene (CNR1) is implicated in adipocyte function.

Objective: We investigated human adipose tissue CNR1 mRNA in relation to obesity, clinical and metabolic variables, adipocyte function and adiponectin (ADIPOQ) levels.

Methods: Subcutaneous fat biopsies from 96 obese and non-obese subjects and omental fat biopsies from 82 obese and non-obese subjects.

Results: Subcutaneous and omental adipose CNR1 gene expression were similar in obese and non-obese subjects. No association between either subcutaneous or omental adipose CNR1 mRNA levels and BMI, waist circumference, plasma levels of glucose and insulin, lipids or blood pressure was found. Subcutaneous and omental maximal adrenergic lipolytic activation as well as lipolytic adrenoceptor sensitivity were not related to CNR1 gene expression. Lipogenesis in subcutaneous adipocytes also showed no association with CNR1 mRNA levels. Finally, no relation was found between adipose CNR1 gene expression and ADIPOQ mRNA, adipose tissue adiponectin secretion or circulating adiponectin.

Conclusion: We found no association of human adipose tissue CNR1 mRNA expression with measures of body fat, metabolic parameters, fat cell function or ADIPOQ expression. These data do not suggest a major role of human adipose CNR1 in fat cell function or metabolic disease development.
Key words: adipocyte • ADIPOQ • CNR1 • lipogenesis • lipolysis • mRNA




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The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium-Dependent Mechanisms
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[Abstract] [Full Text] [PDF]


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