Context: The Insulin-like Growth Factor 2 gene (IGF2) plays a key role in growth and is a candidate for association with obesity. Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent. The primary aim of this study was to confirm the association with BMI, and secondarily to study the associations with other indices of body size. Methods: In a sample of 2797 women and 2203 men aged 39-79 participating in the Norfolk arm of the European Prospective Investigation of Cancer (EPIC), we genotyped three SNPs in the IGF2 gene that were previously associated with BMI (6815 A/T, 1156 T/C (G/A), 820 G/A (ApaI)). Results: No significant associations were observed between these SNPs and BMI. However, all three SNPs were significantly associated with height (p=0.03 to 0.001). In a backwards elimination regression analysis, two SNPs 1156 T/C (G/A) and 820 G/A remained independently associated with height (p=0.003 and p=0.038 respectively). Haplotype analysis of these two SNPs showed that carriers of the GA haplotype were shorter than carriers of each of the other three haplotypes (p<0.001 for all comparisons). Conclusion: We did not confirm the previously reported associations between IGF2 polymorphisms and BMI. However our results suggest that common variation in the IGF2 gene may be associated with adult height. IGF2 could be considered as a candidate gene for future research on mechanisms for the association between height and chronic diseases such as cancer, diabetes and coronary heart disease.