help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on February 6, 2007
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-1757
A more recent version of this article appeared on April 1, 2007
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
92/4/1391    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gastaud, F
Right arrow Articles by Bougnères, P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gastaud, F
Right arrow Articles by Bougnères, P

Submitted on August 14, 2006
Accepted on January 26, 2007

Impaired sexual and reproductive outcomes in women with classical forms of congenital adrenal hyperplasia

F Gastaud, C Bouvattier, L Duranteau, R Brauner, E Thibaud, F Kutten, and P Bougnères*

Centre de Référence des Maladies Rares de la Différenciation Sexuelle, Lyon-Paris; Pediatric and Adult Endocrinology, Necker Hospital, AP-HP, Paris V University, Paris; Pediatric Endocrinology, Saint Vincent de Paul Hospital, AP-HP, Paris V University, Paris

* To whom correspondence should be addressed. E-mail: pierre.bougneres{at}wanadoo.fr.

Objectives: 1) A detailed description of sexual and reproductive outcomes in adult women with congenital adrenal hyperplasia (CAH) of different phenotypic severity at birth 2) Comparisons of these outcomes among CAH subtypes and between CAH women and non-CAH control women.

Design: A cross-sectional study using a face-to-face interview, a written questionnaire, the Female Sexual Function Index (FSFI), and a gynaecological examination.

Patients: 35 women with CAH, representing Prader stages I-V at birth, aged 18-43 years, who had been treated from birth to adolescence in the same pediatric endocrine clinics. 69 non-CAH healthy control women selected from hospital-staff families.

Results: None of the CAH women expressed doubts about their gender assignment. 20% (7/35) had homosexual inclinations. 23% (8/35) were married. 3 reported a complete lack of sexual activity. 37% (13/35) said they never had heterosexual intercourse with vaginal penetration. Sexual functioning as assessed by the FSFI was much lower in CAH women than controls, and lowest in CAH women with high Prader stages. 81% (18/22) experienced pain during vaginal penetration. Only 8 women became pregnant, and 17% (6/35) had children.

Conclusions: Despite expert medical and surgical care by physicians dedicated to this rare disease, women with CAH still suffer major limitations in their sexual function and reproductive life.




This article has been cited by other articles:


Home page
 Hum ReprodHome page
K. Hagenfeldt, P.O. Janson, G. Holmdahl, H. Falhammar, H. Filipsson, L. Frisen, M. Thoren, and A. Nordenskjold
Fertility and pregnancy outcome in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Hum. Reprod., July 1, 2008; 23(7): 1607 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. P. Merke
Approach to the Adult with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 653 - 660.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Nordenskjold, G. Holmdahl, L. Frisen, H. Falhammar, H. Filipsson, M. Thoren, P. O. Janson, and K. Hagenfeldt
Type of Mutation and Surgical Procedure Affect Long-Term Quality of Life for Women with Congenital Adrenal Hyperplasia
J. Clin. Endocrinol. Metab., February 1, 2008; 93(2): 380 - 386.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2007 by The Endocrine Society