help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on December 5, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-1268
A more recent version of this article appeared on February 1, 2007
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
92/2/386    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sharma, A. M.
Right arrow Articles by Staels, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sharma, A. M.
Right arrow Articles by Staels, B.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*GLUCOSE
Medline Plus Health Information
*Nutrition
*Obesity

Submitted on June 14, 2006
Accepted on November 29, 2006

Peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) and adipose tissue -- understanding obesity-related changes in regulation of lipid and glucose metabolism

Arya M. Sharma* and Bart Staels

Canada Research Chair for Cardiovascular Obesity Research and Management, McMaster University, Hamilton, ON; Institut Pasteur de Lille, Département d'Athérosclérose, Lille, F-59019 France; Inserm U545, Lille, F-509019 France; Université de Lille 2, Lille, F-59006 France

* To whom correspondence should be addressed. E-mail: sharma{at}cardio.on.ca.

Context: Adipose tissue is a metabolically dynamic organ, serving as a buffer to control fatty acid flux and a regulator of endocrine function. In obese subjects, and those with type 2 diabetes or the metabolic syndrome, adipose tissue function is altered -- adipocytes display morphological differences alongside aberrant endocrine and metabolic function and low-grade inflammation.

Evidence Acquisition: Articles on the role of PPAR{gamma} in adipose tissue of healthy individuals and those with obesity, metabolic syndrome, or type 2 diabetes were sourced using MEDLINE (1990-2006).

Evidence Synthesis: Articles were assessed to provide a comprehensive overview of how PPAR{gamma} activating ligands improve adipose tissue function and how this links to improvements in insulin resistance and the progression to type 2 diabetes and atherosclerosis.

Conclusions: PPAR{gamma} is highly expressed in adipose tissue, where its activation with thiazolidinediones alters fat topography, adipocyte phenotype, and upregulates genes involved in fatty acid metabolism and triglyceride storage. Furthermore, PPAR{gamma} activation is associated with potentially beneficial effects on the expression and secretion of a range of factors including adiponectin, resistin, IL-6, TNF{alpha}, PAI-1, MCP-1 and angiotensinogen, as well as a reduction in plasma NEFA supply. The effects of PPAR{gamma} also extend to macrophages, where they suppress production of inflammatory mediators. As such, PPAR{gamma} activation appears to have a beneficial effect on the relationship between the macrophage and adipocyte that is distorted in obesity. Thus, PPAR{gamma} activating ligands improve adipose tissue function and may have a role in preventing progression of insulin resistance to diabetes and endothelial dysfunction to atherosclerosis.
Key words: PPAR{gamma} • adipose tissue • thiazolidinediones • lipid metabolism • glucose metabolism




This article has been cited by other articles:


Home page
 J EndocrinolHome page
J. Takada, M. H. Fonseca-Alaniz, T. B. F. de Campos, S. Andreotti, A. B. Campana, M. Okamoto, C. d. N. Borges-Silva, U. F. Machado, and F. B. Lima
Metabolic recovery of adipose tissue is associated with improvement in insulin resistance in a model of experimental diabetes
J. Endocrinol., July 1, 2008; 198(1): 51 - 60.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. Macias-Gonzalez, F. Cardona, M. Queipo-Ortuno, R. Bernal, M. Martin, and F. J. Tinahones
PPAR{gamma} mRNA Expression Is Reduced in Peripheral Blood Mononuclear Cells after Fat Overload in Patients with Metabolic Syndrome
J. Nutr., May 1, 2008; 138(5): 903 - 907.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
G. J. Hausman, S. P. Poulos, T. D. Pringle, and M. J. Azain
The influence of thiazolidinediones on adipogenesis in vitro and in vivo: Potential modifiers of intramuscular adipose tissue deposition in meat animals
J Anim Sci, April 1, 2008; 86(14_suppl): E236 - E243.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Zhang, X. Chen, J. Aravindakshan, and M. R. Sairam
Changes in Adiponectin and Inflammatory Genes in Response to Hormonal Imbalances in Female Mice and Exacerbation of Depot Selective Visceral Adiposity by High-Fat Diet: Implications for Insulin Resistance
Endocrinology, December 1, 2007; 148(12): 5667 - 5679.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Qatanani and M. A. Lazar
Mechanisms of obesity-associated insulin resistance: many choices on the menu
Genes & Dev., June 15, 2007; 21(12): 1443 - 1455.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2006 by The Endocrine Society