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This version published online on October 3, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-1100
A more recent version of this article appeared on December 1, 2006
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Submitted on May 22, 2006
Accepted on September 26, 2006

Association of Interleukin-8 with Hot Flashes in Pre-, Peri- and Postmenopausal Women and Bilateral Oophorectomized Women

Toshiyuki Yasui*, Hirokazu Uemura, Junko Tomita, Yuka Miyatani, Masayo Yamada, Akira Kuwahara, Toshiya Matsuzaki, Masahiko Maegawa, Naoko Tsuchiya, Mitsutoshi Yuzurihara, Shuichi Takeda, and Minoru Irahara

Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan; Pharmacology Research Department, Tsumura Central Research Institute, 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan; Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

* To whom correspondence should be addressed. E-mail: yasui{at}clin.med.tokushima-u.ac.jp.

Objective: The purpose of this study was to identify serum cytokine concentrations in pre-, peri- and postmenopausal women and bilateral oophorectomized women with hot flashes.

Methods: Serum concentrations of 17 cytokines were simultaneously measured using a multiplexed human cytokine assay in 129 pre-, peri-, postmenopausal and 50 bilateral oophorectomized women.

Results: Serum interleukin (IL)-8 concentrations in midlife women and bilateral oophorectomized women with severe hot flashes were significantly higher than the concentrations in women without hot flashes and women with mild and moderate hot flashes. Serum macrophage inflammatory protein (MIP)-1{beta} concentration in women with severe hot flashes was significantly higher than those in women without hot flashes and women with mild and moderate hot flashes.

Conclusion: Serum IL-8 concentrations in pre-, peri- and postmenopausal women and bilateral oophorectomized women with hot flashes were significantly higher than those in women without hot flashes. IL-8 may be associated with peripheral vasodilation in women with hot flashes.
Key words: hot flashes • interleukin-8 • midlife women • bilateral oophorectomized women




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