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This version published online on July 18, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-1079
A more recent version of this article appeared on October 1, 2006
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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*MENOTROPINS
*TESTOSTERONE

Submitted on May 18, 2006
Accepted on July 7, 2006

Time course of the serum gonadotropin surge, inhibins and anti-müllerian hormone (AMH) in normal newborn males during the first month of life

Ignacio Bergadá, Carlos Milani, Patricia Bedecarrás, Luz Andreone, M. Gabriela Ropelato, Silvia Gottlieb, César Bergadá, Stella Campo, and Rodolfo A. Rey*

Centro de Investigaciones Endocrinológicas and División de Endocrinología, Hospital de Niños R. Gutiérrez, C1425EFD Buenos Aires (I.B., C.M., P.B., L.A., M.G.R., S.G., C.B., S.C., R.A.R.), Instituto de Análisis Clínicos, 6000 Junín (C.M.), and Departamento de Histología, Biología Celular, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires (RAR), Argentina

* To whom correspondence should be addressed. E-mail: rodolforey{at}cedie.org.ar.

Context. Newborns with ambiguous genitalia or males with non palpable gonads usually require an early assessment of the presence and functional state of testicular tissue.

Objective. To characterize the precise ontogeny of the serum patterns of gonadotropins, testosterone, AMH and inhibins in normal newborn boys.

Design. Cross-sectional and longitudinal study.

Subjects. Serum samples were obtained in 57 boys and 13 girls at day 2 of life. A second sample was obtained at days 7, 10, 15, 20 and 30 (boys), and at day 30 (girls).

Main Outcome Measures. Serum levels of gonadotropins, testosterone, AMH and inhibins.

Results. In males, LH and FSH were undetectable or very low at D2. By D7, LH increased to 3.94 ± 3.19 IU/L (mean ± SD) and FSH to 2.04 ± 1.67 IU/L. LH/FSH ratio was 0.40 ± 0.11 (D2) and 2.02 ± 0.20 (D30). AMH rose from 371 ± 168 pmol/L (D2) to 699 ± 245 pmol/L (D30), and inhibin B from 214 ± 86 ng/L (D2) to 361 ± 93 ng/L (D30). Pro-{alpha}C remained stable during the first month of life. Testosterone levels were 66 ± 42 ng/dL (D2), 82 ± 24 ng/dL (D20) and 210 ± 130 ng/dL (D30). A sexual dimorphism was observed in AMH and inhibin B (lower in girls at D2 and D30), in LH/FSH ratio (lower in girls at D30) and in testosterone (lower in girls at D30).

Conclusions. Sertoli cell markers AMH and inhibin B are the earliest useful markers indicating the existence of normal testicular tissue.
Key words: FSH • LH • Müllerian inhibiting substance • testis • hypothalamic-pituitary-gonadal axis




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