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Submitted on May 15, 2006
Accepted on September 8, 2006
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan; Kanagawa Health Service Association, Japan
* To whom correspondence should be addressed. E-mail: kdobashi{at}med.uoeh-u.ac.jp.
Context: Japanese are prone to obesity-induced metabolic derangement, which is linked to serum adipocytokine profile even in children.
Objective: To determine whether high molecular weight adiponectin (H-Adn) more specifically relates to metabolic derangement in obese children than total adiponectin (T-Adn).
Design & Setting: A case (n = 59) control (n = 28) study was performed at pediatric clinic of university hospital.
Patients: Japanese obese children (38 boys and 21 girls) were consecutively enrolled. The age ranged from 5 to 15 (10.3 ± 0.3; mean ± SEM) years. Nonobese children (15 boys and 13 girls) were assigned as age-matched control.
Main Outcome Measures: Serum adiponectin multimeric complexes were assayed by an ELISA kit. Its relationship to metabolic abnormalities was evaluated.
Results: T-Adn (5.1 ± 0.2 vs. 8.8 ± 0.4 µg/ml), H-Adn (1.3 ± 0.1 vs. 4.8 ± 0.4 µg/ml) and medium molecular weight-Adn were significantly lower in obese than in control children. After adjustment for age and sex, both T- and H-Adn were inversely correlated with insulin and HOMA-IR, while H-Adn (but not T-Adn) inversely correlated with visceral fat area, as determined by CT. Seven obese children were estimated to have metabolic syndrome (MS), and showed selective decrease in H-Adn and H/T-Adn.
Conclusion: H-Adn reflects metabolic abnormalities due to obesity better than T-Adn in children. H-Adn is associated with the development of MS, even in childhood.
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