help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
This version published online on July 11, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-0544
A more recent version of this article appeared on October 1, 2006
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
91/10/3780    most recent
Author Manuscript (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow View responses
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grewal, J.
Right arrow Articles by Lin, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grewal, J.
Right arrow Articles by Lin, X.

Submitted on March 13, 2006
Accepted on July 5, 2006

LOW BONE MINERAL DENSITY IN THE EARLY MENOPAUSAL TRANSITION: ROLE FOR OVULATORY FUNCTION

Jagteshwar Grewal PhD, MaryFran R. Sowers PhD*, John F. Randolph Jr MD, Sioban D. Harlow PhD, and Xihong Lin PhD

University of Michigan, Department of Epidemiology, School of Public Health, Ann Arbor, Michigan, USA; University of Michigan, Department of Obstetrics and Gynecology, Ann Arbor, Michigan, USA; University of Michigan, Department of Biostatistics, School of Public Health, Ann Arbor, Michigan, USA

* To whom correspondence should be addressed. E-mail: mfsowers{at}umich.edu.

Objective and Context: To determine if luteal abnormalities or measures of sex steroid hormones collected across a menstrual cycle were associated with bone mineral density (BMD) at the total hip or lumbar spine.

Design and Setting: The Study of Women's Health Across the Nation (SWAN) is a longitudinal, community-based study conducted at seven clinical sites. SWAN includes a Daily Hormone Study sub-study in which daily urine samples are collected for one menstrual cycle (up to a maximum of 50 days) each year.

Participants: 643 pre- and peri-menopausal women, aged 43-53 yr.

Main Outcome Measures: BMD of the lumbar spine and total hip was measured by dual energy x-ray densitometry. Daily urine samples were assayed for estrone conjugates (uE1C), pregnanediol glucuronide (uPdG), LH (uLH), and follicle-stimulating hormone (uFSH) and the information from across the menstrual cycle expressed as area under the curve (AUC). BMD levels were evaluated in relation to three menstrual cycle attributes: (1) absence or presence of ovulation; (2) luteal phase length to menstrual cycle length ratio; and (3) ovulatory disturbances, defined as anovulatory cycles or cycles with short luteal phases (<10 days).

Results: Lower uE1C AUC and higher uFSH AUC were significantly associated with lower BMD. However, luteal abnormalities based on menstrual cycle attributes were not significantly associated with BMD at the total hip or lumbar spine, following adjustment for age, BMI, urinary hormone concentrations, menopausal status, and race/ethnicity.

Conclusions: Direct measures of urinary hormones, not menstrual cycle luteal abnormalities, were associated with lower levels of BMD.
Key words: bone mineral density • menstrual cycle • menopausal transition




eLetters:

Read all eLetters

RE: Failure to find a Cross-Sectional Bone-Ovulation Relationship in SWAN
Shirin Kalyan, et al.
JCEM Online, 12 Feb 2007 [Full text]

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2006 by The Endocrine Society