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Submitted on February 21, 2006
Accepted on April 25, 2006
Unit of Paediatric and Perinatal Epidemiology, Department of Community-Based Medicine, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ; Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR; Department of Paediatrics, University of Cambridge, Addenbrookes Hospital, Level 8, Box 116, Cambridge, CB2 2QQ; Division of Surgery, University of Bristol, Bristol, BS8 2HW
* To whom correspondence should be addressed. E-mail: Imogen.Rogers{at}bristol.ac.uk.
Objective: Insulin-like growth factor I (IGF-I), a major regulator of childhood growth, is also associated with the risk of several cancers in adult life. Adult height and particularly leg length are also associated with cancer risk. Prepubertal growth is more in leg than trunk length, and it has been suggested that leg length might be a biomarker of childhood IGF-I. However, there is little information on the association between childhood IGF-I and subsequent leg and trunk growth. In this study we investigated the association of IGF-I measured at 5y and 7-8y with growth in height and the components of height (leg and trunk length) from 5y to 9-10y.
Participants: 675 children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC).
Results: IGF-I was strongly positively associated with growth in height in both sexes. Among boys, IGF-I was strongly associated with subsequent growth in both leg and trunk length, but there was no evidence that IGF-I was more strongly associated with one component of growth than the other. Among girls IGF-I was strongly positively associated with growth in trunk but not leg length, although there was only weak evidence that these two associations differed in strength (P = 0.058).
Conclusions: These results support the contention that the associations between height and cancer may be mediated by variation in childhood IGF-I. However, they provide no evidence to support the hypothesis that leg length is a better biomarker of childhood IGF-I levels than trunk length.
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