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This version published online on June 6, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-0218
A more recent version of this article appeared on September 1, 2006
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Submitted on January 31, 2006
Accepted on May 30, 2006

Impaired sexual activity in male adults with partial androgen insensitivity

Claire Bouvattier, Brigitte Mignot, Hervé Lefèvre, Yves Morel, and Pierre Bougnères*

Pediatric Endocrinology, Hôpital Cochin-Saint Vincent de Paul, APHP and Université Paris V, Paris, France; Biochemistry and Molecular Biology, Hôpital Debrousse, Lyon, France

* To whom correspondence should be addressed. E-mail: pierre.bougneres{at}paris5.inserm.fr.

Context: Choosing the sex of rearing of a XY neonate with a major sexual ambiguity and a mutated androgen receptor (AR) remains one of the more difficult question of neonatal endocrinology. A direct consequence of this choice is the accomplishment of sexual function in adulthood. There is a very limited knowledge of the sexual performances of patients with partial androgen insensitivity (PAIS).

Objective: Describe physical acts of sexuality in PAIS patients reared as males.

Design: We were able to obtain factual information regarding the sexual activity of 15 adult patients who had been reared as males and followed at our institution since birth. We evaluated their sexual performances using two validated questionnaires (GRISS and IIEF-5),

Results: We documented a major impairment of all parameters of sexual activity.

Conclusion: This long-term insight into the consequences of male sex assignment will have to be balanced by a study of the consequences of female sex assignment.






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