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Submitted on January 31, 2006
Accepted on May 26, 2006
Department of Molecular & Clinical Endocrinology and Oncology (F.O. Jr, T.C., L.V., G.L., A.C.), University "Federico II" Naples, Italy; Department of Clinical Medicine (F.G., C.V.), Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, University "Federico II" Naples, Italy; Department of Obstetrics and Gynecology (S.P., T.R.), University "Magna Graecia" of Catanzaro, Catanzaro, Italy; Gastroenterology Unit (F.M.), "Cardarelli" Hospital, Naples, Italy, Department of Obstetrics and Gynecology (A.T.), University "Federico II" Naples, Italy
* To whom correspondence should be addressed. E-mail: francescoorio{at}virgilio.it.
Context: Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and it is related to mitochondrial function, particularly with maximal oxygen consumption (VO2max). At the moment no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed.
Objective: To assess cardiopulmonary functional capacity in young PCOS overweight patients.
Design: Prospective baseline-controlled clinical study.
Setting: University "Federico II" of Naples, School of Medicine (Italy).
Patients: Forty-five PCOS patients matched with 45 healthy women mean age (21.3 ± 2.0 vs. 21.6 ± 1.9, yrs±SD, respectively) and body mass index (29.4 ± 3.6 vs. 29.0 ± 3.4, kg/m2±SD, respectively).
Mean Outcome Measures: Hormonal and metabolic pattern, and functional capacity by cardiopulmonary exercise testing evaluating: maximal oxygen consumption (VO2max), oxygen consumption at anaerobic threshold (VO2AT), and the maximal workload at peak exercise (Wattmax).
Results: VO2max (17.±3.7 vs. 26.8 ± 3.5, ml/Kg/min), VO2AT (13.9 ± 3.0 vs. 21.2 ± 3.8, ml/Kg/min), and Wattmax (101.3 ± 25.2 vs. 135 ± 22.6, W) resulted significantly (P < 0.001) reduced in PCOS subjects compared with healthy women. The multiple linear regression analysis showed that only homeostasis model assessment (HOMA) appears to have a strong negative linear relation with VO2max in PCOS. No relation was found in controls.
Conclusions: Our data firstly demonstrate a reduced cardiopulmonary functional capacity in young PCOS patients.
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