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This version published online on March 28, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-0108
A more recent version of this article appeared on June 1, 2006
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*Compound via MeSH
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Medline Plus Health Information
*Diabetes Type 1
Hazardous Substances DB
*TESTOSTERONE

Submitted on January 18, 2006
Accepted on March 22, 2006

DIAGNOSTIC CRITERIA FOR POLYCYSTIC OVARY SYNDROME AND OVARIAN MORPHOLOGY IN WOMEN WITH TYPE 1 DIABETES MELLITUS

ETHEL CODNER*, NESTOR SOTO, PATRICIA LOPEZ, LEÓN TREJO, ALEJANDRA ÁVILA, FRANCISCA C. EYZAGUIRRE, GERMÁN ÍNIGUEZ, and FERNANDO CASSORLA

Institute of Maternal and Child Research (I.D.I.M.I.), School of Medicine, University of Chile (EC, PL, LT, FCE GI, FC), Santiago, 836-0160 and Hospital San Borja Arriarán (NS, AA), Santiago, Chile 836-0160

* To whom correspondence should be addressed. E-mail: ecodner{at}med.uchile.cl.

Context: The criteria for diagnosis of polycystic ovary syndrome (PCOS) have been modified and now include polycystic ovary morphology (PCOM).

Objective: The purpose of this study was to determine the frequency of PCOS and PCOM in women with DM1.

Design. We evaluated the clinical, hormonal and ultrasonographic characteristics in women with DM1, and compared them to a carefully matched group of normal women in a cross-sectional study.

Setting. Academic research institute located within a General Hospital.

Patients: All the women with DM1 attending our hospital, who had experienced menarche at least 2.5 yr earlier, were invited to participate and compared with healthy women with regular menses and without a history of hyperandrogenism (C).

Results: Hirsutism was present in 28.6% and 0.0% of DM1 and C, respectively (P < 0.001). Biochemical hyperandrogenism was present in 23.8 and 7.9% of DM1 and C, respectively. DM1 women had higher levels of testosterone, androstenedione, larger ovarian volume, and follicle number by ovary than C. PCOM was present in 54.8% of DM1 and 13.2% of C (P < 0.001). Oligomenorrhea was present in 19% of women with DM1. The frequency of PCOS was 40.5% and 2.6% in DM1 and C, respectively (relative risk: 15.4; 95% confidence interval: 2.2-110.2; P < 0.0001). The proportion of women using intensive insulin treatment was higher in women with PCOM/PCOS (P < 0.05). Intensive treatment was a significant factor over having PCOM/PCOS (P < 0.05).

Conclusions: A high frequency of hyperandrogenism, PCOM and PCOS is observed in DM1, which appears to be associated with intensive insulin treatment.
Key words: Polycystic Ovary Syndrome • Type 1 Diabetes Mellitus • ultrasonography • hyperandrogenism • hirsutism • polycystic ovary syndrome morphology




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