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Submitted on January 3, 2006
Accepted on June 12, 2006
Department of Endocrinology and Metabolic Diseases C4-R, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands
* To whom correspondence should be addressed. E-mail: o.m.dekkers{at}lumc.nl.
Objective. Although a reduced quality of life (QoL) has been reported after long-term cure of functioning pituitary adenomas, the effect of successful treatment of non-functioning pituitary macroadenoma (NFMA) on QoL has not been fully addressed. Therefore, we evaluated a broad spectrum of QoL parameters in patients successfully treated for NFMA in our center.
Design. Case-control study.
Patients and Methods. We assessed QoL in 99 adult patients (mean age 61.9, range 24-86 yr), in remission during long-term follow up after surgical (n = 99) and additional radiotherapeutical (n = 37) treatment for NFMA by four validated health-related questionnaires (HADS, MFI-20, NHP, SF-36). Patient outcomes were compared with 125 controls and to age-adjusted reference values derived from literature.
Results. NFMA patients reported significantly impaired QoL in all questionnaires, compared with the 125 controls and the age-adjusted reference values. All subscales of fatigue, assessed using the MFI-20 (general fatigue, physical fatigue, reduction in activity, reduction in motivation, mental fatigue) were impaired. The scores in the NHP pointed toward reduced energy and affected emotional reaction. In several subscales of the SF-36 (social functioning, role limitations due to physical problems, role limitations due to emotional problems and general health perception) NFMA patients reported a reduced QoL.
Conclusion Quality of Life is considerably reduced in patients after successful treatment of NFMA.
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