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This version published online on October 3, 2006
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2005-2846
A more recent version of this article appeared on December 1, 2006
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Submitted on December 30, 2005
Accepted on September 27, 2006

Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta

KOZO KADOWAKI*, MASAKO WAGURI, ISAO NAKANISHI, YOSHIHIRO MIYASHITA, MASAHIRO NAKAYAMA, NORIYUKI SUEHARA, TOHRU FUNAHASHI, IICHIROU SHIMOMURA, and TOMIO FUJITA

Department of Obstetrics(K.K., N.S.), Internal Medicine(M.W.,I.N.,Y.M.,Tom.F) and Pathology(M.N.), Osaka Medical Center and Research Institute for Maternal and Child health, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan and the Department of Internal Medicine and Molecular Science(Toh.F.,I.S.), Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan

* To whom correspondence should be addressed. E-mail: kozo1223{at}aol.com.

Context: Adiponectin(APN) concentration in umbilical cord serum is higher than that in adult serum. Except for the positive association between birth weight and cord APN concentration, little is known about the pathophysiological function of APN in fetal development.

Objective: The objective of this study is to evaluate the relationship of cord serum APN and IGF-I concentrations with the development of the fetoplacental unit.

Design and Methods: Umbilical cord serum APN and IGF-I concentrations were measured in term singleton deliveries (n = 94). The association of cord APN and IGF-I concentrations were evaluated in relation to fetal weight, placental weight and fetoplacental (F/P) weight ratio.

Results: Mean concentrations and SD of APN and IGF-I were 36.1 ±14.0(µg/ml) and 58.6±27.0(ng/ml) respectively. Cord APN concentration was positively associated with F/P weight ratio(r=0.375,P < 0.001) as well as fetal weight(r=0.389,P < 0.001) but not with placental weight. Cord IGF-I concentration was positively associated with fetal weight(r=0.405,P < 0.001) and placental weight(r=0.400,P < 0.001) but not with F/P weight ratio. In multiregression analysis, only APN concentration resulted in a significant determinant of F/P weight ratio among variables({beta}=0.376, P < 0.001).

Conclusion: In cord hyperadiponectinemia fetuses tend to be disproportionately larger for their placental weight and vice versa in cord hypoadiponectinemia. Adiponectin is shown to be the first biomarker positively associated with fetoplacental weight ratio.
Key words: Adiponectin • IGF • Fetus • Fetoplacental weight ratio • Placenta • Barker • hypertension • diabetes mellitus • metabolic disease




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S. M. Nelson, D. J. Freeman, N. Sattar, and R. S. Lindsay
Role of Adiponectin in Matching of Fetal and Placental Weight in Mothers With Type 1 Diabetes
Diabetes Care, June 1, 2008; 31(6): 1123 - 1125.
[Abstract] [Full Text] [PDF]


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